• Title/Summary/Keyword: IL-la

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Effect of D-Range Neutral Control of Automatic Transmission on LA-4 Mode Fuel Economy (정지구간에서 자동변속기 D단 중립 제어가 LA-4 모드 주행 연비에 미치는 영향)

  • Wi, Hyo-Seong;Jung, Youn-Sik;Park, Jin-Il;Park, Kyoung-Seok;Lee, Jong-Hwa
    • Transactions of the Korean Society of Automotive Engineers
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    • v.17 no.1
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    • pp.19-23
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    • 2009
  • This paper focuses on vehicle fuel economy improvement using D-Range neutral control of automatic transmission. The system objected to reducing of fuel consumption during idle. Usually, turbine of conventional auto transmission is mechanically linked to wheel during idling condition. Therefore speed ratio of torque converter is zero for that period. This causes needless power loss by the torque converter slip. To improve this inefficiency automobile makers develops electronically-controlled D-range neutral control system. The D-range neutral control system minimizes slip on the torque converter by shifting gear to a neutral position during vehicle stoped with D-range gear position. However there's insufficient study about the effect of D-range neutral control system on vehicle fuel economy. In this paper, researches are performed on effect of D-range neutral control system on vehicle fuel economy by experiment with two different vehicle. And it is also estimated the effect on vehicle fuel economy using computer simulation. As a result, 1.8% of LA-4 mode fuel economy improvement can be achieved in a vehicle by D-range neutral control system.

Studies on the Chemical Nutagen-induced DNA Repair Synthesis in Relation to Chromosome Exchanges (突然變異誘發原에 의한 DNA回復合成과 染色體交換과의 聯關性에 관한 硏究)

  • Park, Sang-Dai;Um, Kyung-Il;Park, Kyung-Hee
    • The Korean Journal of Zoology
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    • v.19 no.4
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    • pp.179-186
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    • 1976
  • DNA repari synthesis and chromosome aberrations induced by various concentrations of alkylating agents (MMS, MNNG, MMC) in cultured human lymphocytes and HeLa $S_3$ cells were studied to determine the possibility of correlation between these two types of biological phenomena, and the results obtained were as follows: DNA repair synthesis was detected in MMC, MNNG and MMS treated HeLa $S_3$ cells at the concentrations of $3 \\times 10^{-7}M, 1 \\times 10^{-6}M, 5 \\times 10^{-4}M$, respectively. These results indicate that MMC is the most potent mutagen followed by MNNG, and MMS is the least potent among these three types of alkylating agents. MMC and MNNG did not show any significant increases of DNA repair synthesis as dose increased, while MMS did. Chromosome aberrations induced by MMC in human lymphocytes was increased as dose increased, but not chromosome exchanges. MNNG did not induce any significant amount of chromosome aberrations with doses, and exchanges were not observed in MNNG treated cells. MMS, however, induced both chromosome aberrations and exchanges, and their rates were increased as dose increased. These results suggest that DNA repair synthesis induced by these alklating agents may not be directly related to the production of chromosome aberrations and exchanges.

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Preparation and Oxygen Permeation Properties of La0.07Sr0.3Co0.2Fe0.8O3-δ Membrane (La0.07Sr0.3Co0.2Fe0.8O3-δ 분리막의 제조 및 산소투과 특성)

  • Park, Jung Hoon;Kim, Jong Pyo;Baek, Il Hyun
    • Applied Chemistry for Engineering
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    • v.19 no.5
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    • pp.477-483
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    • 2008
  • $La_{0.7}Sr_{0.3}Co_{0.2}Fe_{0.8}O_{3-{\delta}$ oxide was synthesized by a citrate method and a typical dense membrane of perovskite oxide has been prepared using as-prepared powder by pressing and sintering at $1300^{\circ}C$. Precursor of $La_{0.7}Sr_{0.3}Co_{0.2}Fe_{0.8}O_{3-{\delta}$ prepared by citrate method was investigated by TGA and XRD. Metal-citrate complex in precursor was decomposed into perovskite oxide in the temperature range of $260{\sim}410^{\circ}C$ but XRD results showed $SrCO_3$ existed as impurity at less than $900^{\circ}C$. Electrical conductivity of membrane increased with increasing temperature but then decreased over $700^{\circ}C$ in air atmosphere ($Po_2=0.2atm$) and $600^{\circ}C$ in He atmosphere ($Po_2=0.01atm$) respectively due to oxygen loss from the crystal lattice. The oxygen permeation flux increased with increasing temperature and maximum oxygen permeation flux of $La_{0.7}Sr_{0.3}Co_{0.2}Fe_{0.8}O_{3-{\delta}$ membrane with 1.6 mm thickness was about $0.31cm^3/cm^2{\cdot}min$ at $950^{\circ}C$. The activation energy for oxygen permeation was 88.4 kJ/mol in the temperature range of $750{\sim}950^{\circ}C$. Perovskite structure of membrane was not changed after permeation test of 40 h and the membrane was stable without secondary phase change with 0.3 mol Sr addition.

