• IMMUNE NETWORK
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• 제22권1호
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• pp.11.1-11.26
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• 2022

When epithelial cells are exposed to potentially threatening external stimuli such as allergens, bacteria, viruses, and helminths, they instantly produce "alarmin" cytokines, namely, IL-33, IL-25, and TSLP. These alarmins alert the immune system about these threats, thereby mobilizing host immune defense mechanisms. Specifically, the alarmins strongly stimulate type-2 immune cells, including eosinophils, mast cells, dendritic cells, type-2 helper T cells, and type-2 innate lymphoid cells. Given that the alarm-raising role of IL-33, IL-25, and TSLP was first detected in allergic and infectious diseases, most studies on alarmins focus on their role in these diseases. However, recent studies suggest that alarmins also have a broad range of effector functions in other pathological conditions, including psoriasis, multiple sclerosis, and cancer. Therefore, this review provides an update on the epithelium-derived cytokines in both allergic and non-allergic diseases. We also review the progress of clinical trials on biological agents that target the alarmins and discuss the therapeutic potential of these agents in non-allergic diseases.

• Physical Therapy Rehabilitation Science
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• 제6권3호
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• pp.146-151
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• 2017

Objective: The purpose of this study was to investigate the effects rhythmic and non-rhythmic aerobic exercises on depression and balance of healthy elderly people. Design: Randomized controled trial. Methods: Nineteen older subjects were randomly divided into 2 groups for rhythmic and non-rhythmic aerobic exercises. Both aerobic exercises consisted of functional movements such as turning in opposite directions, and running in place, the exercise consisted of movements that could activate balance. The rhythmic training group initially used music with 8 beats, and then later progressed to 16 beats. Additionally, we adjusted the pace of the music using songs from 125 beats per minute (bpm) to 160 bpm. Both groups were exercised for 50 minutes a day, twice a week, for a total of 8 weeks. We measured the condition of the patients before the intervention, and after 8 weeks of intervention. The Beck depression inventory (BDI) was used to measure the degree of depression. The Berg balance scale (BBS) was used to measure static and dynamic balance ability. We measured the subject's subjective balance confidence using the fall efficacy scale (FES). Results: Both groups showed significant improvement in BDI, BBS, and FES (p<0.05). The rhythmic aerobic exercise group showed a significant improvement only in the BBS change values compared to the non-rhythmic group (p<0.05). Conclusions: According to this study, both rhythmic and non-rhythmic aerobic exercises resulted in significant improvement in the degree of depression and balance ability of the elderly. The rhythmic aerobic exercise was more effective for dynamic balance ability.

• 대한정형도수물리치료학회지
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• 제28권2호
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• pp.35-44
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• 2022

Background: This study aimed to compare the effects of the Mulligan mobilization with movement and McKenzie exercise after applying conservative physical therapy to patients with knee pain. Methods: Patients were randomly allocatied into two groups: the Mulligan mobilization with movement (10 subjects) and the McKenzie technique (10 subjects). Each group was givenr conservative physical therapy and manual therapy sessions, three times week, for four weeks. The pain intensity was measured using the visual analogue scale (VAS). The cervical range of motion (ROM) was measured with a goniometer. Balance was measured using the modified Berg balance scale (BBS). Results: After four weeks of therapy, VAS (p<.05) decreased significantly, and ROM and balance increased siginficantly in both groups(p<.05). There was a significant improvement in knee extension (p<.05) in the McKenzie group compared to the Mulligan group. No intergroup differences were found with respect to the knee flex, VAS, and BBS (p>.05). Conclusion: The McKenzie exercises are more effective than Mulligan mobilization with movement for improving knee extension. Both interventions have the same effects on pain relief, in increasing knee flexion ROM and improving balance in patients with knee pain.

