• Journal of Korean Society of Occupational and Environmental Hygiene
• /
• v.29 no.2
• /
• pp.195-207
• /
• 2019

Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years, Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid (${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The geometric mean concentration of lead in plasma was $0.23{\mu}g/L$ for the retired lead workers and $0.10{\mu}g/L$ for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased. Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.

• Journal of Environmental Science International
• /
• v.27 no.7
• /
• pp.477-488
• /
• 2018

In this study, heavy metal levels at the sediment monitoring network site upstream of the Gangjeong-Goryeong weir in the Nakdong River were surveyed from 2012 to 2016. We assessed the sediment pollution level using various pollution indexes based on ICP-MS analysis. The stream sediment pollution assessment standard, established through Regulation No. 687 of the National Institute of Environmental Research (2015), pollution load index (PLI), potential ecological risk index (RI), and mean PEL Quotient (mPELQ) were used to evaluate the sediment pollution level. We verified the representativeness of the monitoring point through the distribution of sedimentation and scour behavior by river bed surveying using anacousticDopplercurrentprofiler.

• Analytical Science and Technology
• /
• v.22 no.3
• /
• pp.201-209
• /
• 2009

Four heavy metals (Pb, Cd, As, and Hg) in 38 species (total 325 samples) of oriental animality medicines were monitored by inductively coupled plasma-mass spectrometry (ICP-MS) and automatic mercury analyzer (AMA). The detected concentration range of Pb, Cd, As was presented as $0.02{\mu}gkg^{-1}$ $(D.L){\sim}11.29mgkg^{-1}$, $0.01{\mu}gkg^{-1}$ $(D.L){\sim}2.50 mgkg^{-1}$, $0.12{\mu}gkg^{-1}$ $(D.L){\sim}5.27mgkg^{-1}$, respectively. In case of Hg, it the concentration range was $0.01{\sim}77.11mgkg^{-1}$ except one sample which exceeded detection limit. In all samples of Amydae Carapax and Gallnut, it was not detected over the maximum residue limits of metals. Pb is in charge of the greatest portion of contamination in 22 species of animality medicines, and in case of Hg, 54.46% of total samples were over the maximum residue limits. Therefore, environmental levels of Pb and Hg are needed to continue the researches and the studies for tracking pollution source are required.

• Journal of Food Hygiene and Safety
• /
• v.37 no.6
• /
• pp.385-393
• /
• 2022

The contamination level of inorganic arsenic, a human carcinogen, was investigated in 87 grains and 66 processed grain foods. Two inorganic arsenic species arsenite (As(III)) and arsenate (As(V)) and four organic arsenic monomethylarsonic acid, dimethylarsinic acid, arsenobetaine, arsenocholine were analyzed using HPLC-ICP/MS with high separation and sensitivity and ICP/MS was used to quantify total arsenic. Inorganic arsenic was detected in all grains. And the total arsenic in grains consists of about 70-85% inorganic arsenic and about 10-20% DMA. The concentration of inorganic arsenic was high in rice and black rice cultivated in paddy soil with irrigated water, while the miscellaneous grain in field was low. Mean concentration of inorganic arsenic in rice germ, brown rice and polished rice was 0.160 mg/kg, 0.135 mg/kg, 0.083 mg/kg, respectively, indicating that rice bran contains more arsenic. In processed grain foods, inorganic arsenic concentration varied according to the kind of ingredients and content, and the detection amount was high in processed food with brown rice and germ. The arsenic content of all samples did not exceed each standard, but the intake frequency is high and it is considered that continuous monitoring is necessary for food safety.

• Analytical Science and Technology
• /
• v.36 no.3
• /
• pp.135-142
• /
• 2023

The total arsenic and 6 arsenic species were investigated in 56 fish collagen products using ICP-MS (Inductively coupled plasma-mass spectrometer) and HPLC-ICP-MS(High performance liquid chromatography-Inductively coupled plasma-mass spectrometer). The mean concentrations of total arsenic and arsenic species were 40.103±81.133 ㎍/kg (N.D.~586.686) and 30.070±50.378 ㎍/kg (N.D.~313.871), respectively. The mean concentration of inorganic arsenic was 24.610±32.706 ㎍/kg (N.D.~129.331), and the As(V) (Arsenate) was the most dominant. The standards and specifications of arsenic have not been established for fish collagen products. Our study presents that arsenic levels are relatively safe compared with not only previous studies but also domestic and international standards. However, in one sample, the total arsenic concentration was 586.686 ㎍/kg, showing the inorganic was 8.119 ㎍/kg, and the DMA was 305.752 ㎍/kg, which was high than the Canadian standard for organic arsenic. In conclusion, it is necessary to monitor arsenic levels consistently and establish standards and specifications of arsenic in fish collagen products to assure consumer safety.

