• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3735-3740
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• 2015

Context: Insulin-like growth factor peptides play important roles in regulating cell growth, cell differentiation, and apoptosis, and have been demonstrated to promote the development of colorectal cancer (CRC). Objective: To examine the association of insulin-related biomarkers including insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and C-peptide with CRC risk and assess their relevance in predictive models. Materials and Methods: The odds ratios of colorectal cancer for serum levels of IGF-1, IGFBP-3 and C-peptide were estimated using unconditional logistic regression models in 100 colorectal cancer cases and 100 control subjects. Areas under the receiving curve (AUC) and integrated discrimination improvement (IDI) statistics were used to assess the discriminatory potential of the models. Results: Serum levels of IGF-1 and IGFBP-3 were negatively associated with colorectal cancer risk (OR=0.07, 95%CI: 0.03-0.16, P for trend <.01, OR=0.06, 95%CI: 0.03-0.15, P for trend <.01 respectively) and serum C-peptide was positively associated with risk of colorectal cancer (OR=4.38, 95%CI: 2.13-9.06, P for trend <.01). Compared to the risk model, prediction for the risk of colorectal cancer had substantially improved when all selected biomarkers IGF-1, IGFBP-3 and inverse value of C-peptide were simultaneously included inthe reference model [P for AUC improvement was 0.02 and the combined IDI reached 0.166% (95 % CI; 0.114-0.219)]. Conclusions: The results provide evidence for an association of insulin-related biomarkers with colorectal cancer risk and point to consideration as candidate predictor markers.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3288-3293
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• 2007

Compressed natural gas has good potential for alternative vehicle fuel due to its economical and clean characteristics. However, the composition of natural gas based on production location is known to affect performance and emissions of CNG engine. Thus, the objective of this paper is to clarify the effect of fuel composition on combustion and emissions of CNG engine. This paper presents combustion characteristics obtained from running a 2.5L, 4-cylinder CNG engine retrofitted IDI diesel engine with engine dynamometer. BSFC, emissions, fuel consumption and combustion pressure were measured under steady state operating conditions especially at partial load for CNG engine. Based on the experimental results, we found that CNG composition affects engine performance, fuel conversion efficiency and burning rate.

• Journal of Mechanical Science and Technology
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• v.18 no.9
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• pp.1640-1647
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• 2004

This study was to investigate the effects of water induction through the air intake system on the characteristics of combustion and exhaust emissions in an IDI diesel engine. The fuel injection timing was also controlled to investigate a method for the simultaneous reduction of smoke and NOx when water was injected into the combustion chamber. The formation of NOx was significantly suppressed by decreasing the gas peak temperature during the initial combustion process because the water played a role as a heat sink during evaporating in the combustion chamber, while the smoke was slightly increased with increased water amount. Also, NOx emission was significantly decreased with increase in water amount. A simultaneous reduction in smoke and NOx emissions was obtained when water was injected into the combustion chamber by retarding more 2$^{\circ}C$A of the fuel injection timing than without water injection.

• Journal of Advanced Marine Engineering and Technology
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• v.21 no.3
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• pp.302-310
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• 1997

In this paper, we find a method to improve ignitability using methanol which is prospective as an alternative fuel. The constant volume combuster is divided into main chamber and sub-cham¬ber. These two chambers are linked by an adapter which is shaped like a cup. We also compare CDI to HIS that is revised in our laboratory for making a scrutiny into the effects of ignition char¬acteristics. Besides, we analyze a flame propagation process in the main and sub-chamber through taking pictures 10, 000 frames per second by high speed camera at the state being fabricated quartz glass aside main and sub-chamber.

• Proceedings of the KSME Conference
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• 2003.04a
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• pp.2186-2191
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• 2003

This study is to investigate the effects of water induction through the air intake system on the characteristics of combustion and exhaust emissions in diesel engine. The effects of water induction through the air intake port were considered in IDI diesel engine in this study. The formation of NOx was significantly suppressed by decreasing the gas peak temperature during the initial combustion process because the water play a role as a heat sink during evaporating in the combustion chamber, but the smoke was slightly increased with increased water amount. Also, NOx significantly decreased with increase in water amount. A simultaneous reduction in smoke and NOx emissions can be obtained when water is injected into the combustion chamber by retarding the fuel injection timing more than without water injection.

