• Journal of Chest Surgery
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• 제33권6호
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• pp.476-486
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• 2000

Background: Pulmonary atresia with intact ventricular septum(PA/IVS) is an anatomically heterogenous anomaly with a variety of surgical strategies possible. The purpose of the study is to evaluate the influence of right ventricular size on the early and midterm results of surgical repair of PA/IVS. Material and method: Medical records of 20 consecutive patients with PA/IVS operated on between January 1993 and August 1999 were retrospectively reviewed. There were 12 boys and 8 girls whose ages ranged from 2 days to 14.5 months (median 6 days). Their body weight ranged from 2.52kg to 9.35 kg(median 3.18kg). The preoperative Z-value of the diameter of the tricuspid valve(T-valve) was less than or -4 in 5 patients, between -4 and -2 in 1, between -2 and 0 in 7, between 0 and 2 in 6, and greater than or 2 in 1. All patients who had z-value of tricuspid valve greater than -2.05 were attempted biventricular repair(n=15) and all patients who had it smaller than -4.4 underwent systemic-pulmonary shunt operation only(n=3) or bidirectinal cavopulmonary shunt with right ventricular reconstruction(n=2). Result: Two early deaths(2/20, 10%) occurred. Both were infants who underwent transannular patch with shunt. One of these two had huge right ventricle(Z-value of tricuspid valve = 5). There were 2 late non-cardiac deaths 3 and 7 months after operations respectively. Follow-up was completed in all children at a mean of 35.3 months(range, 5 to 54 months). 10 of 11 survivors who underwent transannular patch or valvotomy with or without shunt procedure were in NYHA functional class I even though some of them had small interatrial communication or patent shunt. All three patients who had shunt procedure only at initial palliation completed Fontan procedures with no death. Two patients who underwent right ventricular outflow reconstruction with bidirectional cavopulmonary shunt were also in good condition. Conclusion: The transanular RVOT patch or valvotomy with or without systemic-pumonary shunt as an initial palliative procedure to achieve biventricular repair for the patients who had neither too small nor too large right ventricle(-2.05$\leq$Z-value of T-value of T-valve$\leq$2) could be performed at low operative risk(1/14 7.1%). Systemic-pulmonary shunt procedure and bidirectional cavopulmonary shunt procedure for the patients who had small right ventricle(Z-value of T-valve$\leq$4.4) could be also performed with low risk. But a patient with huge right atrium and ventricle(Z-value of t-valve=5) had poor operative result.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권4호
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• pp.229-238
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• 2017

Objectives: The primary purpose of this study was to investigate the factors related with additional administration of sedative agent during intravenous conscious sedation (IVS) using midazolam (MDZ). The secondary purpose was to analyze the factors affecting patient satisfaction. Materials and Methods: Clinical data for 124 patients who had undergone surgical extraction of mandibular third molar under IVS using MDZ were retrospectively investigated in this case-control study. The initial dose of MDZ was determined by body mass index (BMI) and weight. In the case of insufficient sedation at the beginning of surgery, additional doses were injected. During surgery, peripheral oxygen saturation, bispectral index score (BIS), heart rate, and blood pressure were monitored and recorded. The predictor variables were sex, age, BMI, sleeping time ratio, dental anxiety, Pederson scale, and initial dose of MDZ. The outcome variables were additional administration of MDZ, observer's assessment of alertness/sedation, intraoperative amnesia, and patient satisfaction. Descriptive statistics were computed, and the P-value was set at 0.05. Results: Most patients had an adequate level of sedation with only the initial dose of MDZ and were satisfied with the treatment under sedation; however, 19 patients needed additional administration, and 13 patients were unsatisfied. In multivariable logistic analysis, lower age (odds ratio [OR], 0.825; P=0.005) and higher dental anxiety (OR, 5.744; P=0.003) were related to additional administration; lower intraoperative amnesia (OR, 0.228; P=0.002) and higher BIS right before MDZ administration (OR, 1.379; P=0.029) had relevance to patient dissatisfaction. Conclusion: The preoperative consideration of age and dental anxiety is necessary for appropriate dose determination of MDZ in the minor oral surgery under IVS. The amnesia about the procedure affects patient satisfaction positively.