Exfoliation of Dion-Jacobson Layered Perovskite into Macromolecular Nanoplatelet

  • Lee, Won-Jae;Yeo, Hyun Jung;Kim, Do-Yun;Paek, Seung-Min;Kim, Young-Il
    • Bulletin of the Korean Chemical Society
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    • v.34 no.7
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    • pp.2041-2043
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    • 2013
  • A layered perovskite of Dion-Jacobson phase, $RbLaTa_2O_7$, was successfully exfoliated into colloidal suspension via successive ion-exchange and intercalation reaction. The pristine perovskite $RbLaTa_2O_7$ was synthesized by conventional solid-state reaction, and then, it was ion-exchanged with hydrochloric acid to obtain a protonic form of perovskite. The resulting proton-exchanged perovskite was reacted with ethylamine to increase interlayer spaces for further intercalation reaction. Finally, the ethylamine-intercalated form was exfoliated into nanosheets via an intercalation of bulky organic cations (tetrabutylammonium). According to X-ray diffraction (XRD) analysis, the TBA-intercalated form showed remarkably increased interlayer spacing (${\Delta}d$ = 1.67 nm) in comparison with that of the pristine material. Transmission electron microscopic image of exfoliated perovskite clearly revealed that the present exfoliated perovskite were composed of very thin layers. This exfoliated perovskite nanosheets could be applicable as building blocks for fabricating functional nanocomposites.

Improvement of Dry-blasting Efficiency for Ballast used as Aggregate of Paved Track (포장궤도 골재용 도상자갈의 건식 블라스팅 효율 향상 연구)

  • Lee, Il-Wha
    • Journal of the Korean Society for Railway
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    • v.13 no.1
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    • pp.78-83
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    • 2010
  • On the paved track, the ballast is used as aggregate for the filling layer using the pre-packed concrete technique. The most important condition of aggregate is adhesive strength with mortar. To satisfy this condition, surface of aggregate should be cleaned by water or others. In a paved-track method to be introduced domestically, an environment-friendly dry-washing technology which will replace the water-washing method has been developed. A dry-washing method was designed to blast the crushed weight material with a diameter of 0.3~0.5mm at high pressure to peel the surface of the aggregate. The study was intended to enhance the washing efficiency of dry-blasting technology and to that end, the tests including blasting material, content of fine aggregate depending on time elapsed, content of chloride, LA abrasion rate and compressive strength were conducted to recommend the efficient washing material and the process.

Effect of ZrO2 Buffer Layers for Pt/Bi3.25La0.75Ti3O12/ZrO2/Si (MFIS)-FET Structures (Pt/Bi3.25La0.75Ti3O12/ZrO2/Si (MFIS)-FET 구조를 위한 ZrO2 Buffer Layer의 영향)

  • Kim, Kyoung-Tae;Kim, Chang-Il
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.18 no.5
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    • pp.439-444
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    • 2005
  • We investigated the structural and electrical properties of BLT films grown on Si covered with $ZrO_{2}$ buffer layer. The BLT thin film and $ZrO_{2}$ buffer layer were fabricated using a metalorganic decomposition method. The electrical properties of the MFIS structure were investigated by varying thickness of the $ZrO_{2}$ layer. AES and TEM show no interdiffusion and reaction that suppressed using the $ZrO_{2}$ film as a buffer layer The width of the memory window in the C-V curves for the MFIS structure decreased with increasing thickness of the $ZrO_{2}$ layer. It is considered that the memory window width of MFIS is not affected by remanent polarization. Leakage current density decreased by about four orders of magnitude after using $ZrO_{2}$ buffer layer. The results show that the $ZrO_{2}$ buffer layers are prospective candidates for applications in MFIS-FET memory devices.

Synthesis and in vitro cytotoxicity of a homologous series of 5-halosubstituted $1,3-Bis(\omega-cyanoalkyl)$uracil analogues

  • Kim, Jack-C.;Dong, Eun-Soo;Park, Jin-Il;Kim, Young-Hyeun;Choi, Soon-Kyu
    • Archives of Pharmacal Research
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    • v.19 no.1
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    • pp.62-65
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    • 1996
  • A homologous series of twenty, hitherto unreported, analogues of 5-halosubstituted $1, 3-Bis(\omega-cyanoalkyl)uracil$acyclic nucleosides were synthesized by the series of alkylation reactions of 5-halouracils with the corresponding chloroacetonitrile, chloropropionitrile, chlorobutyronitrile and 5-chlorovaleronitrile $(Cl-(C_ 2)_n-CN: n=l, 2, 3, 4)\; in\; anhydrous\; DMSO\; (or DMF)/K_2CO_3(or NaH)\; under\; 75^{\circ}C$ temperature. Antitumor activities for the synthesized compounds were determined against three cell lines (FM-3A cell, P-388 cell and U-938 cell lines). The compounds that exhibited moderate activity to significant activity, included la-b, 2a-b, 3a-c, and 4a, whose compounds were active against P-388, FM-3A and U-937 cell lines with the compounds la, lb, and 2a, showing significant antitumor activity (inhibitory concentrations $(IC_{50})$ ranged from 2.2 to $7.0\mug/ml$). Their strucrure-activity relationship did not show any activity differences in their effective chain length (methyl, ethyl, propyl, butyl) in 1, 3-bis(.omega.-cyanoalkyl) uracils.

