• PNF and Movement
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• 제16권3호
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• pp.451-460
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• 2018

Purpose: The purpose of this study was to investigate the effects of a modified constraint induced movement therapy (mCIMT) using proprioceptive neuromuscular facilitation (PNF) on the upper extremity function and activities of daily living (ADLs) in patients with subacute stroke. Methods: Fourteen participants with subacute stroke were randomly assigned to a group using both mCIMT and PNF or a group using mCIMT alone. Each group underwent twenty sessions (1 h/d, 5 d/wk) for 4 weeks. Patients were assessed with the action research arm test (ARAT), the Fugl-Meyer assessment for the upper extremities (FMA-UE), the Modified Barthel Index (MBI), and motor activity logs (MALs; amount of use [AOU] and quality of movement [QOM]). Results: Both the experimental group and the control group showed significant intragroup improvement in the ARAT, FMA-UE, MBI, and MAL-AOU (p<0.05). The group using both mCIMT and PNF exhibited greater improvement in the ARAT, FMA-UE, MBI, and MAL-AOU than did the group using mCIMT alone. Statistical analyses showed significant differences in the ARAT (p=0.01), FMA-UE (p=0.01), MBI (p=0.00), and MAL-AOU (p=0.01) between the groups. Conclusion: This study applied mCIMT combined with PNF for subacute stroke patients, and the results showed significant improvements in the patients' upper extremity function and ADLs. Therefore, mCIMT using PNF may be more effective than mCIMT alone in improving upper limb function and ADLs in patients with subacute stroke.

• 대한한의학방제학회지
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• 제17권2호
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• pp.233-238
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• 2009

Objective : To carry out the oriental medicine treatment on a patient with oculomotor nerve palsy accompanied by Diabetes mellitus complication history Methods : We conducted one patient with oculomotor nerve palsy at Won-Kwang University Kwang-Ju Oriental Medical Hospital. We treated patient by herbal medicine, acupuncture, etc. Results : We had an effect that one patient's symptom had improved. Conclusion : We suggest that the oriental medical treatment and management have an effect with oculomotor nerve palsy accompanied by DM complication history.

• 한국수학사학회지
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• 제18권3호
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• pp.39-54
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• 2005

중국 산학에서는 구장산술의 제곱근과 세제곱근의 해법을 일반화하여 고헌이 도입한 증승개방법을 통하여 다항방정식의 해의 근사값을 구한다. 이 때 도구로 사용되는 조립제법에서 음수와 그 연산을 정확히 사용하지 않아서 번적, 익적이라는 개념이 나타나는데, 이는 조선 산학에도 그대로 사용되었다. 먼저 중국과 조선에서 번적, 익확에 대한 역사를 조사하고, 19세기 중엽에 조선 산학자 남병길과 이상혁이 번적과 익적에 대한 충분조건을 얻어내고 이를 증명한 사실을 밝혀낸다.

• 동의생리병리학회지
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• 제25권5호
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• pp.807-815
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• 2011

This study was designed to investigate the effects of Mokhyangjoki-san extract (MJS) on the improvement in cerebral blood flow (rCBF) in cerebral ischemic rats, and further to determine cytokines production (IL-1${\beta}$, TNF-${\alpha}$, IL-10, TGF-${\beta}$) of MJS. The results in cerebral ischemic rats were as follows ; The rCBF was significantly and stably increased by MJS (10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. In cytokine production in serum from femoral arterial blood 1 hr after middle cerebral arterial occlusion, MJS significantly decreased IL-1${\beta}$ and TNF-${\alpha}$ production, and increased IL-10 production compared with control group. In cytokine production in serum from femoral arterial blood 1 hr after reperfusion, MJS significantly decreased IL-1${\beta}$ and TNF-${\alpha}$ production compared with control group. IL-10 and TGF-${\beta}$1 production in MJS group were significantly increased compared with control group. These results suggested that MJS significantly and stably increased rCBF by inhibiting the production IL-1${\beta}$ and TNF-${\alpha}$, and accelerating that of IL-10 and TGF-${\beta}$. The result in nerve cells was as follows ; MJS significantly inhibited lactate dehydrogenase activity in vitro in a dose-dependent manner. This result suggested that MJS prevented the neuronal death.