• Journal of Korean Society for Quality Management
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• v.46 no.1
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• pp.11-26
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• 2018

Purpose: This study is to help the construction of smart factories of other manufacturing enterprises through IDIS 's case of smart factory construction. Methods: We introduce the four phases of implementing smart factory building by IDIS company, which produces a small quantity of multi-odd units. Results: Through the smart factory construction, the cost of product is reduced due to the improvement of total productivity such as office work, production work, and energy saving, and sales are enhanced by customized production, quality / delivery reliability improvement. Conclusion: We present the actual examples needed to build the manufacturer's smart factory.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.1
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• pp.1-9
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• 2000

In the present study, the IDI-type constant volume chamber, which utilizes the indirect injection stratified charge method, is used to solve several problems including misfires and cycle-variations caused by unstable initial ignitions. A subchamber has been used to make an ignitable mixture under the low mean equivalence ratio. After burned in the subchamber, the flame jet getting through the passage hode enters the main chamber and burns the lean charge. There are many factors which affect the combustion characteristics of the indirect injection stratified engine. The passage hole angle is the most important since it determines the direction of flame flows into the main chamber. In the present study, we measured the combustion pressure, and the wall temperature, and computed the heat flux through the cylinder wall in order to understand the combustion characteristics depending on passage hole angle and the equivalence ratio.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.3
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• pp.62-67
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• 2009

In this study, the potential possibility of biodiesel fuel was investigated as an alternative fuel for a naturally aspirated indirect injection diesel engine. The smoke emission of biodiesel fuel was reduced remarkably in comparison with diesel fuel, that is, it was reduced approximately 36% at 2000rpm, full load condition. And, power, torque and brake specific energy consumption showed no significant differences. However, NOx emission of biodiesel fuel was increased compared with commercial diesel fuel. Also, the effects of exhaust gas recirculation(EGR) to reduce the NOx emission has been investigated. It was found that simultaneous reduction of smoke and NOx was achieved with biodiesel fuel(20vol-%) and cooled EGR method$(10{\sim}15%)$.

• Transactions of the Korean Society of Automotive Engineers
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• v.3 no.2
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• pp.77-85
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• 1995

Among mechanical friction losses in an engine, the piston assembly and cylinder components accounts for the majority of the losses. The movable bore technique has been developed and turned out to be the most reliable technique in measuring the instantaneous friction of piston assembly. The weakness of this system, however, was the presence of the protruded top of movable bore necessary for pressure balancing. Because of the protruded part the piston could not be taken out without disassembling the crankshaft. Present study was carried out with a system of removable top of the movable bore so that it was possible to make frequent piston removals. The effects from engine speed, oil viscosity, engine load and elastic contact pressure of piston rings on the frictional characteristics have been evaluated with the improved equipment. Also, frictions of each member of piston assembly were measured.

• Journal of Power System Engineering
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• v.1 no.1
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• pp.22-34
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• 1997

Circumstances require improving diesel engine, and many studies have been done in constant volume chamber(CVC). Because the combustion mechanism of a diesel engine has many difficulties with non-homogeneous nature, there has been a limitation to analyzing the combustion mechanism with CVC. Studies are often given in a real engine, but also it has difficulties in modifying configuration of combustion chamber etc. To get more easy way for mote engine-like test, a rapid compression mechanism has been introduced. This study addresses to designing a rapid compression expansion machine(RCEM) driven by compressed air, and to applying it on IDI diesel combustion chamber which has a glow plug. RCEM is introduced first and its characteristics are tested, then spray/combustion characteristics of diesel spray impinging on a glow plug in RCEM combustion chamber are investigated. The results show active combustion in the system employing spray impinging on a glow plug so as to improve combustion efficiency.