• Radiation Oncology Journal
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• 제29권3호
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• pp.147-155
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• 2011

Purpose: This study was designed to determine the influencing factors and clinical course of pathologically proven cases of radiation-induced brain injury (RIBI). Materials and Methods: The pathologic records of twelve patients were reviewed; these patients underwent surgery following radiotherapy due to disease progression found by follow-up imaging. However, they were finally diagnosed with RIBI. All patients had been treated with 3-dimensional conventional fractionated radiotherapy and/or radiosurgery for primary or metastatic brain tumors with or without chemotherapy. The histological distribution was as follows: two falx meningioma, six glioblastoma multiform (GBM), two anaplastic oligodendroglioma, one low grade oligodendroglioma, and one small cell lung cancer with brain metastasis. Results: Radiation necrosis was noted in eight patients and the remaining four were diagnosed with radiation change. Gender (p = 0.061) and biologically equivalent dose $(BED)_3$ (p = 0.084) were the only marginally influencing factors of radiation necrosis. Median time to RIBI was 7.3 months (range, 0.5 to 61 months). Three prolonged survivors with GBM were observed. In the subgroup analysis of high grade gliomas, RIBI that developed <6 months after radiotherapy was associated with inferior overall survival rates compared to cases of RIBI that occurred ${\geq}6$ months (p = 0.085). Conclusion: Our study demonstrated that RIBI could occur in early periods after conventional fractionated brain radiotherapy within normal tolerable dose ranges. Studies with a larger number of patients are required to identify the strong influencing factors for RIBI development.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제31권6호
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• pp.461-468
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• 2009

Purpose: Platelet derived growth factor(PDGF)-BB and bone morphogenetic protein(BMP)-2 are well-known representative growth factors. The purposes of this study were to investigate the effect of rhPDGFBB and rhBMP-2 on osseointegration of titanium implants at periimplant bone defects grafted with hydroxyapatite and to evaluate the feasibility of imaging bone structures around screw-type titanium implant with micro-CT. Materials and Methods: The first molar and all premolars in the mandible region of four beagle dogs were extracted. Following a healing period of 4 months, three $8{\times}8{\times}6mm$-sized bony defects were formed and screw-type titanium implants were placed with hydroxyapatite(HA) block and growth factors; Control group, PDGF group and BMP group. Two months post-implantation, the mandible was harvested. Bone volume(BV), bone-to-implant contact(BIC) and bone mineral density(BMD) were analyzed with micro-CT and histology. Results: According to micro-CT analysis, BV and BMD measures of PDGF and BMP group were significantly higher than control group(BV; PDGF group: $p{\fallingdotseq}0.011$, BMP group: $p{\fallingdotseq}0.006$/BMD; PDGF group: $p{\fallingdotseq}0.020$, BMP group: $p{\fallingdotseq}0.011$) and BIC measures of BMP group were significantly higher than PDGF group($p{\fallingdotseq}0.015$). In histologic evaluation, BIC measures of BMP group was significantly higher than PDGF group($p{\fallingdotseq}0.048$). The values of BV in histologic sections were higher than in micro-CT images and the values of BIC in micro-CT images were higher than in histologic sections. Conclusion: The findings of this experimental study indicates that the use of rhPDGF-BB and rhBMP-2 can increase new bone formation in a large bony defect around titanium implant, and rhBMP-2 is more effective than rhPDGF-BB. Micro-CT can be considered useful for assessment as a rapid and nondestructive method for 3-dimensional measurement of bone healing around implants. Further study is necessary, however, to remove metal artifacts around titanium implant and to standardize the method.

