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정상 뇌의 수소 자기공명분광 소견: 1.5 T Signa와 Echospeed 자기공명영상기기에서의 비교 ([ $^1H$ ] MR Spectroscopy of the Normal Human Brains: Comparison between Signa and Echospeed 1.5 T System)

  • 강영혜;이윤미;박선원;서창해;임명관
    • Investigative Magnetic Resonance Imaging
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    • 제8권2호
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    • pp.79-85
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    • 2004
  • 목적: 정상인 뇌에서 측정한 신호대잡음비율, 주사 시간, 그리고 대사물질의 상대 비율을 이용하여 서로 다른 1.5T 자기공명영상기기에서의 수소자기공명분광법의 유용성과 차이점을 알아보고자 하였다. 대상 및 방법: 총 10명의 정상인 (20-45세)에서 PROBE (PROton Brain Exam) 라는 자동화된 방법을 이용하여 수소 자기공명분광술을 시행하였다. 수소 자기공명분광술은 1 channel 코일의 기존의 자기공명영상기기(Signa Horizon)와 1 channel 및8 channel 코일을 이용한 다른 자기공명영상기기(Echospeed plus with EXCITE)에서 3번씩 시행하였다. 각각 방법에서 팬톰과 생체에서의 스펙트럼의 신호 대 잡음비와 주사 시간을 측정하였다. 모든 정상인에서 뇌의 2 부분, 즉 기저핵과 심부백질 부위를 위의 방법으로 각각 검사하였고 각 부위에서 대사물질의 상대적인 비율의 차이(NAA/Cr, Cho/Cr, mI/Cr)를 측정하였다. 모든 스펙트럼에서 STEAM(Stimulated Echo Acquisition Method) 방법을 이용하여 다음과 같은 조절치로 검사하였다: TR=3.0/2.0 sec, TE=30 msec, TM=13.7 msec, SW=2500 Hz, SI=2048 pts, AVG=64/128, NEX=2/8 (Signa/Echospeed). 결과 : 신호대잡음비율은 Echo speed 기계에서 약 $30\%$이상 더 높았고 주사 시간은 거의 같았다. 각각의 방법에서 모두에서 믿을만한 스펙트럼을 얻었고 정상 뇌의 2부분에서 얻은 스펙트럼 모양과 대사물질의 상대적인 비율의 차이는 서로 의미있는 차이를 보이지 않았다 (p>0.05). 결론: 새로운 자기공명영상기기와 코일을 이용한 수소자기공명분광소견은 매우 믿을만 하였고 높은 신뢰성과 재현도를 보였으며 기존의 자기공명영상기기의 수소자기공명분광소견과 의미있는 차이는 없었다.C의 높은 T2 자기이완율은 T2 강조영상에서의 정상 간실질의 신호강도를 감소시켜 간실질과 VX2 암종의 구분을 쉽게 하였다. MnPC 주입시 T1 강조영상에서는 간세포 특이성 조영제의 주입시보다 종양의 경계가 명확하였고, 조영증강은 주입후 최소한시간 이상 높게 유지되었다. 결론 : MnPC가 간세포로 흡수되어 담관으로 배설된다는 사실은 Mn-DPDP와 유사한 특성이며 이는 MnPC가 새로운 간특이성 조영제임을 확인시켜 준다. 또한 MnPC의 R2값이 기존의 조영제에 비해 매우 크다는 사실은 T1 조영제로서 뿐만 아니라 T2 조영제로서의 사용 가능성을 보여준다. 이러한 사실들을 좀더 정확하게 뒷받침하기 위해서는 임상적으로 사용되기 이전에 생체 내 그리고 시험관내 연구가 더 필요하며 다른 동물모델에서의 추가적인 연구가 요구된다.유발 가능자를 1차 적으로 선별 할 수 있는 지표 개발 가능성을 제시하였다고 사료된다.대상자 선정이 어려워서 자원자를 대상으로 연구가 행해졌다. 둘째. 적은 수의 연구 대상자를 대상으로 연구가 행해졌다. 셋째. 연구기간이 짧았던 까닭에 좀더 상세한 사례 연구가 이루어질 수 없었다 좀 더 신뢰할 수 있는 표본 추출 방법을 통하여 선정된, 많은 연구 대상자를 가지고, 심도 있는 연구가 추후 반복적으로 이루어져야 할 것이다.더욱 더 발전을 거듭하고 있으며, 외식은 여행과 여가 활동의 필수적인 요소로써 그 역할을 일조하고 있다. 이와 같은 여가시간의 증가는 독신자들에게는 좀더 많은 여유시간을 가족을 이루고 있는 가족구성원들에게는 가족과의 유대를 강화하는 휴식과 오락의 소비 트렌드를 창출시켰다. 이와 더불어 외식은 식사를 해결하기 위한 단순한 수단에서 벗어나 동기와 동반자에 따라 달라지는 행동 패턴을 나타내고 있으며, 연령과 목적에 따라 세분화되는 분명한 선호도를 나타낸다. 지난 10여 년간 외국으로부터 수입된 다양한 음식과 레스토랑 업태 등은 우리나라의 외식문화 발전과 소비자들의 외식 선택

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보건소내(保健所內) 한방의료(漢方醫療)에 대(對)한 임상통계연구(臨床統計硏究) (전주시(全州市) 완산구(完山區) 보건소(保健所) 중심으로) (A Study on the Clinical Statistics of Oriental Medicine Service in the Health Center)

