• Journal of Korea Technology Innovation Society
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• v.16 no.1
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• pp.279-302
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• 2013

This paper empirically examines the effect of government R&D support on the performance of the firm in Korea. In particular, we examine to what extent the government R&D support affected the firm's exploratative performance. Using a novel dataset combining patent information with national government R&D funding data and firm performance indicators from 2005-2008, we construct and run an empirical model where a firm's exploratative activity, measured by a firm patenting in a different field, is a function of the government R&D support a firm receives. The empirical results show that the government R&D support has a positive effect on the firm's exploratative activity. Especially, this effect is stronger for the small and medium size firms, while large firms are relatively relying on their own R&D funding for exploration. This result indicates that the government needs to focus more on R&D funding for small and medium size firms, if it wants more exploratative outcomes to enhance potential resources for economic development.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.1
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• pp.11-19
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• 2021

The purpose of this study is to check whether the satisfaction of the R&D (Research & Development) project directly affects the R&D performance, and to find out whether the satisfaction with regional connectivity and the satisfaction with the R&D operation management significantly mediate the relationship that the satisfaction with the R&D project has on the R&D performance. In order to verify the research hypothesis on this, a total of 51 companies located in Jeollanam-do that actually conducted R&D research projects were surveyed and analyzed. In order to conduct an empirical study based on the collected questionnaire, a survey questionnaire related to the variables of the study model was composed based on a sample of 51 questionnaires. We used the SPSS program to verify the hypotheses in this study, and the hypotheses were verified by analyzing the validity, reliability, correlation, and deflection. As a result, there was a positive (+) significant relationship between R&D project satisfaction and R&D performance. In addition, it was found that the relationship between R&D project satisfaction and R&D performance was significantly mediated by the satisfaction with R&D regional connectivity and satisfaction with R&D project operation management.

• YAKHAK HOEJI
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• v.41 no.2
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• pp.225-232
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• 1997

The in vitro antibacterial activity of DWP20367 (1-Cyclopropyl-6-fluoro-8-chloro-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid), a new broad-spectrum fluoroquinolone, was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20367 was showed antibacterial activity much higher than CPFX, SPFX and OFLK against gram-positive bacteria, while it was slightly more superior to quinolones against gram-negative bacteria. DWP20367 was particularly effective against MRSA, and its $MlC_{90}$ against clinical isolates of methicillin-susceptible S. aureus, low methicillin-resistant S. aureus and high methicillin-resistant S. aureus were 0.098, 0.781 and 1.563 micro g/ml, respectively. Against S. pneumoniae, MIC90 of DWP20367 was 2- to 8-fold higher than those of CPFX. With a view of MIC90, DWP20367 showed slightly more potent activity against P. aeruginosa and E. coli isolates than the control quinolones. DWP20367 activity was not affected by inoculum size and medium pH. But addition of $Mg^{2+}, \;Ca^{2+} $Mg2+, Ca2+ or horse serum (25%) decreased its antibacterial activity. DWP20367 was showed rapidly bactericidal activity within 2 to 4 h, and regrowth was not observed even after 24 h incubation at concentrations near the 4-fold of MIC.

• Journal of Technology Innovation
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• v.23 no.1
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• pp.61-86
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• 2015

This study provides an empirical analysis based on 2012 Korea Innovation Survey (STEPI) to investigate the relation between R&D cooperation and in-house R&D investment. The study further analyzes the effect of the R&D cooperation and in-house R&D investment on technical innovation. First, the relation between company's in-house R&D investment and R&D cooperations is estimated with the two equations using SUR models. Second, the effect of in-house R&D investment and R&D cooperation on the company's technical innovation is estimated using Probit model. This study differs from other existing R&D studies using Korean data in that empirical models are based on structural relationships among in-house R&D, R&D cooperation, and technical innovation. The results can be summarized as follows; the R&D cooperation expands the in-house R&D investment and the in-house R&D strengthen the R&D cooperation. Furthermore, In-house R&D investment increases the chances of success in innovation. As we obtain evidence of complementary relation between R&D cooperation and in-house R&D investment, it is necessary to develop environment conducive to this complementarity in order to have more efficient R&D system.

• Journal of Technology Innovation
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• v.21 no.2
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• pp.137-167
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• 2013

This article estimates the scale of impact of expanding governmental fiscal expenditure for R&D investment on the private business enterprise's investment for R&D, and the relationship between business enterprise and university for expanding investment of R&D. According to my results, first, an expanding fiscal expenditure from government for R&D investment leads to increase R&D investment from business enterprise. However, an expanding expenditure from university rather leads to decrease R&D investment from business enterprise. Secondly, the crowding-out effect of expanding R&D investment from University on business enterprise's is very strong, and it is affected by structural changes such as the country's economic power, fiscal stance and cyclical volatility. Third, the more governmental expenditure on university expansive is, the stronger asymmetric relationship between business enterprise and university is, and investment sources of university from business enterprise is the main factor of this relationship. Finally, it is not easy to solve out this asymmetric relationship even through the governmental subsidy.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.87-107
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• 2003

