• IMMUNE NETWORK
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• v.23 no.4
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• pp.35.1-35.16
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• 2023

Defining the molecular dynamics associated with T cell differentiation enhances our understanding of T cell biology and opens up new possibilities for clinical implications. In this study, we investigated the dynamics of CD5 expression in CD8⁺ T cell differentiation and explored its potential clinical uses. Using PBMCs from 29 healthy donors, we observed a stepwise decrease in CD5 expression as CD8⁺ T cells progressed through the differentiation stages. Interestingly, we found that CD5 expression was initially upregulated in response to T cell receptor stimulation, but diminished as the cells underwent proliferation, potentially explaining the differentiation-associated CD5 downregulation. Based on the proliferation-dependent downregulation of CD5, we hypothesized that relative CD5 expression could serve as a marker to distinguish the heterogeneous CD8⁺ T cell population based on their proliferation history. In support of this, we demonstrated that effector memory CD8⁺ T cells with higher CD5 expression exhibited phenotypic and functional characteristics resembling less differentiated cells compared to those with lower CD5 expression. Furthermore, in the retrospective analysis of PBMCs from 30 non-small cell lung cancer patients, we found that patients with higher CD5 expression in effector memory T cells displayed CD8⁺ T cells with a phenotype closer to the less differentiated cells, leading to favorable clinical outcomes in response to immune checkpoint inhibitor (ICI) therapy. These findings highlight the dynamics of CD5 expression as an indicator of CD8⁺ T cell differentiation status, and have implications for the development of predictive biomarker for ICI therapy.

• Nuclear Engineering and Technology
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• v.44 no.3
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• pp.237-248
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• 2012

Corium behavior in the lower plenum of the reactor vessel during a severe accident is very important, as this affects a failure mechanism of the lower head vessel and a thermal load to the outer reactor vessel under the IVR-ERVC (In-Vessel corium Retention through External Reactor Vessel Cooling) condition. This paper discusses the state of the art and technical issues on corium behavior in the lower plenum, such as initial corium pool formation characteristics and its transient behavior, natural convection heat transfer in various geometries, natural convection heat transfer with a phase change of melting and solidification, and corium interaction with a lower head vessel including penetrations of the ICI (In-Core Instrumentation) nozzle are discussed. It is recommended that more detailed analysis and experiments are necessary to solve the uncertainties of corium behavior in the lower plenum of the reactor vessel.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.2
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• pp.528-544
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• 2015

Base Station Cooperation (BSC) has been a promising technique for combating the Inter-Cell Interference (ICI) by exchanging information through a high-speed optical fiber back-haul to increase the diversity gain. In this paper, we propose a novel pilot symbol assisted data fusion scheme for distributed Uplink BSC (UBSC) based on Differential Evolution (DE) algorithm. Furthermore, the proposed scheme exploits the pre-defined pilot symbols as the sample of transmitted symbols to constitute a sub-optimal Weight Calculation (WC) model. To circumvent the non-linear programming problem of the proposed sub-optimal model, DE algorithm is employed for searching the proper fusion weights. Compared with the existing equal weights based soft combining scheme, the proposed scheme can adaptively adjust the fusion weights according to the accuracy of cooperative information, which remains the relatively low computational complexity and back-haul traffic. Performance analysis and simulation results show that, the proposed scheme can significantly improve the system performance with the pilot settings of the existing standards.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.2
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• pp.583-599
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• 2015

We apply the Bayesian matching pursuit (BMP) algorithm to the estimation of time-frequency selective channels in orthogonal frequency division multiplexing (OFDM) systems. By exploiting prior statistics and sparse characteristics of propagation channels, the Bayesian method provides a more accurate and efficient detection of the channel status information (CSI) than do conventional sparse channel estimation methods that are based on compressive sensing (CS) technologies. Using a reasonable approximation of the system model and a skillfully designed pilot arrangement, the proposed estimation scheme is able to address the Doppler-induced inter-carrier interference (ICI) with a relatively low complexity. Moreover, to further reduce the computational cost of the channel estimation, we make some modifications to the BMP algorithm. The modified algorithm can make good use of the group-sparse structure of doubly selective channels and thus reconstruct the CSI more efficiently than does the original BMP algorithm, which treats the sparse signals in the conventional manner and ignores the specific structure of their sparsity patterns. Numerical results demonstrate that the proposed Bayesian estimation has a good performance over rapidly time-varying channels.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.127-132
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• 2001

An experimental study on penetration integrity of the reactor vessel has been performed under external vessel cooling during a core melt accident. In this study a series of experiments are performed for the verification of the effects of coolant in the annulus between the ICI(In-Core Instrumentation) nozzle and the thimble tube and also the effects of external vessel cooling on the integrity of the penetration using the test section including only one penetration and $Al_{2}O_{3}$ melt as a corium simulant. The experimental results have shown that penetration is more damaged in the case of no external vessel cooling compared with the case of external vessel cooling. It is preliminarily concluded that the external vessel cooling is very effective measure for the improvement of the penetration integrity. Also it is confirmed from the experimental results that the coolant in the annulus reduces the melt penetration distance through the annulus and enhance the integrity of the reactor vessel penetration in the end.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2014.06a
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• pp.243-245
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• 2014

