• Title/Summary/Keyword: INVASIVE

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Expression of Cyclooxygenase-2 in Intestinal Epithelial Cells in Response to Invasive Bacterial Infection and its Role of Epithelial Cell Apoptosis (침습성 세균 감염에 의한 사람 장상피세포에서의 Cyclooxygenase-2 발현 및 이의 발현이 상피세포 Apoptosis에 미치는 영향)

  • Kim, Jung-Mogg;Kang, Shin-Jae;Cho, Yang-Ja
    • The Journal of the Korean Society for Microbiology
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    • v.34 no.5
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    • pp.479-489
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    • 1999
  • Invasion of enteric bacteria, such as Salmonella and invasive E. coli, into intestinal epithelial cells induces proinflammatory gene responses and finally epithelial cell apoptosis. In this study, we asked whether invasive bacterial infection of human intestinal epithelial cells could upregulate cyclooxygenase-2 (COX-2) gene expression and whether increased COX-2 expression could influence intestinal epithelial cell apoptosis. Expression of COX-2 mRNA and prostaglandin (PG) $E_2$ production were upregulated in HT-29 colon epithelial cells which were infected with S. dublin or invasive E. coli, as examined by quantitative RT-PCR and radioimmunoassay. Inhibition of COX-2 expression and $PGE_2$ production using NS-398, a specific COX-2 inhibitor, showed a significant increase of epithelial cell apoptosis and caspase-3 activation in HT-29 cells infected with invasive bacteria. However, the addition of valerylsalicylate, a specific COX-1 inhibitor, did not change apoptosis in S. dublin-infected HT-29 cells. These results suggest that up regulated COX-2 expression and $PGE_2$ production in response to invasive bacterial infection could contribute to host defense by inhibiting apoptosis of intestinal epithelial cells.

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Influences of Invasive Plant on Extracellular Enzyme Activities in Riparian Ecosystems (하변토양의 미생물체외효소활성에 미치는 칩입성 식물의 영향)

  • Park, Soon-Young;Kim, Jae-Keun;Kang, Ho-Jeong
    • Journal of Wetlands Research
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    • v.14 no.1
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    • pp.47-57
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    • 2012
  • We have measured soil enzyme activities, which represent the rates of organic matter decomposition, in four riparian ecosystems in Korea. ${\beta}$-glucosidase, N-acetylglucosaminidase, phosphatase and arylsulfatase activities were determined in five occasions over a year period in soils of control plots and plots with invasive plants, namely Sicyos angulatus and Humulus japonicus. Significantly higher enzyme activities were found in soils with invasive plant in barren land, but the difference was season and enzyme-specific. Although it was not universal changes, the invasive plants appeared to accelerate organic matter decomposition in some disturbed riparian ecosystems.

Ureterosciatic hernia causing obstructive uropathy successfully managed with minimally invasive procedures

  • Kim, Yeong Uk;Cho, Jae Ho;Song, Phil Hyun
    • Journal of Yeungnam Medical Science
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    • v.37 no.4
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    • pp.337-340
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    • 2020
  • Ureterosciatic hernia is extremely rare. In ureteral herniation, ureter prolapses occur through either the greater or lesser sciatic foramen. Atrophy of the piriformis muscle, hip joint diseases, and defects in the parietal pelvic fascia are predisposing factors for the development of ureterosciatic hernia. Most symptomatic patients have been treated surgically, with conservative treatment reserved only for asymptomatic patients. To the best of our knowledge, long-term follow-up outcomes after ureterosciatic hernia management are sparse. In this paper, we report the case of a 68-year-old woman who presented with colicky left abdominal pain. After computed tomography (CT) scan and anterograde pyelography, she was diagnosed ureterosciatic hernia with obstructive uropathy. We performed ureteral balloon dilatation and double-J ureteral stent placement. After this minimally invasive procedure, CT scan demonstrated that the left ureter had returned to its normal anatomical position without looping into the sciatic foramen. The patient remained asymptomatic with no adverse events 7 years after the minimally invasive procedures. This brief report describes ureterosciatic hernia successfully managed with minimally invasive procedures with long-term follow-up outcomes.