It was demonstrated that Transactivating transcriptional activator(TAT) protein from HIV-1 shown to enter cells when added to the surrounding media. TAT peptide chemically attached to various proteins was able to deliver these proteins to various cell and even in tissues in mice with high levels in heart and spleen. In this study, the tripeptide GKH(Glycine-Lysine-Histidine) derived from Parathyroid hormone (PTH), which was known as lipolytic peptide, is attached to 9-poly Lysine(TAT) to be used as a cosmetic ingredient for slimming products. When Glycerol release, expressed as extracellular glycerol concentration, is lipolysis index, TAT-GKH at $10^{-5}$mo1/L induces approximately 41.5% maximal lipolytic effects in epididymal adipocytes isolated from rats, compared with basal lipolysis. Epididymal adipose tissues of male rats is assessed ex vivo by microdialysis. Probes are perfused with Ringer solution in which increasing concentrations of TAT-GKH. The perfusion of TAT-GKH induces lipolytic effect. Penetration study showed that TAT-GKH efficiently elevates 36 times higher penetration into the excised hairless mice skin than GKH. in vivo study showed that TAT-GKH had a better effect upon the relative volume of eye bag after 28 days of application on twenty(+2) healthy female volunteers. It was identified that TAT-GKH increases penetration enhancement and lipolytic effects in both in vitro, ex vivo and in vivo.

• Journal of Korea Technology Innovation Society
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• v.20 no.4
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• pp.1192-1211
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• 2017

Today, innovation is driven by the challenge of existing paradigms and by cooperating with many other fields as well as their own, and thus the importance of open innovation is emphasized. This study analyzed the effect of open innovation on innovation activities and examined the role of organizational innovation in various innovation activities. For the analysis, Korean Innovation Survey (KIS) data from Science and Technology Policy Institute (STEPI) in 2016 was used. A total of 1,453 manufacturing firms were selected as a sample and logistic regression was performed. As a result, R&D cooperation has a positive effect on product innovation as the most representative means to acquire new knowledge and technology, while R&D cooperation has no relation with process innovation. In the case of organizational innovation, it strengthens positive effects of R&D cooperation on both product innovation and process innovation. Organizational change can be explained to play a positive role in new innovation activities, and then firms will need to consider organizational innovation in relation to R&D cooperation. This study is meaningful in that it analyzes the causal relationship and role in relation to various types of innovation, and will contribute to the firms to smoothly perform innovation activities in the future.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.457-462
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• 2004

Anti-wrinkle effect of N-Acetyl-D-glucosamine (NAG) was evaluated by collagen synthesis and proliferation of normal human fibroblast. NAG was obtained by purifying deacetylated chitin which can be derived from chitin-rich crab shell. We studied in in-vitro cultures of human normal fibroblast, whether synthesis of collagens and fibroblast growth activation in these cells can be enhanced in the presence of NAG. It 야d not show any adverse effects in human shin irritation patch test. In in-vivo mouse test, it showed anti-wrinkle effect in hairless mouse (6W/F). From the HPLC analysis, the stability of NAG in the cosmetics product could be maintained for a long time. These results demonstrated that NAS can be useful anti-wrinkle cosmetic ingredient.

• Proceedings of the Technology Innovation Conference
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• 2004.02a
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• pp.83-107
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• 2004

This study investigates how and through which channels R&D activities influences the national economy, using a macro-econometric model. The macro-econometric model in this study includes 24 behavioral equations and 25 identities and was estimated using the annual data. From a simulation analysis, it is shown that the R&D investment has a permanent effect on real variables; lowering prices, wages and interest rates, and increasing potential and real GDP in the long run. It is noted that the national account was recalculated to avoid double-counting in estimation of R&D stocks.

• YAKHAK HOEJI
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• v.41 no.2
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• pp.233-240
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• 1997

The in vitro antibacterial activity of DWP20418 (1R, 5S, 6S)-6-[1-(R)-Hydroxyethyl)-l-methyl-2-[(2S,4S)-2-(piperazinylcarbonyl)-1-(R)-hydroxyethyl)pyrrolidine-4-thio]carb apen-2-em-3-carboxylic acid), a new carbapenem antibiotic, was compared with those of imipenem (IPM) and meropenem (MEPM). DWP20418 was comparable or slightly more superior to MEPM against gram-positive bacteria, and it showed more potent activity to IPM against gram-negative bacteria. DWP20418 was particularly active against MRSA, and its $MIC_{90}$ of methicillin-susceptible S. aureus, low methicillin-resistant S. aureus and high methicillin-resistant S. aureus were 0.391, 25 and 50 ${\mu}g/ml$, respectively. With a view of $MIC_{90}$, DWP20418 was comparable than the other carbapenems against P. aeruginosa and E. coli isolates. The activity of DWP20418 was not affected in the presence of $Mg^{2+},\;Ca^{2+}$ or horse serum. But inoculum size and alterations in pH of medium affected its antibacterial activity. DWP20418 showed rapidly bactericidal activity within 1h, and regrowth was not observed even incubation of 24hrs at the concentrations near the MIC.