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Biodistribution and Scintigraphy of Iodine-131-Iododeoxyadenosine in Rats Bearing Breast Cancer (흰쥐에서 Iodine-131-Iododeoxyadenosine의 생체분포 및 유방암 영상화에 관한 연구)

  • Kim, Seon-Gu;Kim, Chang-Guhn;Lee, Kang-Mo;Kim, Hye-Won;Min Byung-Cheol;Choi, See-Sung;Lee, Jong-Deuk;Yang, David J.;Kim, E. Edmund;Lee, Hyun-Chul;Won Jong-Jin
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.4
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    • pp.374-381
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    • 1998
  • Purpose: I-131 labeled (2'-deoxy-2'-iodo-${\beta}$-D-arabinofuranosyl) adenine (IAD) may be involved in DNA synthesis during active proliferation of tumor cells. We conducted this study to find out the biodistribution of IAD and it's feasibility for scintigraphic tumor imaging. Materials and Methods: Tosyl acetyl-adenosine was dissolved in acetonitrile, and I-131-NaI was added and heated to synthesize IAD. Female Fisher 344 rats innoculated with breast tumor cells were injected with 0.27 MBq of IAD. Rats were sacrificed at 0.5, 1, 2, 4, 24h and the % of injected dose per gram of tissue (%ID/g) was determined. For scintigraphy, rats bearing breast cancer were administered with 1.11 MBq of IAD and imaging was performed after 2 and 24h. Then, rat body was fixed and microtomized slice was placed on radiographic film for autoradiography. Results: %ID/g of tumor was 0.74 (0.5h),0.73 (1h), 0.55 (2h), 0.38 (4h), and 0.05 (24h), respectively. At 1h after injection, %ID/g of tumor was higher than that of heart (0.34), liver (0.42), spleen (0.47), kidney (0.69), muscle (0.14), bone (0.33) and intestine (0.51). However, %ID/g of tumor was lower than blood (1.06), lung (0.77), and thyroid (177.71). At 4h, %ID/g of tumor in comparison with other tissue did not change. Tumor contrast expressed by tumor to blood ratio was 0.69 and tumor to muscle ratio was 5.11 at 1h. However, these ratios did not improve through 24h. On autoradiogram and scintigraphy at 2 and 24 hour, the tumor was well visualized. Conclusion: This results suggest that IAD may have a potential for tumor scintigraphy. However, further work is needed to improve localization in tumor tissue.

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Measurement of Diaphragm in Normal Human (정상인의 가로막(diaphragm) 높이와 만곡도 계측)

  • Kim, Ham-Gyum;Ma, Sang-Chull
    • Journal of radiological science and technology
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    • v.30 no.4
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    • pp.335-341
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    • 2007
  • General anatomy classifies diaphragm as muscle of boundary between chest and abdomen, while radiology divides it into right and left hemidiaphragm, because it is more advantageous in radiological diagnosis on chest and abdomen. Based on these anatomic characteristics of diaphragm, this study aimed to measure the height and curvature of right and left diaphragm in simple chest radiography. As a result, this study came to the following conclusions : 1. For all subjects who joined this study, it was found that their mean transverse diameter in internal diameter of thorax(ID) amounted to 293.3 mm(min. 221.0 mm, max 335.3 mm). 2. For the right and left height of diaphragm, it was found that 81.4% showed higher right diaphragm ; 16.2% showed equivalent height between right and left diaphragm ; and only 2.4% showed higher left diaphragm. 3. For higher right diaphragm, it was found that the mean height of right diaphragm amounted to 15.2 mm(min. height = 2.0 mm, max. height = 41.7 mm). 4. For higher left diaphragm, it was found that the mean height of left diaphragm amounted to 11.5 mm(min. height = 4.7 mm, max. height = 30.4 mm). 5. The mean curvature of right diaphragm amounted to 22.9 mm(min. curvature = 10.4 mm, max. curvature = 37.3 mm). 6. The mean curvature of left diaphragm amounted to 22.4 mm(min. curvature = 11.3 mm, max. curvature = 42.2 mm). 7. For possible associations between ID and right/left diaphragm curvature, it was noted that ID was in significantly positive correlations with right diaphragm curvature(r= .427, p<.001) and left diaphragm curvature(r= .425, p<.001) on statistical level. 8. For possible associations between right and left diaphragm curvature, it was found that right diaphragm curvature was in significantly positive correlations with left diaphragm curvature(r= .403, p<.001).

