• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4581-4585
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• 2012

Fms-like tyrosine kinase 3 (FLT3) performs a vital role in the pathogenesis of hematopoietic malignancies. Therefore in recent times, the focus of several studies was on use of FLT3 as a prognostic marker. The present study investigated the molecular characterization and incidence of FLT3 mutations in acute leukemia patients in Pakistan. A total of 55 patients were studied, of which 25 were suffering from acute lymphoblastic leukemia (ALL) and 30 were suffering from acute myeloid leukemia (AML). The polymerase chain reaction demonstrated FLT3/ITD mutations in 1 (4%) of 25 ALL patients, a male with the L2 subtype. In AML cases the rate was 4 (13.3%) of 30, three males and one female. The AML-M4 subtype was found in three and the AML M2 subtype in the other. In the AML cases, a statistically significant (p=0.009) relationship was found between WBC (109/L) and FLT3/ITD positivity. However, no significant relationship was found with other clinical parameters (p>0.05). In acute myeloid leukemia (AML) $FLT3/ITD^+$ mutation was more prevalent in elderly patients 31-40 age groups, 21-30 and 51-60 age groups respectively. In acute lymphoblastic leukemia (ALL) statistically no significant relationship was found between clinical features and FLT3/ITD positivity (p>0.05). However, in acute lymphoblastic leukemia (ALL) $FLT3/ITD^+$ mutation was more commonly found in age groups of 21-30.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.751-755
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• 2005

We propose a sound source localization method using the Head-Related-Transfer-Function (HRTF) to be implemented in a robot platform. In conventional localization methods, the location of a sound source is estimated from the time delays of wave fronts arriving in each microphone standing in an array formation in free-field. In case of a human head this corresponds to Interaural-Time-Delay (ITD) which is simply the time delay of incoming sound waves between the two ears. Although ITD is an excellent sound cue in stimulating a lateral perception on the horizontal plane, confusion is often raised when tracking the sound location from ITD alone because each sound source and its mirror image about the interaural axis share the same ITD. On the other hand, HRTFs associated with a dummy head microphone system or a robot platform with several microphones contain not only the information regarding proper time delays but also phase and magnitude distortions due to diffraction and scattering by the shading object such as the head and body of the platform. As a result, a set of HRTFs for any given platform provides a substantial amount of information as to the whereabouts of the source once proper analysis can be performed. In this study, we introduce new phase and magnitude criteria to be satisfied by a set of output signals from the microphones in order to find the sound source location in accordance with the HRTF database empirically obtained in an anechoic chamber with the given platform. The suggested method is verified through an experiment in a household environment and compared against the conventional method in performance.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4319-4322
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• 2016

Background: FLT3 is mutated in about 1/3 of acute myelogenous leukemia (AML) patients. The aim of the present study was to report the prevalence of FLT3 mutations and comparison with prognostic factors in AML patients in the Northeastern of Iran. Materials and Methods: This cross-sectional study concerned 100 AML cases diagnosed based on bone marrow aspiration and peripheral blood. DNA for every AML patient was extracted and underwent PCR with FLT3-ITD primers. Results: The mean age at diagnosis was 28.5 years (range, 1-66 years), 52 patients (52%) being male. Out of 100 AML patients, 21 (21%) had FLT3 mutation, (17 with FLT3-ITD, 81%, and 4 with FLT3-D825, 19%). Of the 21, 14 (66.7%) had heterozygous mutation. There was no significant difference between age, sex and organomegaly between patients with FLT3 mutation versus FLT3 wild-type. Conclusions: Our frequency of FLT3 is in line with earlier fidnings of approximately 20 to 30% and also the prevalence of FLT3-ITD is more than FLT3-D35 mutation. There was no significant difference between prognostic factors (age and sex) in the patients with FLT3 mutation versus FLT3 wild-type. The prevalence of FLT3 heterozygous mutations is more that homozygous mutations in AML patients.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.1009-1013
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• 2007