• Journal of Korean Neurosurgical Society
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• 제29권6호
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• pp.738-743
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• 2000

Objectives : The less invasive stereotactic surgery of hypertensive intracerebral hematoma has been preferred. Many techniques were developed to facilitate aspiration of a dense blood clot in acute stage. Authors describe a method for evacuation of putaminal hematoma via computerized tomography(CT)-aided free-hand stereotactic infusion of urokinase and frequent negative pressure aspiration. Patients and Methods : A total of ten patients with spontaneous putaminal hematoma underwent surgery with negative pressure aspiration in the three-year period. All procedures were performed within 12 hours of insult. A silicone ventricular catheter was inserted into the center of hematoma through a burr hole at the Kocher's point under local anesthesia. In a typical case of putaminal hematoma, the trajectory of catheter was pointed the center of hematoma parallel to sagittal plane vertically and the external auditory meatus posteriorly. Immediately after the first trial of hematoma aspiration low-dose urokinase solution(2,000IU/5ml saline) was administrated through the catheter and drain was clipped for 30 minutes. Subsequently, the partially liquified hematoma was manually aspirated using a 10ml syringe with a negative pressure of less than 2 to 3ml. The procedure was carefully repeated every 1 hour until the hematoma was near totally evacuated. Results : The patients population consisted composed of 4 men and 6 women with a mean age of 61.6 years. All had major neurological deficits preoperatively. The mean hematoma volume was 44.3 ml and hematoma was drained for 20 to 48 hours. No complications such as rebleeding, meningitis, or malplaced catheter were noted. Outcome was moderately disabled in four patients and good recovery in three patients. Conclusion : Although the frequent negative pressure aspiration and low-dose urokinase infusion has the disadvantage of possbility of rebleeding and infection, it is consisdered to be an effective method because it allows a simple, safe, and complete removal of hematoma.

• 대한한의학회지
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• 제41권4호
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• pp.1-11
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• 2020

Objectives: Objectives: The object of this study was to elucidate the possible effects on the pharmacokinetics of tamoxifen after single oral co-administration of Gamisoyo-san (GMSYS) with 2.5 hr-intervals combination therapy of tamoxifen with GMSYS. Methods: After 2.5 hr of 50 mg/kg of tamoxifen treatment, GMSYS 100 mg/kg was administered. The plasma was collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMSYS treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen were analysis as compared with tamoxifen single administered rats. Results: Although single co-administration with GMSYS with 2.5 hr-interval induced increased trends of plasma tamoxifen concentrations, there are no significant changes on the plasma concentrations of tamoxifen were demonstrated in tamoxifen and GMSYS 100 mg/kg co-administrated rats with 2.5 hr-intervals as compared to those of tamoxifen single 50 mg/kg treated rats, and also GMSYS co-administrated rats did not showed any significant changes on the all pharmacokinetic parameters as compared to those of tamoxifen single formula treated rats. Conclusions: According to the this study, single co-administration of GMSYS with 2.5 hr-intervals did not critically influenced on the oral bioavailability of tamoxifen, suggesting GMSYS did not critically influenced on the absorption and excretion of tamoxifen, the oral bioavailability, when they were co-administered with 2.5 hr-intervals, at the dose levels of tamoxifen 50 mg/kg and GMSYS 100 mg/kg.

• 동의생리병리학회지
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• 제34권4호
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• pp.201-208
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• 2020

The effects of Gamisoyo-san (GMSYS) co-administration within 5 min on the pharmacokinetics (PK) of tamoxifen were observed. After 50 mg/kg of tamoxifen oral treatment, GMSYS 100 mg/kg was orally administered within 5 min to 7-wk old male SPF.VAF Outbred Crl:CD [Sprague-Dawley (SD)] rats. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of GMSYS treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. Tmax, Cmax, AUC, t1/2 and MRTinf of tamoxifen were analysis as compared with tamoxifen single administered rats. Although co-administration with GMSYS did not critically influenced on the pharmacokinetic parameters of oral tamoxifen, they induced increased trends of plasma tamoxifen concentrations, especially significant (p<0.05) increases of plasma tamoxifen concentrations were demonstrated at 0.5 hr after end of co-administration with GMSYS as compared with tamoxifen single formula treated rats, at dosage levels of tamoxifen 10 mg/kg and GMSYS 100 mg/kg within 5 min. It is considered that pharmacokinetic studies should be tested like the effects of GMSYS on the pharmacokinetics of tamoxifen, when they were co-administered with prolonger intervals than Tmax of tamoxifen oral administration (about 2.5 hr-intervals), to achieve the optimal dosing regimen of GMSYS and tamoxifen co-administration.

