• Annals of Clinical Neurophysiology
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• 제1권1호
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• pp.31-35
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• 1999

Dignosis of migraine is only based on the medical history, and objective methods to aid the clinical diagnosisare absent. Although transcranial Doppler ultrasonography (TCD) abnormalities in headache-free migraineurs have been reported previously, diagnostic criteria for migraine is still lacking and this may limit the practical application of TCD for migraine. We prospectively studied several abnormal TCD indices in interictal migraineurs and their sensitivity and specificity to define the optimal diagnostic criteria. Young (20 yrs$age=29.0{\pm}6.1yrs$) were compared to 69 controls (M:F=25:44, Mean $age=31.2{\pm}5.5yrs$). Elevated MFV (> 2SD)was observed in 63% of migraineurs while n 12% of control (p<0.01). High AI (>25%) or high HI (>3.0) was present in 17% of migraineurs, while 3% and none in controls (p<0.01). Sensitivity of elevated MFV, high AI, and high HI was 63%, 17%, 17% and specificity was 88%, 97%, 100%, respectively. If all these indices were combined, sensitivity and specificity reached 69% and 86%. These preliminary results suggest pathophysiological implication of vasospasm in interictal migraineurs, and TCD may be practically applicable for migraine. Optimal diagnostic criteria and therapeutic options for patients with abnormal TCD findings remain to bo determined.

• 한국환경복원기술학회지
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• 제9권6호
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• pp.1-12
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• 2006

Remote sensing cannot provide a direct measurement of vegetation index (VI) but it can provide a reasonably good estimate of vegetation index, defined as the ratio of satellite bands. The monitoring of vegetation in nearby urban regions is made difficult by the low spatial resolution and temporal resolution image captures. In this study, enhancing spatial resolution method is adapted as to improve a low spatial resolution. Recent studies have successfully estimated normalized difference vegetation index (NDVI) using improved resolution method such as from the Moderate Resolution Imaging Spectroradiometer (MODIS) onboard EOS Terra satellite. Image enhancing spatial resolution is an important tool in remote sensing, as many Earth observation satellites provide both high-resolution and low-resolution multi-spectral images. Examples of enhancement of a MODIS multi-spectral image and a MODIS NDVI image of Cheongju using a Landsat TM high-resolution multi-spectral image are presented. The results are compared with that of the IHS technique is presented for enhancing spatial resolution of multi-spectral bands using a higher resolution data set. To provide a continuous monitoring capability for NDVI, in situ measurements of NDVI from paddy field was carried out in 2004 for comparison with remotely sensed MODIS data. We compare and discuss NDVI estimates from MODIS sensors and in-situ spectroradiometer data over Ochang plain region. These results indicate that the MODIS NDVI is underestimated by approximately 50%.

• Clinical and Experimental Pediatrics
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• 제58권12호
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• pp.484-490
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• 2015

Purpose: To determine the efficacy and safety of oral propranolol as a first-line treatment for superficially located infantile hemangioma (IH) and propose an assessment tool to measure treatment response. Methods: Patients with superficial IH under 1 year of age were prospectively recruited between May 2012 and December 2013 at the Department of Pediatrics of Chungbuk National University Hospital. Propranolol was administered to 12 infants (median age, 3.8 months) while monitoring cardiovascular and adverse metabolic effects. If a patient showed no adverse events, the dosage was gradually increased up to 3 mg/kg/day and maintained for 1 year. We used our own scoring system to assess treatment response using parameters like change in color, and longest diameter, and thickness of the IH. Results: Eleven out of 12 patients completed the protocol with consistent improvement of hemangiomas during therapy. Patients on propranolol showed a more than 50% involution in the first 3 months, with additional steady involution until 1 year. Patients with the highest scores at 1 month maintained their score and showed better responses until treatment termination. The patient with the lowest score at 1 month did not show any further regression and stopped propranolol treatment 4 months after initiation. In two children with recurrences after successful therapeutic regression, propranolol was effective after being reintroduced. Propranolol treatment was not interrupted in any patient due to adverse events. Conclusion: Oral propranolol at 3 mg/kg/day showed a consistent, rapid, and therapeutic effect on superficial IHs without significant adverse events.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2133-2137
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• 2012