• 한국방사선학회논문지
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• 제2권1호
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• pp.17-21
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• 2008

본 연구에서는 뇌수막종이 늦게 조영증강 된다는 점을 착안하여 뇌수막종을 최대 조영 증강시킨 검사를 시작하였다, 검사 후에 두개내의 수막종과 혈관과의 관계를 알아보고 전산화 단층 촬영 조영술의 3차원 CT 영상 기법(이하, 3차원 CT 영상 기법)과 고식적 혈관 촬영 조영술의 영상을 비교하였다. 연구대상은 3차원 CT 영상 기법과 고식적 혈관 촬영 조영술을 병행 시행하였던 6명의 환자를 대상으로 하였으며. 그 중 추체접형골동사대부 5예, 방시상동에 생긴 1예였다. 검사방법으로는 조영제를 초당 3/120 ml를 주입하여, GE Medical System Program(smart prep)을 이용하여 CT Number 값이 100에 도달한 후, 검사를 시작하였다. 스캔파라미터는 조영제가 모두 주입된 직후에 1.25 mm / 3.75 mm, HQ-Mode로 scan한 후 1 mm interval로 재구성하였다. 검사한 영상을 3D-Med Software Program(Rapidia)을 이용하여 3차원 CT 영상 기법으로 영상을 재구성한 다음 고식적 혈관 촬영 조영술과 비교하였다. 결과를 살펴보면 뇌수막종의 최대조영 시간은 조영제을 주입한 후 약120-180초에 혈관과 종양과의 관계를 가장 잘 구별할 수 있었다. 3차원 CT 영상 기법으로 재구성한 6예는 모두 종양과 혈관과의 관계를 잘 구별할 수 있었다. 또한 종양과 동반된 동맥류도 1예에서 잘 보여주었다. 이를 종합하여 보면 두 개 내 뇌수막종의 환자에서 조영제를 주입하여 3차원 CT 영상을 시행하였던 영상은 종양과 혈관과의 관계를 입체적으로 구분할 수 있어 수술에 많은 도움이 되었다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권6호
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• pp.566-574
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• 2006

Purpose : This study was performed to provide an anatomical information of the mandibular ramus for the successful inferior alveolar nerve block. Three dimensional images were reconstructed from the computerized tomography (CT) and the anatomical evaluation of the mandibular ramus was done. Materials and methods : Sixty-four patients who had been taken the facial CT scans from 2000, Jan to 2003, June was selected. The patients who had the anterior or posterior teeth misssing, edentulous ridge, and jaw fracture were excepted. In the occulusal plane, the lingual surface angle (LSA) between the mid-sagittal plane and the mandibular molar lingual surface from the 2nd premolar to the 2nd molar, the inner ramal surface angle (IRSA), the maximum inner ramal surface angle (MxIRSA), and the outer ramal surface angle (ORSA) to the-mid sagittal plane were measured. The inner ramal surface angle in the ligular tip level (IRSA-L) and the outer ramal surface angle in the ligular tip level (ORSA-L), the ramal length (RL), and the anterior ramal length (ARL) were also measured in the lingular tip level. Results : In the lingular tip level, the mean IRSA-L and ORSA-L were $28.6{\pm}6.3^{\circ}$ and $17.9{\pm}4.9^{\circ}$ respectively. The larger was the IRSA, the larger was the ORSA. In the lingular tip level, the mean ramal length was 35.8${\pm}$3.4 mm. The larger was the IRSA-L, the shorter was the ramal length. On the lingular tip level, the mean anterior ramal length from anterior ramus to lingular tip was 19.6${\pm}$3.3 mm. when the ramal length was longer, the anterior ramal length was also longer. On the lingular tip level, there was positive correlation vetween the IRSA and the ORSA, negative correlation between the IRSA and the ramal length, and positive correlation between the ramal length and the lingular tip level to the anterior ramus. There was no statistical meaning of data between sex and age. Conclusion : In the clinical view of the results so far achieved, if the direction of needle is closer to posterior it is able to contact bone on lingular tip when the internal surface of ramus is wided outer.

