• 디지털산업정보학회논문지
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• 제16권2호
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• pp.95-104
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• 2020

Bribery is one of the world's most destructive and challenging issues. Yet despite efforts on national and international levels to tackle bribery, it remains a significant issue. Recognizing this, ISO has developed a new standard to help organizations fight bribery and promote an ethical business culture, which is "ISO 37001 - Anti-bribery Management Systems" in 2016. ISO 37001 can provide the tools and systems to greatly reduce the risk and help organizations deal with it effectively if it does arise. It is a flexible tool, which can be adapted according to the size and nature of the organization and the bribery risk it faces. After enforcing the Improper Solicitation and Graft Act, Korean government standardized ISO 37001, one of the Business Ethics of Global Standard, harmonizing International Standards into Korean Industrial Standards (KS) in 2017. It is meaningful in that Korean companies have localized regulation which applies to global standard anti-bribery management systems. Only about 100 organizations, however, have adopted ISO 37001 so far. The primary purpose of this paper is to examine the expectation and awareness of ISO 37001. Results show that still many organizations lack of awareness of ISO 37001 and it is implicated that much promotion and education will be necessary. This study has originality and value in that it can provide the guidelines for activation of ISO 37001.

• 한국안광학회지
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• 제11권4호
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• pp.351-355
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• 2006

본 연구는 국내 콘택트렌즈의 규격화 현황에 관하여 연구하였다. 최근 콘택트렌즈의 착용률이 증가하고 있음에도 불구하고 한국 산업 규격은 단지 국제 표준화 기구인 ISO(International Organization for Standardization)의 규정을 그대로 번역하여 사용하고 있으며, 아직 국내의 독자적인 규정이 없는 상태이다. 따라서 본 연구는 콘택트렌즈의 ISO(국제표준화 규격)를 조사, 연구하여 국제 규격이 우리의 현 실태와의 어느 정도 부합되는지와 이에 따른 문제점을 파악하여 개선되어야 할 부분에 대해 연구하였다.

• 토지주택연구
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• 제5권4호
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• pp.315-323
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• 2014

본 연구는 외단열시스템 성능평가의 주요인자인 선형열관류율을 국제규격(ISO)에서 제시하고 있는 평가방법에 의거, 내단열시스템 대비 외단열시스템의 열성능에 대한 우수성을 정량적으로 파악하고, 향후 외단열시스템의 열성능 평가를 위한 기초자료로의 활용을 목적으로 한다. 이를 위해 공동주택의 대표적 열교부위인 3개 부위를 내단열과 외단열 시스템으로 설계하고, 각 부위별 단열형태별로 선형열관류율을 평가하였다. 그 결과, 외벽-발코니 슬라브 부위는 열교차단재 설치가 필수적인 것으로 분석되었으며, 열교차단재를 설치할 경우 외단열시스템이 내단열시스템보다 선형열관류율이 1/2 이상 줄어드는 것으로 나타났다. 측벽-발코니 부위와 같이 슬라브가 외부로 돌출되지 않는 구조에서는 외단열시스템을 적용할 경우, 선형열관류율이 거의 0인 것으로 나타났다. 내단열로 설계된 외벽-경계벽의 경우, 선형열관류율은 0.451W/m 로 내단열로 설계된 외벽-발코니 슬라브 등 열교가 있는 부위와 비슷한 값을 보이며, 외단열로 설치될 경우 이 또한 거의 0인 것으로 나타났다. 향후, 공동주택의 외단열시스템 도입 및 성능평가를 위해서는 국제기준을 적용한 국내 평가기준의 제도화마련이 필요하며, 특히 제도화 마련과정에서 선형열관류율 계산 인자 중의 하나인 벽체길이의 계산방법은 국가차원의 결정이 필요할 것으로 판단된다.

