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Effects of Opioid Agonists on the Suppressed Spontaneous Alternation Behaviour in Rats (아편양 순응제가 백서의 억제된 자발적 교대행동에 미치는 영향)

  • Lee, Gi-Chul;Jeon, Seong-Il;Chang, Hwan-Il;Lee, Jung-Ho;Choi, Young-Min;Kim, Seong-Ho;Ryu, Jeong-Hwan;Choi, Mi
    • Korean Journal of Biological Psychiatry
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    • v.6 no.2
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    • pp.193-201
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    • 1999
  • This study was designed to evaluate the effects of opioid receptor agonists on the spontaneous alternation behaviour in an animal model of obsessivecompulsive disorder in rats. According to the theory that dopamine is related to the biological etiology of obsessive-compulsive disorder, the effect of the nalbuphine(opioid kappa agonist) and the tramadol(opioid mu agonist), which act as manipulating agents on the inhibition or stimulation of dopamine release, in the spontaneous alternation behaviour were evaluated. 24 hours prior to the experiment, rats were food-deprived. These rats were put into the T-maze, in which white and black goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for each time. After identifying the stable baseline of spontaneous alternation behaviour, nonselective 5-HT agonist 5-MeODMT(1.25mg/kg/IP) disrupted spontaneous alternation. Rats were stratified into fluoxetine(10mg/kg/IP), nalbuphine(10mg/kg/IP), tramadol(46.4mg/kg/IP), and saline(0.5cc/IP) injection group with experimental drug treatment for 21 days. The effects on the 5-MeODMT(1.25mg/kg/IP) induced disruption of spontaneous alternation behaviour were checked at the next day of discontinuation of drug treatment. The results were as follows ; 1) At the day after 21 days of the drug treatment, the nalbuphine treated group and the fluoxetine treated group showed significant difference from the tramadol treated group and the saline treated group in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. 2) Within each drug treatment group, the fluoxetine treated group showed significant difference between before and after the treatment of fluoxetine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. And also, the nalbuphine treated group showed significant difference between before and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. There was no difference between the baseline and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. We indentified that the opioid kappa agonist that act as dopamine release inhibitor affect the spontaneous alternation behaviour which is an animal model of obsessive-compulsive disorder in rat.

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Performance Evaluation of Scheduling Algorithm for VoIP under Data Traffic in LTE Networks (데이터 트래픽 중심의 LTE망에서 VoIP를 위한 스케줄링 알고리즘 성능 분석)

  • Kim, Sung-Ju;Lee, Jae Yong;Kim, Byung Chul
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.12
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    • pp.20-29
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    • 2014
  • Recently, LTE is preparing to make a new leap forward LTE-A all over the world. As LTE privides high speed service, the role of mobile phones seems to change from voice to data service. According to Cisco, global mobile data traffic will increase nearly 11-fold between 2013 and 2018. Mobile video traffic will reach 75% by 2018 from 66% in 2013 in Korea. However, voice service is still the most important role of mobile phones. Thus, controllability of throughput and low BLER is indispensable for high-quality VoIP service among various type of traffic. Although the maximum AMR-WB, 23.85 Kbps is sufficient to a VoIP call, it is difficult for the LTE which can provide tens to hundreds of MB/s may not keep the certain level VoIP QoS especially in the cell-edge area. This paper proposes a new scheduling algorithm in order to improve VoIP performance after analyzing various scheduling algorithms. The proposal is the technology which applies more priority processing for VoIP than other applications in cell-edge area based on two-tier scheduling algorithm. The simulation result shows the improvement of VoIP performance in the view point of throughput and BLER.

Development of 360° Omnidirectional IP Camera with High Resolution of 12Million Pixels (1200만 화소의 고해상도 360° 전방위 IP 카메라 개발)

  • Lee, Hee-Yeol;Lee, Sun-Gu;Lee, Seung-Ho
    • Journal of IKEEE
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    • v.21 no.3
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    • pp.268-271
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    • 2017
  • In this paper, we propose the development of high resolution $360^{\circ}$ omnidirectional IP camera with 12 million pixels. The proposed 12-megapixel high-resolution $360^{\circ}$ omnidirectional IP camera consists of a lens unit with $360^{\circ}$ omnidirectional viewing angle and a 12-megapixel high-resolution IP camera unit. The lens section of $360^{\circ}$ omnidirectional viewing angle adopts the isochronous lens design method and the catadioptric facet production method to obtain the image without peripheral distortion which is inevitably generated in the fisheye lens. The 12 megapixel high-resolution IP camera unit consists of a CMOS sensor & ISP unit, a DSP unit, and an I / O unit, and converts the image input to the camera into a digital image to perform image distortion correction, image correction and image compression And then transmits it to the NVR (Network Video Recorder). In order to evaluate the performance of the proposed 12-megapixel high-resolution $360^{\circ}$ omnidirectional IP camera, 12.3 million pixel image efficiency, $360^{\circ}$ omnidirectional lens angle of view, and electromagnetic certification standard were measured.

