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Anti-proliferative Effects of Celastrol, A Quinine Methide Triterpene Extracted from the Perennial Vine Tripterygium wilfordii, on Obesity-related Cancers (미역줄나무 뿌리 추출물인 셀라스트롤의 비만관련 암증식 억제효과)

  • Park, Sunmi;Moon, Hyun-Seuk
    • Journal of Food Hygiene and Safety
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    • v.31 no.1
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    • pp.59-66
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    • 2016
  • It has been generally accepted that obesity and overweight are associated with metabolic diseases and cancer incidence. In fact, obesity increased risks of cancers i.e. breast, liver, pancreatic and prostate. Celastrol is a pentacyclic triterpenoid isolated from Thunder god vine, was used as a Chinese traditional medicine for treatment of inflammatory disorders such as arthritis, lupus erythematosus and Alzheimer's disease. Also, celastrol has various biological properties of chemo-preventive, neuro-protective, and anti-oxidant effects. Recent studies demonstrated that celastrol has anti-proliferation effects in different type of obesity-related cancers and suppresses tumor progression and metastasis. Anticancer effects of celastrol include regulation of $NF-{\kappa}B$, heat shock protein, JNK, VEGF, CXCR4, Akt/mTOR, MMP-9 and so on. For these reasons, celastrol has shown to be a promising anti-tumor agent. In this review, we will address the anticancer activities and multiple mechanisms of celastrol in obesity-related cancers.

The Study on Compartment Fire Experiment According to Fire Load (화재하중에 따른 구획화재 실험 연구)

  • Kweon, Oh-Sang;Kim, Heung-Youl
    • Fire Science and Engineering
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    • v.31 no.6
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    • pp.16-22
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    • 2017
  • In Korea, performance-based fire safety designs are being discussed to deal with the various risks of fire in complex and diverse types of structure. However, performance-based fire safety designs are not actively employed because it is difficult to estimate the fire characteristics related to the various factors in buildings. In this study, real scale fire tests were conducted based on fire severity levels and fire loads provided in He New Zealand Building Code, in order to use the results as guidelines and fundamental data for performance-based designs. In the real scale fire tests conducted in a 10MW full-scale calorimeter, wood cribs were placed in a $2.4(L){\times}3.6(W){\times}2.4(H)m$ mock-up of a compartment which had one $0.8(L){\times}2.0(H)$ opening for different fire loads and heating was continued until all of the wood cribs were burned down. The heat release rate started to increase rapidly 90 seconds after the wood cribs caught fire. In the test with a fire load level 1, the maximum heat release rate of 4743.4 kW was reached at 244 second. In the test with fire load level 2, a maximum heat release rate of 5050.9 kW was reached at 497 second. In the test with fire load level 3, a maximum heat release rate of 4446.9 kW was reached at 677 second.

Landslide Susceptibility Mapping by Comparing GIS-based Spatial Models in the Java, Indonesia (GIS 기반 공간예측모델 비교를 통한 인도네시아 자바지역 산사태 취약지도 제작)

  • Kim, Mi-Kyeong;Kim, Sangpil;Nho, Hyunju;Sohn, Hong-Gyoo
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.37 no.5
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    • pp.927-940
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    • 2017
  • Landslide has been a major disaster in Indonesia, and recent climate change and indiscriminate urban development around the mountains have increased landslide risks. Java Island, Indonesia, where more than half of Indonesia's population lives, is experiencing a great deal of damage due to frequent landslides. However, even in such a dangerous situation, the number of inhabitants residing in the landslide-prone area increases year by year, and it is necessary to develop a technique for analyzing landslide-hazardous and vulnerable areas. In this regard, this study aims to evaluate landslide susceptibility of Java, an island of Indonesia, by using GIS-based spatial prediction models. We constructed the geospatial database such as landslide locations, topography, hydrology, soil type, and land cover over the study area and created spatial prediction models by applying Weight of Evidence (WoE), decision trees algorithm and artificial neural network. The three models showed prediction accuracy of 66.95%, 67.04%, and 69.67%, respectively. The results of the study are expected to be useful for prevention of landslide damage for the future and landslide disaster management policies in Indonesia.