  • 송범용;육태한
    • 대한한의학회지
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    • 제18권1호
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    • pp.40-57
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    • 1997
  • 연구배경(硏究背景) 및 목적(目的) 최근(最近) 한방공중보건사업(韓方公衆保健事業)에 대(對)한 연구(硏究)와 제도개선(制度改善)이 이루어지면서, 한방의료시혜(韓方醫療施惠)를 통(通)해 국민(國民)들의 보건지도(保健指導) 및 건강증진(健康增進) 향상(向上)에 많은 영향(影響)을 끼칠 것으로 보인다. 1995년(年)부터 1년여(年餘)에 걸쳐 한방병원(韓方病院)과 보건소(保健所)가 함께 보건소내(保健所內) 한방의료(韓方醫療)를 실시(實施)하면서 주민(住民)들로부터 많은 호응(呼應)을 받았다. 이에 보건소(保健所)에 내원(來院)하여 한방진료(韓方診療)를 받은 환자(患者)들의 일반적(一般的)인 특징(特徵)과 질환(疾患)의 특성(特性) 및 치료효과(治療效果) 등(等)에 대(對)하여 조사(調査)하였다. 대상(對象) 및 방법(方法) 1996년(年) 1월(月) 4일(日)부터 1996년(年) 12월(月) 26일(日)까지 1년간(年間) 전라북도(全羅北道) 전주시(全州市) 완산구(完山區) 보건소(保健所)에서 주(週) 1회(回) 또는 3회(回)에 걸쳐 총(總) 60회(回)동안 실시(實施)한 한방진료(韓方診療)를 받은 환자(患者) 234명(名)의 질환(疾患) 234건(件)을 대상(對象)으로 통계연구(統計硏究)하였다. 결과(結果) 및 결론(結論) 1. 환자(患者)의 남녀비율(男女比率)은 1 : 6.8로 여성(女性)이 월등(越等)히 많았다. 2. 환자중(患者中) 51세이상(歲以上)이 88.89%로 고령환자(高齡患者)가 대부분(大部分)을 차지했다. 3. 총질환(總疾患) 238건중(件中) 근골격계(筋骨格系) 및 결합조직질환(結合組織疾患)이 82.77%로 대부분(大部分)을 차지했다. 4. 병력기간(病歷期間)은 1년(年)에서 5년(年)사이가 32.35%로 가장 높아 관련질환(關聯疾患)이 만성화(慢性化)상태임을 알려준다. 5. 초진시(初診時) 증상(症狀)은 심(甚)한 자각증상(自覺症狀)을 갖고 생활(生活)에 많은 지장을 초래(招來)하는 경우(境遇)(Grade III)가 55.88%로 가장 많았다. 6. 양호이상(良好以上)의 치료효과(治療效果)를 보인 경우(境遇)는 62.18%였고, 저효이상(抵效以上)의 효과(效果)는 78.99%로 나타났다. 7. 치료기간(治療期間)을 2회(回)에서 5회(回) 내원(來院)하여 치료(治療)받은 경우(境遇)가 34.03%로 가장 높았고, 1회(回)만 내원(來院)한 경우(境遇)에 비(比)하여 2회(回)에서 10회(回) 내원(來院)하여 치료(治療)받은 환자(患者)들이 4배정도(倍定度)의 높은 치료율(治療率)을 보였다. 8. 처방(處方)은 오적산(五積散), 팔미환(八味丸), 향사평위산(香砂平胃散), 소경활혈탕(疎經活血湯), 육미지황탕(六味地黃湯) 등(等)의 순(順)으로 많이 사용(使用)되었다. 9. 침(針)은 1일평균(日平均) 22.58명(名)을 시술(施術)하였고, 구(灸)(뜸)는 1일평균(日平均) 0.58명(名)을, 사혈(瀉血)은 1일평균(日平均) 2.28명(名)을 시술(施術)하였다. 10. 한양방향시치료시(韓洋方同時治療時) 양호이상(良好以上)의 효과(效果)를 보인 경우(境遇)가 30건중(件中) 21건(件)으로 70%의 치료효과(治療效果)를 보여 한방단일진료시(韓方單一診療時)보다 다소 높은 치료효과(治療效果)를 나타냈다. 11. 1일평균(日平均) 한방진료건수(韓方診療件數)는 26.95명(名)이었고, 1일평균(日平均) 한방초진환자수(韓方初診患者數)는 3.9명(名)으로 나타났으며, 한방진료(韓方診療)가 양한방(洋韓方) 총진료(總診療)의 23.20%를 차지했고, 1일(日) 평균(平均) 한양방(韓洋方) 총진료건수(總診療件數)에 대(對)해 1일(日) 평균(平均) 한방초진건수(韓方初診件數)가 21.51%를 차지하는 것으로 나타났다.

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$Hg^{2+}$에 의한 cis-[Co(en)$_2$(L)Cl]$^{2+}$ (L = 아민류) 착물의 아쿠아화 및 킬레이트화 반응 ($Hg^{2+}$-promoted Aquation and Chelation of cis-[Co(en)$_2$(L)Cl]$^{2+}$ (L = Amines) Complexes)

  • 오창언;윤두천;김복조;도명기
    • 대한화학회지
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    • 제36권4호
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    • pp.565-578
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    • 1992
  • 수용액 및 유기용매-물 혼합용매속에서 L이 $NH_3$, $NH_2$$CH_3$, $glyOC_2H_5$, $glyOCH_3$, $dl-alaOC_2$$H_5$, $NH_2$$CH_2$$CONH_2$, $NH_2$CH$_2$CN 이 배위된 cis-[Co(en)$_2$(L)Cl]$^{2+}$ (en = 1,2-diaminoethane)에 $Hg^{2+}$을 작용시켰을 때 속도론적인 자료, 원평광이색성 스펙트라, 이온교환 크로마토그래피에 의한 생성물 분석 및 용매의 성질인 Y(ionizing power)를 이용한 m(Grunwald-Winstein의 기울기)값의 결과들로 부터 반응은 I$_{d-}$메카니즘으로 제안되었다. 반응 결과 L이 $NH_3$과 NH$_2$CH$_3$이 배위된 cis-[Co(en)$_2$(L)Cl]$^{2+}$은 Cl$^-$이 해리되어 H$_2$O 분자가 치환되었으며, L이 glyOC$_2$H$_5$, glyOCH$_3$, dl-alaOC$_2$H$_5$, NH$_2$CH$_2$CONH$_2$과 NH$_2$CH$_2$CN이 배위된 cis-[Co(en)$_2$(L)Cl]$^{2+}$은 Co(Ⅲ)에 대한 각 리간드 L의 킬레이트화가 일어났다. 에탄올-물 혼합용매 속에서 cis-[Co(en)$_2$(NH$_2$CH$_2$CN)Cl]$^{2+}$을 제외한 cis-[Co(en)$_2$(L)Cl]$^{2+}$은 에탄올의 양이 증가될수록 속도상수(k)의 값이 증가되었고, 또한 30${\%}$ 유기용매-물 혼합용매 속에서의 속도상수의 값은 30${\%}$ 2-프로판올-물>30${\%}$ 에탄올-물>물의 순서를 나타내었다. 그러나 cis-[Co(en)$_2$(NH$_2$CH$_2$CN)Cl]$^{2+}$은 이와 반대의 결과를 나타내었다. 각 착물들의 속도상수의 차이에 있어서 cis-[Co(en)$_2$(NH$_3$)Cl]$^{2+}$ 및 cis-[Co(en)$_2$(NH$_2$CH$_3$)Cl]$^{2+}$은 리간드장 파라메타(${\Delta}$)와 관계가 있었지만, cis-[Co(en)$_2$(L)Cl]$^{2+}$(L = $glyOC_2$H$_5$, glyOCH$_3$, dl-alaOC$_2$H$_5$, $NH_2$CH$_2$CONH$_2$, $NH_2$CH$_2$CN)은 이와 관계가 없었다. cis-[Co(en)$_2$(L)Cl]$^{2+}$에 대하여 $NO_3^-$을 첨가시켜 $Hg^{2+}$이 촉매로서 작용하는 반응에서 $NO_3^-$에 의하여 그 반응 메카니즘이 변화되는 것이 아니라 단지 속도만 변화되었다.

