• 생약학회지
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• 제47권2호
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• pp.172-178
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• 2016

Using high-fat diet-induced obese (DIO) mice, the mechanism of anti-adiposity and anti-obesity actions produced by Inonotus obliquus water extract (IOE) was investigated. Significant reduction in body weight in DIO mice orally administrated with IOE for 8 weeks compared to IOE-non-treated control mice was observed, which was attributed to the reduction of epididymal and mesenteric adipose tissue, but not the liver and skeletal muscle. Adiponectin synthesis in epididymal adipose tissue (EAT) and AMPK phosphorylation in the liver were significantly increased in IOE-treated DIO mice. Gene expression analysis showed that IOE-treated DIO mice had higher expression levels of lipogenic genes in EAT and fatty-acid oxidative genes in the liver, but lower expression levels of hepatic pro-inflammatory cytokines compared to IOE-non-treated controls. Our findings confirm a therapeutic potential of Inonotus obliquus for reducing adiposity and ameliorating hyperlipidemia to treat metabolic disorders.

• 생약학회지
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• 제42권3호
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• pp.253-259
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• 2011

Macrophages play a vital role in the innate immune system involving defensive cytokines such as TNF (tumor necrosis factor)-${\alpha}$ and nitric oxide (NO). Therefore, we try to elucidate the anti-inflammatory activity of Chaga mushroom (Inonotus Obliquus, IO) in murine macrophages. Raw 264.7 cells and peritoneal macrophages of mice were cultured with or without LPS/LPS + IFN-${\gamma}$ in the presence of IO aqueous extracts (IOE 0.2, 2, 20, 100 ${\mu}g$/mL) for 24 hr and 48 hr, respectively. Exposure of IOE caused the decrease of NO production and increase of TNF-${\alpha}$ production in dose-dependent manner in activated peritoneal macrophage in vitro. To further investigate anti-inflammatory effects of IO ex vivo, we orally administrated capsaicin (PC, 3 mg/kg/day) and IOE (100, 200, 400 mg/kg/day) for 4 consecutive days to C57BL/6 mice (7~9 weeks old, female), then observed the NO secretion and cytokine (TNF-${\alpha}$) production of LPS/LPS + INF-${\gamma}$-stimulated peritoneal macrophages. IOE inhibits NO secretion in dose-dependent manner both ex vivo and in vitro and increases the production of TNF-${\alpha}$ in vitro. In addition, we found that IOE possessed suppressive effects of LPS-stimulated TNF-${\alpha}$, IL-$1{\beta}$, COX-2, as well as iNOS expressions in Raw 264.7 cells. These findings indicate that IOE suppress not only the LPS-induced NO overproduction of murine peritoneal macrophages, but also iNOS, COX-2, TNF-${\alpha}$, and IL-$1{\beta}$ overexpression of LPS-induced Raw 264.7 cells. Consequently, our results suggest that IO may have the anti-inflammatory effects via suppression of the inflammatory cytokines and mediators, and be useful for the treatment of inflammatory diseases.

• 한국식품과학회지
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• 제45권2호
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• pp.199-205
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• 2013

본 연구는 패 추출물의 항비만 효과를 조사하기 위해 C57BL/6J mice에 4주 동안 고지방 식이를 공급하여 비만을 유도한 후에, 6주간 패 추출물을 첨가한 고지방 사료를 섭취시키고 체중, 간, 신장 및 부고환 지방조직 무게, 혈액과 간의 지질 농도 및 혈중 렙틴 함량을 분석하였다. 실험 결과 HFD군에서는 고지방식이로 인하여 체중이 유의하게 증가하였으나, HFDIO군에서는 HFD군보다 체중의 증가가 유의하게 적었으며, 부고환 지방조직의 무게도 HFDIO군이 HFD군보다 유의하게 감소하였다. 고지방식이로 혈중 중성지방, 총 콜레스테롤, LDL콜레스테롤의 함량은 HFD군에서 가장 높게 나타났으나 HFDIO군에서는 유의하게 낮아졌으며 반면에 HDL콜레스테롤의 함량은 HFDIO군이 HFD군보다 유의하게 높았다. 이에 동맥경화지수와 심혈관질환위험도가 HFD군에 비해 HFDIO군에서 유의하게 낮아졌으며, 혈중 렙틴의 양도 HFDIO군이 유의하게 낮아지는 결과를 얻었다. 간 기능의 지표가 되는 ALT, AST, ${\gamma}$-GTP는 HFD군에서 유의하게 높은 값을 나타냈지만 모두 정상범위 내의 값을 나타내었고, 혈중 BUN과 혈중 Creatinine의 농도도 정상 범위 내의 값을 나타내었다. 이상의 실험 결과 고지방식이와 함께 급여한 패 추출물은 체중, 간 및 지방조직의 무게 감소와 더불어 혈장 및 간의 지질농도 개선과 혈장 렙틴 농도를 감소시키는 유용한 항비만 소재가 될 수 있을 것으로 사료된다. 앞으로 패의 어떠한 성분이 이러한 작용을 하는 지에 대한 더욱 체계적인 연구가 필요한 것으로 판단된다.

