• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.339-339
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• 1994

It has been reported that Indole-3-carbinol (I3C), a naturally occurring compound In cruclferous vegetables, exerts anticarcinogenic activity In several organs In rodents. The modifying effects of I3C were therefore assessed uging a rat multi-organ carcinogenesis model. A total of 100 male Sprague-Dawley rats were divided Into 3 groups. Animals of groups 1 and 2 were sequentially treated with diethylnitrosamine (DEN; 100 mg/kg b.w., i.p.), N-methylnitrosourea (NNU; 20 mg/kg b.w., 4 times for 2 weeks, i.p), and dihydroxy-di-N-propylnitrosauine (DHPN; 0.1% In d.w. for 2 weeks) for 4 weeks (DMD treatment). Animals of groups 1 and 3 were given the diet of 0.25% I3C for 20 weeks after DMD initiation and then were given basal diet for 28 weeks. All animals were sacrificed at week 24 and 52, respectively. I3C has been clearly demonstrated promoting effects on the development of glutathione S-transferase placental form (GST-P) positive hepatic foci at 24 weeks of the experiment. And I3C also exerted promoting potential In the hepatocellular adenoma (4/14; 29%) and the adenoma (7/14; 50%) of the thyroid gland at 52 weeks of the experiment. Therefore, I3C may promote hepatocarcinogenesis and thyroid tumorigenesis in the rat multi-organ carcinogenesis model.

• Journal of Ginseng Research
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• v.21 no.2
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• pp.109-114
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• 1997

The effect of total saponin fraction of Ginseng injected intrathecally (i.1.) or in- tracerebroventricularly (i.c.v.) on the antinociception induced by D-$Pen^{2,5}$- enkephalin (DPDPE) ad ministered i.c.v. was studied in ICR mice in the present study. The antinociception was assessed by the tail-flick test. Total saponin fraction at doses 0.1 to 1.0 $\mu\textrm{g}$, which administered i.t. Alone did not affect the latencies of tail-flick threshold, attenuated dose-dependently the inhibition of the tail-flick response induced by i.c.v. administered DPDPE (10 $\mu\textrm{g}$). However, total saponin fraction at doses 1 to 20 $\mu\textrm{g}$, which administered i.c.v. Alone did not affect the latencies of the tail-flick response, did not affect i.c.v. administered DPDPE (10 $\mu\textrm{g}$)-induced antinociception. The duration of antagonistic action of total saponin fraction against DPDPE-induced antlnociception was lasted at least for 6 hrs. Various doses of ginsenosides Rd, but not $\Rb_2$, Rc, Rg1, and $\Rb_1$ and Re, injected i.t. Dose-dependently attenuated antinociception induced by DPDPE administered i.c.v. Our results indicate that total saponin fraction injected spinally appears to have antagonistic action against the antinociception induced by supraspinally applied DPDPE. Ginsenoside Rd appears to be responsible for blocking j.c.v. administered DPDPE-induced antinociception. On the other hand, total ginseng fraction, at supraspinal sites, may not have an antagonistic action against the antinociception induced by DPDPE.

• Molecules and Cells
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• v.41 no.4
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• pp.290-300
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• 2018

Using an in vitro model of intestinal organoids derived from intestinal crypts, we examined effects of indole-3-carbinol (I3C), a phytochemical that has anticancer and aryl hydrocarbon receptor (AhR)-activating abilities and thus is sold as a dietary supplement, on the development of intestinal organoids and investigated the underlying mechanisms. I3C inhibited the in vitro development of mouse intestinal organoids. Addition of ${\alpha}$-naphthoflavone, an AhR antagonist or AhR siRNA transfection, suppressed I3C function, suggesting that I3C-mediated interference with organoid development is AhR-dependent. I3C increased the expression of Muc2 and lysozyme, lineage-specific genes for goblet cells and Paneth cells, respectively, but inhibits the expression of IAP, a marker gene for enterocytes. In the intestines of mice treated with I3C, the number of goblet cells was reduced, but the number of Paneth cells and the depth and length of crypts and villi were not changed. I3C increased the level of active nonphosphorylated ${\beta}$-catenin, but suppressed the Notch signal. As a result, expression of Hes1, a Notch target gene and a transcriptional repressor that plays a key role in enterocyte differentiation, was reduced, whereas expression of Math1, involved in the differentiation of secretory lineages, was increased. These results provide direct evidence for the role of AhR in the regulation of the development of intestinal stem cells and indicate that such regulation is likely mediated by regulation of Wnt and Notch signals.

• The Journal of the Korea institute of electronic communication sciences
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• v.6 no.6
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• pp.839-847
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• 2011

Instrumentation & Control(I&C) System in NPP(Nuclear Power Plant) plays a important role as the brain of human being, it performs protecting, controling and monitoring safety operation of NPP. Recently, the I&C system is digitalized as digital technology such as PLC, DSP, FPGA. The different aspect of digital system which use digital communication to analog system is that it has potential vulnerability to cyber threat in nature. Possibility that digital I&C system is defected by cyber attack is increasing day by day. The result of cyber attack can be adverse effect to safety function in NPP. Therefore, I&C system required cyber security counter-measures that protect themselves from cyber threat efficiently and also cyber security design should be taken into consideration at concept stage in I&C system development process. In this study, we proposed the digital asset analysis method for cyber security assessment of I&C system design in NPP and we performed digital asset analysis of I&C system by using the proposed method.

