• Korean Journal of Digital Imaging in Medicine
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• v.1 no.1
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• pp.1-7
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• 1995

• Korean Journal of Radiology
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• v.22 no.11
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• pp.1858-1874
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• 2021

Recent advances in the molecular and genetic characterization of central nervous system (CNS) tumors have ushered in a new era of tumor classification, diagnosis, and prognostic assessment. In this emerging and rapidly evolving molecular genetic era, imaging plays a critical role in the preoperative diagnosis and surgical planning, molecular marker prediction, targeted treatment planning, and post-therapy assessment of CNS tumors. This review provides an overview of the current imaging methods relevant to the molecular genetic classification of CNS tumors. Specifically, we focused on 1) the correlates between imaging features and specific molecular genetic markers and 2) the post-therapy imaging used for therapeutic assessment.

• Korean Journal of Optics and Photonics
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• v.7 no.3
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• pp.183-190
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• 1996

To design three-mirror telescope system (F/8, 120 inch in focal length) for visible and infra-red band imaging, methods for power configuring and correction of the third order aberrations were studied. In the design of the telescope system, a three-mirror system corrected for spherical aberration, coma, and astigmatism was used for infra-red imaging, and the aberrations were corrected by using conic surfaces. For visible imaging, a singlet corrector lens was appended at the front of the focal plane to correct filed curvature. The telescope system has diffraction limited performance for 10 ${\mu}{\textrm}{m}$ in wavelength within 2.4$^{\circ}$ of field-of-view. In the visible band imaging, the rms spot size of the telescope system is less than 25 ${\mu}{\textrm}{m}$ within 3$^{\circ}$ of field-of-view for monochromatic light, and the telescope system satisfies flat field condition for CCD application.

• Proceedings of the Korean Vacuum Society Conference
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• 2015.08a
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• pp.51.2-51.2
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• 2015

Understanding interfacial phenomena has been one of the main research issues not only in semiconductors but only in life sciences. I have been trying to meet the atomic scale surface and interface analysis challenges from semiconductor industries and furthermore to extend the application scope to biomedical areas. Optical imaing has been most widely and successfully used for biomedical imaging but complementary ion beam imaging techniques based on mass spectrometry and ion scattering can provide more detailed molecular specific and nanoscale information In this presentation, I will review the 27 years history of medium energy ion scattering (MEIS) development at KRISS and DGIST for nanoanalysis. A electrostatic MEIS system constructed at KRISS after the FOM, Netherland design had been successfully applied for the gate oxide analysis and quantitative surface analysis. Recenlty, we developed time-of-flight (TOF) MEIS system, for the first time in the world. With TOF-MEIS, we reported quantitative compositional profiling with single atomic layer resolution for 0.5~3 nm CdSe/ZnS conjugated QDs and ultra shallow junctions and FINFET's of As implanted Si. With this new TOF-MEIS nano analysis technique, details of nano-structured materials could be measured quantitatively. Progresses in TOF-MEIS analysis in various nano & bio technology will be discussed. For last 10 years, I have been trying to develop multimodal nanobio imaging techniques for cardiovascular and brain tissues. Firstly, in atherosclerotic plaque imaging, using, coherent anti-stokes raman scattering (CARS) and time-of-flight secondary ion mass spectrometry (TOF-SIMS) multimodal analysis showed that increased cholesterol palmitate may contribute to the formation of a necrotic core by increasing cell death. Secondly, surface plasmon resonance imaging ellipsometry (SPRIE) was developed for cell biointerface imaging of cell adhesion, migration, and infiltration dynamics for HUVEC, CASMC, and T cells. Thirdly, we developed an ambient mass spectrometric imaging system for live cells and tissues. Preliminary results on mouse brain hippocampus and hypotahlamus will be presented. In conclusions, multimodal optical and mass spectrometric imaging privides overall structural and morphological information with complementary molecular specific information, which can be a useful methodology for biomedical studies. Future challenges in optical and mass spectrometric imaging for new biomedical applications will be discussed.