• Journal of Korean Neurosurgical Society
• /
• v.47 no.4
• /
• pp.252-257
• /
• 2010

Objective : Barbiturate coma therapy (BCT) is a useful method to control increased intracranial pressure (IICP) patients. However, the complications such as hypotension and hypokalemia have caused conditions that stopped BCT early. The complications of low dose BCT with $Bispectral^{TM}$ index (BIS) monitoring and those of high dose BCT without BIS monitoring have been compared to evaluate the efficacy of low dose BCT with BIS monitoring. Methods : We analyzed 39 patients with high dose BCT group (21 patients) and low dose BCT group (18 patients). Because BIS value of 40-60 is general anesthesia score, we have adjusted the target dose of thiopental to maintain the BIS score of 40-60. Therefore, dose of thiopental was kept 1.3 to 2.6 mg/kg/hour during low dose BCT. However, high dose BCT consisted of 5 mg/kg/hour without BIS monitoing. Results : The protocol of BCT was successful in 72.2% and 38.1% of low dose and high dose BCT groups, respectively. The complications such as QT prolongation, hypotension and cardiac arrest have caused conditions that stopped BCT early. Hypokalemia showed the highest incidence rate in complications of both BCT. The descent in potassium level were $0.63{\pm}0.26$ in low dose group, and $1.31{\pm}0.48$ in high dose group. The treatment durations were $4.89{\pm}1.68$ days and $3.38{\pm}1.24$ days in low dose BCT and high dose BCT, respectively. Conclusion : It was proved that low dose BCT showed less severe complications than high dose BCT. Low dose BCT with BIS monitoring provided enough duration of BCT possible to control ICP.

• Analytical Science and Technology
• /
• v.22 no.2
• /
• pp.128-135
• /
• 2009

This paper is the monitoring results of some heavy metals (lead, cadmium, arsenic, mercury) in herbal medicines and their intake rates. The monitoring of lead, cadmium, arsenic and mercury was carried out on 600 samples with 60 kinds of herbal medicines. And the transfer ratio of heavy metals in the water-boiled drinks w as calculated. The results show that lead was detected over the Maximum Residue Limits (MRL) in 10 samples (7 species). Cadmium was detected over the MRM in 69 samples (19 species). Arsenic was detected over the MRM in 3 samples (3 species). Mercury was detected over the MRM in 13 samples (10 species). We need continuously monitoring to ensure confidence and safety for these herbal medicines. In case of the water-boiled drink, average intake rates of lead, cadmium, arsenic and mercury are 9.77%, 6.72%, 26.1% and 6.79%, respectively.

• Korean Journal of Oriental Medicine
• /
• v.6 no.1
• /
• pp.117-122
• /
• 2000

The purpose of this study is to compare the contents of heavy metals of boiled ssangwhatang with those of herbal ingredients which are composed of ssangwhatang. Ssangwhatang is used for antifatigue, tonic and so on. With industrial development, our environment has been very polluted. Herbal medicines also are seriously contaminated by heavy metals and pesticides. The herbal medicines of ssangwhatang were bought at 10 defferent markets. The contents of 14 heavy metals(Ag, As, Ba, Cd, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Sb, Sn, Zn) were analysed using ICP. It was found out that 7 heavy metals(Pb, As, Ba, Cd, Hg, Sb, Sn) were not detected at all in boiled ssangwhatangs. But they were detectable in all ssangwhatangingredients before boiling. For example, the content of Pb in one pack of ssangwhatang before boiling was $0.039^{\circ}{\pm}0.005mg$ and Pb in boiled one was not detected. Herbal medicine itself is seriously contaminated by heavy metals. These results suggest that boiled ssangwhatang which we take is safe from the contamination of heavy metals.

• Journal of Korean Neurosurgical Society
• /
• v.46 no.3
• /
• pp.199-204
• /
• 2009

Objective : This study was done to evaluate the correlation between carpal tunnel pressure (CTP), electrodiagnostic and ultrasonographic findings in patients with carpal tunnel syndrome (CTS). Methods : CTP was measured during endoscopic carpal tunnel release (ECTR) for CTS using Spiegelberg ICP monitoring device with parenchymal type catheter. Neurophysiologic severity and nerve cross sectional area were evaluated using nerve conductive study and ultrasonography (USG) before ECTR in all patients. Results : Tests were performed in a total of 48 wrists in 39 patients (9 cases bilateral). Maximum CTP was $56.7{\pm}19.3$ mmHg ($Mean{\pm}SD$) and $7.4{\pm}3.3$ mmHg before and after ECTR, respectively. No correlation was found between maximum CTP and either neurophysiologic severity or nerve cross sectional area, whereas we found a significant correlation between the latter two parameters. Conclusion : CTP was not correlated with neurophysiologic severity and nerve cross sectional area. Dynamic, rather than static, pressure in carpal tunnel might account for the basic pathophysiology of CTS better.

• Journal of Auto-vehicle Safety Association
• /
• v.12 no.2
• /
• pp.33-39
• /
• 2020

This paper presents an Around View Monitoring (AVM) stop-line detection based longitudinal position correction algorithm for automated driving on urban roads. Poor positioning accuracy of low-cost GPS has many problems for precise path tracking. Therefore, this study aims to improve the longitudinal positioning accuracy of low-cost GPS. The algorithm has three main processes. The first process is a stop-line detection. In this process, the stop-line is detected using Hough Transform from the AVM camera. The second process is a map matching. In the map matching process, to find the corrected vehicle position, the detected line is matched to the stop-line of the HD map using the Iterative Closest Point (ICP) method. Third, longitudinal position of low-cost GPS is updated using a corrected vehicle position with Kalman Filter. The proposed algorithm is implemented in the Robot Operating System (ROS) environment and verified on the actual urban road driving data. Compared to low-cost GPS only, Test results show the longitudinal localization performance was improved.