• 제목/요약/키워드: I-hyang-jeong

검색결과 57건 처리시간 0.028초

Curcumin은 ovalbumin에 의해서 유도된 inducible nitric oxide synthase 억제 (Curcumin Inhibits Ovalbumin-Induced Inducible Nitric Oxide Synthase Expression)

  • 김지수;안희진;신화정;구교정;엄상훈;이청호;민인순;윤형선
    • 한국식품과학회지
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    • 제44권4호
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    • pp.498-501
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    • 2012
  • 본 연구에서 curcumin이 계란 알러젠 중의 하나인 OVA에 의해서 유도된 NF-${\kappa}B$ 활성화 및 iNOS 발현에 어떤 영향을 미치는지 알아보았다. Curcumin은 OVA에 의해서 유도된 NF-${\kappa}B$ 활성화와 iNOS 발현을 억제시켰다. 이러한 결과는 curcumin이 계란 알러젠인 OVA에 의해서 유도된 NF-${\kappa}B$의 활성화와 iNOS의 발현을 억제하여 염증반응이나 알러지와 같은 만성적인 질병들을 조절할 수 있다는 것을 보여주는 중요한 결과라 사료된다. 이러한 연구는 추후 알러지 작용기전 규명 및 알러지 치료제 개발에 중요한 역할을 할 것으로 기대한다.

정신분열병 환자에 있어서 가족력과 임상유형(Type I, Type II)에 따른 안구추적운동의 차이 (Differences of Smooth Pursuit Eye Movement in the Patients with Schizophrenic Disorder in Accordance with Family History and Their Types(Type I and Type II))

  • 정희연;임두원;권영준;주경수;서미경;김동수
    • 생물정신의학
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    • 제2권2호
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    • pp.275-280
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    • 1995
  • Smooth pursuit eye movement, one of the reliable biological markers of schizophrenia, is not always abnormal in schizophrenic patients. Therefore the authors studied it in schizophrenic patients and normal controls and compared the results according to the presence or abscence of family history of psychosis and types (type I and type II). The results are as follows: 1) In the 18 normal control group (8 mole, 10 female), there was no sex difference in the responses of smooth pursuit eye movement. 2) In th 44 schizophrenic group (28 male, 16 female), there also was no sex difference in the responses of smooth pursuit eye movement. 3) In comparison of 44 schizophrenic group to 18 normal control group, there was significantly increased abnormal response in smooth pursuit eye movement in schizophrenic group (P < 0.005). 4) In schizophrenic group, there was no difference in the responses of smooth pursuit eye movement between type I and type II schizophrenia. 5) The presence or abscence of family history of psychosis made no difference in the responses of smooth pursuit eye movement in schizophrenic group. 6) Subdivision of type I or type II in each case of presence or abscence of family history made no difference in the responses of smooth pursuit eye movement in schizophrenic group.

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Triptolide Suppresses the Expression of Cyclooxygenase-2 Induced by Toll-Like Receptor 3 and 4 Agonists

  • Gu, Gyo-Jeong;Eom, Sang-Hoon;Min, In Soon;Youn, Hyung-Sun
    • 대한의생명과학회지
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    • 제19권2호
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    • pp.112-117
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    • 2013
  • Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-${\kappa}B$, leading to the induction of inflammatory gene products such as cyclooxygenase-2 (COX-2). Triptolide (TP), a natural component of Tripterygium wilfordii Hook. F, has been used as folk remedies to treat many chronic diseases for many years. In the present report, we present biochemical evidence that TP inhibits the NF-${\kappa}B$ activation induced by polyriboinosinic polyribocytidylic acid (Poly[I:C], TLR3 agonist) and lipopolysaccharide (LPS, TLR4 agonist). TP also inhibits COX-2 expression induced by Poly[I:C] and LPS. These results suggest that TP can modulate the immune responses regulated by TLR3 and TLR4 signaling pathways.