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절제 불가능한 식도암의 근치적 항암화학방사선치료의 성적 (Results of Definitive Chemoradiotherapy for Unresectable Esophageal Cancer)

  • 노오규;제형욱;김성배;이진혁;박승일;이상욱;송시열;안승도;최은경;김종훈
    • Radiation Oncology Journal
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    • 제26권4호
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    • pp.195-203
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    • 2008
  • 목 적: 절제 불가능한 식도암에서의 근치적 동시항암화학방사선치료의 치료 성적과 재발 양상에 대해 알아보고자하였다. 대상 및 방법: 1994년 2월부터 2002년 12월까지 서울아산병원에서 절제불가능한 국소진행된 식도암으로 진단 받거나 내과적으로 수술이 불가능한 식도암으로 진단 받은 후 근치적 목적의 동시항암화학방사선치료를 시행 받은 168명을 대상으로 하였다. 방사선치료는 원발병소와 종격동, 그리고 원발병소와 림프절 전이의 위치에 따라 쇄골상부림프절과 복강림프절을 포함하여 $42{\sim}46\;Gy$의 외부방사선을 조사하였고, 이후 원발병소와 림프절 전이 부위에는 $54{\sim}66\;Gy$까지 추가 조사하였다. 분할조사 방법은 분할조사선량 $1.8{\sim}2\;Gy$씩 1일 1회 조사하거나, 1.2 Gy씩 1일 2회 조사하였다. 고선량률관내 방사선치료를 실시하는 경우에는 Ir-192를 이용한 고선량률 방식으로 3 Gy씩 $3{\sim}4$회 시행하였다. 항암치료는 5-FU와 cisplatin을 이용하여 동시항암화학방사선치료(5-FU $1,00\;mg/m^2$/day, days $2{\sim}6$, $30{\sim}34$, cispiatin $60\;mg/m^2$/day, days 1, 29)를 2주기 시행하고 방사선치료 후에 2 주기를 추가하여 시행하였다. 결 과: 분석 가능한 환자는 160명 이었으며, 추적관찰 기간은 1개월에서 149개월(중앙값 10개월)이었다. 환자의 AJCC 병기는 I, II, III, IV 기가 각각 5명(3.1%), 38명(23.8%), 68명(42.5%), 49명(30.6%)이었다. 26명(16.3%)의 환자에서는 $9{\sim}12\;Gy$의 추가 관내방사선치료를 시행하였다. 관내방사선치료를 포함하여 총 40 Gy 이상 조사받은 144명의 환자에서 외부 방사선조사량의 범위는 $44.4{\sim}66\;Gy$ (중앙값 59.4)이었고, 총 방사선 조사량의 범위는 $44.4{\sim}72\;Gy$ (중앙값 60)이었다. 분석가능한 160명의 환자 중에서 101명(63.1%)에서 재발하였으며, 재발 양상으로는 국소 재발이 20명(12.5%), 지속적 병변 또는 국소 진행이 61명(38.1%), 원격전이가 15명(9.4%), 국소재발과 원격전이가 함께 있는 경우가 5명(3.)%)이었다. 전체환자의 중앙생존기간은 11.1개월이었고, 2년 및 5년 전체생존율은 각각 31.8%, 14.2%이었다. 중앙무병 생존기간은 10.4개월이었고, 2년 및 5년 무병생존율은 각각 29.0%, 22.7%이었다. 항암화학방사선치료 후에 종양 반응 및 림프절 병기만이 전체생존율에 유의하게 영향을 미치는 예후인자였다. 방사선 조사량(${\geq}50$ Gy vs. < 50 Gy), 관내 방사선치료의 추가 유무, 분할조사(1회/day vs. 2회/day)에 따른 전체 생존율 및 무병생존율에 유의한 차이는 관찰되지 않았다. 결 론: 식도암에서 근치적 동시 항암화학방사선치료의 성적은 다른 연구 결과와 유사한 결과를 보였다. 동시 항암화학 방사선치료 후의 주된 재발 양상은 국소 재발이었다. 방사선 조사량의 증가(${\geq}50\;Gy$), 고선량률관내방사선치료 및 과분할조사법의 시행은 치료 성적을 향상시키지 못하였다.

산업관련표(産業關聯表)에 의(依)한 임업구조분석(林業構造分析)과 유발생산액(誘發生産額) -임업(林業)이 한국경제(韓國經濟)에 미치는 영향(影響)- (Analysis of Forestry Structure and Induced Output Based on Input - output Table - Influences of Forestry Production on Korean Economy -)

