• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.3
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• pp.123-129
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• 2010

R&D innovation is based on the premises of gaining competitive advantage. Innovation is achieved not only through the development of technology for producing newer and better products, but also gaining and sharing information about consumer demands, changes in the market, and competitors actions. Investment in R&D can not adequately be fulfilled solely through market functions because of R&D activities imply high-risk, uncertainty, and because R&D has a public-good characteristic. Most past researches have concentrated on managerial methodologies through research of performance, thus the results are related to studies of innovation performance. This research looks into the effect given on R&D innovation by IT factors and provides a model, and further analysis on how IT factors are applied through this model. By developing a model through the process of re-structuring the model with variables based on the convergent and discriminant validity, and in turn confirming and concentrating on major IT factors through analysis, it will be possible to double the R&D Innovation Performance.

• Journal of Digital Convergence
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• v.14 no.8
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• pp.47-56
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• 2016

This study is on the actual analysis of R&D investment effect through DEA in terms of efficiency resulted from forestry sector climate change response R&D project. Namely, it is clarifying the mechanism of the scientific, technological, social performance result and output, depending on research development cost, employment size as same input. Also, it is in-depth analysis on which performance operates more efficiently in any detailed business. With the study result, we seek political implications to enhance investment effect and core element to consider R&D business project in the future.

• Asia pacific journal of information systems
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• v.32 no.4
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• pp.728-749
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• 2022

The information and communication technology (ICT) value creation process is inherently unobservable. In addition to the direct effect of ICT on productivity, some information or knowledge can create value through other knowledge activities. In this paper, we study the impact of ICT on productivity through R&D. We tested the mediating effect of R&D between ICT and productivity using panel data from 47 US industries from 1987 to 2013 from the Bureau of Labor Statistics. The results show that R&D partially mediates ICT and productivity. That is, ICT directly increases productivity, and some of its effects can be realized through R&D. Recipients who acquire knowledge through ICT have to interpret codified ideas and apply them to practice. The increased absorptive capacity that can be developed through R&D improves interpretation ability, allowing employees to share more complex ideas. Thus, ICT helps people to effectively communicate, but some information and knowledge can be realized and applied through R&D knowledge activities. This is the first study empirically examining the process of ICT value creation through R&D. It also provides practical guidelines for knowledge management, such as making decisions about ICT and R&D investments that are better done concurrently rather than individually to maximize their impact on productivity.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.1
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• pp.79-86
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• 2020

The effects of R&D investment on innovation such as patents and intangible assets, and the effect on the corporate performance such as revenue and profit growth, were analyzed using path analysis. In particular, this study compared and analyzed the performances of non-cooperative R&D and cooperative R&D. The results of this study are summarized as follows. First, R&D investment has a significant impact on innovation performance. This supports the existing research results. Second, patents have a significant impact on intangible asset growth. Third, in the case of corporate groups carrying out cooperative R&D, intangible asset growth forms a significant causal relationship with revenue growth. Fourth, in case of cooperative R&D, intangible asset growth has a significant mediating effect between patent and revenue growth. Like the existing research, the results of this research support the innovation performance of R&D investment. It also supports the existing argument that the results of cooperative R&D are more favorable to increase corporate value. However, unlike the existing research, we found a path leading to increased revenue through patents and intangible assets, and confirmed that such a path is likely to be achieved through cooperative R & D rather than internal R&D.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.1
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• pp.15-26
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• 2021

Peptides are short chain of amino acids linked by peptide bonds. They are widely used as effective and biocompatible active ingredients in cosmetic industry. In this study, we developed novel peptide mixture and identified its anti-pigmentation effect on melanocytes and keratinocytes. Our results revealed that peptide mixture inhibited melanosome biogenesis through the regulation of microphthalmia-associated transcription factor, a key factor of melanogenesis in melanocytes. And we observed that peptide mixture inhibited melanosome uptake through the reduction of protease-activated receptor 2, a phagocytosis-related receptor in keratinocytes. Furthermore, peptide mixture activated autophagy system resulting in degradation of transferred melanosomes in keratinocytes. The anti-pigmentation effect of multi-targeting peptide mixture was assessed in a human skin equivalent model (MelanoDerm). Melanin contents in epidermal layer were significantly decreased by topical treatment of peptide mixture, suggesting that it can be applied as a novel cosmetics material having a whitening function.