Phenethyl Isothiocyanate가 Toll-like Receptor Agonists에 의해 유도된 Nuclear Factor-κB 활성과 Cyclooxygenase-2, Inducible Nitric Oxide Synthase 발현에 미치는 효과 (The Effects of Phenethyl Isothiocyanate on Nuclear Factor-κB Activation and Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression Induced by Toll-like Receptor Agonists)

  • 김수정;박혜정;신화정;김지수;안희진;민인순;윤형선
    • Journal of Applied Biological Chemistry
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    • 제54권4호
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    • pp.279-283
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    • 2011
  • 염증의 중요한 분자학적 기전에는 cyclooxygenase-2 (COX-2)에 의한 prostaglandins (PGs) 생성과 inducible nitric oxide synthase (iNOS)에 의한 nitric oxide (NO) 생성이 있다. 많은 종류의 박테리아나 바이러스가 전사요소인 nuclear factor-${\kappa}$B(NF-${\kappa}$B)를 활성화시켜 여러 타깃 유전자의 발현을 조절해 PGs나 NO와 같은 염증물질을 유도하게 된다. 우리는 이번 실험을 통하여 phenethyl isothiocyanate (PEITC)가 toll-like receptor(TLR) agonists에 의해 유도된 NF-${\kappa}$B활성과 COX-2, iNOS 발현에 어떠한 영향을 미치는지 알아 보았다. PEITC는 lipopolysaccharide (LPS)와 polyinosinic-polycytidylic acid (poly[I:C])에 의해 유도된 NF-${\kappa}$B활성을 억제시켰다. 또한 PEITC는 LPS와 Poly[I:C]에 의해 유도된 iNOS의 발현도 억제시켰다. 하지만 PEITC는 TLR agonists들인 LPS, Poly[I:C], 2 kDa macrophage-activating lipopeptide (MALP-2), oligodeoxynucleotide 1668 (ODN1668)에 의한 COX-2 발현은 억제시키지 못하였다. 즉 PEITC가 TRIF-dependent 신호전달체계만을 조절하여 TRIF-dependent 신호전달체계에 의해 조절되는 iNOS는 억제하지만 MyD88-dependent 신호전달 체계에 의해 조절되는 COX-2는 억제하지 못한다는 것을 설명해준다. 이러한 결과는 iNOS와 COX-2가 서로 다른 메커니즘에 의해 조절된다는 것을 암시하며, PEITC가 여러 병원균들로부터 유도되는 염증반응이나 만성적인 질병들을 조절할 수 있음을 제시하는 중요한 결과이다.

(E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine inhibits Inducible Nitric Oxide Synthase Expression in RAW264.7 Macrophages Stimulated with Lipopolysaccharide

  • Gu, Gyo-Jeong;Eom, Sang-Hoon;Suh, Chang Won;Koh, Kwang Oh;Kim, Dae Young;Youn, Hyung-Sun
    • 대한의생명과학회지
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    • 제19권2호
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    • pp.168-172
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    • 2013
  • Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. TLR4 has been identified as the receptor for lipopolysaccharide (LPS), which is a cell wall component of gram-negative bacteria. The activation of TLR4 signaling by LPS leads to the activation of NF-${\kappa}B$ and the expression of pro-inflammatory gene products such as cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). To evaluate the therapeutic potential of (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), previously synthesized in our laboratory, NF-${\kappa}B$ activation and iNOS and COX-2 expression induced by LPS were examined. NVPP inhibited the activation of NF-${\kappa}B$ induced by LPS. NVPP also suppressed the iNOS expression induced by LPS but it did not suppress COX-2 expression induced by LPS. These results suggest that NVPP has the specific mechanism for anti-inflammatory responses.

