• IMMUNE NETWORK
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• v.3 no.2
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• pp.145-149
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• 2003

Background: Apoptosis has been implicated in pathogenesis of various disease. Apo-1/Fas (CD95) is one of the main pathway of apoptosis. To examine the possible relationship between Apo-1/Fas (CD95) and primary knee osteoarthritis, MvaI restriction length polymorphism (RFLP) in human Apo-1/Fas (CD95) gene was assessed. Methods: Genotype and allele frequencies in promoter region in the Apo-1/Fas (CD95) gene were studied by PCR-RFLP in 226 Korean controls and 148 Korean patients with primary knee osteoarthritis. Results: No statistically significant difference in the genotypic distribution and allelic frequencies was found between the control and the knee oateoarthritis patients. But in the severe grade (grade 3, 4) Kellgren-Lawrence score patients, the frequency of $MvaI^*1$ (G) allele was significantly decreased (P=0.0392) and the of $MvaI^*2$ (A) allele frequency was significantly increased (P=0.0473) compared to the normal controls. Conclusion: Apo-1/Fas (CD95) gene polymorphism is a part a determinant factor of severity in knee osteoarthritis, the patients with $MvaI^*2$ (A) allele is more severe radiologic progression. Further substantiation studies are needed in larger patient samples and various other apoptosis related genes to elucidate the mechanism of osteoarthritis, including the Fas ligand gene analysis.

• Annals of dermatology
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• v.30 no.6
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• pp.676-687
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• 2018

Background: Rosacea is associated with chronic systemic disease. However, research is lacking in Asian countries. Objective: To evaluate the association between rosacea and cardiovascular diseases (CVDs) related systemic comorbidities, and the use of antihypertensive and antihyperlipidemic drugs in Korea. Methods: A five-year retrospective study, using hospital database, was conducted in five medical centers for five years. Totally 1,399,528 patients were evaluated. Results: The overall frequency for diagnosed rosacea was 0.18% over five years (2,536 rosacea patients). Patients with diabetes and patients with dyslipidemia were more likely to have rosacea (odd ratio [OR] 2.724, 95% confidence interval [CI] 1.295~5.730, p=0.016; OR 1.788, 95% CI 1.445~2.212, p<0.001). Patients with CVD were less likely to have rosacea (OR 0.431, 95% CI 0.244~0.760, p=0.003). Patients with ${\alpha}$-blocker prescriptions and patients with ${\beta}$-blocker prescriptions showed a tendency diagnosed with rosacea frequently (OR 1.963, 95% CI 1.200~3.212, p=0.006; OR 3.939, 95% CI 3.512~4.419, p<0.001). Patients with [beta]-hydroxy-[beta]-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and those with fibrate, were prone to have rosacea (OR 1.599, 95% CI 1.390~1.839, p<0.001; OR 1.660, 95% CI 1.056~2.609, p=0.026). As adjusted results, among the patients who took HMG-CoA reductase inhibitor without dyslipidemia, rosacea was less likely to be diagnosed (OR 0.780, 95% CI 0.620~0.982, p=0.034). Conclusion: Rosacea is associated with chronic diseases and drugs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.3
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• pp.333-340
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• 2022

The COVID-19 has made everyone anxious and people need to keep their distance. It is necessary to conduct collective assessment and screening of college students' mental health in the opening season of every year. This study uses and trains a multi-layer perceptron neural network model for deep learning to identify facial emotions. After the training, real pictures and videos were input for face detection. After detecting the positions of faces in the samples, emotions were classified, and the predicted emotional results of the samples were sent back and displayed on the pictures. The results show that the accuracy is 93.2% in the test set and 95.57% in practice. The recognition rate of Anger is 95%, Disgust is 97%, Happiness is 96%, Fear is 96%, Sadness is 97%, Surprise is 95%, Neutral is 93%, such efficient emotion recognition can provide objective data support for capturing negative. Deep learning emotion recognition system can cooperate with traditional psychological activities to provide more dimensions of psychological indicators for health.

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 1998.12a
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• pp.289-301
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• 1998

이동통신에서의 사용자 인증 서비스는 통화도용 방지와 신뢰성 있는 과금을 위한 중요한 보호 서비스이다. 본 논문에서는 IS-95A 인증 시스템에 적용 가능한 안전한 인증 알고리듬과 인증 키 생성 알고리듬을 제안한다. 특히 인증 알고리듬을 활용하여 인증 키 생성알고리듬을 Oracle 해쉬함수의 형태로 구현함으로써 인증 시스템의 높은 안전성과 간결성을 동시에 성취하였다. 그리고 통계적 분석 기법을 사용하여 개발된 알고리듬의 출력 특성을 분석한다.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.407-409
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• 1996

The Direct Arm(DDA) is a SCARA typed direct drive manipulator with three degree of freedom(DOF) using the direct motor of the NSK company. In the paper, we propose a convenient interface for the SCARA-type robot which is practical to use. The proposed Visual Robot Teaching Mode using 3D graphics replaces the current teaching box. And besides this graphical teaching software can be implemented on the PC which is company used as a robot controller. This program was developed for the Windows 95 OS.

• Proceedings of the IEEK Conference
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• 2001.06a
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• pp.293-296
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• 2001

In this paper, we investigate two soft handover algorithms used in the different mobile communication system. These different systems are IS-95 system and 3GPP system. The performances of two different soft handover are compared under similar conditions in terms of propagation, environment and mobility behavior. For performance comparison of soft handover, we model cell environment, radio channel and mobility. With these models the computer simulation are performed and the result of computer simulation are reported.