• Childhood Kidney Diseases
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• 제11권2호
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• pp.178-184
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• 2007

목 적 : 1990년 Mendoza등이 스테로이드 저항성 FSGS에서 Mendoza protocol에 의한 장기간의 MP 충격 요법이 효과적임을 보고한 이후 이 치료법의 효과에 대한 보고가 있어 왔다. 본 연구에서는 cyclosporin이나 cyclophosphamide를 먼저 사용하지 않은 스테로이드 저항성 FSGS에서 Mendoza protocol 에 의한 장기간의 MP 충격 요법의 치료 효과를 알아보고자 하였다. 방 법 : 1986년부터 2006년 사이에 세브란스병원 소아과에서 스테로이드 저항성 FSGS를 진단 받고 MP 충격 요법을 시행했던 10명의 환아를 후향적으로 분석하였다. 결 과 : 평균 발병 연령은 2.6세였으며 치료 시작시의 평균 연령은 5.7세였다. 치료 종료 후 평균 추적 관찰 기간은 35개월이었다 치료 종료 후 5명에서 완전 관해가 유도되었으며(50%) 2명에서 부분 관해가 유도되었으나(20%) 이 중 1명은 후에 재발하였다. 3명은 치료에 반응하지 않았으며(30%) 이 중 2명은 치료 중 말기 신부전으로 진행하여 신이식을 시행하였다. 결 론 : Mendoza protocol에 의한 장기간의 MP 충격 요법은 현재까지의 연구 결과에서는 cyclosporin A, cyclophosphamide를 먼저 투여하지 않고 최초 치료로 사용할 경우 그 치료 효과가 좋지 않았으나 본 연구에서는 50% 정도로 효과를 보이고 있으므로 스테로이드 저항성 FSGS 환아의 초기 치료에 사용할 수 있을 것으로 생각된다. 또한 cyclosporin A 또는 cyclophosphamide를 먼저 사용하고 효과가 없는 경우 MP 충격 요법을 시작하는 경우에도 치료 효과는 좋을 것으로 생각 할 수 있다.

• 대한임상전기생리학회지
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• 제1권2호
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• pp.11-19
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• 2003

The purpose of this study investigated the anesthetic effects of lidocaine gel by phonophoretic transdermal delivery. The anesthetic effects were evaluated by two aspects as quantitative sensory testing and sensory nerve conduction study. Twelve healthy males(aged $23.25{\pm}2.09$ years) were studied. Exclusion criteria were ; pain, history of sensory disturbances and skin conditions in the areas to be examined. The subjects were divided into two groups; group I(lidocaine gel without ultrasound) and group II(lidocaine gel with ultrasound). The following results were obtained; 1. In changes of tactile threshold and electrical pain threshold, all groups were significantly increased(p<0.05). 2. In changes of electrical pain threshold, it was significantly differenced between the groups(p<0.05). We conclude that the transdermal delivery of lidocaine gel by phonophoresis has a possibility to use for surface anesthesia and the pain control of the superficial tissue.

• 대한치과교정학회지
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• 제19권1호
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• pp.219-243
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• 1989

The purpose of this study was to evaluate the effects of the chincap therapy on the craniofacial structure in persons with skeletal Class III malocclusion. The patients selected for this study were treated with extra-oral chincap therapy only. Both control and treatment samples were obtained from Seoul National University Hospital where these longitudinal data were gathered. 55 treated patients and 14 control patients were studied. The mean ages at the 1st evaluation was 8 years 3 months in the treatment sample and 9 years 4 months in the control sample. The duration of chincap therapy was variable but averaged 2 years of treatment. Post-treatment observation procedeeded for 1 year 2 months. Active treatment and post treatment effects were evaluated. The results were as follows: 1. Neither significant restraint nor acceleration of growth was found in the cranial base and maxilla during treatment. 2. A distal rotation of the mandibular complex was seen. 3. Some amount of restraint of growth was found in mandibular body length, ramus height, mandibular length during treatment. 4. The genial angle was reduced. 5. After removal of the chin-cap, forward displacement of the mandible took place.