본 논문에서는 OFDM(Orthogonal Frequency Division Multiplexing)시스템에서 OFDM 심벌 타이밍 옵셋에 따른 4096QAM 의 uncoded-BER(Bit Error Rate) 및 성상도를 측정하였다. uncoded-BER 은 수신기의 FEC(Forward Error Correction) 복호기 이전에서 측정된 BER 을 의미한다. 측정을 위해, OFDM 을 사용하는 DVB-C2(Digital Video Broadcasting for Cable Systems 2) 송수신기를 FPGA(Field Programmable Gate Array)를 이용하여 구현하였으며, OFDM 심벌의 CP(Cyclic Prefix)를 이용하여 OFDM 심벌 동기를 수행하였다. 일반적으로, OFDM 심벌 동기는 OFDM 심벌에서 CP 가 반복된다는 특성을 이용한 상관기를 사용한다. 또한, ISI(Inter Symbol Interference) 및 ICI(Inter Channel Interference)를 최소화하기 위해, 채널의 최대 지연시간을 고려하여 CP 내에서 OFDM 심벌 동기가 획득된다. 이럴 경우 수신기에서는 각 부반송파에 할당된 QAM 심벌들의 위상 회전이 발생하지만, 등화기에서 이러한 위상 회전이 보상된다. 부반송파에 할당된 파일롯 심벌들을 이용하여 채널 추정 및 보상을 하는 등화기에서, 파일롯 심볼들도 OFDM 심벌 타이밍 옵셋에 의해 위상회전이 발생하기 때문에 채널 추정 값에 영향을 미친다. 따라서, 본 논문에서는 4096QAM 과 ZF-LE(Zero Forcing Linear Equalizer)를 사용한 경우, OFDM 심벌 타이밍 옵셋에 따른 uncoded-BER 및 성상도의 측정 결과를 제시하였다.

• Journal of Welding and Joining
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• v.33 no.4
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• pp.7-16
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• 2015

New lasers such as high power, high brightness and short wavelength laser are using diverse industry. Also new technologies are developing actively to solve various issues such as spattering, process monitoring, deep penetration and key-hole stability. ICALEO is the international congress where recent technology for laser material processing and laser system are present. At 2014, it was held at San Diego in USA and more than 260 papers were presented from 28 country. The effect of the laser beam shape such as Gaussian like and top-hat was investigated on acoustic emission signal and pore formation in welding. Inline penetration depth was measured with ICI(Inline Coherent Imaging) technique and the data was verified with real time X-ray image on laser welding. The laser welding performance at low pressure environment was evaluated for the thick plate alloy steel. UV laser was used to weld various metals such as Cu, Aluminum, steel and stainless steel. The effect of the wavelength of the laser on the formation of the wave at the wall of the key-hole front and the absorptivity was investigated.

• Journal of Energy Engineering
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• v.8 no.1
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• pp.34-47
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• 1999

본 연구에서는 촉매상에서 메탄의 산화시 발생되는 반응열을 이용하고 반응생성물과 미반응 메탄과의 개질반응에 의해 합성가스의 수율을 증대시키기 위하여 연소촉매와 개질촉매를 연속적으로 배치한 hybrid 촉매상에서 개질촉매에 따른 메탄의 부분산화반응의 반응 특성과 합성가스 수율에 미치는 영향을 관찰하였다. 메탄의 산화를 위해서 Pt-Rh/cordierite 촉매를 사용하였으며, 개질촉매로는 상업용 개질촉매인 R67, ICI46-1, 수성가스 전환반응촉매인 LX821 촉매와 6 wt% Ni/cordierite 촉매를 사용하였다. 실험결과 연소촉매와 개질촉매를 연속적으로 사용한 경우 메탄의 산화 과정에서 생성된 CO2 및 H2O가 미반응 메탄과의 개질반응 촉진으로 인하여 합성가스이 수율이 증가됨을 확인할 수 있었다. 이때 생성되는 합성가스의 H2/CO 몰비는 온도에 따라 감소하는 것으로 나타났으며, 80$0^{\circ}C$에서 촉매에 따라 2.2~2.8의 값을 가짐을 알 수 있었다. 개질촉매로 R67 및 Ni/cordierite 촉매를 사용하였을 경우 가장 높은 합성가스의 수율을 얻을 수 있었으며, 연소촉매와 개질촉매의 질량비는 1:1~1:2에서 가장 높은 수율의 합성가스를 얻을 수 있었다. 메탄과 산소의 몰비가 2:2에서 메탄의 전환율과 수소 수율이 가장 높게 나타났으며 메탄의 몰비 증가에 따라 감소되는 경향을 보였다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.9
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• pp.3428-3434
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• 2010

In this paper, we proposed and implemented a quality measurement algorithm for IS-95 reverse-link signal. To measure the quality of the received signal, equalization, carrier frequency/phase offset estimation, and timing synchronization are essential. And, all signal processing are carried out with baseband signal. The equalizer works with 4-oversampled samples to remove ICI(InterChip Interference). The frequency/phase offset estimator is followed by timing synchronizer since it can work without aid of data and timing information. As the number of interpolation in timing synchronization increases, the measurement accuracy improves, but computation load increases simultaneously. Therefore, one need to choose adequately the number of interpolation regarding to the platform performance to be used for the proposed algorithm.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.2 no.4
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• pp.519-529
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• 1998

In this paper, we analyze the effects of interference canceller on the performance of multitone DS/CDMA system. Although there are various kinds of interference cancellers suggested by different researchers, we adopt a canceller used by Yoon et at.［9］. We consider three kinds of inteferences, that is, multiPath interference(MPI), interchannel interference(ICI) and multiple access interference(MPI). The equations for variances ate derived for the inteferences and thermal noise used for signal to noise ratio calculation. We also consider RAKE reception over multipath channel and three stage interference canceller used for performance improvement. We draw some conclusions that interference canceller is effective in multitone DS/CDMA system and the performance is further improved with the higer order of diversity and larger number of PN chips.