• Journal of Korea Society of Digital Industry and Information Management
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• v.16 no.2
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• pp.95-104
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• 2020

Bribery is one of the world's most destructive and challenging issues. Yet despite efforts on national and international levels to tackle bribery, it remains a significant issue. Recognizing this, ISO has developed a new standard to help organizations fight bribery and promote an ethical business culture, which is "ISO 37001 - Anti-bribery Management Systems" in 2016. ISO 37001 can provide the tools and systems to greatly reduce the risk and help organizations deal with it effectively if it does arise. It is a flexible tool, which can be adapted according to the size and nature of the organization and the bribery risk it faces. After enforcing the Improper Solicitation and Graft Act, Korean government standardized ISO 37001, one of the Business Ethics of Global Standard, harmonizing International Standards into Korean Industrial Standards (KS) in 2017. It is meaningful in that Korean companies have localized regulation which applies to global standard anti-bribery management systems. Only about 100 organizations, however, have adopted ISO 37001 so far. The primary purpose of this paper is to examine the expectation and awareness of ISO 37001. Results show that still many organizations lack of awareness of ISO 37001 and it is implicated that much promotion and education will be necessary. This study has originality and value in that it can provide the guidelines for activation of ISO 37001.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.4
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• pp.351-355
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• 2006

For this study we investigated situation of domestic standardization in contact lens field. The rate of contact lens wearing have increased lately, nevertheless Korean Industrial Standard just has been translated into the regulations of ISO(International Organization for Standardization), and it has been applied. Moreover there is not any the domestic original regulation yet. Therefor, for this study we investigated current situation of the ISO in contact lens field and fitness of standard in our present actual condition. Also, by grasping the problems which it follows.

• Land and Housing Review
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• v.5 no.4
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• pp.315-323
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• 2014

In this study, thermal transmittance which is a parameter to measure the thermal performance was evaluated for an internal insulation versus an external insulation. Then the ISO regulation was applied to evaluate it, and the superiority of an external insulation was verified by the thermal transmittance values. The three zones of apartment housing were selected to evaluate the performance. (1) The junction of an outer wall and a protruded slab : If there is no a thermal bridge protection system, then the values are about same in the two insulation systems, so the protection system should certainly be installed. If it is installed, then the value for the external insulation is 2 times lower than internal system. (2) The junction of a side wall and a flat slab: The value is 0.509W/mK for the internal insulation and about zero for the external insulation. (3) The junction of an outer wall and a division wall: The value is 0.451W/mK for the internal insulation and also about zero for the external insulation. A domestic regulation that could evaluate a thermal transmittance has to be established by applying the ISO regulation for the evaluation of external insulation systems in apartment housing in the future. Additionally, the government must decide which length should be used for the national standard.

• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.199-213
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• 2022

EN ISO 14971:2012 a risk management standard approved and applied as a European standard in 2012, will be adopted and applied as ISO 14971:2019 published in December 2019, ISO/TR 24971(Guidance) published in June 2020 from May 2022. After that, it is applied to IVDD surveillance and IVDR new and conversion, and the manufacturer is already preparing for application or is starting preparation for application. In addition, 98/78/EEC IVDD applied from 1998 will also be applied as REGULATION (EU) 2017/746 IVDR from May 2022. In particular, in IVDR, the requirements for post-marketing investigations such as Post Market Surveillance (PMS), Summary of safety and performance(SSP), Periodic Safety Update Report(PSUR) and Post Market Performance Follow Up(PMPF), which were not required in the existing IVDD, increased, and the contents were also specified. This study focused on ISO14971:2019 among these strengthened and newly applied regulations, and tried to present a detailed analysis and application plan of Post Market Surveillance (PMS) required by 2017/746 IVDR.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.3
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• pp.203-217
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• 2019

The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide dismutase [SOD] and glutathione [GSH]), and expression of heat shock protein (Hsp) 70 and connexin 43 (Cx-43) in myocardial muscles in isoproterenol (ISO) induced myocardial infarction (MI). Thirty two adult male Sprague Dawely rats were divided into 4 groups (each 8 rats): normal control (NC) group, ISO group: received ISO at dose of 150 mg/kg body weight intraperitoneally (i.p.) for 2 successive days; ISO + Trizma group: received (ISO) and Trizma (solvent of CoPP) at dose of 5 mg/kg i.p. injection 2 days before injection of ISO, with ISO at day 0 and at day 2 after ISO injections; and ISO + CoPP group: received ISO and CoPP at a dose of 5 mg/kg dissolved in Trizma i.p. injection as Trizma. We found that, administration of ISO caused significant increase in heart rate, corrected QT interval, ST segment, cardiac enzymes (lactate dehydrogenase, creatine kinase-muscle/brain), cardiac HO-1, Hsp70 with significant attenuation in myocardial GSH, SOD, and Cx-43. On the other hand, administration of CoPP caused significant improvement in ECG parameters, cardiac enzymes, cardiac morphology; antioxidants induced by ISO with significant increase in HO-1, Cx-43, and Hsp70 expression in myocardium. In conclusions, we concluded that induction of HO-1 by CoPP ameliorates ISO-induced myocardial injury, which might be due to up-regulation of Hsp70 and gap junction protein (Cx-43).