• Imaging Science in Dentistry
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• 제44권4호
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• pp.257-262
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• 2014

Purpose: This study was performed to evaluate the effect of changing the orientation of a reconstructed image on the accuracy of linear measurements using cone-beam computed tomography (CBCT). Materials and Methods: Forty-two titanium pins were inserted in seven dry sheep mandibles. The length of these pins was measured using a digital caliper with readability of 0.01 mm. Mandibles were radiographed using a CBCT device. When the CBCT images were reconstructed, the orientation of slices was adjusted to parallel (i.e., $0^{\circ}$), $+10^{\circ}$, $+12^{\circ}$, $-12^{\circ}$, and $-10^{\circ}$ with respect to the occlusal plane. The length of the pins was measured by three radiologists, and the accuracy of these measurements was reported using descriptive statistics and one-way analysis of variance (ANOVA); p<0.05 was considered statistically significant. Results: The differences in radiographic measurements ranged from -0.64 to +0.06 at the orientation of $-12^{\circ}$, -0.66 to -0.11 at $-10^{\circ}$, -0.51 to +0.19 at $0^{\circ}$, -0.64 to +0.08 at $+10^{\circ}$, and -0.64 to +0.1 at $+12^{\circ}$. The mean absolute values of the errors were greater at negative orientations than at the parallel position or at positive orientations. The observers underestimated most of the variables by 0.5-0.1 mm (83.6%). In the second set of observations, the reproducibility at all orientations was greater than 0.9. Conclusion: Changing the slice orientation in the range of $-12^{\circ}$ to $+12^{\circ}$ reduced the accuracy of linear measurements obtained using CBCT. However, the error value was smaller than 0.5 mm and was, therefore, clinically acceptable.

• Journal of Trauma and Injury
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• 제22권2호
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• pp.206-211
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• 2009

Purpose: Abdominal CT (computed tomography) is a principal diagnostic imaging modality for torso trauma at the Emergency Department (ED). When acute osseous pelvic injuries are detected by abdominal CT, additional three-dimensional (3D) reconstruction pelvic CT is often performed. We compared abdominal CT with pelvic CT to provide information about acute osseous pelvic injuries. Methods: A retrospective investigation of patients'electronic medical records during the five year period between January 1, 2004 and December 31, 2008 among Korean soldiers who underwent pelvic CT after abdominal CT at the ED was conducted. Axial images of abdominal CT were compared with axial images and 3D reconstruction images of pelvic CT. Results: Sixteen patients underwent subsequent pelvic CT after abdominal CT. Axial images of abdominal CT showed the same results in terms of fracture detection and classification when compared to axial images and 3D reconstruction images of pelvic CT. Pelvic CT (including 3D reconstruction images) followed by abdominal CT neither detected additional fracture nor changed the fracture type. Conclusion: This study has failed to show any superiority of pelvic CT (including 3D reconstruction images) over abdominal CT in detecting acute osseous pelvic injury. When 3D information is deemed be mandatory, 3D reconstructions of abdominal CT can be requested rather than obtaining an additional pelvic CT for 3D reconstruction.

• Annals of Clinical Neurophysiology
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• 제1권2호
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• pp.112-117
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• 1999

부중심소엽 주변의 경막하 전극들에서 기록한 PTSEP는 전극의 위치에 따라 다양한 파형을 나타내며, 파형의 최대치는 주로 부중심소엽의 후 상부에 위치한다. 특히 최대값이 주변보다 확연히 차이 나며 10uV이상의 파형으로 기록될 경우는 40 msec에서 양극성을 나타낸다. 또한 주변의 전극과 상역전을 형성할 수 있는데 최대 전극의 뒤에서 형성될 경우는 더욱 분명한 상역전을 관찰할 수 있다. 따라서 경막하전극을 통한 PTSEP는 내측 반구의 부중심소엽 주변의 위치를 파악하는데 도움을 줄 수 있다고 생각된다.