조선 후기 궁중무용복식의 복색사상 연구( I ) -육화대.무산향.춘앵전을 충심으로- (A Study on the Colors of Court Dancing Suits in the latter period of Chosun Dynasty - Centering around dances YukHwaDae.MuSanHyang.ChoonAgengJeon-)

  • 남후선
    • 복식
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    • 제50권4호
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    • pp.73-87
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    • 2000
  • The court dancing suit, so-called "JeongJae(呈才) suit," has been worn by court dancers on the occasion of the royal court′s feasts or festivals such as auspicious events of a country, court banquets, and parties or receptions for national quests from foreign countries. There are 53 kinds of court dancing suits, ranging from the age of the ancient Three Kingdoms to the period of Chosun Dynasty. The court dancing suits are divided into two styles : DangAk-JeongJae(唐樂呈才) style and HyangAk-feongjae(鄕樂呈才) style, depending on dancing styles. Since the court dancing suits in the age of the ancient Three Kingdoms and Koryo Dynasty have already been studied previously, this study discussed the change of dancing suit styles created in the latter period of Chosun Dynasty, such as YukHwaDae(六花隊), MuSanHyang(舞山香) and ChoonAengJeon(春鶯), and the thought of Yin-Yang and five elements(陰陽五行思想) that the colors of the court dancing suits imply. The purpose of this study is to understand the thoughts contained in the ancient suits as well as their styles in order to inherit and uphold our traditional culture properly.

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자기공명분석기를 이용한 통증관리 (Clinical Study of Acute and Chronic Pain by the Application of Magnetic Resonance Analyser $I_{TM}$)

  • 박욱;진희철;조명현;윤석준;이진승;이정석;최석환;김성열
    • The Korean Journal of Pain
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    • 제6권2호
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    • pp.192-198
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    • 1993
  • In 1984, a magnetic resonance spectrometer(magnetic resonance analyser, MRA $I_{TM}$) was developed by Sigrid Lipsett and Ronald J. Weinstock in the USA, Biomedical applications of the spectrometer have been examined by Dr. Hoang Van Duc(pathologist, USC), and Nakamura, et al(Japan). From their theoretical views, the biophysical functions of this machine are to analyse and synthesize a healthy tissue and organ resonance pattern, and to detect and correct an abnormal tissue and organ resonance pattern. All of the above functions are based on Quantum physics. The healthy tissue and organ resonance patterns are predetermined as standard magnetic resonance patterns by digitizing values based on peak resonance emissions(response levels or high pitched echo-sounds amplified via human body). In clinical practice, a counter or neutralizing resonance pattern calculated by the spectrometer can correct a phase-shifted resonance pattern(response levels or low pitched echo-sounds) of a diseased tissue and organ. By administering the counter resonance pattern into the site of pain and trigger point, it is possible to readjust the phase-shifted resonance pattern and then to alleviate pain through regulation of the neurotransmitter function of the nervous system. For assessing clinical effectiveness of pain relief with MRA $I_{TM}$ this study was designed to estimate pain intensity by the patient's subjective verbal rating scale(VRS such as graded to no pain, mild, moderate and severe) before application of it, to evaluate an amount of pain relief as applied the spectrometer by the patients subjective pain relief scale(visual analogue scale, VAS, 0~100%), and then to observe a continuation of pain relief following its application for managing acute and chronic pain in the 102 patients during an 8 months period beginning March, 1993. An application time of the spectrometer ranged from 15 to 30 minutes daily in each patient at or near the site of pain and trigger point when the patient wanted to be treated. The subjects consisted of 54 males and 48 females, with the age distribution between 23~40 years in 29 cases, 41~60 years in 48 cases and 61~76 years in 25 cases respectively(Table 1). The kinds of diagnosis and the main site of pain, the duration of pain before the application, and the frequency of it's application were recorded on the Table 2, 3 and 4. A distinction between acute and chronic pain was defined according to both of the pain intervals lasting within and over 3 months. The results of application of the spectrometer were noted as follows; In 51 cases of acute pain before the application, the pain intensities were rated mild in 10 cases, moderate in 15 cases and severe in 26 cases. The amounts of pain relief were noted as between 30~50% in 9 cases, 51~70% in 13 cases and 71~95% in 29 cases. The continuation of pain relief appeared between 6~24 hours in two cases, 2~5 days in 10 cases, 6~14 days in 4 cases, 15 days in one case, and completely relived of pain in 34 cases(Table 5~7). In 51 cases of chronic pain before the application, the pain intensities were rated mild in 12 cases, moderate in l8 cases and severe in 21 cases. The amounts of pain relief were noted as between 0~50% in 10 cases, 51~70% in 27 cases and 71~90% in 14 cases. The continuation of pain relief appeared to have no effect in two cases. The level of effective duration was between 6~12 hours in two cases, 2~5 days in 11 cases, 6~14 days in 14 cases, 15~60 days in 9 cases and in 13 cases the patient was completely relieved of pain(Table 5~7). There were no complications in the patients except a mild reddening and tingling sensation of skin while applying the spectrometer. Total amounts of pain relief in all of the subjects were accounted as poor and fair in 19(18.6%) cases, good in 40(39.2%) cases and excellent in 43(42.2%) cases. The clinical effectiveness of MRA $I_{TM}$ showed variable distributions from no improvements to complete relief of pain by the patient's assessment. In conclusion, we suggest that MRA $I_{TM}$ may be successful in immediate and continued pain relief but still requires several treatments for continued relief and may be gradually effective in pain relief while being applied repeatedly.