• 한국심리학회지 : 문화 및 사회문제
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• 제25권2호
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• pp.157-177
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• 2019

본 연구에서는 Han(2017)의 연구에서 수정된 오정보 효과 검증을 위한 실험재료를 번역한 후 이 실험재료를 사용하여 한국인들에게서도 오정보 효과를 관찰할 수 있는지 확인하였다(연구 1). 또한 한국인들의 자료와 Han(2017)의 연구에서 사용된 미국인들의 자료를 통합하여 오정보 제시여부, 정보의 유형 및 서로 다른 인지양식을 반영할 것으로 기대되는 참가자 국적에 따른 시간적 구조 및 대상정보에 대한 기억을 비교하였다(연구 2). 연구 결과, 연구 1에서 번역한 Han(2017)의 실험재료를 사용하여 한국인들에게서 오정보 효과를 관찰할 수 있었으며, 오정보 효과는 시간정보와 대상정보 모두에서 관찰되었다. 연구 2에서 오정보 제시여부, 정보유형, 참가자 국적에 따라 재인검사의 정답률을 비교한 결과, 세 독립변인의 주효과, 오정보 제시여부와 정보유형의 이원 상호작용효과 및 세 독립변인의 삼원 상호작용효과가 통계적으로 유의한 것으로 나타났다. 요약하면, 오정보를 제시 받지 않은 정보와 대상정보에 대한 정답률이 높았고, 미국자료의 정답률이 한국자료의 정답률보다 높았다. 오정보 효과는 시간정보보다 대상정보에서 더 크게 나타났으나, 오정보 제시여부와 정보유형의 이원 상호작용효과는 한국자료에서만 관찰되었다. 논의에서는 본 연구의 학문적 가치와 제한점에 대해 논의하였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 Ⅳ
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• pp.2295-2298
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• 2003

The correspondence problem for stereo image matching plays an important role in expanding view points as multi view video applications become more popular. The conventional disparity estimation algorithms have limitation to find exact disparities because they consider not image features but similiar intensity points. Thus we propose an efficient disparity estimation algorithm considering features of stereo image pairs. As simulation results, our proposed method confirms better intermediate views than the existing block-matching methods.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(1)
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• pp.64-69
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• 1998

KALMER 우라늄 금속핵연료노심의 평형주기에 대하여 주기길이, 농측도, 중식비의 관점에서 설계인자 변경에 따른 변화를 분석하였다. 유효노심높이, 반경방향 블랑캣의 batch수, 개스팽창모듈(GEM)의 적용성, 노용기내핵 연료저장(IVS)의 사용. 핵연료핀의 직경 증가 둥에 대한 설계 변경이 고려되었다. 본 연구결과를 통하여, 평탄화된 출력분포 및 핵연료의 이용도 향상을 기하면서 설계변경이 타 분야에 미치는 영향을 최소화하고 본래 KALMER의 안전성을 유지하고자 핵연료핀의 직경을 증가시킨 fat pellet 설계방안을 채택하였다

• 대한임베디드공학회논문지
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• 제5권3호
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• pp.118-127
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• 2010

Inter-vehicle communication is one of the most important parts in Intelligent Vehicle System. Through this communication, drivers can recognize what is happening out of their sights, such as the freezing condition of the street, traffic accidents, and so on. Each car in IVS gives various services to the drivers after analyzing those received information from cars or a base station. If the message is, however, exchanged from car to car directly, the computation cost which is needed for all the car to authenticate the transmitted message between nearby cars is tremendously high. Therefore, one can naturally think that the message communication between cars is performed with the help of the base station to reduce the computation cost. In this case where the base station collects all the information transmitted from cars and broadcasts them nearby, there should be an efficient way both for the base station to authenticate the car message within its communication range and for the car to authenticate the information received from the base station. In this paper, we present a two-way authentication protocol using a hash chain to efficiently exchange GPS information between a car and a base station. This information can be used to provide a driver with the navigation which displays all the moving cars around him in real time. When a car goes into an area of a base station, the car authenticates itself to the base station using its private key of PKI, sends a commitment of a hash chain, then starts to send a message with the hash value for authentication. The message includes GPS information, driver's status and so on. The base station also authenticates itself to the nearby cars using its private key, transmits the commitment of the hash chain, and sends all the messages gathered from cars with authentication information.

• 대한유전성대사질환학회지
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• 제4권1호
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• pp.5-12
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• 2004