Definition of Invasive Disturbance Species and its Influence Factor: Review (침입교란종 개념 정립 및 영향요인 고찰)

  • Kim, Eunyoung;Song, Wonkyong;Yoon, Eunju;Jung, Hyejin
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.19 no.1
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    • pp.155-170
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    • 2016
  • This study established the definition of invasive disturbance species for a sustainable management and biodiversity, and derived the influence factors caused by the species. To define the species, the paper reviewed similar words such as alien species and invasive species, using standard definitions. Also reviewed the results of recent research on the factors of the species. The paper defined the invasive disturbance species as an species whose establishment and spread threaten ecosystems, habitats or species with economic or environmental harm including native and non-native. Through the reviews, The factors were classified as geographic (altitude, slope, and soil, etc.), climate (temperature, precipitation, climate change, etc.) and, anthropogenic (land use, population, road, and human activity, etc.), and species & vegetation structure (species property, local-species richness, and canopy, etc.). Especially, human activity such as urbanization and highways may be associated with both higher disturbance and higher propagule pressure. In the further study, it is required development of mitigation strategies and vegetation structure model against invasive disturbance species in urban forest based on this study.

Perception of Physicians and Nurses on Presence of Family during Invasive Procedures (침습적 시술 시 가족입회에 대한 의사와 간호사의 인식)

  • Sim, Sang-Hee;Lee, Eun-Nam
    • Journal of Korean Academy of Nursing
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    • v.40 no.3
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    • pp.326-335
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    • 2010
  • Purpose: The purpose of this descriptive study was to determine the perception of physicians and nurses on family presence during invasive procedures. Methods: The study population consisted of 100 physicians and 100 nurses from five hospitals which have more than 500 beds in B city. Data collection was done from August 20 to September 19, 2007. The Family Presence During Resuscitation (FPDR) Inventory developed by Fulbrook, Albarran and Latour (2005) was used as the study instrument. The collected data was analyzed by t-test, ANOVA and Duncan's multiple range test using SPSS/WIN 14.0 version. Results: Nurses had more positive attitudes to allowing family members to be present during invasive procedures than physicians did. However, compared to physicians, nurses had more concern about problems of confidentiality, arguing with medical team, and increased rate of legal action if family members were present during invasive procedure. Conclusion: The results of this study indicate that educational programs and policy for family presence be required within the hospital to enhance the perception of physicians and nurses to the family presence.

Reliability of Stool Antigen Tests: Investigation of the Diagnostic Value of a New Immunochromatographic Helicobacter pylori Approach in Dyspeptic Patients

  • Korkmaz, Huseyin;Findik, Duygu;Ugurluoglu, Ceyha;Terzi, Yuksel
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.2
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    • pp.657-660
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    • 2015
  • Background: A diagnosis of H. pylori infection can be made by invasive or non-invasive methods. Several noninvasive diagnostic tests based on the detection of H. pylori stool antigen (HpSA) have been developed. The Genx H. pylori stool antigen card test is a new rapid, non-invasive test that is based on monoclonal immunochromatographic assay. The aim of this study was to determine its sensitivity, specificity, and diagnostic accuracy for diagnosing H. pylori infection in adult patients. Materials and Methods: A total of 162 patients were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered H. pylori positive if two invasive tests (histological and rapid urease tests) were positive. Results: Using the reference test, 50.6% of the samples were positive for H. pylori infection. The Genx H. pylori antigen test was positive in 19.7% of patients. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the Genx H. pylori antigen test were 51.6%, 96.0%, 88.8%, 76.1%, and 79.0%, respectively. Conclusions: The Genx H. pylori stool antigen card test is a new non-invasive method that is fast and simple to perform but provides less reliable results.

A Case of Invasive Thymoma with Endotracheal Polypoid Growth

  • Hwang, Jin Tae;Kim, Min Hee;Chang, Ki Jun;Chang, Hyo Jeong;Choi, Soo Jeon;Yuh, Young Jin;Kim, Jung Yeon;Park, Hye Kyeong
    • Tuberculosis and Respiratory Diseases
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    • v.73 no.6
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    • pp.331-335
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    • 2012
  • Thymomas are one of the most common neoplasms of the mediastinum derived from thymic epithelium. It is common that invasive thymoma invades the lung, pericardium, and great vessels. Airway compression by mass effect also occurs, but direct polypoid tumor growth into the airway is extremely rare. Only 20 cases of invasive thymoma with endobronchial polypoid growth have previously been reported globally. However, there is no case report of invasive thymoma with endotracheal growth. Herein, we report a rare case of invasive thymoma with endotracheal polypoid growth in a 28-year-old woman.

