• Journal of Nutrition and Health
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• v.52 no.2
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• pp.176-184
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• 2019

Purpose: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The effect of emodin against palmitic acid (PA) - induced ER stress in HepG2 cells was investigated. Methods: HepG2 cells were treated with varying concentrations of palmitic acid to determine the working concentration that induced ER stress. ER stress associated genes such as ATF4, XBP1s, CHOP and GRP78 were checked using RT- PCR. In addition, the expression levels of unfolded protein response (UPR) associated proteins such as $IRE1{\alpha}$, $eIF2{\alpha}$ and CHOP were checked using immunoblotting to confirm the induction of ER stress. The effect of emodin on ER stress was analyzed by treating HepG2 cells with $750{\mu}M$ palmitic acid and varying concentrations of emodin, then analyzing the expression of UPR associated genes. Results: It was evident from the mRNA and protein expression results that palmitic acid significantly increased the expression of UPR associated genes and thereby induced ER stress. Subsequent treatment with emodin reduced the mRNA expression of ATF4, GRP78, and XBP1s. Furthermore, the protein levels of $p-IRE1{\alpha}$, $p-eIF2{\alpha}$ and CHOP were also reduced by the treatment of emodin. Analysis of sirtuin mRNA expression showed that emodin increased the levels of SIRT4 and SIRT7, indicating a possible role in decreasing the expression of UPR-related genes. Conclusion: Altogether, the results suggest that emodin could exert a protective effect against fatty acid-induced ER stress and could be an agent for the management of various ER stress related diseases.

• Journal of the Korean Society of Safety
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• v.12 no.3
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• pp.76-82
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• 1997

Flash points ire used to classify flammable liquids according to their relative flammability. Such a classification is important for the safe handling of flammable liquids which constitute the solvent mixtures. MRSM(modified response surface methodology)-1 and MRSM-2 models we suggested for the prediction of the flash points in the flammable ternary system. By means of this methodology, it is possible to predict the flash points of the flammable mixtures system using computer graphics in the triangular coordinate for the ternary system. The proposed methodology(MRSM) has been tested and compared successfully with previously reported flash points in journal for the ternary system.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.117.1-117
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• 2001

A motion handling technique that transforms existing animation motion data to a mathematically well-defined form. The transformed data can be utilized in any kind of autonomous motion creation process that handles such cases as changed environment, structure (kinematic / dynamic) modification, or changed constraints. To overcome the computational burden of traditional spacetime optimization, we divide full motion data frame into several parts, and we applied the transformation technique to each part using an optimizing tool(CFSQP). To show Ire feasibility of the proposed method, a comparison study results with traditional technique is included.

• Journal of Korean Society for Quality Management
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• v.35 no.1
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• pp.97-112
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• 2007

Six Sigma methodology has been evolved since it was first introduced in late 1980's and the number of company which adopts Six Sigma is getting increased. Therefore, it is timely that ire review research papers on Six Sigma extensively. We review 85 papers published in Korea by April 2006 and classify them based on research contents and methodology. We suggest future research issues and fields which can adopt Six Sigma methodology.

• Fire Science and Engineering
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• v.8 no.1
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• pp.26-33
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• 1994

The review of field model for fire simulation is presented. The approach to predict ire growth by solving the conservation equations over time and 2- or 3-dimentional space with appropriate boundary conditions is called field model. The finite difference method is adopted to solve the governing equations. The results is give qualititively and quantitatively good results but complicate and difficult to handle. But it is useful tool to understand detail phenomenons and to make decision for fire safety.

• Journal of the Korean School Mathematics Society
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• v.22 no.4
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• pp.439-460
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• 2019

In this study, we examined classroom interaction to explore the relationships among teacher questions, turn-taking patterns, and student talks in mathematics classrooms. We analyzed lessons given by three elementary teachers (two first-grade teachers and one second-grade teacher) who worked in the same school using a conversation-analytic approach. We observed individual classrooms three times in a year. The results revealed that when teachers provided open-ended questions, such as "why and how" questions and "agree and disagree" questions, and used a non-IRE pattern (teacher initiation-student response-teacher feedback; Mehan, 1979), students more actively engaged in classroom discourse by justifying their ideas and refuting others' thinking. Conversely, when teachers provided closed-ended questions, such as "what" questions, and used an IRE pattern, students tended to give short answers focusing on only one point. The findings suggested teachers should use open-ended questions and non-IRE turn-taking patterns to create an effective math-talk learning community. In addition, school administrators and mathematics educators should support teachers to acquire practical knowledge regarding this approach.

