Browse > Article

Anti-wrinkle Effect of N-Acetyl-D-glucosamine (NAG)  

Kim Kwang Soo (R&D Center, Nadri Cosmetics Co., Ltd.)
Choi Gun Ho (R&D Center, Nadri Cosmetics Co., Ltd.)
Choi Jang Woo (R&D Center, Nadri Cosmetics Co., Ltd.)
Choi Jun Hak (R&D Center, Nadri Cosmetics Co., Ltd.)
Han Song Hee (R&D Center, Nadri Cosmetics Co., Ltd.)
Nam Sang Yun (Department of Biological Science, School of Science and Technology, Jeonju University)
Lee Seung Hwa (R&D Center, Nadri Cosmetics Co., Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.30, no.4, 2004 , pp. 457-462 More about this Journal
Abstract
Anti-wrinkle effect of N-Acetyl-D-glucosamine (NAG) was evaluated by collagen synthesis and proliferation of normal human fibroblast. NAG was obtained by purifying deacetylated chitin which can be derived from chitin-rich crab shell. We studied in in-vitro cultures of human normal fibroblast, whether synthesis of collagens and fibroblast growth activation in these cells can be enhanced in the presence of NAG. It 야d not show any adverse effects in human shin irritation patch test. In in-vivo mouse test, it showed anti-wrinkle effect in hairless mouse (6W/F). From the HPLC analysis, the stability of NAG in the cosmetics product could be maintained for a long time. These results demonstrated that NAS can be useful anti-wrinkle cosmetic ingredient.
Keywords
anti-wrinkle; collagen synthesis; stable ingredient; hairless mouse;
Citations & Related Records
연도 인용수 순위
  • Reference
1 V. James, E. G. Suzanne, J. Gary, and J. V. John, Inhibition of type I procollagen production in photodamage: correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesis, J. Inv. Der., 119(1), 122 (2002)
2 Y. Tsukada, K. Miyazawa, and N. Kitamura, High intensity ERK signal mediates hepatocyte growth factor-induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2, J. Biol. Chem, 276, 40968 (2001)
3 E. R. Savolainen, B. Goldberg, M. A. Leo, M. Velez, and C. S. Lieber, Diagnostic value of serum procollagen peptide measurements in alcoholic liver disease, Alcohol Clin Exp. Res., 8(4), 384 (1984)
4 U. Hiroshi, Y. Haruo, T. Ichiro, K. Naoki, M. Mitsunobu, O. Masahiro, K. Tsuyoshi, and F. Toru, Accelerating effects of chitosan for healing at early phase of experimental open wound in dogs, Biomaterials, 20, 1407 (1999)
5 Y. Niitsu, N. Ito, K. Kohda, M. Owada, K. Morita, S. Sato, N. Watanabe, Y. Kohgo, and I. Urushizaki, Immunohistochemical identification of type I procollagen in tumor cells of scirrhous adenocarcinoma of the stomach, Br. J. Cancer, 57(1), 79 (1988)
6 T. Sayo, S. Sakai, and S. Inoue, Regulation of hyaluronan synthesis in keratinocytes and its modulator, IFSCC (2002)
7 F. De Marchis, D. Ribatti, C. Giampietri, A. Lentini, D. Faraone, M. Scoccianti, M. C. Capogrossi, and A. Facchiano, Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its alpha receptor, Blood, 99(6), 2045 (2002)
8 A. M. Parfitt, L. S. Simon, A. R. Villanueva, and S, M. Krane, Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone, Correlation with iliac bone formation rates and comparison with total alkaline phosphatase, J. Bone Miner Res., 2(5), 427 (2000)
9 A. A. Van de Loosdrecht, E. Nennie, G. J. Ossenkoppele, and R. H. Beelen, Langenhuijsen MM. cell mediated cytotoxicity against U937 cells by human monocytes and macrophages in a modified colorimetric MTT assay, A methodological study, J. Immunol. Methocls, 141(1), 15 (1991)
10 M. B. Taubman, B. Goldberg, and C. Sherr, Radioimmunoassay for human procollagen, Science, 186 (4169), 11150 (1974)