  • 이승윤
    • Journal of the Korean Wood Science and Technology
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    • 제2권4호
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    • pp.4-14
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    • 1974
  • The total forest land area in Korea accounts for some 67 percent of the nation's land total. Its productivity, however, is very low. Consequently, forest production accounts for only about 2 percent of the gross national product and a minor proportion of no more than about 5 percent versus primary industry. In this case, however, only the direct income from forestry is taken into account, making no reference to the forestry output induced by other industrial sectors. The value added Or the induced forestry output in manufacturing the primary wood products into higher quality products, makes a larger contribution to the economy than direct contribution. So, this author has tried to analyze the structure of forestry and compute the repercussion effect and the induced output of primary forest products when utilized by other industries for their raw materials, Hsing the input-output table and attached tables for 1963 and 1966 issued by the Bank of Korea. 1. Analysis of forestry structure A. Changes in total output Durng the nine-year period, 1961-1969, the real gross national product in Korea increased 2.1 times, while that of primary industries went up about 1. 4 times. Forestry which was valued at 9,380 million won in 1961, was picked up about 2. 1 times to 20, 120 million won in 1969. The rate of the forestry income in the GNP, accordingly, was no more than 1.5 percent both in 1961 and 1962, whereas its rate in primary industries increased 3.5 to 5.4 percent. Such increase in forestry income is attributable to increased forest production and rise in timber prices. The rate of forestry income, nonetheless, was on the decrease on a gradual basis. B. Changes in input coefficient The input coefficient which indicates the inputs of the forest products into other sectors were up in general in 1966 over 1963. It is noted that the input coefficient indicating the amount of forest products supplied to such industries closely related with forestry as lumber and plywood, and wood products and furniture, showed a downward trend for the period 1963-1966. On the other hand, the forest input into other sectors was generally on the increase. Meanwhile, the input coefficient representing the yolume of the forest products supplied to the forestry sector itself showed an upward tendency, which meant more and more decrease in input from other sectors. Generally speaking, in direct proportion to the higher input coefficient in any industrial sector, the reinput coefficient which denotes the use of its products by the same sector becomes higher and higher. C. Changes in ratio of intermediate input The intermediate input ratio showing the dependency on raw materials went up to 15.43 percent m 1966 from 11. 37 percent in 1963. The dependency of forestry on raw materials was no more than 15.43 percent, accounting for a high 83.57 percent of value added. If the intermediate input ratio increases in any given sector, the input coefficient which represents the fe-use of its products by the same sector becomes large. D. Changes in the ratio of intermediate demand The ratio of the intermediate demand represents the characteristics of the intermediary production in each industry, the intermediate demand ratio in forestry which accunted for 69.7 percent in 1963 went up to 75.2 percent in 1966. In other words, forestry is a remarkable industry in that there is characteristics of the intermediary production. E. Changes in import coefficient The import coefficient which denotes the relation between the production activities and imports, recorded at 4.4 percent in 1963, decreased to 2.4 percent in 1966. The ratio of import to total output is not so high. F. Changes in market composition of imported goods One of the major imported goods in the forestry sector is lumber. The import value increased by 60 percent to 667 million won in 1966 from 407 million won in 1963. The sales of imported forest products to two major outlets-lumber and plywood, and wood products and furniture-increased to 343 million won and 31 million won in 1966 from 240million won and 30 million won in 1963 respectively. On the other hand, imported goods valued at 66 million won were sold to the paper products sector in 1963; however, no supply to this sector was recorded in 1963. Besides these major markets, primary industries such as the fishery, coal and agriculture sectors purchase materials from forestry. 2. Analysis of repercussion effect on production The repercussion effect of final demand in any given sector upon the expansion of the production of other sectors was analyzed, using the inverse matrix coefficient tables attached to the the I.O. Table. A. Changes in intra-sector transaction value of inverse matrix coefficient. The intra-sector transaction value of an inverse matrix coefficient represents the extent of an induced increase in the production of self-support products of the same sector, when it is generated directly and indirectly by one unit of final demand in any given sector. The intra-sector transaction value of the forestry sector rose from 1.04 in 1963 to 1, 11 in 1966. It may well be said, therefore, that forestry induces much more self-supporting products in the production of one unit of final demand for forest products. B. Changes in column total of inverse matrix coefficient It should be noted that the column total indicates the degree of effect of the output of the corresponding and related sectors generated by one unit of final demand in each sector. No changes in the column total of the forestry sector were recorded between the 1963 and 1966 figures, both being the same 1. 19. C. Changes in difference between column total and intra-sector transaction amount. The difference between the column total and intra-sector transaction amount by sector reveals the extent of effect of output of related industrial sector induced indirectly by one unit of final demand in corresponding sector. This change in forestry dropped remarkable to 0.08 in 1966 from 0.15 in 1963. Accordingly, the effect of inducement of indirect output of other forestry-related sectors has decreased; this is a really natural phenomenon, as compared with an increasing input coefficient generated by the re-use of forest products by the forestry sector. 3. Induced output of forestry A. Forest products, wood in particular, are supplied to other industries as their raw materials, increasng their value added. In this connection the primary dependency rate on forestry for 1963 and 1966 was compared, i. e., an increase or decrease in each sector, from 7.71 percent in 1963 to 11.91 percent in 1966 in agriculture, 10.32 to 6.11 in fishery, 16.24 to 19.90 in mining, 0.76 to 0.70 in the manufacturing sector and 2.79 to 4.77 percent in the construction sector. Generally speaking, on the average the dependency on forestry during the period 1963-1966 increased from 5.92 percent to 8.03 percent. Accordingly, it may easily be known that the primary forestry output induced by primary and secondary industries increased from 16, 109 million won in 1963 to 48, 842 million won in 1966. B. The forest products are supplied to other industries as their raw materials. The products are processed further into higher quality products. thus indirectly increasing the value of the forest products. The ratio of the increased value added or the secondary dependency on forestry for 1963 and 1966 showed an increase or decrease, from 5.98 percent to 7.87 percent in agriculture, 9.06 to 5.74 in fishery, 13.56 to 15.81 in mining, 0.68 to 0.61 in the manufacturing sector and 2.71 to 4.54 in the construction sector. The average ratio in this connection increased from 4.69 percent to 5.60 percent. In the meantime, the secondary forestry output induced by primary and secondary industries rose from 12,779 million Wall in 1963 to 34,084 million won in 1966. C. The dependency of tertiary industries on forestry showed very minor ratios of 0.46 percent and 0.04 percent in 1963 and 1966 respectively. The forestry output induced by tertiary industry also decreased from 685 million won to 123 million won during the same period. D. Generally speaking, the ratio of dependency on forestry increased from 17.68 percent in 1963 to 24.28 percent in 1966 in primary industries, from 4.69 percent to 5.70 percent in secondary industries, while, as mentioned above, the ratio in the case of tertiary industry decreased from 0.46 to 0.04 percent during the period 1963-66. The mining industry reveals the heaviest rate of dependency on forestry with 29.80 percent in 1963 and 35.71 percent in 1966. As it result, the direct forestry income, valued at 8,172 million won in 1963, shot up to 22,724 million won in 1966. Its composition ratio lo the national income rose from 1.9 percent in 1963 to 2.3 per cent in 1966. If the induced outcome is taken into account, the total forestry production which was estimated at 37,744 million won in 1963 picked up to 105,773 million won in 1966, about 4.5 times its direct income. It is further noted that the ratio of the gross forestry product to the gross national product. rose significantly from 8.8 percent in 1963 to 10.7 percent in 1966. E. In computing the above mentioned ratio not taken into consideration were such intangible, indirect effects as the drought and flood prevention, check of soil run-off, watershed and land conservation, improvement of the people's recreational and emotional living, and maintenance and increase in the national health and sanitation. F. In conclusion, I would like to emphasize that the forestry sector exercices an important effect upon the national economy and that the effect of induced forestry output is greater than its direct income.