• 대한한방부인과학회지
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• 제33권2호
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• pp.90-111
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• 2020

Objectives: The purpose of this study was to analyze randomized controlled trials (RCTs) related to the effect and safety of Korean Traditional Medicine treatment for postpartum pain, and to suggest desirable future clinical research trend. Methods: Randomized controlled trials (RCTs) on postpartum pain were searched using domestic and foreign search engines to investigate the effect and safety of Korean Traditional Medicine on postpartum pain, and 12 studies were selected as a result. Results: There were 4 studies using Acupoint Therapy, 3 studies using Herbal Medicine, 3 studies using Using Acupoint Therapy and Herbal Medicine together, and 2 studies using Manipulative Therapy for postpartum pain. As control interventions, non-treatment, other Korean Traditional Medicine treatment, or Western medicine were used. All the studies reported a significant effect in experimental group compared to the control group, with no or minor side effects. Conclusions: Korean Traditional Medicine treatment showed effectiveness and safety for postpartum pain. In the future, it is necessary to eliminate the ambiguity of recruiting subjects and to study the most effective application method of Korean Traditional Medicine treatment for postpartum pain.

• Radiation Oncology Journal
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• 제2권1호
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• pp.33-39
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• 1984

One hundred and twenty patients with brain metastases were seen and evaluated in the Dept. of Therapeutic Radiology, Seoul National University Hospital between 1979 and 1983. Of these, 90 Patients received whole brain irradiation with 2,000 ra4 in 1 week or 3,000 rad in 2 weeks for Palliative Purpose and 30 patients failed to complete the planned treatment. Carcinoma of the lung(44 cases), choriocarcinoma(11 cases), breast(8 cases) were common Primary tumors of 90 patients receiving planned treatment. Symptomatic subjective response was obtained in $92\%$ of Patients and meurologic functional improvement was obtained in $42\%$ of patients. Median survival was 6.4 months in patients with complete treatment an·d less than 2 months in Patients with incomplete treatment, overall survival rate at 1 year and 2 year were $26\%,\;16\%$ in Patients with complete treatment and $8\%,\;0\%$ in patients with incomplete treatment. Primary site, extent of metastases and interval from diagnosis of primary tumor to brain metastases were identified as prognostic factors.

• 대한물리의학회지
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• 제7권1호
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• pp.49-58
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• 2012

Purpose : The purpose of this study was to investigate the effects of trunk stabilization exercise using swiss ball and core stabilization exercise on balance and gait in elderly women. Methods : Subjects 19 elderly women were randomly divided by the swiss ball exercise group (n=10) and the core stabilization exercise group (n=9). In a period of 4 weeks, they took trunk stabilization exercise using swiss ball and core stabilization exercise for 60 minutes 3 times a week. Balance and gait were measured by Functional Reach Test (FRT), One Leg Stand Test with Open Eye (OLSTOE), One Leg Stand Test with Closed Eye (OLSTCE), Timed Up and Go Test (TUG) and 6 m Walking Test (6MWT). These tests were measured at before exercise, 4 weeks after exercise and after the follow-up period of 2 weeks. Results : As a result, in all measurement values there was no significant difference in two groups (p>.05). In FRT, TUG, OLSTOE and 6MWT before exercise and 4 weeks after exercise, there was significant difference in both of two groups (p<.05). Moreover, according to results from 4 weeks after exercise and after the follow-up period of 2 weeks, without any particular exercise, in FRT and 6MWT there was no significant difference (p>.05). Conclusion : These finding indicate that trunk stabilization exercise using swiss ball could improve balance and gait in elderly women. Accordingly, In this study trunk stabilization exercise using swiss ball and core stabilization exercise is judged to be used for elderly people with gait and balance problems to prevent hurts from fall.

• 대한임상전기생리학회지
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• 제9권2호
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• pp.13-23
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• 2011

Purpose : The purpose of this study is to investigate the effect on the static balance ability according to vestibular training using ball. Methods : Twenty normal subjects participated and were randomly assigned to either a vestibular training group using ball or a control group. The vestibular training using a ball group exercised 3 times per week over 3 weeks. The static balance was assessed by the center of pressure to the stance position. The participants stood barefoot on a force platform in a normal stance and a one-legged stance with a visual close. Results : In the normal stance, there were no significant differences at CoP surface and CoP speed. However, in a one-legged stance, there were significant differences in the vestibular training group between before and after the program. There was also a significant difference between the vestibular training group and the control group. Conclusion : Vestibular training using ball can be implemented as a therapeutic intervention to improve static balance ability in health adults.