• Animal cells and systems
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• v.10 no.2
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• pp.79-83
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• 2006

Tissue plasminogen activator (tPA) is used to lyse clots and reperfuse brain in ischemic stroke. However, sideeffects of intracerebral hemorrhage (ICH) and edema limit their clinical application. In part, these phenomena has been linked with elevations in matrix metalloproteinase-9 (MMP-9) in neurovascular unit. However little is known about their regulatory signaling pathways in brain cells. Here, I examine the role of MAP kinase pathways in tPA-induced MMP-9 regulation in rat cortical astrocytes. tPA $(1-10\;{\mu}g/ml)$ induced dose-dependent elevations in MMP-9 and MMP-2 in conditioned media. Although tPA increased phosphorylation in two MAP kinases (ERK, JNK), only inhibition of the JNK pathway by the JNK inhibitor SP600126 significantly reduced MMP-9 upregulation. Neither ERK inhibition with U0126 nor p38 inhibition with SB203580 had any significant effects. Taken together, these results suggest that c-jun N-terminal kinase (JNK) plays an essential role for tPA-induced MMP-9 upregulation.

• The Journal of the Acoustical Society of Korea
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• v.4 no.1
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• pp.35-42
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• 1985

This paper suggests a method on the use of very long linear array microphone in order to obtain clear loud sound reinforcement system without howling. According to the results of the theoretical investigation, we have made that a linear array microphone. This is made of one hundred small condenser microphone having 2 cm of spatical period. To estimate the effect of sound reinforcement system physically and subjectively, four cases have been experimented : In case of using no sound reinforcement, nondirectivity microphone, rectangular window and Hnning window in linear array microphone. The experimental results prove that the case of Hnning window in linear array microphone is more excellent.

• Nuclear Engineering and Technology
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• v.44 no.5
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• pp.437-452
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• 2012

The Tohoku earthquake (Mw9.0) occurred on March 11, 2011 and caused a large tsunami. The Fukushima Dai-ichi NPP (F1-NPP) were overwhelmed by the tsunami and core damage occurred. This paper describes the overview of F1-NPP accident and the usability of tsunami PRA at Tohoku earthquake. The paper makes reference to the following current issues: influence on seismic hazard of gigantic aftershocks and triggered earthquakes, concepts for evaluating core damage frequency considering common cause failure with correlation coefficient against seismic event at multi units and sites, and concepts of "seismic-tsunami PSA" considering a combination of seismic motion and tsunami effects.

• Journal of the Korean Society of Safety
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• v.13 no.3
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• pp.3-10
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• 1998

In general, the stratified charge for direct injection gasoline engine should be introduced to achieve ultra-lean combustion scheme. In order to apply the concept of stratified charge into direct injection gasoline engine, a reflector was adapted on cylinder head. An installation of the reflector in front of the injector nozzle leads the mixture to be rich near spark plug. Therefore, the mixture near the spark plug is locally ich to ignite while the lean mixture is wholly introduced into the combustion chamber. In this paper, the characteristics of combustion is analyzed with the variations of injection pressure and load in a stratified-charge direct injection single cylinder gasoline engine.

• Proceedings of the Korean Society of Potoscience Conference
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• 2005.06a
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• pp.103-103
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• 2005

• Proceedings of the Korean Society of Potoscience Conference
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• 2005.06a
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• pp.137-137
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• 2005

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.87.1-87.1
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• 2003

With the issuance of the ICH “Guidance for industry S7A Safety Pharmacology Studies For Human Pharmaceuticals” in July 2001 came the preference for the use of unanesthetized animals when evaluation the safety profile of new pharmaceutical agents. Telemetry provides a means of obtaining measurements of physiological functions in conscious animals without the problems associated with classical cardiovascular measuring methods. The Korea Institute of Toxicology (KIT) established the telemetric measurement of cardiovascular parameters, such as Blood pressure, Heart rate, ECG (PR, RR, QRS, QT and QTcB interval) under GLP conditions. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.287.2-287.2
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• 2002