An Analysis of the Relationship between the Achievement of Intellectual Property Education and Its Factors of College Students (대학생의 지식재산 교육 성취와 그 영향요인간의 관계 분석)

  • CHEE, Seonkoo;SUL, In Hwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.3
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    • pp.227-233
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    • 2021
  • To obtain a fruitful outcome in intellectual property (IP) education in colleges, it is essential to identify the affecting factors. The relationships between the factors were to be analyzed as a structural equation model. The IP education achievement was measured by the IP total score. The students' characteristics (input factor) were measured by defining the characteristics, parents' expectations, and IP interest. The characteristics after highschool (process factor) were observed as college satisfaction and learning attitude. Students with excellent defining characteristics have not only high college satisfaction but also an excellent learning attitude, so they have a high IP total score. Using indirect effects analysis, the path through which the defining characteristics indirectly affects the IP total score through college satisfaction and learning attitude was identified. This is consistent with the prediction that self-directed students will have high participation in IP classes and achieve excellent results. The IP interest was found to have no significant effect on the IP total score. This contradicts the belief that students with high IP interest will actively participate in IP classes and earn high scores, which is because it overlooks the possibility that participation in IP activities in high school is semi-forced.

Research Trends in Induced Polarization Exploration in Korea (국내 유도분극 탐사의 연구동향)

  • Park, Samgyu
    • Geophysics and Geophysical Exploration
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    • v.24 no.4
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    • pp.202-208
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    • 2021
  • Induced polarization (IP) was first published in a Korean academic journal in 1973, and it was soon applied to coal and metal ore exploration. Then, in universities and research institutes, IP modeling studies using the finite element approach and experimental studies on IP responses for artificial samples were conducted. In the mid-1980s, the spectral IP (SIP) measurement module was introduced to Korea, and physical scale modeling and inversion approaches were developed. Due to the decline of the mineral resource industry, this method was not actively applied. However, the SIP method was not applied In the 1990s, IP exploration was applied in the investigation of hydrothermal deposits of sulfide minerals and bentonite mineralization zones, as well as to areas where the groundwater was contaminated by intruding seawater. In the 2000s, three-dimensional inversion of the IP approach was developed, and high-precision geophysical exploration was required to secure domestic and overseas mineral resources, so SIP experiments on rock samples and approaches for field exploration were developed. The SIP approach was proven useful for the exploration of metal deposits containing sulfide minerals by applying it to explore the mineralization zone of gold-silver deposits in the Haenam region. The IP method is considered to be effective in exploring critical minerals (lithium, cobalt, and nickel) in high-tech industries. It also is expected to be useful for environmental and geotechnical investigations.

MRI Predictors of Malignant Transformation in Patients with Inverted Papilloma: A Decision Tree Analysis Using Conventional Imaging Features and Histogram Analysis of Apparent Diffusion Coefficients

  • Chong Hyun Suh;Jeong Hyun Lee;Mi Sun Chung;Xiao Quan Xu;Yu Sub Sung;Sae Rom Chung;Young Jun Choi;Jung Hwan Baek
    • Korean Journal of Radiology
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    • v.22 no.5
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    • pp.751-758
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    • 2021
  • Objective: Preoperative differentiation between inverted papilloma (IP) and its malignant transformation to squamous cell carcinoma (IP-SCC) is critical for patient management. We aimed to determine the diagnostic accuracy of conventional imaging features and histogram parameters obtained from whole tumor apparent diffusion coefficient (ADC) values to predict IP-SCC in patients with IP, using decision tree analysis. Materials and Methods: In this retrospective study, we analyzed data generated from the records of 180 consecutive patients with histopathologically diagnosed IP or IP-SCC who underwent head and neck magnetic resonance imaging, including diffusion-weighted imaging and 62 patients were included in the study. To obtain whole tumor ADC values, the region of interest was placed to cover the entire volume of the tumor. Classification and regression tree analyses were performed to determine the most significant predictors of IP-SCC among multiple covariates. The final tree was selected by cross-validation pruning based on minimal error. Results: Of 62 patients with IP, 21 (34%) had IP-SCC. The decision tree analysis revealed that the loss of convoluted cerebriform pattern and the 20th percentile cutoff of ADC were the most significant predictors of IP-SCC. With these decision trees, the sensitivity, specificity, accuracy, and C-statistics were 86% (18 out of 21; 95% confidence interval [CI], 65-95%), 100% (41 out of 41; 95% CI, 91-100%), 95% (59 out of 61; 95% CI, 87-98%), and 0.966 (95% CI, 0.912-1.000), respectively. Conclusion: Decision tree analysis using conventional imaging features and histogram analysis of whole volume ADC could predict IP-SCC in patients with IP with high diagnostic accuracy.

