• KIEE International Transactions on Power Engineering
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• 제3A권1호
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• pp.35-41
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• 2003

To ensure resource adequacy in restructured electricity markets, policymakers have adopted installed capacity (ICAP) markets in some regions of the United States. These markets ensure that adequate generation exists to satisfy regional Loss of Load Probability(LOLP) criterion. Since the incentives created through ICAP mechanisms directly impact new generation and transmission investment decisions we examine one important factor that links ICAP markets with LOLP calculations;, determining the amount of ICAP credit assigned to particular generation units. First, we review and critique the literature on electric power systems' market failure resulting from demand exceeding supply. We then summarize the method of computing (the LOLP) as a means of assessing reliability and relate this method to ICAP markets. We find that only the expected value of available generation is used In current ICAP markets while ignoring the second and higher order moments, which tends to mis-state the ICAP value of a specific resource. We then consider a proposal whose purpose is to avoid this ICAP assignment issue by switching from ICAP obligations to options. We find that such a proposal may fail to not provide the benefits claimed and suffers from several practical difficulties. Finally, we conclude with some policy recommendations and areas for future research.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1998년도 Proceedings of UNESCO-internetwork Cooperative Regional Seminar and Workshop on Bioassay Guided Isolation of Bioactive Substances from Natural Products and Microbial Products
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• pp.193-194
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• 1998

Recently, evaluation of brain transport of taurine which is possible to effect on Alzheimer's disease has investigated in rats. Also, internal carotid artery perfusion (ICAP) method is very useful for measuring of blood-brain barrier (BBB) permeability in rats. But ICAP has difficulties to evaluate of BBB permeability in mice especially. In the present study examines neuropharmaceutials permeability through the BBB in mice by common carotid artery perfusion (CCAP) method that modify ICAP method and require simple surgery. The external carotid artery (ECA) is cannulated with coagulating pterygopalatine artery (PPA) on ICAP method, while CCA is cannulated without coagulating PPA on CCAP method. The CCAP method require 4-5 fold higher infusion rate than ICAP method because an additional factor of 2 must be incorporated to adjust for fluid loss to the extracerebral circulation.

• Journal of Pharmaceutical Investigation
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• 제30권2호
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• pp.99-105
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• 2000

This study compared the permeability of $[^3H]taurine,\;[^3H]phenylalanine,\;and\;[^3H]oxytocin$ through the blood-brain barrier (BBB) in mice and rats with common carotid artery perfusion (CCAP) method that modified internal carotid artery perfusion (ICAP) method. External carotid artery (ECA) was cannulated with coagulating pterygopalatine artery (PPA) in ICAP method, while CCA was cannulated without coagulating PPA in CCAP method. Also, for evaluation of BBB permeability of drugs in mice and rats, we used intravenous injection technique. The results of CCAP method in mice at a perfusion flow-rate of 2 ml/min, the brian volume of distribution $(V_D)$ of $[^{14}C]sucrose,\;[^3H]taurine,\;[^3H]phenylalanine,\;and\;[^3H]oxytocin$ were similar to the result of ICAP method in rats at perfusion flow rate of 4 ml/min. The area under the plasma concentration-time curve and brain uptake of $[^3H]taurine$ by intravenous injection technique, were $65.5{\pm}9.7%ID^*min/ml\;and\;0.515{\pm}0.093%ID/g$, respectively, in mice, and the corresponding values were $8.00{\pm}0.03%ID^*min/ml\;and\;0.052{\pm}0.003%ID/g$ in rats. But the BBB permeability surface-area product of $[^3H]taurine$ was similar between mice and rats. In conclusion, the CCAP method in mice was simple, fast and comparable to ICAP method in rats for drug permeability through the BBB.