To do a HRTF customization, researchers used a spherical head model for modeling the head block of structural modeling of HRTF, which is the one of the technique for HRTF customization, because of its simplicity. In this paper, an analytic spheroidal HRTF caused by an incident point source will be introduced. Using proposed spheroidal HRTF, near-field HRTF customization can be applicable through a structural modeling of HRTF. To see the necessity of sheroidal head model, comparison of two analytic solutions, which are classical spherical HRTF and proposed spheroidal HRTF, will be shown. On the view point of ITD, optimal head model which matches with the measured ITD of KEMAR HRTF can be obtained. ITD results show that there are only slight differences between spherical and spheroidal head model. Magnitude comparison is made by constructing head model using measured head size. Although magnitude comparison is not studied between optimal models, the results of 24 of 36 subjects are shown that spheroidal head model matches notch frequency pattern of measured HRTF better than those of spherical one, where the sound source is at contralateral position.

• 한국안광학회지
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• 제1권1호
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• pp.109-114
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• 1996

정상적인 한국 노인 (61 - 90세) 336명을 대상으로 외안각 간격(IOCD), 이측 간격(ITD), 눈꺼풀틈새 폭(WPF), 위눈꺼풀 접힌거리와 위치 그리고 쌍꺼풀의 존재를 조사한 결론은 다음과 같다. 이측 간격은 남자 122.2 mm, 여자 118.5 mm로 외안각 간격보다 남, 여 모두 31 mm 정도 크게 나타났고, 외안각 간격은 나이가 80 대인 경우는 점차 좁아져 60 대보다 6 mm 작았다. 위눈꺼풀 접힌거리는 약 4.7. mm 이며, 남자의 경우가 여자보다 약간 길었고, 쌍꺼풀도 남자에서 많이 조사되었다. 눈꺼풀틈새 폭은 남자가 7.6 mm로 여자보다 약간 넓었고, 나이듬에 따라 작게 관찰되었다. 위눈꺼풀 위치는 조사 대상자의 대부분이 남, 여 관계 없이 각막윤부에 위치하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5341-5344
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• 2013

Objectives: To explore the relationships between age, cytogenetic subgroups, molecular markers, and cells with leukemic aberrant immunophenotype in patients with acute myeloid leukemia (AML). Methods: In this study, we evaluated the correlations between age, cytogenetic subgroups (normal, balanced and unbalance karyotype), molecular mutations (NPM1, FLT3-ITD, and CEBPA mutations) and marrow leukemia cells (LC) identified by flow cytometry in 256 patients with de novo AML. Results: From age group 10-19 years to age group ${\geq}60$ years, the percentage of LC decreased from $67.0{\pm}18.4%$ to $49.0{\pm}25.1%$ (F=2.353, P=0.041). LC percentage was higher in patients with balanced karyotypes ($65.7{\pm}22.4%$), than those with unbalanced karyotypes ($46.0{\pm}26.6%$) (u=3.444, P=0.001) or a normal karyotype ($49.9{\pm}22.1%$) (u=5.093, P<0.001). Patients with FLT3-ITD ($64.3{\pm}19.5%$) had higher LC percentages compared with those without ($54.2{\pm}24.3%$) (u=2.794, P=0.007). Conclusions: Associations between age, cytogenetics, molecular markers, and marrow leukemia cells may offer beneficial information to understand the biology and pathogenesis of AML.

• 대한교통학회지
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• 제24권7호
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• pp.91-100
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• 2006

도로개선사업의 타당성 분석을 위해 장래 수요추정은 필수적이며, 이는 사업 여부를 결정하는데 있어서 핵심적 사안이 되지만 현재 장래 수요추정에 적용되는 4단계 수요예측모형은 장래 고정된 기종점통행량을 이용하여 경로 전환된 통행량에 대해서만 분석할 뿐, 교통시스템의 향상으로 인해 추가로 발생되는 수요(유발통행수요-Induced Highway Travel Demand 또는 잠재수요-Latent Demand)는 충분히 고려되지 않고 있어 정확성에 대한 의심의 여지가 있다. 이에 본 연구는 교통수요가 결정되는 원리와 유사한 경제학 이론을 적용한 유발통행수요 추정모형과 광범위한 분석에 적용할 수 있는 유발통행수요 추정프로그램(I.D.A)을 개발하였다. 본 연구에서 구축된 모형을 통해 서울시 강변북로 일부구간의 도로개선에 따른 유발통행수요를 추정한 결과. 추정된 유발통행수요는 경로전환수요의 15% 정도인 것으로 분석되었다. 본 연구를 통해 유발통행수요가 존재할 것으로 확신되는 사업에 대한 유발통행수요를 계량적으로 추정하여 도로개선의 타당성분석결과에 대한 신뢰성을 보다 향상시킬 수 있을 것으로 기대한다.