• 대한의용생체공학회:의공학회지
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• 제43권4호
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• pp.199-213
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• 2022

EN ISO 14971:2012 a risk management standard approved and applied as a European standard in 2012, will be adopted and applied as ISO 14971:2019 published in December 2019, ISO/TR 24971(Guidance) published in June 2020 from May 2022. After that, it is applied to IVDD surveillance and IVDR new and conversion, and the manufacturer is already preparing for application or is starting preparation for application. In addition, 98/78/EEC IVDD applied from 1998 will also be applied as REGULATION (EU) 2017/746 IVDR from May 2022. In particular, in IVDR, the requirements for post-marketing investigations such as Post Market Surveillance (PMS), Summary of safety and performance(SSP), Periodic Safety Update Report(PSUR) and Post Market Performance Follow Up(PMPF), which were not required in the existing IVDD, increased, and the contents were also specified. This study focused on ISO14971:2019 among these strengthened and newly applied regulations, and tried to present a detailed analysis and application plan of Post Market Surveillance (PMS) required by 2017/746 IVDR.

• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.203-217
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• 2019

The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide dismutase [SOD] and glutathione [GSH]), and expression of heat shock protein (Hsp) 70 and connexin 43 (Cx-43) in myocardial muscles in isoproterenol (ISO) induced myocardial infarction (MI). Thirty two adult male Sprague Dawely rats were divided into 4 groups (each 8 rats): normal control (NC) group, ISO group: received ISO at dose of 150 mg/kg body weight intraperitoneally (i.p.) for 2 successive days; ISO + Trizma group: received (ISO) and Trizma (solvent of CoPP) at dose of 5 mg/kg i.p. injection 2 days before injection of ISO, with ISO at day 0 and at day 2 after ISO injections; and ISO + CoPP group: received ISO and CoPP at a dose of 5 mg/kg dissolved in Trizma i.p. injection as Trizma. We found that, administration of ISO caused significant increase in heart rate, corrected QT interval, ST segment, cardiac enzymes (lactate dehydrogenase, creatine kinase-muscle/brain), cardiac HO-1, Hsp70 with significant attenuation in myocardial GSH, SOD, and Cx-43. On the other hand, administration of CoPP caused significant improvement in ECG parameters, cardiac enzymes, cardiac morphology; antioxidants induced by ISO with significant increase in HO-1, Cx-43, and Hsp70 expression in myocardium. In conclusions, we concluded that induction of HO-1 by CoPP ameliorates ISO-induced myocardial injury, which might be due to up-regulation of Hsp70 and gap junction protein (Cx-43).

• 한국환경과학회지
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• 제16권1호
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• pp.27-32
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• 2007

In this study, the concentrations of offensive odorous compounds seasonally emitted from the chemical plant at Chongju industrial complex in Korea were determined by the analytical methods of gas chromatography, high performance liquid chromatography and uv/vis spectroscopy. The kinds of offensive odorous compounds examined are formaldehyde, acetaldehyde, butyl aldehyde, propion aldehyde, n-valeric aldehyde, iso-valeric aldehyde, hydrogen sulfide, methyl mercaptan, dimethyl sulfide, dimethyl disulfide, trimethyl amine and ammonia. The seasonally emission levels of all odorous compounds except dimethyl sulfide at 13 sampling points of plant were lower than those of the regulation standard levels of the industrial complex in Korea. The levels were the highest in June, and lowest in December. The propion aldehyde and iso-valeric aldehyde in June and December, butyl aldehyde in December, and n-valeric aldehyde were not detected in all the three seasons at any sampling points of the plant examined. But in June, dimethyl sulfide was emitted up to 16 times than that of the regulation level.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2003년도 추계학술대회논문집
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• pp.371-376
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• 2003

The objective of this paper is to compare the site-to-site variability of ISO 10844 pass-by-noise test sites. In order to investigate the site-to-site variance of test surfaces, European commercial tires are tested at seven different test sites. Three Korea test sites and four Europe test sites are selected.. The pass by noise test is executed according to a 2001/43/EC regulation. A]though the ISO surface has a very specific track composition, it does not reduce the variation of pass-by-noise measurements over the surface of test sites. This paper shows that the test results of pass-by-noise level are different depending on the test sites. The correlation obtained in this work is able to predict the pass by noise level for certain test site using the data measured from another test site. 17he prediction value is range with an error within 1dB(A).