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Implementation of Location Based Services Using Satellite DMB System (위성 DMB 시스템을 이용한 위치 기반 서비스 구현)

  • Kwon, Seong-Geun;Lee, Suk-Hwan;Kim, Kang-Wook;Kwon, Ki-Ryong
    • Journal of Korea Multimedia Society
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    • v.15 no.1
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    • pp.32-39
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    • 2012
  • In this paper, the implementation of location based services (LBS) using S-DMB (satellite-digital multimedia broadcasting) system was proposed. In S-DMB System, the frequency of transmitted signal is about 2 GHz which has a characteristics of strong straightness but weak diffraction so that there are many shade areas such as indoors and underground spaces. Therefore the signal transmitted from the satellite should be retransmitted by the earth repeaters called as gap filler. Because each gap filler has its own identification value, the gap filler ID introduces the area in which the gap filler was installed. Generally, the 51st data symbols of S-DMB pilot signal transmitted from the satellite are padded by dummy value and gap filler ID is embedded in this pilot symbol by the gap filler when S-DMB signals are retransmitted by gap fillers. So using gap filler ID of S-DMB system, LBS such as region registration, distance and time to destination, alarm of local area information could be implemented. In the experiment to prove the performance of the proposed LBS system using the gap filler ID of the S-DMB system, the firmware of S-DMB chip composing of RF and baseband parts was lightly modified so that application processor was able to manipulate the gap filler ID and the its related regional information.

A Hybrid Hyper Query Tree Algorithm for RFID System (RFID 시스템을 위한 하이브리드 하이퍼 쿼리 트리 알고리즘)

  • Kim, Tae-Hee;Lee, Seong-Joon;Ahn, Kwang-Seon
    • The KIPS Transactions:PartA
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    • v.15A no.5
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    • pp.287-294
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    • 2008
  • A tag collision arbitration algorithm for RFID passive tags is one of the important issues for fast tag identification, since reader and tag have a shared wireless channel in RFID system. This paper suggests Hyper-Hybrid Query Tree algorithm to prevent the tag-collisions. The suggested algorithms determine the specified point in time for tag to transfer ID to reader by using value 1 of the upper 3 bit based on Query Tree. Also, because the transferred upper 3 bits of tag is different depending on the time of transfer, it is possible to predict in the suggested Algorithm. In the performance evaluation through simulation, it shows the suggested algorithm has higher performance in the number of queries compared to other Tree-based protocols.

The Evaporation Flow Patterns and Heat Transfers of R-22 and R-134a in Small Diameter Tubes (세관내 R-22 and R-134a의 증발 유동양식과 열전달)

  • Son, Chang-Hyo
    • Transactions of the Korean hydrogen and new energy society
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    • v.18 no.3
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    • pp.275-283
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    • 2007
  • 본 논문은 세관(ID<7 mm) 내 R-22와 R-134a의 증발 열전달과 유동양식에 대한 실험적 연구이다. R-22와 R-134a의 유동양식을 관찰하기 위해 내경 2와 8 mm의 파이렉스 튜브를 사용하였고, 열전달 계수는 내경 1.77, 3.35, 5.35 mm의 수평 평활동관에 대해서 측정하였다. 증발 유동양식에서 내경 2 mm의 환상류 영역이 내경 8 mm에 비해 저건도 영역에서 발생하는 것을 확인할 수 있었고, 내경 2 mm의 유동양식은 Mandhane의 선도와 많은 오차를 보였다. 세관(ID<7 mm) 내 증발 열전달 계수는 종래의 대구경관(ID>7 mm)에 비해 관직경에 대한 영향이 많이 나타나는 것을 알 수 있었다. 내경 1.77 mm의 열전달 계수는 내경 3.36 mm와 5.35 mm에 비해서 20내지 30% 정도 높은 것을 나타났다. 또한 종래의 열전달 상관식(Shah's, Jung's, Kandlikar's and Oh-Katsuda's correlation)과 비교한 결과, 실험 데이터는 상관식과 많은 이탈 정도를 보였다. 따라서 실험데이타를 기초로 세관내 R-22와 R-134a에 적용할 수 있는 증발 열전달 상관식을 새로이 제안하였다.

Load-Sharing Algorithm using Digital Parallel Communication (디지털 병렬 통신을 이용한 부하분담 알고리즘)

  • Park, Seong-Mi;Kim, Chun-Sung;Lee, Sang-Hyeok;Lee, Sang-Hun;Park, Sung-Jun;Lee, Bae-Ho
    • The Transactions of the Korean Institute of Power Electronics
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    • v.16 no.1
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    • pp.50-57
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    • 2011
  • In this paper, we proposes a new load-sharing algorithm with a ATmega2560 based digital communication. Proposed algorithm is different from conventional analog method. The high speed communication digital control is performed. To apply the digital communication and real-time control for time-sharing token bus method, we implemented high efficient load-sharing and redundancy. Also this system make down the price by auto ID algorithm and system response is improved by controller's voltage and current integral value sharing. In parallel system prototype, each module have controller and performed load-sharing according to master module integral value. In this paper, we verify the validity of proposed algorithm using PSIM program and prototype.

