• Korean Management Science Review
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• v.28 no.3
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• pp.113-124
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• 2011

Today, change in the information technology field is very fast, the innovative technology or product to be released for the other sectors tend more frequent. In this situation, most of potential users should think carefully about the adoption of innovative technology such as Web2.0. On the other hand, the adoption or acceptance of innovative technology has the paradox of technology. In order to verify the acceptance factors of innovative technology, we are proposed the model based on the DOI and MIR. Conceptually, we examine the four independent variables such as relative benefit, compatibility, complexity, risk that are divided into two parts as positive and negative, a moderating variable effect on independent variables that is the social influence, and their impacts on the acceptance of new technology. The questionnaire which consists of 100 questions was used to analyze the result to IT suppliers and customers in public sector. Finally, our research model was tested in an empirical study, which confirmed all of our hypotheses.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.1
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• pp.103-109
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• 2014

This paper represents the s-cam manufacturing process with the high-carbon steel like S45C using laser welding system. Laser welding of the high-carbon steel is generally difficult because of hardening of the weld zone. Also, existing s-cam manufacturing process, electric resistance welding system, have some problems like increase of production and development cost. To solve those problems, we are introduced the laser welding system with the pre-heating system for precision welding of s-cam with separated shaft and cam part. S-cam manufactured with optimum laser welding conditions is verified the performance like tensile strength, torsional strength and fatigue test. Strength and fatigue test results are described.

• Journal of Powder Materials
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• v.22 no.3
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• pp.157-162
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• 2015

SKD11(ASTM D2) tool steel is a versatile high-carbon, high-chromium, air-hardening tool steel that is characterized by a relatively high attainable hardness and numerous, large, chromium rich alloy carbide in the microstructure. SKD11 tool steel provides an effective combination of wear resistance and toughness, tool performance, price, and a wide variety of product forms. Adding of CNTs increased the performance of mechanical properties more. 1, 3 vol.% CNTs was dispersed in SKD11 matrix by mechanical alloying. SKD11 carbon nanocomposite powder was sintered by spark plasma sintering process. FE-SEM, HR-TEM and Raman analysis were carried out SKD11 carbon nanocomposites.

• BMB Reports
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• v.51 no.2
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• pp.98-103
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• 2018

Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer.

• Journal of the Korean Geotechnical Society
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• v.33 no.7
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• pp.5-16
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• 2017

Soil nailing is the most general method to reinforce the slope by taking pullout and shear resistance force of the nail for stabilizing the slope. Domestic soil nailing design method considers only pullout resistance and does not consider the shear resistance sufficiently. In case of nail, the effect of tensile stress is dominant, but it is desirable to design by considering shear stress as well as tensile stress in case of slope where circle failures occur. Recently, studies on the shear resistance effect of nails have been carried out in the geotechnical field. However, many researches on the shear reinforcement effect of soil nailing have not been conducted until now. Most of the studies are about increasing pullout resistance by improving material, shape and construction method of nail. Therefore, it is necessary to the study on shear resistance of soil nailing and development of new methods to increase the shear force. In this study, large shear test and limit equilibrium analysis have been performed for a new soil nailing method to increase the shear resistance by forming protrusions through pressurized grouting after installing a packer on the outside of deformed bar. The study results showed that shear resistance of protrusion type soil nailing increased compared to soil nailing and it is more effective when applied to the ground with large strength parameters.

• BMB Reports
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• v.55 no.11
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.

• Journal of Digital Convergence
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• v.12 no.12
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• pp.93-106
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• 2014

All of smart phone users not always make a good use of mobile shopping. The main cause is that in case of non-user of mobile shopping, potential apprehension to psychological and security weakness affects building up resistance on mobile shopping. In this paper, we designed models of innovation resistance heavily based on literature reviews and previous studies, and tried to find how perceived risk affects consumer's purchase intention in mobile shopping process. In conclusion, it shows that security, one of psychological factors, affects perceived risk in all aspects, while negative influence of society and cognitive dissonance just affect social risk and delivery risk, and uncertainty also just affects performance risk. Besides, it shows that all of variables made up perceived risk affects resistance of purchase. Especially social risk turns out to be a most influential factor to purchase behavior through smart phone.

• The Journal of Information Technology
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• v.2 no.2
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• pp.177-197
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• 1999

On regarding Problems on information security technology that have its rise in the Introduction of electronic money lately, security evaluation of the types of electronic money is important. Therefore in this paper I tried to analyse introduction viladity based on that,in korea. In perticular, there is a synthetical and systematical study on the security of eletronic money, on the viewpoint of choice combination of cryptography technology and the types of attacks on it. And in case of the electronic money that the criterion of efficiency and functionism is superior to that of security, I emphasize on the fact that it could be valid electronic money if it were supplemented by tamper resistance technology in middle-long term

• Elastomers and Composites
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• v.56 no.1
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• pp.20-31
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• 2021

There is an increasing demand for the rolling resistance reduction in truck bus radial (TBR) tires in the tire industry. In TBR tires, natural rubber is used as a base polymer to prevent wear and satisfy required physical properties (cut and chip). A binary filler system (silica and carbon black) is used to balance the durability of the tire and rolling resistance performance. In this study, natural rubber (NR) compounds applied with a binary filler system were manufactured at different cure temperatures for vulcanizate structure analysis. The vulcanizate structures were categorized into carbon black bound rubber, silica silane rubber network, and chemical crosslink density by sulfur. Regardless of the cure temperature, the cross-link density per unit content of carbon black had a greater effect on the properties than silica due to affinity with NR. The relationship analysis between the mechanical, viscoelastic properties with vulcanizate structure could be a guideline for manufacturing practical TBR compounds.

• Journal of the Korean Society for Precision Engineering
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• v.31 no.6
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• pp.513-519
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• 2014

For depth machining in die and mold, Electrical Discharge Machining (EDM) is used generally. To make deep hole and deep shape efficiently, cemented carbide endmill for depth machining is necessary. For this purpose, cemented carbide endmill was designed using design of experiment (DOE). To improve cutting performance, endmill was coated with multilayer surface treatment, TiAlCrSiN and TiAlCrN, for higher wear resistance. In order to evaluate the endmill, Transverse Rupture Strength (TRS) test was tried for investigating the relationship between surface treatment and strength in endmill body. Scratch test was also used for measuring adhesion force of each surface treatment. To evaluate hardness of surface treatment, Atomic Force Microscope (AFM) analysis was carried out. Wear test was executed for characteristics of each surface treatment in high temperature. Consequently, TiAlCrSiN was superior to the TiAlCrN coating in case of high temperature environment such as cutting.