• 역사민속학
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• 제33호
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• pp.31-72
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• 2010

이 글은 조선후기의 대표적 유서인 이수광(李晬光)의 『지봉유설(芝峯類說)』·홍만선(洪萬選)의 『산림경제(山林經濟)』·이익(李瀷)의 『성호사설(星湖僿說)』·이규경(李圭景)의 『오주연문장전산고(五洲衍文長箋散稿)』에 수록된 민속종교 관련 자료들을 살펴본 것으로, 먼저 4종의 유서에서 민속종교 관련 항목들을 추출하여, 그 내용을 표로 제시하였다. 다음으로 이들 유서류에서 언급된 민속종교 관련 자료들의 성격과 내용을 살펴보았다. ① 이들 유서들은 전대의 것이 후대의 것에 상당한 영향을 미치면서 많은 공통점을 가지게 되었지만, 한편으로는 저술 목적에 따라 차이가 있다. 즉 『지봉유설』·『성호사설』·『오주연문장전산고』는 백과전서식 저술답게 민속종교의 다양한 측면을 전하는데 비해 『산림경제(山林經濟)』는 실생활에서 발생할 수 있는 문제와 그 해결이란 실천적 내용이 중심을 이루고 있다. ② 이들 유서는 민속종교를 부정적인 것으로 인식했다. 그것은 이들 유서가 기본적으로 유교적 관념에 기초했기 때문이다. 그러나 완전한 부정에는 이르지 못하고, 영험성의 일부를 인정하기도 했다. ③ 조선시대 민속종교의 신앙대상들, 즉 성황신·업신·질병신·금부대왕신(金傅大王神)·정득양(鄭得揚)·관왕신(關王神)·부근신(付根神) 등에 대한 유서류의 내용을 살펴보았다. ④ 이들 유서류들은 귀신에 대해서도 공통적으로 관심을 보였는데, 그들의 귀신론은 기본적으로 성리학에 기초한 것이면서도 그 영험성으로 말미암아 민속종교의 귀신론을 일부 수용하고 있다. ⑤ 이들 유서류에서는 공통적으로 점복에 대해 상당한 관심을 가지고 있다. 그렇지만 개인의 운명에 관한 점복은 부정적으로 인식했고, 농사의 풍흉점에 대해서는 긍정적으로 이해하려 했다. ⑥ 이들 유서류에는 저주와 벽사에 관한 항목들도 상당수 있어, 이를 살펴보았다. ⑦ 무격은 민속종교의 성직자로서 민속종교의 핵심에 서 있는 존재이기 때문에 이들 유서류에서 공통의 관심사가 되었다. 이들 유서에서 무격은 부정적으로 묘사되고 있지만, 그 영험성의 일부는 인정하고 있었다. 그렇다고 한다면 이들 유서류들은 비록 민속종교에 대해 부정적인 입장을 취하고 있고 잘못된 정보를 제공하기도 하지만, 조선후기 민속종교의 다양한 사실들을 전한다는 점에서 자료적 가치를 간과할 수 없다. 따라서 이들 유서류들은 향후 민속종교 연구에서 반드시 심도 있게 검토되어야 할 자료라 하겠다.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.226-234
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• 2008

Background and Objective : Acne is very common skin disease encountered by dermatologists. But There is few reports on Acne treated with the Ko-Bang(古方) and the Sa-Am acupuncture. The study was designed to evaluate the effects of Acne patients by the Ko-Bang(古方) and the Sa-Am acupuncture. Methods : We conducted one patient with Acne seen at Won-Kwang University Ik-San Oriental Medical Hospital. We treated Acne by a herbal medicine, acupuncture, etc. Conclusions : We suggest that the oriental medical treatment and management have an effect with Acne which means Jwachang(挫瘡) in Oriental medicine.

• 한방안이비인후피부과학회지
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• 제19권2호
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• pp.313-319
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• 2006

Background and Objective : Localized Pustular Psoriasis(LPP) is a rare form of psoriasis characterized by erythematous papules, plaques studded with pustules(usually on palms or soles) However, the pathophysiology of the LPP remains obscure. Treatment at present is symptomatic and supportive. There is no report on LPP treated with oriental medical treatment. Methods : We conducted one patient with LPP seen at Won-Kwang University Ik-San Oriental Medical Hospital in 2003. We treated LPP in a forty-nine years old man by a herbal medicine, acupuncture, moxa, etc Conclusions : We had a significant results. So we report this case to estimate the efficiency of oriental medic at treatment and management on LPP