• Journal of Korea Technology Innovation Society
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• v.13 no.3
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• pp.558-586
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• 2010

This paper analyze the economic effect of R&D investment for the IT Green growth initiatives in Korea, relating to Green growth which is main force for activating in order to durable growth currently. The IT green growth initiatives can be grouped by IT manufacture, IT service, and S/W and computer-related services in the R&D investment and to be analyzed by the RAS forecasting methods. The results indicate that the production-inducing effect is about 31,853 billion won for the IT manufacture, and IT service is about 14,360 billion won, and the next is S/W and computer-related service whose effect is about 4,482 billion won. The import, value added, and employment effect of IT manufacture is also bigger than those of any other sectors in IT. This is because R&D investment in case of IT manufacture is more huge than IT service. Besides, employment-inducing effects show that IT manufacture is highest in 16,596 persons; IT service is secondly highest in 9,000 persons and S/W; lastly, computer-related service is much lower than those of any other sector. So we can conjecture that the long-term initiatives of IT green growth implementation lead to increasing size of benefits in the IT sectors.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.1040-1043
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• 2009

a-IGZO is an attractive material to make an AMOLED device with uniform TFT properties for use in a large size display. However, this material shows TFT properties that are very sensitive to water or hydrogen. Therefore, it is essential to control these critical factors during fabrication of the backplane in order to improve the TFT performance. In this paper, we report the effect of passivation layer properties on the performance of the oxide TFTs.

• Management & Information Systems Review
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• v.38 no.2
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• pp.225-240
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• 2019

It has been known that health industry clusters promote economy of a nation in a macro view and make growth and development of individual firm. As a result, Korean health industry has been grown to play a role of making a high value added in Kwangkyo, Daedeok, Wonju, and Songdo. Using 156 firms locating in health industry clusters such as Kwangkyo, Daedeok, Wonju, and Songdo in increasing value added, this study investigated the structural relationships among R&D resources, R&D collaboration, policy support, and operational performance. All hypotheses, except a hypothesis for the effect R&D resources on operational performance, are reported to be statistically significant. In other words, the positive effect of R&D resources on policy support is reported. And policy support and R&D collaboration positively affect operational performance, and also the positive effect of policy support on R&D collaboration is reported. From the empirical results, we can know that policy support and R&D collaboration are the crucial factors to promote operational performance of the firms locating in Korean health industry clusters. It is important that this study has been investigated with the firms of health industry developing economy of a nation.

• Analyses & Alternatives
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• v.8 no.2
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• pp.87-115
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• 2024

This study examines the effect of R&D investment on firm performance and value of Chinese private firms. Through R&D investment, firms aim to acquire knowledge and technological resources to create innovation and competitive advantage, which ultimately enhances firm performance and value. However, unlike other investments, R&D investments are characterized by high adjustment costs and risks, uncertainty and asymmetric information. In addition, the effect of R&D investment on firm performance and value has been shown to be mixed results due to various internal and external contextual factors. Therefore, this study intends to consider how the ESG activities of firms, which have recently attracted attention, act as a contextual factor in the results of R&D investment. This is because interaction with stakeholders through ESG activities is considered to be an important factor in securing competitive advantages and sustainable growth. In this context, this study measures the effect of a firm's R&D investment on its business performance by dividing it into financial performance and value, respectively, and examines the moderating effect of ESG score on the relationship. Based on empirical analysis of all Chinese private firms from 2010 to 2019, the results show that a firm's R&D investment has a negative impact on performance and a positive impact on value. Furthermore, a high ESG score of private firms positively moderates each relationship, emphasizing the importance of ESG activities.

• Biomolecules & Therapeutics
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• v.12 no.2
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• pp.114-121
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• 2004

This study was undertaken to evaluate the general pharmacological properties of CJ-11828, an amlodipine adipate, in experimental animals and in vitro system. CJ-11828 had no effects on general behavior, motor coordination, writhing syndromes, pentetrazol-induced chemoshock and electric shock in mice at dose levels of 3,10, anti 30 mg/kg, po. But there were decrease of body temperature, prolongation of sleeping time, and inhibition of intestinal activity in mice treated with CJ-11828 at doses of 10 and 30 mg/kg, po. CJ-11828 decreased the blood pressure in coscuous fog at the dose level of 2mg/kg, po, but it was expected as a result of pharmacological activity of CJ-11828. Any effect on respiratory system was not observed in conscious rat at doses of 3,10, and 30 mg/kg, po. The slight decrease in spontaneous motor activity was observed in mice treated with CJ-11828 at high dose, 30 mg/kg. In vitro experiments, CJ-11828 had no effect on agonists-induced contraction of isolated guinea pig ileum at 0.1, 1, and 10 ${\mu}$M. Based on these results, it was concluded that CJ-11828 had no pharmacological effect ill these studies even up to the 36-fold anticipated clinical dose, 3 mg/kg.