• Biomolecules & Therapeutics
• /
• v.3 no.3
• /
• pp.177-181
• /
• 1995

To investigate the possibility of Panax ginseng as a therapeutic agent for the immune suppression, ginseng total saponin (GTS) extracted from korean red ginseng was tested on immune functions from morphine-induced immune suppressed mice. To study how immune functions are affected by morphine and also to test whether GTS can be an useful therapeutic agent for morphine toxicity, several parameters were employed, body weight, immune organ weight, B cell functions, and T cell function. Morphine impaired the development of body weight and immune organ weight such as spleen and thymus. Morphine also depressed a B-cell function, antibody production. T-cell functions studied by type IV hypersensitivity test were most markedly affected by morphine treatment. GTS restored most of morphine-induced immune suppression. GTS restored the morphine-induced decrease in spleen weight to body weight ratio in a dose dependent manner, but not the body weight decrease. Also all of the morphine-induced impairments of B cell functions and cellmediated immunity were fully recovered by GTS. These results suggest that ginseng product could be very helpful for the treatment of immune suppression occurring in morphine abusers.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.17 no.4
• /
• pp.89-95
• /
• 2007

There are various methods constructing correlation immune functions such as Siegenthaler's, Camion et al's and Seberry et al's. In particular, Soberry et al's is a method which directly constructs balanced correlation immune functions of any order using the theory of Hadamard matrices. In this paper, we have studied Seberry et al's method for constructing a correlation immune function on a higher dimensional space by combining known correlation immune functions on a lower dimensional space. Futhermore, we calculated the nonlinearity of functions which are constructed by combining of several correlation immune functions. That is, we have shown that the direct sum of two correlation immune functions and a combination of four correlation immune functions have higher nonlinearity in comparison with each functions. This functions in stream cipher are safe against correlation attacks.

• ETRI Journal
• /
• v.19 no.4
• /
• pp.389-401
• /
• 1997

In this paper, we consider the relationship between nonlinearity and correlation immunity of Boolean functions. In particular, we discuss the nonlinearity of correlation immune functions suggested by P. Camion et al. For the analysis of such functions, we present a simple method of generating the same set of functions, which makes it possible to construct correlation immune functions with controllable correlation immunity and nonlinearity. Also, we find a bound for the correlation immunity of functions having maximal nonlinearity.

• The Transactions of the Korean Institute of Electrical Engineers D
• /
• v.52 no.5
• /
• pp.259-267
• /
• 2003

In this paper, we propose a nonlinear variable PID controller using a cell-mediated immune response. An immune feedback response is based on the functioning of biological T-cells. An immune feedback response and P-controller of conventional PID controllers resemble each other in role and mechanism. Therefore, we extend immune feedback mechanism to nonlinear PE controller. And in order to choose the optimal nonlinear PID controller games, we also propose the on-line tuning algorithm of nonlinear functions parameters in immune feedback mechanism. The trained parameters of nonlinear functions are adapted to the variations of the system parameters and any command velocity. And the adapted parameters obtained outputs of nonlinear functions with an optimal control performance. To verify performances of the proposed control systems, the speed control of nonlinear BC motor is performed. The simulation results show that the proposed control systems are effective in tracking a command velocity under system variations.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.7 no.2
• /
• pp.3-10
• /
• 1997

Correlation immune functions can be used not only as filter functions or nonlinear combiners in stream ciphers but also as a primitive logic in block cipher. In this paper, we suggest a construction method of correlation immune functions. Using this method, we find lower and upper bound of the cardinality of the correlation immune functions. This result improves Mitchell's result and Yang-Guo's result.

• Korean Journal of Poultry Science
• /
• v.34 no.4
• /
• pp.295-300
• /
• 2007

In addition to reduction in performance, immune functions are reduced in chickens under stress. These birds are more likely to be vulnerable to diseases compared with those raised under better environmental conditions and thus to require medication more frequently to cope with the diseases. In this review, two of the stress markers frequently used in chickens are exemplified first, followed by relationship between stress and immune functions, and the effects of stress on performance and immune functions.

• BMB Reports
• /
• v.35 no.6
• /
• pp.537-546
• /
• 2002

NF-${\kappa}B$/Rel transcription factor family participates in diverse biological processes including embryo development, hematopoiesis, immune regulation, as well as neuronal functions. In this review, the NF-${\kappa}B$/Rel signal transduction pathways and their important roles in the regulation of immune system will be discussed. NF-${\kappa}B$/Rel members execute distinct functions in multiple immune cell types via the regulation of target genes essential for cell proliferation, survival, effector functions, cell trafficking and communication, as well as the formation of lymphoid architecture. Consequently, proper activation of NF-${\kappa}B$/Rel during immune responses to allergens, auto-antigens, allo-antigens, and pathogenic infection is crucial for the integrity of host innate and adaptive immunity.

• 제어로봇시스템학회:학술대회논문집
• /
• 2004.08a
• /
• pp.1296-1301
• /
• 2004

Fuzzy logic, neural network, fuzzy-neural network play an important as the key technology of linguistic modeling for intelligent control and decision making in complex systems. The fuzzy -neural network (FNN) learning represents one of the most effective algorithms to build such linguistic models. This paper proposes learning approach of fuzzy-neural network by immune algorithm. The proposed learning model is presented in an immune based fuzzy-neural network (FNN) form which can handle linguistic knowledge by immune algorithm. The learning algorithm of an immune based FNN is composed of two phases. The first phase used to find the initial membership functions of the fuzzy neural network model. In the second phase, a new immune algorithm based optimization is proposed for tuning of membership functions and structure of the proposed model.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 2004.10a
• /
• pp.303-308
• /
• 2004

Fuzzy logic, neural network, fuzzy-neural network play an important as the key technology of linguistic modeling for intelligent control and decision making in complex systems. The fuzzy-neural network (FNN) learning represents one of the most effective algorithms to build such linguistic models. This paper proposes learning approach of fuzzy-neural network by immune algorithm. The proposed learning model is presented in an immune based fuzzy-neural network (FNN) form which can handle linguistic knowledge by immune algorithm. The learning algorithm of an immune based FNN is composed of two phases. The first phase used to find the initial membership functions of the fuzzy neural network model. In the second phase, a new immune algorithm based optimization is proposed for tuning of membership functions and structure of the proposed model.

• Journal of Microbiology and Biotechnology
• /
• v.33 no.3
• /
• pp.288-298
• /
• 2023

Host defense peptides are expressed in various immune cells, including phagocytic cells and epithelial cells. These peptides selectively alter innate immune pathways in response to infections by pathogens, such as bacteria, fungi, and viruses, and modify the subsequent adaptive immune environment. Consequently, they play a wide range of roles in both innate and adaptive immune responses. These peptides are of increasing importance due to their broad-spectrum antimicrobial activity and their functions as mediators linking innate and adaptive immune responses. This review focuses on the pleiotropic biological functions and related mechanisms of action of human host defense peptides and discusses their potential clinical applications.