• 청정기술
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• 제6권1호
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• pp.7-15
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• 2000

본 연구의 목적은 ISO 14001 환경경영시스템 인증이 기업의 환경법규 준수에 미치는 영향을 조사하여 합리적인 환경경영시스템 구축이 될 수 있도록 하는데 있다. 이 연구는 ISO 14001 인증을 취득한 국내 기업의 설문 조사를 통해 ISO 14001 인증의 효과를 조사하였고, 환경부 보도자료를 이용해 인증기업과 비인증기업의 법규 준수율을 조사하였다. ISO 14001 인증의 동기는 주로 고객의 요구 혹은 국제적인 요구에 의하여 추진하는 경우가 많았고, 인증을 취득한 기업이 인증을 받지 않은 기업에 비하여 환경 법규 준수율이 3배 이상 높게 나타났다. 이렇게 법규 준수율이 높은 이유는 추진목적이 명확하고, 기업의 전 종업원이 참여하여 ISO 14001 요구사항에 따라 자율적인 개선을 도모함으로써 체계적인 환경관리가 가능하게 되었기 때문으로 생각된다. 또한 시스템 구축 후 자율적인 감사와 년 2회 실시되는 인증기관의 심사를 통해 지속적인 감시체계가 가능해졌으며, 최종적으로 최고 경영자에 의한 경영자 검토 과정을 통해 전과정을 확인하는 체계를 구축할 수 있었던 것이 그 중요한 원인으로 추측할 수 있다. 즉, 목적-방법-점검-사후관리의 4-STEP이 효율적으로 가동됨으로서 얻어진 결과로 볼 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3035-3042
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• 2015

Background: Isorhamnetin (Iso), a novel and essential monomer derived from total flavones of Hippophae rhamnoides that has long been used as a traditional Chinese medicine for angina pectoris and acute myocardial infarction, has also shown a spectrum of antitumor activity. However, little is known about the mechanisms of action Iso on cancer cells. Objectives: To investigate the effects of Iso on A549 lung cancer cells and underlying mechanisms. Materials and Methods: A549 cells were treated with $10{\sim}320{\mu}g/ml$ Iso. Their morphological and cellular characteristics were assessed by light and electronic microscopy. Growth inhibition was analyzed by MTT, clonogenic and growth curve assays. Apoptotic characteristics of cells were determined by flow cytometry (FCM), DNA fragmentation, single cell gel electrophoresis (comet) assay, immunocytochemistry and terminal deoxynucleotidyl transferase nick end labeling (TUNEL). Tumor models were setup by transplanting Lewis lung carcinoma cells into C57BL/6 mice, and the weights and sizes of tumors were measured. Results: Iso markedly inhibited the growth of A549 cells with induction of apoptotic changes. Iso at $20{\mu}g/ml$, could induce A549 cell apoptosis, up-regulate the expression of apoptosis genes Bax, Caspase-3 and P53, and down-regulate the expression of Bcl-2, cyclinD1 and PCNA protein. The tumors in tumor-bearing mice treated with Iso were significantly smaller than in the control group. The results of apoptosis-related genes, PCNA, cyclinD1 and other protein expression levels of transplanted Lewis cells were the same as those of A549 cells in vitro. Conclusions: Iso, a natural single compound isolated from total flavones, has antiproliferative activity against lung cancer in vitro and in vivo. Its mechanisms of action may involve apoptosis of cells induced by down-regulation of oncogenes and up-regulation of apoptotic genes.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 춘계학술대회논문집
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• pp.1194-1197
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• 2006

Recently, international standard for measurement of sound absorption in a reverberation room has been amended. In the revised version, temperature, humidity and air pressure conditions are strictly restricted and also the concrete procedures are presented to reduce the differences in test results by adding inspection of diffusion, measurement uncertainty etc. In this paper, the systematic tests are conducted based on the inspection guide of diffusion defined by ISO 354 and the effects of diffusers on the measurement of sound absorption ratio are considered. As a result, we perceived that the averaged sound absorption ratio in mid and high frequency range is expected to measure around $0.05{\sim}0.1$ higher in high sound absorption material. Therefore, as for the reverberation room for measurement of sound absorption, we need to take into consideration not only the spatial standard deviation of sound pressure mandated by ISO 3741, but also, inspection regulation of diffusion showed by ISO 354.