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간흡충증(肝吸虫症)의 역학(疫學) - I. 고도유행지(高度流行地) 김해지방(金海地方)에 있어서의 간흡충감염(肝吸虫感染)의 현황(現況)과 자연추이(自然推移) (Epidemiological Studies of Clonorchiasis. - I. Current Status and Natural Transition of the Endemicity of Clonorchis sinensis in Gimhae Gun and Delta, a High Endemic area in Korea)

  • 김동찬;이온영;이종수;안장수;장영미;손성창;문익상
    • 농촌의학ㆍ지역보건
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    • 제8권1호
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    • pp.44-65
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    • 1983
  • As a part of the epidemiological studies of clonorchiasis, this study was conducted to evaluate the current endemicity and the natural transition of the Clonorchis infection in Gimhae Gun and delta area a high endemic area in Korea in recent years, prior to the introduction of praziquantel which will eventually influence the status of the prevalence. The data obtained in this study in 1983 were evaluated for natural transition of the infection in comparison with those obtained 16 years ago in 1967 by the author(Kim, 1974). The areas of investigation, villages and schools surveyed, methods and techniques used in this study were the same as in 1967, except for the contents of the questionnaire for raw freshwater fish consumption by the local inhabitants. 1) The prevalence rate of clonorchiasis in the general population of the villages was 48.1% on the average out of a total of 484 persons examined. The average of those of the riverside-delta area was 65.2% and 43.0% in the inland area. Among the schoolchildren, the prevalence rate was 8.2% on the average out of a total of 1,423 examined. By area, the prevalence rate was 10.8% in the riverside delta area and 2.8% in the inland area. By sex, difference in the prevalence was seen only in the inhabitants of the inland area showing 52.4% in the male and 33.5% in the female. 2) In the natural transition of the infection, the prevalence rate among the inhabitants has decreased from 68.8% in 1967 to 48.1% in 1983, and in the schoolchildren from 56.4% in 1967 to 8.2% in 1983. The reduction rate was higher in the riverside-delta area than in the inland area. 3) In the prevalence rate by age, 11.9% was first seen in the 5-9 age group and the rate gradually increased up to 75.0% in the 50-59 age group. By sex, the rate was higher in the male than in the female in the 20-29 age group and over. 4) In the natural transition of the prevalence rate by age, the reduction rate of the infection during the past 16 years was greater in the younger age groups up to the 40-49 age group and reached the same level in the age group 50-59. Reduction was seen again in the age group over 60s. By sex, the reduction rate was greater in the female than in the male in the 20-29 age group and over. By area, the reduction rate was greater in the riverside delta area than in the inland area, particularly in the young age groups. 5) In the intensity of the infection among the cases, the mean egg out-put per mg feces per infected cases(EPmg) in the inhabitants was 6.3. EPmg of those of the river-side-delta area was 15.4 and that of the in-land was 2.8. On the other hand, in the schoolchildren, EPmg was 3.2, and no difference was seen between the two areas, the river-side-delta area and the inland area. 6) In the transition of the intensity of the infection by area, EPmg among the inhabitants inexplically increased from 7.8 in 1967 to 15.4 in 1983. This was probably caused by uneven specimen collection in the process of sampling the population. EPmg of the inhabitants in the inland area and those of the schoolchildren of both riverside delta and inland areas showed a similar decrease in the past 16 years. 7) The intensity of the infection by age showed a relatively low level in the 20-29 age group and below, and EPmg 5.1-9.5 was seen in the 30-39 age group and over. Sex, Epmg was 5.8 in the male and 4.7 the female. By in 8) In the transition of the intensity of the infection, EPmg decreased from 6.2 in 1967 to 5.4 in 1983. By age, in contrast to the figures of 1967 in which EPmg gradually increased with some fluctuation from 1.1 in the 0-4 age group to peak 10.5 in the 50-59 age group, in 1983 lower intensity of the infection was seen in the age group from 10-14 to 20-29 with the EPmg range of 0.6-2.7. 9) In the distribution of the clonorchiasis cases by the range of EPmg value, 43.2% of the cases were in 0.1 0.9 and 34.6% in 1.0-4.9. As a whole by cumulative percent, 44.6% of them were under 0.9 as light infection and 86.1% of them under 9.9 up to moderate infection. By sex, no difference was seen in Epmg. 10) In the transition of the distribution by the range of Epmg, the cases were distributed up to the range 80.0-99.9 in 1967 and to 60.0-79.9 in 1983. By cumulative percent, in the range of 0.1-0.9 and less, light infection, 34.3% of them were distributed in 1967 and 44.6% in 1983 with about 10% increase. In the range of 5.0-9.9 and less, up to moderate infection, 83.2% in 1967 and 86.1% in 1983 of the cases were seen, respectively. 11) The practice of raw freshwater fish consumption among the inhabitants seems to have decreased in recent years. Those who admitted to raw freshwater fish consumption in the last two years among the infected inhabitants were 59.3%, although 86.8% of them professed to have experience with raw freshwater fish consumption. 31.7% of those who have had experience of the raw freshwater fish consumption denied any further consumption in recent years. From an interview of 543 school-children, 24.1% of them admitted to an experience of raw freshwater fish consumption. However, those who have practised in the past two years comprized 17.9%. Those who denied raw freshwater fish consumption in recent years among those who had such experience were 26.0% out of 131 interviewed. The rate of raw freshwater fish consumption in both inhabitants and schoolchildren were higher in the male than in the female. On the contrary, the rate of those who did not practise in recent years among those who had experience of raw freshwater fish consumption was higher in the female than in the male. 12) The major reason for the reduction of raw freshwater fish consumption among the local inhabitants was the risk of the fluke infection. However, it has become apparent that such change of taste has resulted from water pollution impact which has affected throughout the areas of the freshwater systems in this locality since last several years. 13) In animal survey, Clonorchis infection was seen in 14.8% of 88 dogs examined and 3.7% of 27 house rats examined. It was noted that populations of dogs and cats have increased in the villages surveyed. Although the prevalence rate was lower in the present survey than those of 1967, the significance of the animals as the reservoir host has not changed. 14) Prevalence rate of Clonorchis infection by cercariae in the first intermediate host, Parafossarulus manchouricus, was 0.6% out of 517 snails examined. The infection rate was lower in comparison with 2.3% out of 2,124 examined in 1967. Moreover, sharp decreases in number and distribution of the intermediate host snails in many watershed areas of the huge freshwater systems in this locality seemed to reduce transmission of Clonorchis in connection with the intermediate host stage of its life cycle. 15) Clonorchis infection in the second intermediate fish hosts was relatively low. The mean number of Clonorchis metacercaria per fish in Pseudorasbora parva was 517 in 1983, whereas it was 1943 in 1968 through 1969. Environmental water pollution has also caused the decreased fish population density in these areas, and this has also apparently affected to the practice of raw freshwater fish consumption among the local inhabitants. 16) In conclusion, endemicity of Clonorchis infection in Gimhae Gum and delta area of the Nagdong River has sharply decreased during the past 16 years. The major cause of the regressive transition of the infection was the water pollution of the land water systems of this locality. The pollution has upset the ecosystems comprizing of the intermediate hosts of Clonorchis in many areas, and also affected to a significant extent to the discontinuance of the local inhabitants for raw freshwater fish consumption.