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조선시대 양동마을 3량 상부 가구의 유형적 특징과 변화 - 평면 구성 변화에 따른 상부 가구의 대응을 중심으로 - (The Typological Characteristic of 3-Dori Type Upper Structure and its Change in Yang-dong Village during the Joseon Dynasty - Focusing on the Response of the Upper Structure according to the Change of Plan Composition -)

  • 배창현
    • 건축역사연구
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    • 제33권2호
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    • pp.7-15
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    • 2024
  • The composition of the upper structure, which can be found in the 3-Dori type buildings in Yang-dong Village, varies significantly from time to time. The upper structure of the Gwan-ga-jeong, known as a house in the mid-Joseon Dynasty, consists of a basic 3-Dori type structure in which a beam is placed under 3-Dori and supported with two flat columns. On the other hand, the upper structure of I-hyang-jeong historic house, built in the 17th century, is different in that it has a stud between the two flat columns. The upper structure of Sa-ho-dang historic house, a 19th-century building is different from the upper structure of the buildings of the previous period in that three flat columns were used. As such, the difference in the composition method of the upper structure according to the construction period is closely related to the introduction of the Toi-maru, which is mainly explained by the boundary space. In addition, it can be expected that the introduction of the Toi-maru originated from the influence of the change in the plan. This study was conducted to examine the correlation between the plan and the composition of the boundary space through various typology of the 3-Dori upper structure distributed intensively in Yang-dong Village.

iNOS inhibitory activity of brazilin from Caesalpinia sappan

  • Kim, Hyang-Rim;Jeong, Yeon-Hee;Min, Hye-Young;Park, Go-Woo-Ni;Lee, Sang-Kook;Seo, Eun-Kyoung
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.194.4-195
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    • 2003
  • Two phenolic flavonoids were isolated from the traditional medicine of Eastern Asia, Caesalpinia sappan L (Leguminosae). Brazilin (1) showed a significant inhibitory activity against inducible Nitric Oxide Synthase (iNOS) in lipopolysaccharides (LPS)-induced macrophage RAW 264.7 cells with an IC$\sub$50/ value of 1.68 mg/ml, which is more potent than the positive control, L-N$\^$6/-(1-iminoethyl)lysine (IC$\sub$50/ 3.49 mM). On the other hand, caesalpine J (2) was found to be inactive in the present iNOS assay system despite of their structural similarities. (omitted)

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