Objective: To investigate the prognostic role of antigen KI-67 (Ki-67) and G1/S-specific cyclin-D1 (cyclin-D1) in patients with laryngeal squamous cell carcinoma (LSCC). Methods: Immunohistochemical staining (IHS) was used to determine the protein expression of Ki-67 and cyclin-D1 in LSCC tissues. Kaplan-Meier survival curves was calculated with reference to Ki-67 and cyclin-D1 levels. Results: Cyclin-D1 and Ki67 were expressed in the nuclei of cancer cells. Among the total of 92 cancer tissues examined by immunohistochemistry, 60 (65.22%) had cyclin-D1 overexpression and 56 (60.87%) had Ki67 overexpression. Cyclin-D1 overexpression is associated with the advanced stage of the cancer (P=0.029), but not with gender, age, stage of cancer, histological differentiation, anatomical site, smoking history and alcohol consumption history. Ki67 overexpression is not associated with the advanced stage, gender, age, histological differentiation, anatomical site, smoking history and alcohol consumption history. A statistically significant correlation was found between lymph node status and the expression of Ki67 (p = 0.025). Overexpression of cyclin-D1 was correlated to shorter relapse-free survival period (P<0.001). Conclusions: Overexpression of cyclin-D1 can be used as a marker to predict relapse in patients with LSCC after primary curative resection.

• 스마트미디어저널
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• 제5권3호
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• pp.74-80
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• 2016

본 논문에서는 Zigbee와 GPS센서를 이용한 해녀 사고예방 스마트 모니터링 시스템을 제안하였다. 이 시스템은 해녀들이 바다속에서 조업중에 있을 때, 물질하는 위치, 체온, 잠수의 깊이, 잠수 시간 등의 정보를 수집하여 안전사고 발생시 곧바로 대처할 수 있다. 본 연구에서는 해녀의 상태 및 물질 활동 정보 측정을 위한 스마트테왁과 스마트물안경을 개발하였다. GPS 수신이 가능한 스마트테왁은 스마트물안경과 Zigbee통신으로 측정된 데이터를 IHSS(IoT based Haenyeo Safety service Software)의 서버로 전송한다. 또한, IHSS는 반응형 웹으로 해녀의 위치 정보와 상태 정보를 스마트폰으로 서비스할 수 있다. 결론적으로 이 시스템은 해녀의 건강관리 및 안전 측면에서 매우 유용할 것이며, 유네스코 세계 무형문화유산 등재 기반 등 제주해녀의 세계화 마케팅에도 크게 기여할 것이다.

• Journal of Oral Medicine and Pain
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• 제30권1호
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• pp.79-85
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• 2005

긴장성두통환자의 통증이 구강악습관과 관련이 있는지를 확인하고자 연구하였다. 일정기간 내원한 긴장성두통환자 58명 중 구강악습관(이갈이, 이악물기, 이갈이와 이악물기) 환자 20명을 실험군으로 하고, 나머지 38명을 대조군으로 하여 국제두통학회의 긴장성두통 진단기준안에 근거하여 설문조사 후 통계처리하였다. 결과는 다음과 같다. 1. 실험군과 대조군간의 성별(p=0.91) 및 나이(p=0.73)는 유의성이 없었다. 2. 통증의 종류에서 두 군 공히 둔통이 많았으며, 유의성은 없었고(p=0.69), 비둔통은 실험군이 대조군에 비해서 많았다. 3. 통증의 강도에서 두 군 공히 비심도가 많았으며, 유의성은 없었고(p=0.40), 심도는 실험군이 대조군에 비해서 많았다. 4. 통증의 양측성 유무에서 두 군 공히 편측성이 많았으며, 유의성은 없었고(p=0.52), 양측성은 실험군이 대조군에 비해서 많았다. 5. 통증의 일상생활시 악화유무에서 두 군 공히 악화가 많았으며, 유의성은 없었고(p=0.74), 악화는 실험군이 대조군에 비해서 많았다. 구강악습관이 있는 긴장성 두통환자의 통증은 구강악습관이 없는 환자에 비해서 양측성이며 심도의 비둔통이 많았고 일상생활에 의해서 더 쉽게 증가되었으나 통계적인 유의성은 없었다. 따라서, 구강악습관은 국제 두통학회에서 제시한 기준으로는 긴장성두통환자의 통증변화에 영향을 미치지 않지만, 일상생활에 의해서 더 쉽게 악화되므로 향후 저작이나 대화 등 구체적인 일상생활의 조건에 따른 변화를 확인하는 것이 필요하리라고 사료된다.

• 성인간호학회지
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• 제17권4호
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• pp.539-547
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• 2005

Purpose: To examine an estimate factor and grasp the relation of difference for Type A Behavior Pattern(TABP), Perceived Stress Questionnaire, Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the $19^{th}$ of October to 10th of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP).These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.