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고려의 원시영역 유목초지, 그 부르칸(불함)이즘과 한국축산의 비전 (Burqanism from the Origin of the Pastoral Nomadic Koryo Region and the Vision of Korean Livestock Farming)

  • 주채혁
    • 한국초지조사료학회지
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    • 제25권1호
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    • pp.71-82
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    • 2005
  • Khori(高麗) refers to the Chaabog(reindeer) that live on lichens(蘚) on Mt. Soyon(鮮) in which pastures are the cold and dry plateau of North Eurasia. Thus, the origin region of the Khori or Koguryo that are the ancestors of the reindeer-herding pastoral nomads(馴鹿 遊牧民) can be said to be the Steppe-Taiga-Tundra pastoral areas of North Eurasia and North America. When the pastoral nomads moved on to the great mountain(大山) zone of the Jangbaek(長白) to the Baekdu(白頭) Mountains, they could have been in contact with pastoral farmers or agricultural farmers living there and they became the farmers remaining on agricultural farms. They were the Koryo people, the ancestors of Korea. Staying in one place, they gradually forgot the origin of their reindeer-herding pastoral nomadic history in the Northwest area of Mt. Soyon, the small mountain(小山) zone of the Steppe-Taiga-Tundra pastoral areas. In other words, they lost their identity as reindeer-herding pastoral nomads when they entered the agricultural area after leaving the pastoral area. However, since their basic genes had already formed when they lived on the cold and dry plateau of North Eurasia, it is possible to study their pastoral nomadic history focusing on 'the minority living in the broad area(廣域少數)', by utilizing highly advanced biotechnological science and focusing on genes and information technology innovation, and removing various past hindrances in research. Therefore, it is not so difficult to restore the reindeerherding pastoral nomadic history of the Koguryo(高句麗) people and secure their pastoral nomadic identity, of which the first steps have already been taken into their historical stages. The Eurasian continent and the Korean peninsula, especially the cold and dry plateau of North Eurasia and the Korean peninsula have been closely related to each other ecologically and historically. They can never be a separate space at all. The Eurasian continent lies horizontally east to west and thus, the continent forms an isothermal zone. Also, since the time of producing their own foods, it was relatively easy for people with their technology to move to other places owing to the pastoral nomadic characteristic of mobility. Unlike the Chungyen(中原) region, western Asia and the regions covering the Siberia-Manchu-Korean peninsula where food production revolution was first made were connected to the Mongolian lichens route(蘚苔之路: Ni, ukinii jam) and steppe roads. Although the ecological conditions of nature have changed a bit throughout a long history, it was natural for the many tribes in North Asia living on the largest Steppe-Taiga-Tundra area in the world to have believed 'the legends related to animals in relation to their founders and ancestors(獸祖傳說)'. Assuming that Siberian tigers and the tigers living on Mt. Baekdu were connected ecologically and genetically because of the ecological characteristics of the animals, and their migration from plateau to plateau, we would suspect that the Chosun(朝鮮) tribe living on Mt. Baekdu were ethnically and culturally more closely connected to the farther removed Ural-Altai tribes that lived on the cold and dry plateau region than to the Han(i14;) tribe who lived in Chungyen(中原) that was close to Mt. Baekdu. More evidence is the structure of the Korean language which has the form of 'Subject + Object + Verb', which is assumed to have originated from the speedy lifestyle of the reindeer-herding pastoral nomads. The structure is quite different from that of the Han(漢) language, which is based on agricultural life. Also, it is natural for reindeer riding reindeerherding pastoral nomads or horse-riding sheep-herding pastoral nomads(騎馬, 羊遊牧民) to have held military and political power over the region and eventually to have established an ancient pastoral nomadic empire in the process of their conquest of agricultural regions. The stages for founding global empires in the history of mankind maybe largely divided into two, in terms of ecological conditions and occupations. They are the steppes and the oceans. Of course, the steppe-based empires were established based on the skills to deal with horses and the ability to shoot arrows while riding horses, along with the use of iron ware in the 8th century BC. The steppe-based empires became the foundation for an oceanic empire, which could have been established by the use of warships and warship guns since the 15th Century. Based on those facts, we know that Chosun, Puyo(夫餘), and Koguryo are the products of a developmental process of pastoral nomadic empires on the steppes. Maybe we can easily find the pastoral nomadic identity of the Koguryo more than we expected when we trace the origins and history of the Korean tribe living in the pastures located in the northwest area of Mt. Jangbaek by focusing on pastoral nomadic mobility and organization just as we have investigated the historic origins of Anglo-Saxons in America by focusing on the times before the 15th Century. In the process, we should keep in mind that English culture originated from the Industrial Revolution and was directly delivered to the American continent, although America was far from England and was not an intermediate point on long sojourns either. Further, American culture came back to England in a more advanced form later. The most important thing currently to be resolved is to cause Koreans to look back on their own history in a freer way of thinking and with diverse, profound, and sharp insight, taking away the old and existing conventional recognition that is entangled with complicated interests with Korean people and other countries. The meanings of Chosun, Khori, and Solongos have been interpreted arbitrarily without any historic evidence by the scholars who followed conventional tradition of fixed-minded aristocrats in an agricultural society. If the Siberian cultural properties of the stone age, the earthenware age, the bronze age, and the iron age are analyzed in such a way, archaeological discovery will never be able to contribute to the restoration of the Koguryo's pastoral nomadic identity. One should transcend the errors that tend to interpret the cultural properties discovered in the pastoral nomadic regions as not being differentiated from those of agricultural regions and just interpret them altogether from the agricultural point of view. A more careful intention is required in the interpretation of cultural properties of ancient Korean empires that seem to have been formed due to mutual interactions of pastoral nomadic and agricultural cultures. Also, it is required that the conventional recognition chain of 'reverse-genes' be severed, which has placed more weight on agricultural properties than pastoral nomadic ones, since their settlement on agricultural farms was made after the establishment of their ancient pastoral nomadic empires. There is no reason at all to place priority on stoneware, earthenware, bronze ware, and iron ware than on wooden ware(木器) and other ware which were made of animal skins(皮器), bones and horns(骨角器), in analyzing the history in the regions of reindeer or sheep pastures. Reading ancient Korean history from the perspective of pastoral nomadic history, one feels strongly the instinctive emotions to return to the natural 'mother place'. The reindeer-herding pastoral nomadic identity of the Koguryo people that has been accumulated in volumes in their genes and hidden deep inside and have interacted organically could be reborn with Burqanism(Burqan refers to 不咸 in Chinese), which was their religion by birth and symbolized as the red willow(紅柳=不咸). The mother place of the Koguryo's people is the endless vast green pastures of North Eurasia and North America, where we anticipated the development of Korean livestock farming following the inherent properties in the genes of the reindeer-herding pastoral nomads with Korean ancestors. We anticipate that the place would be the core resource that could contribute to the development of life of living creatures following the inherent properties of their genes and biotechnological factors. In other words, biotechnology used for a search for clues on the well-being of humans could be the fruit brought by Burqanism of the Koguryo people and the fruit of the globalization of Korean livestock farming. It is the Chosun farmer in China come from the vast nomadic reindeer pastures of North Eurasia that resolved the food problem of a billion Chinese people with lowland paddy rice seeds (水稻) by transforming Heilongjiang Province(黑龍江省) into an oceanic lowland paddy rice field(水田). Even Mao Tse-tung(毛擇東) could not resolve the food problem by his revolution campaigns for tens of years. Today is the very time that requires the development of special livestock farming following the inherent properties of the ancient Korean reindeer-herding pastoral nomads that respected the dignity of life on the cold and dry plateau of North Eurasia and the America continent. I suggest that research should be started from the pastures of the Dariganga Steppe in East Mongolia that was the homeland of Hanwoo(韓牛) and the central horse-herding steppe place(牧馬場) of Chingis Khan's Mongolia. The Dariganga Steppe is awash with an affluent natural environment for pastoral nomadic living however, the quality of life of the pastoral nomads there is still low. I suggest we Koreans, the descendents of the Koguryo, should take our first steps for our livestock farming business project and develop the Northern nomadic pastures, here at the pastures of the Dariganga Steppe, which is the Mongolian core place of state-of-the-art technology for military weapons.