Efficacy and effectiveness of pneumococcal conjugate vaccine in children (폐구균 단백 결합 백신의 효능 및 효과)

  • Lee, Hoan Jong
    • Clinical and Experimental Pediatrics
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    • v.49 no.3
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    • pp.235-241
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    • 2006
  • Streptococus pneumoniae is an important cause of invasive infections as well as non-invasive infections such as acute otitis media and sinusitis both in children and adults. Resistance of S. pneumoniae to multiple antimicrobials is increasing and poses therapeutic challenges, and prevention became more important. 23-valent polysaccharide vaccine has been used for the last several decades, but is not effective in children <2 years of age, the highest risk group of invasive diseases. Recently, a 7-valent pneumococcal protein conjugate vaccine(PCV) which is effective in infants and young children has been developed. The efficacy of PCVs against invasive pneumococcal disease and pneumonia is well established and is documented in several well-conducted studies. However, the effect of PCVs on otitis media is less obvious and more complex. PCVs clearly reduce diseases caused by vaccine-type(VT) pneumococci, but replacement of VT serotypes by non-VT serotypes in nasopharyngeal carriage of S. pneumoniae is responsible for the increase in acute otitis media caused by non-VT serotypes. Three years after introduction of PCV in the US, some increase of invasive infections with serotype 19A possibly due to serotype switching within certain vaccine type strains has been noted. Since most antibiotic-resistance in S. pneumoniae is confined to VT serotypes, vaccine use also reduces antibiotic resistance. With development of PCV, there was a great advance in the prevention of pneumococcal diseases, but replacement with potential virulent organisms and development of antibiotic resistance in non-VT pneumococci is a possibility that needs careful monitoring.

Extracorporeal High Intensity Focused Ultrasound Therapy (체외강력집속초음파치료)

  • Han, Sang-Suk
    • The Journal of the Korean bone and joint tumor society
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    • v.11 no.1
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    • pp.17-24
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    • 2005
  • Local treatment for tumors has developed from extended radical surgery to function preserving surgery on the basis of modern biology. With the development of minimally invasive technique, it changed to be minimal-invasive surgery. And nowadays technical revolution made non-invasive surgery possible with appearance of several kinds of non-surgical knives such as gamma knife, cyber knife, and HIFU (high intensity focused ultrasound) knife. In this article, history, HIFU machine and treatment procedure, histological change and its mechanism, clinical applications, advantage, disadvantage, and future prospect of extracorporeal high intensity focused ultrasound therapy using HIFU knife will be reviewed.

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INVASIVE ASPERGILLOSIS OF THE MAXILLARY ANTRUM AND LUNG IN A PATIENT WITH DIABETES MELLITUS AND LIVER CIRRHOSIS (당뇨 및 간경변 환자의 상악동과 폐에서 발생한 침윤성 국균증의 치험례)

  • Kim, Ill-Kyu;Lee, Seong-Jun;Ha, Soo-Yong;Chu, Young-Chae;Shin, Yong-Woon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.13 no.4
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    • pp.456-461
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    • 1991
  • This is a case report of invasive aspergillosis of the right maxillary antrum and the left lung in a 43 year-old male patient with diabetes mellitus and liver cirrhosis. The results were as follows. 1. Invasive aspergilliosis should be considered in compromised patients who have nasal symptomatology, infraorbital swelling and pain. 2. Invasive aspergillosis is a rapidly progressive mycotic infection of the sinus which may extend to the orbit, nasal cavity and cheek. 3. Surgical intervention is particularly urgent in orbital aspergillosis in patient in whom the eyesight is still preserved. 4. Diagnosis depends upon pathological demonstration of tissue invasion by organism with the typical morphology of aspergillus species. 5. Long-term antifungal drugs should be administrated postoperatively in pathint with invasive aspergillosis.

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