• Journal of Environmental Science International
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• v.16 no.1
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• pp.27-32
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• 2007

In this study, the concentrations of offensive odorous compounds seasonally emitted from the chemical plant at Chongju industrial complex in Korea were determined by the analytical methods of gas chromatography, high performance liquid chromatography and uv/vis spectroscopy. The kinds of offensive odorous compounds examined are formaldehyde, acetaldehyde, butyl aldehyde, propion aldehyde, n-valeric aldehyde, iso-valeric aldehyde, hydrogen sulfide, methyl mercaptan, dimethyl sulfide, dimethyl disulfide, trimethyl amine and ammonia. The seasonally emission levels of all odorous compounds except dimethyl sulfide at 13 sampling points of plant were lower than those of the regulation standard levels of the industrial complex in Korea. The levels were the highest in June, and lowest in December. The propion aldehyde and iso-valeric aldehyde in June and December, butyl aldehyde in December, and n-valeric aldehyde were not detected in all the three seasons at any sampling points of the plant examined. But in June, dimethyl sulfide was emitted up to 16 times than that of the regulation level.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.371-376
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• 2003

The objective of this paper is to compare the site-to-site variability of ISO 10844 pass-by-noise test sites. In order to investigate the site-to-site variance of test surfaces, European commercial tires are tested at seven different test sites. Three Korea test sites and four Europe test sites are selected.. The pass by noise test is executed according to a 2001/43/EC regulation. A]though the ISO surface has a very specific track composition, it does not reduce the variation of pass-by-noise measurements over the surface of test sites. This paper shows that the test results of pass-by-noise level are different depending on the test sites. The correlation obtained in this work is able to predict the pass by noise level for certain test site using the data measured from another test site. 17he prediction value is range with an error within 1dB(A).

• Clean Technology
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• v.6 no.1
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• pp.7-15
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• 2000

The purpose of this articls is to investigate the impacts of ISO 14001 certification on the compliance of environmental regulations by Korean companies. The impact of ISO 14001 certification on the industries obtained the certificates was studied through a survey with questionnaires, and the compliance of environmental regulations was investigated using governmental release data. Motivations of Korean companies' environmental management were mostly caused by customer's request and the requirement from foreign countries. Certified enterprises showed more 3 times compliance of environmental regulation than non-certified ones. Such results were accomplished by systematic environmental management such as clear implementation purpose and all employee's voluntary improving according to ISO 14001 requirement. The continuous monitoring system was possible through internal audit and biannual audit from the certification body, to be finally verified by the top management. The four steps in ISO 14001 environmental management system, which are objective, methodology, inspection and monitoring, has contributed to this achievement.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.3035-3042
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• 2015

Background: Isorhamnetin (Iso), a novel and essential monomer derived from total flavones of Hippophae rhamnoides that has long been used as a traditional Chinese medicine for angina pectoris and acute myocardial infarction, has also shown a spectrum of antitumor activity. However, little is known about the mechanisms of action Iso on cancer cells. Objectives: To investigate the effects of Iso on A549 lung cancer cells and underlying mechanisms. Materials and Methods: A549 cells were treated with $10{\sim}320{\mu}g/ml$ Iso. Their morphological and cellular characteristics were assessed by light and electronic microscopy. Growth inhibition was analyzed by MTT, clonogenic and growth curve assays. Apoptotic characteristics of cells were determined by flow cytometry (FCM), DNA fragmentation, single cell gel electrophoresis (comet) assay, immunocytochemistry and terminal deoxynucleotidyl transferase nick end labeling (TUNEL). Tumor models were setup by transplanting Lewis lung carcinoma cells into C57BL/6 mice, and the weights and sizes of tumors were measured. Results: Iso markedly inhibited the growth of A549 cells with induction of apoptotic changes. Iso at $20{\mu}g/ml$, could induce A549 cell apoptosis, up-regulate the expression of apoptosis genes Bax, Caspase-3 and P53, and down-regulate the expression of Bcl-2, cyclinD1 and PCNA protein. The tumors in tumor-bearing mice treated with Iso were significantly smaller than in the control group. The results of apoptosis-related genes, PCNA, cyclinD1 and other protein expression levels of transplanted Lewis cells were the same as those of A549 cells in vitro. Conclusions: Iso, a natural single compound isolated from total flavones, has antiproliferative activity against lung cancer in vitro and in vivo. Its mechanisms of action may involve apoptosis of cells induced by down-regulation of oncogenes and up-regulation of apoptotic genes.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.1194-1197
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• 2006

Recently, international standard for measurement of sound absorption in a reverberation room has been amended. In the revised version, temperature, humidity and air pressure conditions are strictly restricted and also the concrete procedures are presented to reduce the differences in test results by adding inspection of diffusion, measurement uncertainty etc. In this paper, the systematic tests are conducted based on the inspection guide of diffusion defined by ISO 354 and the effects of diffusers on the measurement of sound absorption ratio are considered. As a result, we perceived that the averaged sound absorption ratio in mid and high frequency range is expected to measure around $0.05{\sim}0.1$ higher in high sound absorption material. Therefore, as for the reverberation room for measurement of sound absorption, we need to take into consideration not only the spatial standard deviation of sound pressure mandated by ISO 3741, but also, inspection regulation of diffusion showed by ISO 354.