• Journal of Life Science
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• v.28 no.10
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• pp.1186-1192
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• 2018

The purpose of this study was to compare the effects of either aerobic exercise or polyphenols supplementation on mRNA expression of endoplasmic reticulum stress in skeletal muscle of high fat diet-induced obese mice. In the study, mice were divided into five groups: (1) NC (normal diet for 16 weeks as a control, n=10), (2) HC (high fat diet for 16 weeks as a control, n=10), (3) H-Re (high fat diet with resveratrol 25 mg/kg supplementation for 16 weeks, n=10), (4) H-Ch (high fat diet with chrysin 50 mg/kg supplementation for 16 weeks, n=10), and (5) HE (high fat diet with aerobic exercise for 16 weeks, n=10). Aerobic exercise was performed on a treadmill for 40~60 min/day at 10~14 m/min, 0% grade, four days/week for 16 weeks. Endoplasmic reticulum stress related genes were measured by real-time polymerase chain reaction. ATF6, PERK, $IRE1{\alpha}$, and BIP/GRP78 mRNA were significantly decreased in HE compared with those in HC (p<0.05). Also, ATF6, $IRE1{\alpha}$, and BIP/GRP78 mRNA were significantly decreased in H-Re compared with those in HC (p<0.05). ATF6 mRNA was significantly decreased in H-Ch compared with that in HC (p<0.05). These findings suggest that aerobic exercise, resveratrol, and chrysin supplementation changed ER stress markers. However, aerobic exercise was most effective on ameliorating the high fat diet induced ER stress markers. Thus, it seems that aerobic exercise might have a more positive effect on skeletal muscle endoplasmic reticulum stress compared with polyphenol supplementation in high fat diet-induced obese mice.

• Journal of Information Management
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• v.26 no.1
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• pp.52-79
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• 1995

The objective of this study is to apply Information Resource Management(IRM) methodology to corporate library and information units. The focus of the study fixes how to start, develop and establish IRM in corporations. The methodology of IRM is based on the way of integrating information contents and systems by information technology. The body of this study consists of three parts. Part 1 surveys the review of IRM progress, its definitions, its components, IRM policy, and IRM human resource. Part 2 suggests a modeling for IRM methodology, which includes the inventory for pinpointing each information resource entity(IRE), the analysis of information needs, the measuring cost of IRE, and the evaluation of information value. Part 3 investigates internal and external information resources of certain corporations and analyses the users' information needs.

• Journal of Broadcast Engineering
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• v.15 no.1
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• pp.76-88
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• 2010

Recently, LED background image devices are used for the production of broadcasting programs. But the effective advantages of LED background image devices are not realized for good HD video quality because the correlations between lighting sources and LED background image devices are not analyzed yet. In this paper, we analyze the color change and light intensity that lighting sources and the light intensity ratio of LED background images influence on a subject, making use of equipments used in real broadcasting, and examine the correlations between HD video quality and the light intensity ratio of LED background images. As a result in this experiment, the video is most expressed having an 20[IRE] effect on a subject when the light intensity of LED background image is 6%. When the LED background image is light, the light and darkness of video is distorted and when the LED background image is dark, the colors of image are distorted.

• The korean journal of orthodontics
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• v.24 no.3 s.46
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• pp.555-567
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• 1994

The purpose of this study is to observe the effect of high pull headgear on the craniofacial structures of mixed dentition with Class II malocclusion. The cephalometric headplates of 16 children treated by high pull headgeaar during 6 months and 18 children during 12 months were traced, digitized and statistically analyzed. The results were as follows. 1. Inhibition of foreward growth of maxilla was observed in both group. 2. Clockwise rotation of maxilla was observed in both group. 3. There were distal movement of maxillary 1st molar and inhibition of alveolar bone growth of maxilla. 4. There was compensatory extrusion on mandibular 1st molar. 5. The ratio of anterior facial height to posterior facial height was almostly not changed. In the treatment plan of C II malocclusion by high pull headgear, ire must prevent the mandibulasr 1st molar from extruding and for orthopedic effect, at least 6 months is needed.