• 약학회지
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• 제46권2호
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• pp.124-128
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• 2002

The nitrone-based free radical trapping reagent, $\alpha$-phenyl-n-tert-butyl nitrone (PBN) has been proposed as therapeutic agent for stroke. We used this for model drug of development of new drug for neuroprotection. The purpose of this study was to evaluate the blood-brain barrier (BBB) permeability of PBN in Sprague-Dawly (SD) rats. The BBB transport of PBN was investigated in SD rats using internal carotid artery perfusion (ICAP) method at a rate of 4 mι/min for 15 second. We also obtained pharmacokinetic parameters of PBN using single intravenous injection technique. When we estimated BBB permeability of PBN with ICAP method, the brain volume of distribution of PBN was 60.0 $\pm$ 12.0 $\mu\textrm{g}$/ι. The brain uptake of PBN after IV injection at 120 min was 0.15 $\pm$ 0.01%ID/g. The PBN was transported to the brain through the BBB well in rats, because PBN is small molecule (MW 177) and lipid-soluble (log P 1.23) compound.

• 조명전기설비학회논문지
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• 제22권2호
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• pp.80-84
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• 2008

본 논문은 다중권선의 비접촉 변압기를 이용한 비접촉 전력공급 방식을 제안한 논문이다. 논문에서 제안한 전력공급 방식은 엘리베이터 카에 신뢰성 높은 전력을 전송하기 위하여 공진주파수 추적 기법을 사용하였다. 제안된 시스템을 검증하기 위하여 ICAP4와 Maxwell을 사용하여 시뮬레이션을 수행하였으며, 5[kW]급 비접촉 전력전송시스템을 제작하여 실험을 수행하였다.

• Archives of Pharmacal Research
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• 제23권4호
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• pp.391-395
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• 2000

To establish the usefulness of oxytocin (OT) as an analgesic for women in delivery, the pharmacokinetic parameters and blood-brain barrier (BBB) permeability of [$^3H$] OT were obtained using an intravenous injection technique or the internal carotid artery perfusion/capillary depletion (ICAP/CDM) method. Brain uptake of OT was similar to that of sucrose, plasma space marker, indicating that OT has a poor BBB permeability. Moreover, the analgesic effects of OT injected through the jugular vein on nociception were evaluated by the tail-flick method. The antinociceptive effects of OT injected at a dose of 0.2 ${m}g/kg$or 2 ${m}g/kg$ were dose-dependent. In addition, the analgesic effects of OT on the CNS were unaffected by naloxone, a m-receptor antagonist. In a similar manner to the opioid system, OT may play a modulatory role in antinociception.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.103-104
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• 2008

This paper proposes an alternative methodology for deciding an optimum deterministic reliability level (IRR; Installed Reserve Rate) by using probabilistic reliability criterion (LOLE; Loss of Load Expectation). Additionally, case studies using the proposed method induce the characteristics of relationship between the probabilistic reliability index (LOLE) and deterministic reliability index (IRR) for 2008 year in Korea power system. The case study presents a possibility that an optimum IRR level in Korea can be assessed using the proposed method. Korea power system has been using the LOLE criterion to determine the adequacy of installed capacity (ICAP) requirement. The criterion in Korea is that the loss of load expectation shall not exceed the available capacity more than five day in ten years (=0.5[days/year]). The probabilistic reliability evaluation and production cost simulation program which is called PRASim is used in order to evaluate the relationship and optimum IRR in this paper.

• 전기학회논문지
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• 제57권8호
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• pp.1318-1326
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• 2008

This paper proposes an alternative methodology for deciding an optimum deterministic reliability level (IRR; Installed Reserve Rate) by using probabilistic reliability criterion (LOLE; Loss of Load Expectation). Additionally, case studies using the proposed method induce the characteristics of relationship between the probabilistic reliability index (LOLE) and deterministic reliability index (IRR) for 2008 and 2010 years in Korea power system. The case study presents a possibility that an optimum IRR level in Korea can be assessed using the proposed method. Korea power system has been using the LOLE criterion to determine the adequacy of installed capacity (ICAP) requirement. The criterion in Korea is that the loss of load expectation shall not exceed the available capacity more than five day in ten years (=0.5[days/year]), The probabilistic reliability evaluation and production cost simulation program which is called PRASim is used in order to evaluate the relationship and optimum IRR in this paper.