• Fisheries and Aquatic Sciences
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• 제23권9호
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• pp.24.1-24.9
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• 2020

Brown alga (Ishige okamurae; IO) dietary supplements have been reported to possess anti-diabetic properties. However, the effects of IO supplements have not been evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age, 7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group), high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet with 75 mg/kg IO extract (HFD/75/IOE). After 4 weeks, the plasma, pancreas, and skeletal muscle samples were collected for biochemical analyses. IOE significantly ameliorated glucose tolerance impairment and fasting and 2 h blood glucose level in HFD mice. IOE also stimulated the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and those of their related transcription factors in the pancreases and skeletal muscles of HFD mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the pancreas and skeletal muscle in HFD-induced diabetes.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 춘계학술대회
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• pp.194-196
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• 2015

본 연구에서는 사물인터넷의 개념의 시작과 현재에 이르기까지 그 발전과정을 살펴보고, 향후 발전 방향과 활용에 대하여 논의 하고자 한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 추계학술대회 논문집 전력기술부문
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• pp.351-353
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• 2006

Preventive maintenance can avail the generating unit to reduce cost and gain more profit in a competitive supply-side power market. so, it is necessary to perform reliability analysis on the systems in which reliability is essential. In this paper, FMECA assessment adopted using real historical failure data in Korean power plants for apply RCM analytical method. The stochastic FMECA is an engineering analysis and a core activity performed by reliability engineers to review the effects of probable failure modes of generating unit and assemblies of the power system on system performance. Optimal RCM schedule which is considered the severity level of each generating unit and failure probability from failure prediction of generating unit can be planned using proposed FMECA with IOE index.

• 셀메드
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• 제6권2호
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• pp.10.1-10.3
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• 2016

Arirang has quite a long history in Korean music. Arirang means the heart is tingling. Jeongseon Arirang is well-known Arirang from the Gangwon province, so it shares certain features of Dongbu minyo (folksong), including the Menaritori. Jeongseon Arirang of Ok-sim Kim is pure and innocent. She has an ingenuous country voice. It is a kind of hope that provides our mental strength. Mental power is as important to our health as a eating right. Jeongseon Arirang sung by Ok-sim Kim is Seoul style of rhythmic pattern and melody. Jeongseon Arirang is designated as the Intangible Cultural Property No. 1 by the Gangwon province in 1971. This article outlines the emotional biography of Jeongseon Arirang of Ok-sim Kim relationship.

• 약학회지
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• 제54권3호
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• pp.187-191
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• 2010

Chaga mushroom (Inonotus obliquus) has been identified to have various biological activities. This study was performed to investigate the potential of chaga mushroom as a immunomodulating functional food. When mouse splenocytes were exposed to various concentration of hot water extracts of chaga mushroom (IOE) with mitogens (Con A, LPS), splenocytes proliferation was significantly increased. Also, IFN-$\gamma$ and IL-4 levels were significantly enhanced. Therefore, our results suggest that chaga mushroom may have the potential of being an immunomodulating functional food.

• 사물인터넷융복합논문지
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• 제2권1호
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• pp.1-6
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• 2016

사물인터넷은 네트워크에 연결된 사람, 사물, 공간 등 모든 것들(Things)이 실시간으로 데이터를 생성하고 해당 객체간의 정보가 수집, 공유, 활용되는 기술이나 환경을 일컫는다. 현재 헬스케어, 스마트홈 등 다양한 분야에서 연구가 진행이며 사물인터넷 환경에 지리적 공간과 인터넷 간의 연결성을 강조한 만물인터넷의 개념도 등장했다. 사람, 사물 등 각 객체간의 연결성이 중요하게 부각되면서 효율적이고 안전한 인증기술에 대한 연구가 진행 중이다. 이 논문에서는 사물인터넷 환경에서 사람, 사물 등 객체간의 상호인증을 위한 개선된 RADIUS(Remote Authentication Dial In User Service) 프로토콜을 제안한다.

• 한국광학회:학술대회논문집
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• 한국광학회 2000년도 하계학술발표회
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• pp.3-3
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• 2000

Adaptive Optical (AO) technology can compensate for wave-front errors in real-time to improve image and beam quality. The research and development on AO in China began in 1979. In 1980, the first laboratory on AO in China was established in Institute of Optics and Electronics (IOE), Chinese Academy of Sciences (CAS). Since then several AO systems have been built in this Laboratory. The 19-element system is the first AO system in the world ever used in inertial confinement fusion (ICF) facility in our knowledge. It corrects the static error of this large laser engineering. The 21-element system was firstly tested at the 1.2m telescope of Kunming Observatory in 1990 and then up-dated as an IR AO system installed at the 2.16m telescope of Beijing Observatory. The 37-element system was used with a turbulence cell in Laboratory on Atmospheric Optics in Hefei to conduct elementary research on Atmospheric Optics. The 61-element system for astronomical observation is newly developed. It has been successfully installed at the 1.2m telescope of Kunming Observatory and a laser guide star system will be integrated with the system. A compact AO system using our newly developed miniature DM for high resolution ophthalmic imaging of retina is also being built. The key elements of these AO systems, deformable mirrors and fast-steering mirrors, are all developed in this Laboratory. In this talk, the main configurations of these AO systems, some test results as well as the specifications of these active mirrors will be presented.