New Directions in Communicating Better Nutrition to Older Adults

  • Guldan, Georgia-Sue;Wendy Wai-Hing Hui
    • Journal of Community Nutrition
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    • v.2 no.1
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    • pp.62-70
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    • 2000
  • Nutrition education should be an important component of ongoing health promotion for older adults and their caregivers. This is because prevention through sound nutrition and food hygiene practices and regular excercise is the most cost-effective way to reduce risks for and deal with their major health problems. nutritions education services should effectively promote optimum intake and successful self-care. Unfortunately, however relative to other vulnerable groups, nutrition education for older adults has not been systematically developed or evaluated. Usually oder adults care a lot about their health, so this should be a relatively easy group to teach - but their increasing numbers, longevity and great diversity with respect to health, physical, and economic status and educational level present challenges. Some older adults may not perceive they would benefit from nutrition education, so interesting and motivating them is a challenge. The food and nutrition knowledge of older people has been acquired through a lifetime of experience. For most older adults in the Asian region, their sources are restricted by their restricted education, so that their major sources of information have been informal sources, such as television, radio, friends, family, and perhaps newspapers and magazines if they are literature. Nonetheless, dietary advice for older people should build on their existing knowledge and ingrained values. It should provide information useful in daily food selection, and focus on food, not nutrients - the same foods and groups considered appropriate for younger people, with consistent messages as given throughout the population. Attention must also be paid to discovering learning styles in older people. When we teach in schools, the young students are a captive audience resigned to their learning role. Learning by an older adult, however, reflects an effort to meet his or her perceived needs. Therefore, nutrition education should be a positive experience in a non-threatening environment, relaxed and non-competitive, and perhaps even social environment. The messages also need to be practical and achievable. A needs assessment is essential, because our ability to provide the most effective nutrition education will depend on our success in matching the needs, both perceived and unperceived. of this vulnerable group. Therefore, go to the potential older learners to assess their interest and preferences. Nutrition education activities for older adults are widespread, but few have been evaluated. Evaluation is therefore also recommended, particularly when new methods are used. Tips from other countries for giving successful nutrition education will be given, including some examples of applications as attempted in Hong Kong. Research needs will also be described. In conclusion, successful nutrition education for older adults depends on positive needs-based messages. This is may be hard to do, as few good examples are available to illustrate these principles.

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The Relationship between the Polymorphism of CYP1A1, GSTM1, GSTT1, GSTP1 and p53 Overexpression in Head and Neck Squamous Cell Carcinoma (두경부 편평세포암종에서 CYP1A1, GSTM1, GSTT1, GSTP1 유전자 다형성 및 p53 과발현)

  • Tae Kyung;Park Hye-Kyung;Lee Seung-Hwan;Kim Kyung-Rae;Lee Hyung-Seok
    • Korean Journal of Head & Neck Oncology
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    • v.19 no.2
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    • pp.148-157
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    • 2003
  • Background and Objectives: Individual genetic susceptibilities to chemical carcinogens have been recognized as a major important host factors in human cancers. The cytochrome P450 family (CYPs) and glutathione S-transferase(GST) have been reported to be associated with risks to the smoking-related human cancers. Inactivation of tumor suppressor genes like p53 playa key role in tumor progression. The purpose of this study is to demonstrate an association between p53 overexpression and the prevalence of the genetic polymorphisms of CYP1A1 and GSTs in Korean head and neck squamous cell carcinoma (HNSCC). Materials and Methods: The polymorphisms of CYPIA1 and GSTs were analyzed by PCR and PCR-RFLP in 98 Korean head and neck squamous cell carcinoma patients. The expression of p53 was analyzed by immunohistochemistry with anti-p53 Ab (DO7). Results: Overexpression of p53 detected in 45.9% of HNSCC. The odds ratio for p53 overexpression in GSTM1(-), GSTT1(-), GSTP1(val/val) and CYP1A1(val/val) were 1.53, 1.83, 1.17 and 1.47, respectively. Among the combined genotypes, the odds ratio of the CYP1A1 val/val, GSTM1 (-), CYP1A1 val/val, GSTT1(-), and CYP1A1 val/val, GSTT1(-) were 2.0, 2.34 and 4.68, respectively. Conclusion: Based on our results, it might be suggested that p53 overexpression is slightly increased in GSTM1(-), GSTT1(-), GSTP1 val/val, CYP1A1 val/val genotypes. The further study is needed to evaluate the relationship and mechanism between the p53 overexpression and the specific CYP1A1 and GSTs genotypes.

The Effect on the Job Performance of Open Source Software Usage in Software Development (오픈소스 소프트웨어 기반의 소프트웨어 개발 과정에서 업무 성과에 미치는 영향을 미치는 요인)

  • Kim, YoonWoo;Chae, Myungsin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.4
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    • pp.74-84
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    • 2016
  • Open Source Software (OSS) is a new paradigm for software development. The system is based on the notion of giving software (including sources) away for free, and making money on services, customizing and maintenance. For these reasons, many software companies have considered adopting and using OSS in Software R&D. A variety of factors may influence the use of decision making of OSS. The objective of this study was to explore the significant factors affecting the use decision of OSS and the job performance of OSS usage in software R&D. A research model was suggested based on the TOE Framework and Information Systems Success Model. These findings show that technical benefits of OSS have significant effects on OSS use. The technical benefits of OSS, and organization context, in turn, have significant effects on the use of OSS. On the other hand, the technical risks of OSS and the environment context have no effects on OSS use. In addition, OSS use and user satisfaction have significant effects on the individual job performance. This research contributes towards advancing the theoretical understanding of the OSS Benefits and Performance in Software Development.