발살바동 동맥류의 외과적 치료 (Surgical Treatment of Aneurysm of the Sinus of Valsalva Eight Year Experience)

  • 오상준;유완준
    • Journal of Chest Surgery
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    • 제29권9호
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    • pp.983-988
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    • 1996
  • 발살바동 동맥류는 매우 드문 질환으로 1987년부터 1994년까지 인제대학교 의과대학 서울백병원 흉부외과학교실에서는 총 12례를 경험하였으며 이는 이 기간중의 심폐체외순환을 이용한 심장수술중 0.7%였다. 남자가 8례, 여자가 4례였고, 연령분포는 8세에서 38세까지로 평균 19.2세 였다. 파열이 있었던 경우는 8례였다. 발살바동 동맥류의 기원은 우측 발살바동에서 10례(83.3%), noncoronary 발살바동에서 2례 (16.6%)였다. 파열된 경우에는 우측 발살바동에서 6례, noncoronary발살바동에서 2례였으며, 우측 발살바동에서 기원한 6례중 5례가 우심실로, 1례가 우심방 및 우심실로 파열됐고, noncoronary 발살바동에서 기원한 2례중 1례가 우심방으로, 1례가 우심실로 파열됐었다. 동반된 심질환은 심실중격결손이 10례(83.3%)였고 이중 9례는 우측 발살바동에서 동반되었으며, 대동맥 판폐쇄부전이 동반된 예는 3례로서 모두 심실중격결손도 같이 동반하고 있었다. 그외 승모판폐쇄부전이 1례, 우심실양분증이 1례였다. 조기사망은 없었고, 만기사망은 술후 15개월에서 1례있었는데 심내막염으로 인하여 사망하였다. 술후 평균 29개월(4~60개월)간의 추적기간 \ulcorner만기사망 1례를 제외한 11례에서 WYHA기능적 분류로 classs I의 상태이다. 수술의 위험도나 사망률이 낮으므로 합병증의 위험이 있으면 파열이 없더라도 수술하여야 하며, 파열이 있는 경우는 진단이 되면 바로 수술을 해야할 것으로 사료된다. 대부분의 경우 대동맥판막 및 동맥류의 정확한 판단 및 교정을 위해 대동맥절개가 필요하다. 한편 동반된 심질환도 동시에 교정해주며 특히 대동맥판막에 대해서는 철저히 교정 해주어야 한다고 생각한다.