• Information and Communications Magazine
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• v.14 no.3
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• pp.65-74
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• 1997

본 고에서는 IS-95A 방식의 CDMA PCS 시스템과 호환되는 업무용 혹은 가정용 CT 구현을 위한 방안에 관하여 논의한다. 이를 위해 CT시스템의 CDMA 물리동기 및 프레임 동기를 획득하는 방안과 PCS/CT 이중모드의 효과적인 운용 방안을 구체적으로 제시한다. 설계의 접근방식으로는 동기방식을 위주로 하였으나 비동기방식에 대해서도 논의하였다. 제안되는 CT 시스템은 주파수 재활용도를 높이는 측면에서 Upbanded IS-95A PCS 시스템의 스펙트럼 상에서 동작하고 PCS 단말내의 H/W 통신 모듈을 변형없이 그대로 사용하므로 개발기간을 단축시키고 PCS 망과의 간섭을 최소화시킬 수 있을 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6181-6186
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• 2014

This meta-analysis was conducted to examine whether the genotype status of Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with endometrial and ovarian cancer risk. Eligible studies were identified by searching several databases for relevant reports published before January 1, 2014. Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. In total, 15 studies (1,293 cases and 2,647 controls for ovarian cancer and 2,174 cases and 2,699 controls for endometrial cancer) were included in the present meta-analysis. When all studies were pooled into the meta-analysis, there was no evidence for significant association between COMT Val158Met polymorphism and ovarian cancer risk (Val/Met versus Val/Val: OR=0.91, 95% CI=0.76-1.08; Met/Met versus Val/Val: OR=0.90, 95% CI=0.73-1.10; dominant model: OR=0.90, 95% CI=0.77-1.06; recessive model: OR=0.95, 95% CI=0.80-1.13). Similarly, no associations were found in all comparisons for endometrial cancer (Val/Met versus Val/Val: OR 0.97, 95% CI=0.77-1.21; Met/Met versus Val/Val: OR=1.02, 95% CI=0.73-1.42; dominant model: OR=0.98, 95% CI=0.77-1.25; recessive model: OR=1.02, 95% CI=0.87-1.20). In the subgroup analyses by source of control and ethnicity, no significant associations were found in any subgroup of population. This meta-analysis strongly suggests that COMT Val158Met polymorphism is not associated with increased endometrial and ovarian cancer risk.

• Tuberculosis and Respiratory Diseases
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• v.84 no.4
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• pp.299-316
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• 2021

Background: The lack of effective medications for coronavirus disease 2019 (COVID-19) has led to a trend of drug repurposing such as the case of azithromycin which shows immunomodulatory and anti-viral effect. Several clinical trials have shown conflicting results. It is currently unclear whether the available evidence is in favor or against the use of azithromycin in COVID-19 patients. Thus, the aim of this study was to investigate the efficacy and safety of azithromycin in COVID-19 patients. Methods: Four independent reviewers selected relevant studies from PubMed, ScienceDirect, EBSCO, and ProQuest published prior to March 2021. The protocol used in this study has been registered in PROSPERO (CRD42020224967). Results: We included 17 studies and found that the mortality rate (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.76-1.19), need of respiratory support (OR, 1.30; 95% CI, 0.98-1.73), hospitalization rate (standardized mean difference, 0.12; 95% CI, -0.02 to 0.27), and intensive care unit transfer (OR, 1.21; 95% CI, 0.79-1.86) of azithromycin-treated group did not differ significantly (p>0.05) from those of the control group. Azithromycin treatment did not significantly increase the risk of getting secondary infection (OR, 1.23; 95% CI, 0.83-1.82), hypoglycemia (OR, 0.73; 95% CI, 0.38-1.40), gastrointestinal problems (OR, 1.03; 95% CI, 0.73-1.45) or electrocardiogram abnormalities (OR, 1.16; 95% CI, 0.94-1.42). The overall quality of evidence ranged from low to very low. Conclusion: Azithromycin did not result in a superior clinical improvement in COVID-19 patients, although it was well-tolerated and safe to use.

• Journal of the Korean Society of School Health
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• v.35 no.2
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• pp.57-64
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• 2022

Purpose: Adolescent suicide is an important issue worldwide. Although literature on preventing suicide among adolescents tends to focus on suicidal ideation, suicidal planning is also an important issue as a stage leading to suicidal behavior. This study aims to identify suicidal planning-related factors, including generalized anxiety disorder, among adolescents who had suicidal ideation. Methods: This secondary study used data generated from the 16th(2020) Korea Youth Risk Behavior Web-based Survey, which included 5,979 students who had suicidal ideation. Factors related to suicidal planning were identified by performing a logistic regression analysis of the participants. All analyses were performed using SPSS 27.0. Results: Among adolescents who had suicidal ideation, 23.8% had suicide plans. The suicidal plans were significantly related to school level (middle, OR=1.38, 95% CI=1.22~1.55), whether they were living with family (no, OR=1.36, 95% CI=1.06~1.75), perceived body image (normal, OR=1.23, 95% CI=1.05~1.44; Obese, OR=1.33, 95% CI=1.14~1.54), depression (yes, OR=1.47, 95% CI=1.25~1.72), tobacco use (yes, OR=1.31, 95% CI=1.12~1.54), alcohol use (yes, OR=1.21, 95% CI=1.06~1.38), drug use (yes, OR=1.96, 95% CI=1.44~2.66), and/or generalized anxiety disorder (severe, OR=1.76, 95% CI=1.44~2.14). Conclusion: The findings of the study suggest that in addition to the commonly recognized factors for adolescent suicide, generalized anxiety disorder should also be considered when establishing strategies to prevent suicide planning in adolescents who had suicidal ideation.