Purpose Phenylketonuria is an inborn error of metabolism, which is inherited as an autosomal recessive trait. PKU is resulting from deficiency of phenylalanine hydroxylase. PAH gene spans about 90 kb on chromosome 12q and comprises 13 exons. In order to define the genetic basis of PKU and the frequencies and distribution of PAH mutations in the Korean population, we analyzed PAH gene in independent 80 patients with PKU. Methods All 13 exons including exon-intron boundaries and 2 kb of 5' upstream region of the PAH gene were analyzed by PCR-direct sequencing methods. Results PAH gene analysis revealed 39 different mutations including 10 novel mutations. The novel mutations consisted of 9 missense mutations (P69S, G103S, N207D, T278S, P281A, L293M, G332V, S391I and A447P) and a novel splice site variant (IVS10-3C>G). R243Q, IVS4-1G>A, and E6-96A>G were the most relevant mutations and they accounted in the whole for 38% of the mutant alleles identified in this study. We also observed that. $BH_4$ responsibility was. associated with genotype of R241C, R53H and R408Q. Conc1ustion Our present study with 80 participants extends the previous results to more comprehensive understanding of PAH allele distribution and frequency in Koreans. Although Korean mutation profile of PAH is similar to those of the nearest oriental populations (Japanese, Chinese, and Taiwanese), several different characteristic features are revealed. The characterization of the genotype-phenotype relationship was also performed. Our data would be very useful information for diagnosis, genetic counseling and planning of dietary and therapeutic strategies in Korean PAH patients.

• Journal of Chest Surgery
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• 제38권11호
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• pp.773-775
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• 2005

최근 30년 동안 선천성 심기형의 수술적 교정은 많은 발전을 거듭해, 어리고 적은 체중에서도 큰 문제없이 시행되고 있지만, 아직 저체중(low birth weight), 극저체중(very low birth weight) 출산아의 개심술에는 많은 어려움을 겪고 있다. 본원에서는 대혈관전위증(TGA)을 동반한 태내주수 35주, 출생체중 1140g의 미숙아를 생후 27일까지 키워 체중 1317gm일때 동맥치환술을 성공적으로 시행하였으며, 추적관찰한 결과 양호하였기에 보고하는 바이다.

• BMB Reports
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• 제36권6호
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• pp.533-537
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• 2003

The nonsyndromic cleft lip and palate (NSCL/P) is a congenital deformity of multifactorial origin with a relatively high incidence in the oriental population. Various etiologic candidate genes have been reported with conflicting results, according to race and analysis methods. Recently, the ablation of the TGF-${\beta}3$ gene function induced cleft palates in experimental animals. Also, polymorphisms in the TGF-${\beta}3$ gene have been studied in different races; however, they have not been studied in Koreans. A novel A $\rightarrow$ G single nucleotide polymorphism (defined by the endonuclease SfaN1) was identified in intron 5 of TGF-${\beta}3$ (IVS5+104 A > G). It resulted in different genotypes, AA, AG, and GG. The objective of this study was to investigate the relationship between the SfaN1 polymorphism in TGF-${\beta}3$ and the risk of NSCL/P in the Korean population. The population of this study consisted of 28 NSCL/P patients and 41 healthy controls. The distribution of the SfaN1 genotypes was different between the cases and controls. The frequency of the G allele was significantly associated with the increased risk of NSCL/P [odds ratio (OR) = 15.92, 95% confidence interval (CI) = 6.3-41.0]. The risk for the disease increased as the G allele numbers increased (GA genotype: OR = 2.11, 95% CI = 0.38-11.68; GG genotype: OR = 110.2, 95% CI = 10.67 - 2783.29) in NSCL/P. A stratified study in patients revealed that the SfaN1 site IVS5+104A > G substitution was strongly associated with an increased risk of NSCL/P in males (p < 0.001), but not in females. In conclusion, the polymorphism of the SfaN1 site in TGF-${\beta}3$ was significantly different between the NSCL/P patients and the control. This may be a good screening marker for NSCL/P patients among Koreans.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1219-1224
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• 2015

Background: To date several common mutations in BRCA1 and BRCA2 associated with breast cancer have been reported in different populations. However, the common BRCA1 and BRCA2 mutations among breast cancer patients in Iran have not been described in detail. Materials and Methods: To comprehensively assess the frequency and distribution of the most common BRCA1 and BRCA2 mutations in Iranian breast cancer patients, we conducted this meta-analysis on 13 relevant published studies indentified in a literature search on PubMed and SID. Results: A total of 11 BRCA1 and BRCA2 distinct common mutations were identified, reported twice or more in the articles, of which 10 (c.2311T>C, c.3113A>G, c.4308T>C, c.4837A>G, c.2612C>T, c.3119G>A, c.3548A>G, c.5213G>A c.IVS16-92A/G, and c.IVS16-68A/G) mutations were in BRCA1, and 1 (c.4770A>G) was in BRCA2. The mutations were in exon 11, exon 13, intron 16, and exon 20 of BRCA1 and exon 11 of BRCA2. All have been previously reported in different populations. Conclusions: These meta analysis results should be helpful in understanding the possibility of any first true founder mutation of BRCA1/BRCA2 in the Iranian population. In addition, they will be of significance for diagnostic testing, genetic counseling and for epidemiological studies.