• Journal of Advanced Navigation Technology
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• v.23 no.5
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• pp.386-391
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• 2019

This paper presents analysis results for the effect of the directional group delay of the antenna to implement a precision radio navigation system. The analysis was conducted through antenna simulation and test, and the test was performed in an anechoic chamber. The directional group delay of the antenna was calculated in phase-based analysis method. The results showed that a variation of up to 7.7ns in group delay occurred per antenna direction. The group delay variation from the analysis is 2.31 meters when converted into distance. It was tested using a real radio navigation system based on the time of arrival (TOA). The test verified the distance variation of 2.1 meters, and this value is similar to those obtained from the simulation and chamber test analysis.

• Textile Coloration and Finishing
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• v.33 no.1
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• pp.31-39
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• 2021

In this study, the dyeing properties of supercritical fluid dyed nylon fabrics were investigated which use two types of dyes for dyeing nylon. For other dyeing conditions were referred to related literature, and dyeing was performed with different dyeing concentrations. Dyeability was confirmed through measurement of washing fastness and color coordinate, and a calibration curve of each dye was drawn up and the absorbance of the residual dye was measured to confirm the amount of residual dye and the dye exhaustion rate at the corresponding concentration. As a result of color difference measurement, the color intensity increased as the concentration increased, but the increase was insignificant at high concentration. This tendency was more obvious in C.I. Disperse Orange 155 than in C.I. Disperse Yellow 42. The dye absorption rate also decreases as the concentration increases, but at 0.85% o.w.f concentration, C.I. Disperse Yellow 42 was 97.29% and C.I. Disperse Orange 155 was 93.77%. For both dyes, the wash fastness dropped by 0.5 to 1 class from the sample that was dyed at a concentration of 0.5% o.w.f in the wash fastness test.

• Textile Coloration and Finishing
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• v.32 no.4
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• pp.217-225
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• 2020

In this study, the dyeing characteristics of nylon fabric which is dyed with supercritical fluid were investigated. There were two dyes used in the dyeing experiment: C.I. Disperse Red 167 and C.I. Disperse Violet 93. Dyeing temperature, pressure, and leveling time were fixed at 110℃, 250bar, 60minutes, and the experiment was conducted with dyeing concentration of 0.1, 0.3, 0.5, and 0.85% o.w.f. The analysis of the experimental results was found out through the measurement of washing fastness and color coordinate. In addition, the calibration curve of each dye was drawn up and the amount of remaining dye was checked by measuring the absorbance of the residual dye. As a result of color difference measurement, as the concentration increased, the L⁎ value decreased and the K/S value increased. However, the increase in K/S value compared to the amount of input decreased as the concentration increased. The comparative experiment on the amount of residual dye(C.I. Disperse Red 167) in the pot showed that 99.14% of the amount was dyed at the concentration of 0.1% o.w.f, while it rapidly decreased to 77% at 0.85% o.w.f. C.I. Disperse Violet 93 dye also decreased from 0.5% o.w.f to 93.91%. In the washing fastness experiment of both dyes, the level of washing fastness began to decrease from samples dyed at 0.5% o.w.f. It may be because the simply absorbed dye was produced instead of completely being fixed in the amorphous region of the nylon fiber.

• Journal of Advanced Navigation Technology
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• v.26 no.2
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• pp.78-84
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• 2022

In this paper, we propose a closed-form based 3D localization method in the presence of multiple signal sources. General localization methods such as TDOA, AOA, and FDOA can estimate a location when a single signal source exists. When there are multiple unknown signal sources, there is a limit in estimating the location. The proposed method calculates a cross-correlation vector of signals received by sensors having an array antenna, and estimates TDOA and AOA values from the cross-correlation values. Then, the coordinate transformation is performed using the position of the reference sensor. Then, the coordinate rotation is performed using the estimated AOA value for the transformed coordinates, and then the three-dimensional position of each emitter is estimated. The proposed method verifies its performance through computer simulation.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.6
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• pp.655-663
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• 2021

In this paper, DFT-Based channel estimation with channel response mirroring is proposed and analyzed. In General, pilot symbols for channel estimation in MIMO(Multi-Input Multi-Output) OFDM(Orthogonal Frequency-Division Multiplexing) Systems have a diamond shape in the time-frequency plane. An interpolation technique to estimate the channel response of sub-carriers between reference symbols is needed. Various interpolation techniques such as linear interpolation, low-pass filtering interpolation, cubic interpolation and DFT interpolation are employed to estimate the non-pilot sub-carriers. In this paper, we investigate the conventional DFT-based channel estimation for noise reduction and channel response interpolation. The conventional method has performance degradation by distortion called "edge effect" or "border effect". In order to mitigate the distortion, we propose an improved DFT-based channel estimation with channel response mirroring. This technique can efficiently mitigate the distortion caused by the DFT of channel response discontinuity. Simulation results show that the proposed method has better performance than the conventional DFT-based channel estimation in terms of MSE.

• Nuclear Engineering and Technology
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• v.55 no.12
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• pp.4367-4381
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• 2023

Nuclear power plants are increasingly being equipped with digital I&C systems. Although some probabilistic safety assessment (PSA) models for the digital I&C of nuclear power plants have been constructed, there is currently no specific internationally agreed guidance for their modeling. This paper presents an initiative by the OECD Nuclear Energy Agency called "Digital I&C PSA - Comparative application of DIGital I&C Modelling Approaches for PSA (DIGMAP)", which aimed to advance the field towards practical and defendable modeling principles. The task, carried out in 2017-2021, used a simplified description of a plant focusing on the digital I&C systems important to safety, for which the participating organizations independently developed their own PSA models. Through comparison of the PSA models, sensitivity analyses as well as observations throughout the whole activity, both qualitative and quantitative lessons were learned. These include insights on failure behavior of digital I&C systems, experience from models with different levels of abstraction, benefits from benchmarking as well as major contributors to the core damage frequency and those with minor effect. The study also highlighted the challenges with modeling of large common cause component groups and the difficulties associated with estimation of key software and common cause failure parameters.