• Current Optics and Photonics
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• v.8 no.4
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• pp.355-365
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• 2024

Wavefront coding (WFC) imaging systems can redistribute the energy of an interference laser spot on an image plane sensor by wavefront phase modulation and reduce the peak intensity, realizing laser protection while maintaining imaging functionality by leveraging algorithmic post-processing. In this paper, a spiral axicon WFC imaging system is proposed, and the performance for laser protection is investigated by constructing a laser transmission model. An Airy disk on an image plane sensor is refactored into a symmetrical hollow ring by a spiral axicon phase mask, and the maximum intensity can be reduced to lower than 1% and single-pixel power to 1.2%. The spiral axicon phase mask exhibits strong robustness to the position of the interference laser source and can effectively reduce the risk of sensor damage for an almost arbitrary lase propagation distance. Moreover, we revealed that there is a sensor hazard distance for both conventional and WFC imaging systems where the maximum single-pixel power reaches a peak value under irradiation of a power-fixed laser source. Our findings can offer guidance for the anti-laser reinforcement design of photoelectric imaging systems, thereby enhancing the adaptability of imaging systems in a complex laser environment. The laser blinding-resistant imaging system has potential applications in security monitoring, autonomous driving, and intense-laser-pulse experiments.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08b
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• pp.1239-1241
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• 2007

In this paper, we present a tiled display system for tangible meeting. We built our system as a distributed system and use GPU based warping and image blending technique for real-time processing. For efficiency, we update specific area only, where the remote user exist, in real-time and blended it with static panoramic image of remote site.

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.1314-1317
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• 2006

The problem of the conflict between eye convergence and accommodation can be induced at Stereoscopic or multi-view 3D display system using binocular disparity. A multi-focus 3D display system was developed, which can solve the problem. LEDs are used instead of galvano scanner and laser to avoid mechanical moving part at the 3D display system.

• Journal of Korea Multimedia Society
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• v.15 no.10
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• pp.1264-1272
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• 2012

Three-dimensional volume rendering method which shows the inside of human body is widely used in medical imaging area. Existing medical imaging system using a volume rendering method already has provided a variety of three-dimensional results. Recently existing results in the medical imaging among physicians and patients to facilitate communication have been studied since smart device which has advantage of portability applied in the medical imaging. In this paper, we propose 3D volume visualization system for a relatively low spec portable smart devices by using 2D textures and we also implements 2D diagnostic images of portable medical imaging visualization system.

• Nuclear Engineering and Technology
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• v.55 no.10
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• pp.3844-3853
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• 2023

Although radiation and chemotherapy methods for cancer therapy have advanced significantly, surgical resection is still recommended for most cancers. Therefore, intraoperative imaging studies have emerged as a surgical tool for identifying tumor margins. Intraoperative imaging has been examined using conventional imaging devices, such as optical near-infrared probes, gamma probes, and ultrasound devices. However, each modality has its limitations, such as depth penetration and spatial resolution. To overcome these limitations, hybrid imaging modalities and tracer studies are being developed. In a previous study, a multi-modal laparoscope with silicon photo-multiplier (SiPM)-based gamma detection acquired a 1 s interval gamma image. However, improvements in the near-infrared fluorophore (NIRF) signal intensity and gamma image central defects are needed to further evaluate the usefulness of multi-modal systems. In this study, an attempt was made to change the NIRF image acquisition method and the SiPM-based gamma detector to improve the source detection ability and reduce the image acquisition time. The performance of the multi-modal system using a complementary metal oxide semiconductor and modified SiPM gamma detector was evaluated in a phantom test. In future studies, a multi-modal system will be further optimized for pilot preclinical studies.

• 한국정보디스플레이학회:학술대회논문집
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• 2007.08b
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• pp.1235-1238
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• 2007

There are several researches on 2D gaze tracking techniques to the 2D screen for the Human-Computer Interaction. However, the researches for the gaze-based interaction to the stereo images or 3D contents are not reported. This paper presents a gaze-based 3D interaction technique on autostereoscopic display system.