Estimation of Economic Impacts of SARS Disaster to Tour Demands of Four Major Countries in Korea

  • Kim, Geun-Young;Moore II, James E.;Chae, Seon-Hee
    • Journal of the Korean Society of Hazard Mitigation
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    • v.9 no.6
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    • pp.77-87
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    • 2009
  • Potential risks of communicable disease outbreaks have significantly increased in the era of global society. However, contingency planning of local governments for communicable diseases is not prepared to the proper level in various governmental sectors of many countries. Human being has been remarkable advances in medical science and public health. However, Severe Acute Respiratory Syndrome (SARS) still remains as a very dangerous transmissible disease that has great potential to create catastrophic consequences of casualties. The SARS outbreak between November 2002 and July 2003 resulted in 8,096 known infected cases and 774 deaths with a mortality rate of 9.6% worldwide (WHO, 2004). It is regarded as one of the human health disasters. Since about sixty-six percent of total SARS cases in the world were reported in People's Republic of China, Korean tour industry was significantly affected as a neighboring country. The objective of this research is to investigate major factors of Korea entry data sets, and to analyze economic impacts of Korean tour business interruption due to the period of SARS outbreak with tourist cases of four countries: Japan, U.S.A., China, and Taiwan. Results from this research show the seasonal and long-term trends of entry data sets of four countries, and direct and indirect impacts of SARS to Korean tour industry.

A Study on the Urethane Foam Material Characteristics and Appropriate Soil Covering for Mine Reclamation Emergency Action through Atificial Fire Test (인공 화재 실험을 통한 광해방지 응급조치용 우레탄 폼 재료 특성 및 적정 복토에 관한 연구)

  • Kim, Soo Lo;Park, Jay Hyun;Lee, Jin Soo;Yang, In Jae
    • Economic and Environmental Geology
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    • v.53 no.3
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    • pp.287-296
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    • 2020
  • Mine Reclamation Project is being carried out with the aim of ensuring a sustainable green living and helping to develop eco-friendly mines by analyzing, removing and preventing the harmful factors. Mines developed during the japanese colonial period and mining boom period are still not repaired throughout the country, and from these scattered risks, public safety is worth pursuing as a top priority. The project that is close to public safety in the mine recalmation project is an emergency treatment, and the most widely used method is a filling method similar to the ground subsidence prevention. If dangerous mine cavity or tunnels are located in the mountains, charging with existing materials may not be possible, or unreasonable cases may occur, and new methods of technological development are required. Emergency actions should be carried out safely and efficiently to prevent the loss of precious people's lives on the hiking paths adjacent to dangerous mining sites. In these field conditions, urethane foam materials may be an alternative. In this study, the applicability of urethane foam materials in mining was reviewed through overseas cases. It was also tested on the appropriate depth of top soil for the protection of urethane foam materials through forest fire simulation test. The test result show that approximately 15cm of soil covering (recommended 20cm over) was suitable for maintaining the function of foam materials from forest fires.

A Comparative Study of on-site Action Manual for People with Disaster Vulnerability (재난취약자의 현장조치 행동매뉴얼 비교연구 - 한국과 일본의 장애인 대상으로)

  • Kim, Soodong;Lee, Sahong;Choi, Kilhyun;Cheung, Chongsoo
    • Journal of the Society of Disaster Information
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    • v.13 no.2
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    • pp.155-162
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    • 2017
  • This study has some issues about the elderly, the disabled, and the vulnerable groups whose economic ability is low even if the disaster or disaster situation is not a big problem for the people. we should emphasize the necessity of disaster preparedness action manual considering the characteristics of disaster vulnerable classes and taking serious risks to them even in the same situation. We also want to conduct research only for people with disabilities who are choosing the same definition of the world among the vulnerable groups. I would like to provide a basis for developing a site action manual for people with disabilities by comparing the cases of Korea and Japan. Therefore, through the cases of Japan and Korea, it is possible to maintain the independence of everyday life during disasters, the communication function in disasters, the method of moving information and mobile information, the function of recognizing emergency response, Action Emphasize the urgency of developing action manuals. From this domestic situation, we will conclude the discussion on the disaster safety and action manual for the disabled.

Potential Hazard Classification of Aged Cored Fill Dams (노후 코어형 필댐의 잠재 위해성 유형 분류)

  • Park, DongSoon;Oh, Je-Heon
    • The Journal of Engineering Geology
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    • v.26 no.2
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    • pp.207-221
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    • 2016
  • As greater numbers of fill dams and reservoirs become old, the risks of damage or embankment collapse increases. However, few studies have considered the deterioration and hazard classification of the internal core layers of fill dams. This study reports the results of geotechnical investigations of 13 earth-cored fill dams in Korea, based on no-water borehole drilling, Standard Penetration Test, and 2D and 3D electrical resistivity surveys along with in situ and laboratory testing. High-capacity no-water boring minimized core layer disturbance while providing continuous core sample recovery. The results allow the classification of potential hazards related to the existing core layers based on both visual inspection of the recovered samples and the results of engineering surveys and tests. Four types of potential hazard are classified: locally fluidized core with a high water content, rapid water inflow to a borehole, cores with granular materials, and relatively low stiffness of core. Among these, the locally fluidized core is the most critical hazard that requires remedial action because it is related to the potential internal flow path and internal erosion. The other three hazard types are of medium importance and require careful monitoring and regular inspection. Of note, there was no correlation between age and core deterioration. The results are expected to aid the safe management and potential upgrading of aging cored fill dams.