Analysis of Business Overview and use of 'C'group's Internet phone of National Information and Communication Services (국가정보통신서비스의 'C'그룹 인터넷전화 사업현황과 이용 분석)

  • Shin, Jin;Park, Dea-Woo
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.15 no.11
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    • pp.2391-2398
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    • 2011
  • National Information and Communication Services of Public Administration and Security organized by the 'A 'group (Line service network), 'B' group (IP service network), 'C' Group (Voice over Internet protocol(VoIP) service, IP application services) are provided by constructing the infrastructure. National Information and Communications Services 'C' group, providers are providing VoIP services. In this paper, national information and communications service 'C' group, providers of domestic calls, international calls, including calls to move we will study the basic telephone service. And text messaging, video telephony, IP-Centrex services, etc. we will study the seven value-added services. In addition, national information and communication service providers on the status of the project based on the analysis of national information and communication Internet telephone network using Internet telephony is the type of analysis. In this study, national information and communications services industry, will serve as the basis for the development.

Effect of Magnetic Force on Rheological and Compressive Properties of Magneto-Rheological Rubber Composites with Iron Particle and Carbon Nanotubes (자기력이 철 분말 및 탄소나노튜브 강화 자기유동 고무 복합재료의 유동 및 압축 특성에 미치는 영향)

  • Ryu, Sang Ryeoul;Lee, Dong Joo
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.2
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    • pp.153-160
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    • 2013
  • An orthotropic magneto-rheological rubber composite (MRRC) based on a general-purpose rubber can be manufactured by using an electromagnetic device during the curing processes of rubber mixtures. The magnetic transmissivity of MRRCs increases with the iron particle (IP) content, and that of aligned MRRCs with a 2-T magnetic field is 1.8 to 2 times higher as compared to that of randomly dispersed MRRCs. The effect of a 2-T magnetic field on carbon nanotube (CNT) reinforced MRRC has been identified clearly, and the magnetic transmissivity is found to be 3.7%. The compressive stress of MRRC (IP 90 + CNT 5, 2 T alignment) under a magnetic field of 0.49 T is 2.1 times higher as compared to that of the matrix. The MR effect of MRRC increases with the IP content, and that of aligned MRRC with the IP 90 and 2 T magnetic field is 20.4%. It is confirmed that the magnetic field when making the specimen and when performing the compression test greatly impacts the compression characteristics.

Design of Compact Data Integration and Convergence Device Using Esp8266 Module (Esp8266모듈을 이용한 소형 데이터 통합 및 융합장치 설계)

  • Lee, Dong-Seok;Lim, Joong-Soo
    • Journal of the Korea Convergence Society
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    • v.8 no.2
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    • pp.15-20
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    • 2017
  • In this paper, Esp8266, Node.js, and TCP / IP socket communication are used to design a compact data integration device. This device is designed to configure server and client using Esp8266 module that supports Wifi connection and to support bidirectional data transmission using TCP / IP socket communication. The server is configured using the Node.js operating system, and the database is integrated using Mysql. The network is designed to have a separate IP address by assigning a private IP address to the router, such as a home network. This device can transmit data bidirectionally, store individual client data on the server side, and can check the flow of data transmitted bidirectionally through wire-shark, so that it can be used as a compact real-time data integration and convergence device.

FDANT-PCSV: Fast Detection of Abnormal Network Traffic Using Parallel Coordinates and Sankey Visualization (FDANT-PCSV: Parallel Coordinates 및 Sankey 시각화를 이용한 신속한 이상 트래픽 탐지)

  • Han, Ki hun;Kim, Huy Kang
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.30 no.4
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    • pp.693-704
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    • 2020
  • As a company's network structure is getting bigger and the number of security system is increasing, it is not easy to quickly detect abnormal traffic from huge amounts of security system events. In this paper, We propose traffic visualization analysis system(FDANT-PCSV) that can detect and analyze security events of information security systems such as firewalls in real time. FDANT-PCSV consists of Parallel Coordinates visualization using five factors(source IP, destination IP, destination port, packet length, processing status) and Sankey visualization using four factors(source IP, destination IP, number of events, data size) among security events. In addition, the use of big data-based SIEM enables real-time detection of network attacks and network failure traffic from the internet and intranet. FDANT-PCSV enables cyber security officers and network administrators to quickly and easily detect network abnormal traffic and respond quickly to network threats.