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DNA Repair Synthesis Induced by Bleomycin in HeLa $S_3$ Cells Pretreated with Base Analogs (鹽基相似體를 前處理한 HeLa $S_3$ 細胞에 있어 Bleomycin에 의한 DNA 回復合成)

  • Um, Kyung-Il;Park, Sang-Dai
    • The Korean Journal of Zoology
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    • v.20 no.1
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    • pp.41-48
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    • 1977
  • Dose response of DNA repair synthesis induced by bleomycin was dose-dependent in lower doses, and maximum rate of it at 5 $\\mu$g/ml represents about 15% of total cells analyzed. At higher doses DNA-repair synthesis was reduced and the rate of it remained unchanged even prolonged treatment. Pretreatment with BUdR or IUdR was found to enhance DNA repair synthesis and also to interfere with semiconservative DNA synthesis at higher doses. Time dependence study showed that DNA repair synthesis occurred as long as for 24 hours after removal of bleomycin. These results seem to suggest that bleomycin is not to be an effective chemical in inducing excision repair and that damages induced in DNA by this drug might include not only strand breaks but other types of DNA damage.

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A Computational Study on the Adsorption Characteristics of Hydrocarbons (Propylene, n-Butane and Toluene) by uing Cation-exchanged ZSM-5 Zeolites

  • Lee, Hyun Chul;Kim, Kyung Min;Choi, Sung Il;Kim, Yong Ha;Woo, Hee Chul;Won, Yong Sun
    • Korean Chemical Engineering Research
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    • v.56 no.6
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    • pp.909-913
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    • 2018
  • A hydrocarbon trap (HT) plays an important role of controlling vehicle emissions in the so-called cold emission period by holding hydrocarbons until three way catalysts (TWCs) are thermally activated. In this study, we have investigated the adsorption characteristics of cation (H, La, K, and Ag)-exchanged ZSM-5 zeolites for hydrocarbons (propylene, n-butane, and toluene) by DFT (density functional theory)-based computational chemistry. Cation exchange is to improve the hydrothermal stability of zeolites and their adsorption capacity, thereby rendering cation-exchanged zeolites promising materials for HT. The idea of cluster approximation makes the calculation of adsorption energies superbly efficient in computation. The results showed that Ag-exchanged ZSM-5 would be the best for the adsorption of all three adsorbates, without often encountered Ag oxidation in experiments. Besides, the hydrothermal stability of La-exchanged ZSM-5 was confirmed from the change of geometrical parameters by cation exchange, and it showed good adsorption capacity for propylene and toluene. Hydrogen-exchanged ZSM-5 was also good for hydrogen adsorption, but had poor hydrothermal stability.

Anti-tumor Metastatic Effect and Activation of Innate Immunity by Extract of Mori Radicis Cortex (상백피(桑白皮)의 선천면역 활성화에 의한 항암 효과)

  • Jeong, Jae-Hyuk;Lee, Jin-Moo;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.1
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    • pp.31-40
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    • 2009
  • Purpose: This study was carried out to investigate the anti-tumor metastasis effect and activation of innate immunity by extracts of Mori radicis cortex. Methods: Anti-tumor metastatic experiment was conducted in vitro and in vivo by using colon 26-M3.1 carcinoma cell, L5178Y-R lymphoma cell and HeLa cell. To observe the activation of innate immunity by extracts of Mori radicis cortex, we estimated IL-6, IL-10, IL-12, TNF-${\alpha}$ from peritoneal macrophages. And we evaluated the activation of NK cell by using anti-asialo-GM1 serum. Results: We found that the administration of Mori radicis cortex extracts significantly inhibited tumor metastasis. In an in vitro cytotoxicity analysis, Mori radicis cortex affected tumor cell growth above specific concentration. Mori radicis cortex also stimulated peritoneal macrophage, which was followed by the production of various cytokines such as IL-6, IL-10, IL-12, TNF-${\alpha}$. The depletion of NK cells by anti-asialo GM1 serum partly abolished the inhibitory effect of Mori radicis cortex on tumor metastasis. Conclusion: Mori radicis cortex appears to have considerable activity on the anti-metastasis by activation of innate immunity.