• 한국음향학회지
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• 제20권3호
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• pp.98-103
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• 2001

인간의 청각기관은 소리의 방향과 거리인지에 있어서 여러 가지의 정보들을 복합적으로 이용한다. 이러한 양 귀에 들어오는 소리세기의 차이, 위상의 차이, 그리고 주파수 스펙트럼의 차이 등의 정보들을 종합적으로 포함하고 있는 것이 머리전달함수이다. 본 논문에서는 이 머리전달함수를 이용한 3차원 음상정위를 위해 사람의 청각기관에 알맞은 1/3-옥타브 대역통과필터를 이용한 알고리즘을 제안한다. 먼저 측정된 머리전달함수의 음색왜곡 및 음질저하를 최소화하기 위해 1/3-옥타브 대역통과필터를 이용해 간략화시켰으며, 간략화된 데이터베이스를 크기와 시간의 부분으로 나누어 모듈을 구성하였다. 이의 성능평가를 위해 객관평가와 주관평가를 실시하였으며, 실험결과 85.7％정도의 음상정위의 성능 개선을 가져왔다.

• 대한신경집중치료학회지
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• 제11권2호
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• pp.86-92
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• 2018

Background: A delay of transfer for patients with acute stroke needing emergent revascularization is a huge hurdle for efficacy of revascularization. The objective of this study was to investigate changes of transportation time calculated by image to door (ITD) time (from checking brain images at first contact hospital to arriving at our emergency center) before and after 2015. Methods: This study was performed in a retrospective manner from 2013 into 2017. Acute ischemic stroke (AIS) patients having intravenous thrombolysis and/or mechanical thrombectomy during the observation period were enrolled. Among them, those who had revascularization under 'Drip-and-Ship' or 'Ship-and-Drip' paradigm were selected. Results: During the observation period, 225 patients were treated under 'Drip-and-Ship' or 'Ship-and-Drip' paradigm. Twenty-three were excluded due the lack of detailed data. Among 202 patients, 73 and 129 were treated under Drip-and-Ship and Ship-and-Drip paradigms, respectively. In 2013, 35 patients from 18 hospitals (median distance, 25 km) were transferred to our regional stroke center and their median ITD time was 116 minutes. It was gradually decreased after 2015. In 2017, ITD time was significantly (P<0.01) shortened to 85 minutes without significant changes in transfer distance. The median onset to puncture time was also significantly (P=0.03) decreased from 365 minutes in 2013 to 270 minutes in 2017. Conclusion: Our results implicate that many hospitals in our stroke region might have recognized the importance of rapid transportation for AIS after 2015.

• 환경영향평가
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• 제30권3호
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• pp.155-163
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• 2021

환경영향평가의 훼손수목량은 온실가스 배출량, 임목폐기물 산정 등 다양한 부분에 활용되는 환경지표이다. 지금까지 훼손수목량은 식생조사표의 임목밀도에 의존하였고, 이에 따른 표본편향으로 훼손수목량 추정의 불확실성이 가중되었다. 훼손수목량 추정의 정확성을 높이려면 전수조사를 대안으로 제시할 수 있으나 불가능한 것이 현실이다. 대안으로 드론영상을 이용한 개별 수목 탐지 방법이 있으며, 이 연구는 개별 수목 탐지 방법론으로 표본조사(방형구법)와 드론영상 분석법으로 추정된 훼손수목량을 전수조사 결과와 비교하였다. 연구 결과 전수조사 기준으로 드론 영상 분석법은 25주 과대추정 하였고 방형구법(평균)은 58주 과대 추정하였다. 그러나 기존 환경영향평가에서 시행하는 방형구법은 방형구의 개수, 방형구의 위치에 따른 표본편향의 영향을 많이 받을 것으로 예상된다.