Angiotensin-converting enzyme gene insertion/deletion polymorphism is not associated with BMI in Korean adults

  • Kwon, Insu
    • Korean Journal of Exercise Nutrition
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    • v.24 no.1
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    • pp.24-28
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    • 2020
  • [Purpose] Recent studies have demonstrated a probable association between ACE I/D polymorphism and obesity. Thus, this study aimed to investigate whether ACE I/D polymorphism influenced the susceptibly of developing obesity in Korean adults. [Methods] A total of 353 healthy Korean adults aged between 30 and 82 years were recruited, including 157 males and 196 females. Among the participants, 103 (29.2 %) were classified as normal (BMI < 23 kg/m2), 117 (33.1 %) as overweight (23 kg/m2 ≤ BMI < 25 kg/m2), and 133 (37.7 %) as obese (BMI ≥ 25 kg/m2). ACE polymorphism (rs1799752) analysis was performed using the MGB TaqMan® SNP Genotyping assay with 3 types of primers and 2 types of probes. The distributions of the ACE genotypes and allele frequencies were analyzed among the three groups using the Hardy-Weinberg equilibrium, chi-square tests, and multiple regression analysis. [Results] The distribution of the ACE genotypes were as follows: normal [II: n=38 (36.9 %), ID: n=46 (36.8 %), DD: n=19 (18.4 %)], overweight [II: n=43 (36.8 %), ID: n=55 (47.0 %), DD: n=19 (16.2 %)], and obese [II: n=41 (30.8 %), ID: n=76 (57.0 %), DD: n=16 (12.0 %)]. Unexpectedly, the I allele, rather than the D allele, was common in the obese group. [Conclusion] ACE I/D polymorphism is not associated with BMI in Korean adults. Thus, it is unlikely to be a powerful candidate gene for obesity in Korean adults.

A study on the smart band, technologies, and case studies for the vulnerable group. - The Digital Age and the Fourth Industrial Revolution.

  • YU, Kyoungsung;SHIN, Seung-Jung
    • International Journal of Internet, Broadcasting and Communication
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    • v.14 no.1
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    • pp.182-187
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    • 2022
  • This study aims to study non-rechargeable wrist-type smart bands for those vulnerable to the digital environment. The transition to the digital age means improving the efficiency of human life and the convenience of management. In the digital age, it can be a very convenient infrastructure for the digital generation, but otherwise, it can cause inconvenience. COVID-19 is spreading non-face-to-face culture. The reality is that the vulnerable are complaining of discomfort in non-face-to-face culture. The core of the digital environment is smartphones. Digital life is spreading around smartphones. Technology that drives the digital environment is the core technology of the Fourth Industrial Revolution. The technologies are lot, big data, Blockchain, Smart Mobility, and AI. Related technologies based on these technologies include digital ID cards, digital keys, and nfc technologies. Non-rechargeable wrist-type smart bands based on related technologies can be conceptualized. Through these technologies, blind people can easily access books and manage their ID cards conveniently and efficiently. In particular, access authentication is required wherever you go due to COVID-19, which can be used as a useful tool for the elderly who feel uncomfortable using smartphones. It can also eliminate the inconvenience of the elderly finding or losing their keys.

Pitch Measurement of One-dimensional Gratings Using a Metrological Atomic Force Microscope and Uncertainty Evaluation (미터 소급성을 갖는 원자간력 현미경을 이용한 1차원 격자 피치 측정과 불확도 평가)

  • Kim Jong-Ahn;Kim Jae Wan;Park Byong Chon;Eom Tae Bong;Kang Chu-Shik
    • Journal of the Korean Society for Precision Engineering
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    • v.22 no.4
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    • pp.84-91
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    • 2005
  • We measured the pitch of one-dimensional (ID) grating specimens using a metrological atomic force microscope (M-AFM). The ID grating specimens a.e often used as a magnification standard in nano-metrology, such as scanning probe microscopy (SPM) and scanning electron microscopy (SEM). Thus, we need to certify the pitch of grating specimens fur the meter-traceability in nano-metrology. To this end, an M-AFM was setup at KRISS. The M-AFM consists of a commercial AFM head module, a two-axis flexure hinge type nanoscanner with built-in capacitive sensors, and a two-axis heterodyne interferometer to establish the meter-traceability directly. Two kinds of ID grating specimens, each with the nominal pitch of 288 nm and 700 nm, were measured. The uncertainty in pitch measurement was evaluated according to Guide to the Expression of Uncertainty in Measurement. The pitch was calculated from 9 line scan profiles obtained at different positions with 100 ㎛ scan range. The expanded uncertainties (k = 2) in pitch measurement were 0.10 nm and 0.30 nm for the specimens with the nominal pitch of 288 nm and 700 nm. The measured pitch values were compared with those obtained using an optical diffractometer, and agreed within the range of the expanded uncertainty of pitch measurement. We also discussed the effect of averaging in the measurement of mean pitch using M-AFM and main components of uncertainty.