The safety pharmacological core battery studies of AS2-006A. a newly developed wound healing drug, were investigated according to the ICH S7A guidelines in compliance with Good Laboratory Practice(GLP) Regulations, The doses given were 0, 100. 300 and 1000 mg/kg and drugs were administered subcutaneously. The animals used for this study were mice, rats and guinea pigs. AS2-006A showed no effects on the central nervous system such as motor activity. behaviotal changes. coordination, sensory/motor reflex responses and body temperature. no effects on blood pressure(BP). heart rate(HR), and ECG profiles and respiratory system. it was concluded that AS2-006A possess no general pharmacological effects at all doses tested. (omitted)

• Genomics & Informatics
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• v.8 no.4
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• pp.206-211
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• 2010

The Fas (TNF receptor superfamily, member 6) (FAS)/FAS ligand (FASLG) interaction plays a central role in the regulation of programmed cell death. FAS and FASLG polymorphisms in promoter regions affect transcriptional activities. To investigate whether FAS and FASLG polymorphisms are associated with the development and clinical phenotypes of stroke, 2 promoter single nucleotide polymorphisms (SNPs) in FAS (rs1800682, -670C/T) and FASLG (rs763110, -844C/T) were selected and genotyped by direct sequencing in 220 stroke patients [107 ischemic stroke (IS), 77 intracerebral hemorrhage (ICH), and 36 subarachnoid hemorrhage (SAH)] and 369 control subjects. For the analysis of clinical symptoms, all stroke patients were divided into 3 clinical phenotypes according to the respective results of the National Institutes of Health Stroke Survey (NIHSS) and the Modified Barthel Index (MBI) and the presence or absence of complex regional pain syndrome (CRPS). The SNPStats, SNPAnalyzer, and Helixtree programs were used to analyze the genetic data. Multiple logistic regression models (codominant, dominant, and recessive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. The promoter SNP rs1800682 was associated with stroke in the codominant (OR=0.48, 95% CI=0.25-0.94, p=0.04) and dominant models (OR=0.51, 95% CI=0.30-0.87, p=0.011). However, a FASLG SNP (rs763110) was not in Hardy-Weinberg equilibrium (p<0.05). In the analysis of stroke types, rs1800682 was associated with IS in the codominant (OR=0.30, 95% CI=0.12-0.74, p=0.025), dominant (OR=0.44, 95% CI=0.23-0.88, p=0.018), and recessive models (OR=0.45, 95% CI=0.21-0.99, p=0.042). The genotype frequencies of rs1800682 were different between ICH and controls in the dominant model (OR=0.49, 95% CI=0.26-0.94, p=0.031) but not between SAH and controls. In the analysis of clinical symptoms, however, rs1800682 was not related to the 3 clinical phenotypes (NIHSS, MBI, and CRPS). These results suggest that a promoter SNP (rs1800682, -670C/T) in FAS may be associated with the development of stroke in the Korean population.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.630-637
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• 2018

Harmony search (HS) is a recently developed metaheuristic optimization algorithm. HS is inspired by the process of musical improvisation and repeatedly searches for the optimal solution using three operations: random selection, memory recall (or harmony memory consideration), and pitch adjustment. HS has been applied by many researchers in various fields. The increasing complexity of real-world optimization problems has created enormous challenges for the current technique, and improved techniques of optimization algorithms and HS are required. We propose an improved clustering harmony search (ICHS) that uses a clustering technique to group solutions in harmony memory based on their objective function values. The proposed ICHS performs modified harmony memory consideration in which decision variables of solutions in a high-ranked cluster have higher probability of being selected than those in a low-ranked cluster. The ICHS is demonstrated in various optimization problems, including mathematical benchmark functions and water distribution system pipe design problems. The results show that the proposed ICHS outperforms other improved versions of HS.