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자돈 및 비육돈에 있어 옥수수의 가공 효과 (Effects of Extruded Corn in Nursery and Finishing Pigs)

  • 한영근;김인호;홍종욱;권오석;민병준;이원백;손경승;이지훈
    • Journal of Animal Science and Technology
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    • 제45권6호
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    • pp.949-956
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    • 2003
  • 시험 1은 자돈에 있어 중국산 옥수수의 이용성을 높이기 위하여 중국산 옥수수를 익스트루젼 가공하였을 때 성장 및 영양소 소화율에 미치는 영향을 평가하기 위하여 실시하였다. 개시시 체중 15.95${\pm}$0.09kg의 3원 교잡종 자돈 60두를 공시하여 28일간 사양시험을 실시하였다. 시험설계는 미산 옥수수-대두박 위주로 시험사료를 배합한 처리구(UCORN), 중국산 옥수수-대두박 위주로 시험사료를 배합한 처리구 (CCORN) 그리고 익스트루젼 가공한 중국산 옥수수-대두박 위주로 시험사료를 배합한 처리구 (ECCORN)로 3개 처리로 하였다. 전체 사양시험 기간동안, 일당증체량에 있어서는 ECCORN 처리구가 CCORN 처리구보다 더 높았으나 (547 vs 522 g/d) 유의적인 차이는 보이지 않았다. 사양시험 개시후 10일째 되는 날에 채취한 분을 이용하여 분석한 건물과 가소화 에너지 소화율에 있어서는 UCORN 처리구와 ECCORN 처리구가 CCORN 처리구보다 유의적으로 높은 것으로 평가되었다(P〈0.05). 또한, 사양시험 개시후 24일째 되는 날에 채취한 분을 이용하여 분석한 건물 소화율에 있어서는 UCORN 처리구와 ECCORN 처리구가 CCORN 처리구보다 유의적으로 높은 것으로 평가되었으며(P〈0.05), 가소화 에너지 소화율에 있어서는 UCORN 처리구가 다른 처리구와 비교하여 가장 높았다 (P〈0.05). 또한, CCORN 처리구와 비교하여 ECCORN 처리구가 유의적으로 높게 평가되었다(P〈0.05). 시험 2는 비육돈에 있어 중국산 옥수수를 익스트루젼 가공이 외관상 아미노산 및 영양소 소화율에 미치는 영향을 평가하기 위하여 실시하였다. 개시시 체중 54.09kg의 3원 교잡종 거세돈 3두를 공시하여 대사시험을 실시하였으며, 처리구는 시험 1과 동일하였다. 시스틴의 외관상 아미노산 소화율에 있어서는 UCORN과 EECORN 처리구가 CCORN 처리구와 비교하여 유의적으로 높게 평가되었다(P〈0.05). 건물 소화율에 있어서는 UCORN과 ECCORN 처리구가 CCORN 처리구보다 분 소화율이 유의적으로 높은 것으로 나타났다(P〈0.05). 또한, 질소 소화율에 있어서도 UCORN과 ECCORN 처리구가 CCORN 처리구보다 분 소화율이 유의적으로 높은 것으로 나타났다(P〈0.05). 결론적으로, 자돈에 있어서 중국산 옥수수를 익스트루젼 가공 처리하면 성장 및 건물과 가소화 에너지 소화율을 향상시킬 수 있으며, 비육돈에 있어서는 건물과 질소의 분 소화율을 향상시킬 수 있는 것으로 사료된다.

비육돈 사료내 Bacillus subtilis의 첨가가 성장, 면역세포 변화, 분내 암모니아태질소 함량 및 도체 특성에 미치는 영향 (Effect of Dietary Bacillus subtilis on Growth Performance, Immunological Cells Change, Fecal NH3-N Concentration and Carcass Meat Quality Characteristics in Finishing Pigs)

  • 조진호;진영걸;민병준;김해진;손경승;권오석;김진동;김인호
    • Journal of Animal Science and Technology
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    • 제47권6호
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    • pp.937-946
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    • 2005
  • 본 연구의 목적은 Bacillus subtilis의 첨가에 의한 비육돈에 있어 성장능력, 면역세포 변화, 분내 암모니아태 질소 함량 및 도체특성에 미치는 영향을 평가하기 위해 실시하였다. 3원 교잡종(Landrace$\time$Yorkshire$\time$Duroc) 비육돈 60두를 공시하였으며 시험개시시의 체중은 89.5$\pm$ 0.11kg 이었고 42일간 실시하였다. 처리는 대조구, 대조구 사료에 Bacillus subtilis를 0.1% (BS0.1)과 0.2%(BS0.2) 첨가구로 3개 처리를 하여 처리당 5반복, 반복당 4마리씩 완전임의 배치하였다. 시험 0-3주 동안 증체량과 사료섭취량은 처리구간에 유의적인 차이는 없었다. 사료효율은 BS0.1 처리구가 대조구와 BS0.2 처리구와 비교하여 유의적으로 높게 나타났다. 시험 4-6주 동안 증체량과 사료효율은 BS0.1 처리구가 대조구와 BS0.2 처리구와 비교하여 유의적으로 높게 나타났고 사료섭취량은 BS0.1 처리구가 대조구보다 유의적으로 높은 결과를 보였다. 전 시험기간 동안 일당 증체량은 BS0.1 처리구가 증가하는 경향을 보였으나 유의적인 차이는 없었고, 사료효율에서는 BS0.1 처리구가 대조구와 BS0.2 처리구보다 유의적으로 높은 결과를 보였다. 영양소 소화율에서는 BS0.1처리구가 대조구와 비교하여 건물 및 질소 소화율이 유의적으로 높게 나타났고 암모니아태 질소의 함량은 BS0.2 처리구가 낮았지만 유의적인 차이는 없었다. Total protein, albumin, WBC 및 lymphocyte의 증가량은 처리구간에 유의적인 차이를 보이지 않았다. 적혈구 수의 증가량은 전 처리구에서 BS0.2 처리구가 가장 높은 결과를 보였다. 도살 후 육의 pH, 육즙손실, 근내지방도 및 경도에서는 처리구간에 유의적인 차이를 보이지 않았고 육색에서는 BS0.2 처리구가 대조구보다 유의적으로 높게 나타났다. 육색에서는 적색도를 나타내는 a*값은 bacillus subtilis 첨가수준에 따라 증가하였고 BS0.2 처리구가 가장 높았다. 처리구별 A등급 출현율은BS0.2(60%), BS0.1(55%)와 CON(20%) 순으로 나타났으며 A 및 B 등급의 출현율은 BS0.1 (100%), BS0.2(100%), CON(75%)로 나타났다. 결론적으로 비육돈 사료내 bacillus subtilis의 첨가는 영양소 소화율의 향상, 적혈구 수의 증가, 육색 및 도체등급에 영향을 미치는 것으로 사료된다.