• Title/Summary/Keyword: I50

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In vitro Acetolactate Synthase Inhibition of LGC-40863 in Rice and Barnyardgrass (시규제초제 LGC-40863의 벼와 피에 대한 Acetolactate synthase 저해 활성)

  • Bae, Y.T.;Lee, J.H.;Koo, S.J.
    • Korean Journal of Weed Science
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    • v.17 no.1
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    • pp.66-70
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    • 1997
  • LGC-40863(proposed common name ; pyribenzoxim), (benzophenone O-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime) is a new rice herbicide being developed by LG Chemical Ltd. The herbicide is highly selective between rice(Oryza sativa L.) and weeds including barnyardgrass (Echinochloa crus-galli(L.) P. Beauv.), and assumed to inhibit acetolactate synthase(ALS ; EC 4.1.3.18) because other structurally related herbicides inhibit the enzyme. To know inhibitory activity and the mode of inhibition of LGC-40863, $I_{50}$(concentration inhibiting ALS activity by 50%) and inhibition kinetics were investigated using ALS extracted from rice and barnyardgrass. $I_{50}$ values of LGC-40863 were 14 and 16mM in rice and barnyardgrass, respectively. In contrast to imazapyr(2-[4,5-dihydro-4-mythyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-3-pyridine-carboxylic acid) which showed an uncompetitive inhibition pattern, LGC-40863 was a noncompetitive inhibitor to ALS with respect to pyruvate similar to chlorsulfuron(2-chloro-N-((4-methoxy-6-methyl-l,3,5-triazin-2-yl) aminocarbonyl)benz-enesulfonamide) in both plants.

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Measurement of neutron spectra in MC50 cyclotron using Bonner sphere spectrometer with LiI scintillation detector (LiI 섬광검출기 기반의 보너구 스펙트로메터를 이용한 MC50 사이클로트론의 중성자스펙트럼 측정)

  • Ha, Wi-Ho;Park, Seyoung;Yoo, Jaeryong;Yoon, Seokwon;Lee, Seung-Sook;Kim, Jungho;Kim, Jong Kyoung
    • Journal of Radiation Protection and Research
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    • v.38 no.3
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    • pp.143-148
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    • 2013
  • Operational nuclear facilities such as nuclear power plants and particle accelerators show various neutron spectra according to the type of facilities and specific position. Necessities of neutron dose management and neutron monitoring for radiation protection of radiation workers in such a kind of facilities have continuously increased in recent years. Bonner sphere spectrometers are widely used for measurement of neutron spectra. Data on response function of neutron detector, default neutron spectra and count rates of Bonner sphere spectrometer are required to obtain unfolded neutron spectra in specific workplaces. In this study, we carried out measurement of neutron spectra produced in MC50 cyclotron using Bonner sphere spectrometer with LiI scintillation detector. Additionally, we estimated quantitative data on neutron flux, mean neutron energy and ambient dose equivalent rate according to the incident proton energies and positions in MC50 cyclotron.

Preparation of Hydrophobic Antimicrobal Compounds Encapsulated Nanoparticles Using Alkoxysilane-functionalized Amphiphilic Polymer Precursor and Their Antimicrobial Properties (실란 기능화 양친성 고분자 전구체를 이용한 소수성 항균물질 담지 나노 입자 제조 및 항균 특성)

  • Kim, Nahae;Kim, Juyoung
    • Journal of Adhesion and Interface
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    • v.18 no.1
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    • pp.13-24
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    • 2017
  • In this study, nanoparticles which encapsulated hydrophobic antimicrobial compounds with 50wt% of payload and 70%of solid content were prepared. These nanoparticles could be dispersed at water as well as various medium. Water dispersible organic-inorganic (O-I) hybrid nanoparticles were first prepared using alkoxysilane-functionalized amphiphilic polymer precursors through a conventional sol-gel process. Hydrophobic antimicrobial compound, Eugenol encapsulated nanoparticles were prepared using these O-I hybrid nanoparticles through a new nanoprecipitation process. The effect of various preparation on the size of nanoparticles, amount of payload, antimicrobial activity, and release rate of encapsulated compounds was investigated. All eugenol-encapsulated O-I nanoparticles regardless of preparation condition showed the same minimal inhibitory concentration (MIC) (50mg/ml) and 99% of antimicrobial activity for every strain. Their antimicrobial activity could maintain longer than two weeks. Especially, eugenol-encapsulated O-I nanoparticles prepared using tetraethoxysilane (TEOS) exhibited the highest payload (50wt%) and the lowest release rate which was owing to higher inorganic content in the O-I nanoparticles. And these O-I nanoparticles dispersed in hexanediol (HD) showed the highest antimicrobial activity and solid content (70wt%) because HD acted as a solvent as well as a antimicrobial agent.

