• The Korean Journal of Physiology and Pharmacology
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• 제18권5호
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• pp.391-396
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• 2014

Although interleukin-11 (IL-11) has been reported to be elevated in hypoxic tumors and has been associated with a poor prognosis in various cancers, little is known about its precise role in promoting metastasis in hypoxic tumors. In the present study, the molecular mechanism underlying the effects of IL-11 on MDA-MB-231 breast cancer cells migration and invasion in relation to metastasis under hypoxic conditions has been defined. Inhibition of IL-11 expression or function using small interfering RNA (siRNA) or a neutralizing antibody attenuated hypoxic MDA-MB-231 breast cancer cell migration and invasion through down-regulation of matrix metalloproteinases (MMPs) and activation of epithelial-to-mesenchymal transition (EMT) related gene expression. In addition, hypoxia-induced IL-11 increased STAT3 phosphorylation and STAT3 knockdown suppressed hypoxic MDA-MB-231 breast cancer cell invasion due to reduced MMP levels and reprogrammed EMT-related gene expression. These results suggest that one of the hypoxic metastasis pathways and the regulation of this pathway could be a potential target for novel cancer therapeutics.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7831-7834
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• 2014

Objective: To explore the influence of different ways of blood transfusion on the expression levels of interleukins (IL) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) inperi-operative patients with esophageal cancer. Materials and Methods: A total of 80 patients with esophageal cancer who underwent radical operations were selected as study patients and randomly divided into an observation group (treated with autologous blood transfusion) and control group (with homologous blood transfusion). Changes of intra-operative indexes and peri-operative blood indexes, from hemoglobin (Hb) and hematocrit value (Hct), to levels of inflammatory factors like interleukins-6 (IL-6), IL-8, IL-10 and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) were compared. Results: Operations for patients in both groups were successfully conducted, and no significant differences in mean surgical duration and intra-operative hemorrhage volume, fluid infusion volume and blood transfusion volume were detected (p>0.05). Compared with values before surgery, Hb and Hct levels decreased significantly while white blood cell count (WBC) increased 1, 5 and 7 d after operation (p<0.05, p<0.01). In addition, WBC was apparently higher in observation group than in control group 5 and 7 d after operation (p<0.01). Compared with before surgery, in the observation group, levels of IL-6, IL-8 and IL-10 had no significant differences after operation (P>0.05), but TNF-${\alpha}$ level increased y (p<0.01), whereas in control group, IL-6 level had no significant difference (p>0.05), IL-8 level decreased obviously (p<0.05), IL-10 level increased markedly first and then decreased gradually as time passed but its level remained elevated (p<0.01), and TNF-${\alpha}$ level increased first and then decreased, and there was no significant difference 7 d after operation (p>0.05). Conclusions: Decreased IL-8 and increased IL-10 levels are two important reasons for immunosuppression after homologous blood transfusion, whereas autologous blood transfusion can alleviate this while increasing the TNF-${\alpha}$ level, which also has potential to improve anti-tumor immunity in the human body.

• 한국수학사학회지
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• 제20권4호
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• pp.1-21
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• 2007

18세기 초 중인(中人) 홍정하(洪正夏)($1684{\sim}?$)의 구일집(九一集)과 양반(兩班) 조태구(趙泰耉)($1660{\sim}1723$)의 주서관견(籌書管見)에 들어 있는 구고술(句股術)을 조사한다. 구조적 접근과 천원술(天元術)을 통하여 홍정하(洪正夏)는 동양(東洋)에서 가장 앞선 구고술(句股術)의 결과를 얻어내었다. 또 17세기 중엽에 서양(西洋) 수학(數學)이 조선(朝鮮)에 유입된 후 조선(朝鮮) 산학(算學)에 이론적 접근이 이루어지는 과정을 조태구(趙泰耉)의 구고술(句股術)을 통하여 연구한다.

• 소음진동
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• 제18권2호
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• pp.22-27
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• 2008

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1998년도 제37차 추계학술대회
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• pp.37.2-37.2
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• 1998

• 방송과미디어
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• 제18권1호
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• pp.67-73
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• 2013

• 대한한방내과학회지
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• 제44권2호
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• pp.222-230
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• 2023

Objectives: This study reports the effectiveness of acupuncture and moxibustion for Diabetic Peripheral Neuropathy concurrent with Chemotherapy-Induced Peripheral Neuropathy. Case presentation: A 58-year-old male was admitted for hand numbness and foot pain after his sixth chemotherapy. He was treated with acupuncture and moxibustion for 18 days. Symptoms were evaluated with a numeric rating scale (NRS). After 18 days of treatment, his foot pain improved from NRS 4 to NRS 2. His hand numbness disappeared. Conclusion: This study suggests that acupuncture and moxibustion can be used for managing diabetic peripheral neuropathy concurrent with chemotherapy-induced peripheral neuropathy.

• Journal of Microbiology and Biotechnology
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• 제33권10호
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• pp.1281-1291
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• 2023

Infectious diseases caused by drug-resistant Escherichia coli (E. coli) pose a critical concern for medical institutions as they can lead to high morbidity and mortality rates. In this study, amygdalin exhibited anti-inflammatory and antioxidant activities, as well as other potentials. However, whether it could influence the drug-resistant E. coli-infected cells remained unanswered. Amygdalin was therefore tested in a cellular model in which human macrophages were exposed to resistant E. coli. Apoptosis was measured by flow cytometry and the lactate dehydrogenase (LDH) assay. Western immunoblotting and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) were used to quantify interleukin-18 (IL-18), interleukin-1β (IL-1β), and interleukin-6 (IL-6). The production of reactive oxygen species (ROS) in macrophages was detected by ROS kit. The expression of pan-apoptotic proteins in macrophages was measured by qRT-PCR and Western immunoblotting. Drug-Resistant E. coli inhibited cell viability and enhanced apoptosis in the cellular model. In cells treated with amygdalin, this compound can inhibit cell apoptosis and reduce the expression of pro - inflammatory cytokines such as IL-1β, IL-18 and IL-6. Additionally, it decreases the production of PANoptosis proteins, Furthermore, amygdalin lowered the levels of reactive oxygen species induced by drug-resistant E. coli, in cells, demonstrating its antioxidant effects. Amygdalin, a drug with a protective role, alleviated cell damage caused by drug-resistant E. coli in human macrophages by inhibiting the PANoptosis signaling pathway.

• 동의생리병리학회지
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• 제18권3호
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• pp.841-845
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• 2004

This experiment was designed to investigate the effect of Gamcho(Glycyrrhiza uralensis Fisch, GLU) in asthma. We measured histamine, IL-1β, IL-4, 1L-5, IL-6, IL-10, IL-13, in plasma of ovalbumin induced asthmatic mouse. The results were obtained as follows: GLU decreased the proliferation of histamine, IL-1β, IL-4, IL-5, IL-6, IL-13 significantly. GLU increased the proliferation of IL-10 significantly. According to the above results, it is suggested that GLU extract might be useful applied for prevention and treatment of allergic asthma.

• 한국석유지질학회:학술대회논문집
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• 한국석유지질학회 2004년도 제11차 학술발표회 초록집
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• pp.18-18
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• 2004