• Restorative Dentistry and Endodontics
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• 제36권5호
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• pp.367-376
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• 2011

치아우식증의 조기 발견은 외과적 삭제를 피하면서, 적절한 치료를 할 수 있는 좋은 기회를 제공한다. 광간섭단층촬영술은 최근 각광받기 시작한 3차원 이미지 기술로서, 안과에서 광학적 생검의 목적으로 빈번히 이용되는 것을 필두로 다양한 의학 분야에 적용되어 왔고, 최근 초기 우식증의 발견에 전도유망하여 다양한 연구가 진행 중이다. 이 기술은 저 상관도 간섭계의 원리에 근거하고 있으며, 장점으로는 비침습적이고, 방사선을 사용하지 않으며, 3차원 이미지 구축이 가능하다는 점이다. 본 연구에서는 광간섭단층촬영술의 원리와 개략적인 개발 과정에 대한 기술과 함께 치아우식증에 관한 연구들에 대하여 고찰해 보았고, 이를 통해 이 기술의 응용 가능성을 확인하였다. 그럼에도 불구하고, 임상적인 유용성을 입증하기 위해서는 몇 가지 기술적 문제를 해결해야 하고, 보다 많은 생체 내 실험이 뒷받침되어야 할 것이다.

• Imaging Science in Dentistry
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• 제38권4호
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• pp.203-208
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• 2008

Purpose : The purpose of this study was to develop a system for the measurement and simulation of the TMJ movement and to analyze the mandibular movement quantitatively. Materials and Methods : We devised patient-specific splints and a registration body for the TMJ movement tracking. The mandibular movements of the 12 subjects with facial deformity and 3 controls were obtained by using an optical tracking system and the patient-specific splints. The mandibular part was manually segmented from the CT volume data of a patient. Three-dimensional surface models of the maxilla and the mandible were constructed using the segmented data. The continuous movement of the mandible with respect to the maxilla could be simulated by applying the recorded positions sequentially. Trajectories of the selected reference points were calculated during simulation and analyzed. Results : The selected points were the most superior point of bilateral condyle, lower incisor point, and pogonion. There were significant differences (P<0.05) between control group and pre-surgical group in the maximum displacement of left superior condyle, lower incisor, and pogonion in vertical direction. Differences in the maximum lengths of the right and the left condyle were 0.59${\pm}$0.30 mm in pre-surgical group and 2.69${\pm}$2.63 mm in control group, which showed a significant difference (P<0.005). The maximum of differences between lengths of the right and the left calculated during one cycle also showed a significant difference between two groups (P<0.05). Conclusion : Significant differences in mandibular movements between the groups implies that facial deformity have an effect on the movement asymmetry of the mandible. (Korean J Oral Maxillofac Radiol 2008; 38 : 203-8)

• 지구물리와물리탐사
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• 제12권1호
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• pp.49-55
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• 2009

이 논문은 2007년 9월에 발생한 태풍이 동반한 폭우 후에 일본 사이타마현의 아라강 유역의 제방근처 지형변형 지역에서 실시된 3차원 GPR 탐사에 관하여 기술하였다. 폭우에 의해 생긴 포장된 도로 위의 수직균열 주변에 근접한 4방향의 2차원 탐사들로 이루어진 고밀도의 3차원 GPR 탐사가 수행되었다. 2차원 탐사의 방향은 각각 도로에 대해 $0^{\circ}$, $90^{\circ}$. $45^{\circ}$ 그리고 $-45^{\circ}$로, 측선 사이의 간격은 0.5 m 이하로 설정하였다. 3차원적인 지하구조가 3차원 Kirchhoff 형태의 구조보정 자료처리 기법을 통하여 정밀하게 영상화 되었다. 그 결과 포장포로 밑의 폭우로 인해 발생된 균연들의 위치와 수직 연결성 등을 명확하게 확인 할 수 있었다. 이 영상은 균열 형성과정의 매커니즘을 이해하는데 큰 도움을 줄것으로 기대된다. 또한 3차원 GPR 탐사 결과 공기로 채워진 공동이 존재하지 않는 것으로 확인되어 2차적인 피해가 발생될 가능성은 매우 낮은 것으로 판명되었다.