Comparative Study on the Committed Dose Equivalent for Adults and Infants (예탁선양치(預託線量値)에서 본 성인(成人)과 유아(幼兒)와의 비교연구(比較硏究))

  • Sung, Kye-Yong;Yook, Chong-Chul;Ha, Chung-Woo
    • Journal of Radiation Protection and Research
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    • v.9 no.2
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    • pp.76-89
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    • 1984
  • Weighted committed dose equivalents($W_T\;H_{50}$) per intake of unit activity of four nuclides-I-131, I-133, Cs-134 and Cs-137-, which was based on the concepts of ICRP Pub. 30, are calculated for adult who is 70 kg and 25 years old and, for infant who is 10 kg and 1 year old. Metabolism of iodine taken through oral or inhalation pathway is described by using the three-compartment model which consists of inorganic, thyroid and organic compartment. After intake, the amount of iodine in every compartment is calculated by solving the transfer equations among the these compartments. As soon as caesium is taken into the body, it is distributed uniformly in the body through the transfer compartment. In this case, the amount of caesium in total body is calculated by using the total body compartment model which is divided into two tissue compartments because of their different biological half-lifes of caesium in body. As a result of calculations, whether oral or inhalation pathway, the values of ($W_T\;H_{50}$) per intake of unit activity of I-131 for infants are about ten times as much as those of adults. On the other hand, for Cs-134 and Cs-137, the values of $W_T\;H_{50}$ per intake of unit activity show that, whether adults of infants, they have almost the same values.

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Dihydrotanshinone l is an Inhibitor of Farmesy-Protein Transferase (Farmesy-Protein Transferase의 저해제 Dihydrotanshinone l.)

  • Lee, Dong-Sun;Lee, Sang-Han;Ha, Sang-Chul;Kim, Jong-Guk;Seu, Young-Bae;Hong, Soon-Duck
    • Journal of Life Science
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    • v.8 no.2
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    • pp.158-161
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    • 1998
  • An inhibitor of farnesy-protein transferae is known to be a fgood candidate for antitumor agent that block the oncogenic activity of Ras protein . We recently isolated and characterized dihydrotanshinone I from Salvia miltiorrhiza Bunge (Danshen), an oriental herb, which has an inhibitory activity of toposimerase I to some cancer cell lines. In order to examine the molecular mechanism of dihydrotanshinone I, we studied the farmesy-Protein Transferase activity by dihydrotanshinone I. As a result, we found that result, we found that dihydrotanshinone I showed inhibitory effect on farnesyl-protein transferase with $IC_{50}$ value of 15 ug/ml. This result suggest that dihydrotanshinone I may be an useful anticancer agent with the inhibitory activity of farnesyl-protein transferase.

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THE COMPETITION INDEX OF A NEARLY REDUCIBLE BOOLEAN MATRIX

  • Cho, Han Hyuk;Kim, Hwa Kyung
    • Bulletin of the Korean Mathematical Society
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    • v.50 no.6
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    • pp.2001-2011
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    • 2013
  • Cho and Kim [4] have introduced the concept of the competition index of a digraph. Similarly, the competition index of an $n{\times}n$ Boolean matrix A is the smallest positive integer q such that $A^{q+i}(A^T)^{q+i}=A^{q+r+i}(A^T)^{q+r+i}$ for some positive integer r and every nonnegative integer i, where $A^T$ denotes the transpose of A. In this paper, we study the upper bound of the competition index of a Boolean matrix. Using the concept of Boolean rank, we determine the upper bound of the competition index of a nearly reducible Boolean matrix.