• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.436-445
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• 2019

This study quantitatively evaluates the economic value of an intelligent crime-zero testbed by using the contingent valuation method (CVM), which is the most effective for non-market valuations in fields like crime prevention. To minimize hypothetical convenience and increase respondents' awareness regarding the actual situation, an analysis was conducted for Indukwon District, Anyang City, Gyeonggi-do, by using the intelligent crime prevention technologies and solutions being developed by the KICT Research Center. This analysis was aimed at providing a systematic basis for determining the feasibility of crime prevention-related public projects. As a result, the WTP of Anyang citizens in the intelligent crime prevention demonstration district was estimated to be 7,160 won. The analysis shows that the area of Gwanyang 2, where the test bed belongs, has a high economic value of KRW 660 million per year, and KRW 51.4 billion per year when expanded to Anyang City. This study is significant in that it provides the first domestic evaluation of the crime-zero testbed. In addition, it has academic and practical value for a future-oriented service model by using intelligent crime prevention technologies and solutions that can be applied in real life and to the crime-zero testbed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.2
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• pp.460-469
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• 2020

The purpose of this study was to examine the predictive factors for health promotion behaviors of older adults in rural areas. A theoretical substruction was constructed to test hypothetical models based on Pender's health promotion model. The data was collected from 199 older adults aged 65 years or older, who resided in G city, by using a structured questionnaire. The questionnaires contained items on individual characteristics, health literacy, self efficacy and health promoting behavior. The data was analyzed with a t-test, ANOVA, Pearson's correlation coefficients and hierarchical multiple regression analysis using SPSS 20.0 for Windows. The predictive factors for the health promotion behavior were the number of health information channels (β=.16, p=.031) and self efficacy (β=.53, p<.001). The total explanatory power of these factors was 30.8%. A nursing intervention plan for improving health promoting behaviors of older adults should be developed and applied, with a focus on self-efficacy and health information channels. Further longitudinal studies are needed to help confirm relevant measurement of the level of health promoting behaviors of older adults.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.799-805
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• 2016

Background: There is no standard treatment for patients with platinum-resistant or refractory epithelial ovarian cancer. Single agent chemotherapies have evidence of more efficacy and less toxicity than combination therapy. Most are very expensive, with appreciable toxicity and minimal survival. Since it is difficult to make comparison between outcomes, economic analysis of single-agent chemotherapy regimens and best supportive care may help to make decisions about an appropriate management for the affected patients. Objective: To evaluate the cost effectiveness of second-line chemotherapy compared with best supportive care for patients with platinum-resistant or refractory epithelial ovarian cancer. Materials and Methods: A Markov model was used to estimate the effectiveness and total costs associated with treatments. The hypothetical patient population comprised women aged 55 with platinum-resistant or refractory epithelial ovarian cancer. Four types of alternative treatment options were evaluated: 1) gemcitabine followed by BSC; 2) pegylated liposomal doxorubicin (PLD) followed by BSC; 3) gemcitabine followed by topotecan; and 4) PLD followed by topotecan. Baseline comparator of alternative treatments was BSC. Time horizon of the analysis was 2 years. Health care provider perspective and 3% discount rate were used to determine the costs of medical treatment in this study. Quality-adjusted life-years (QALY) were used to measure the treatment effectiveness. Treatment effectiveness data were derived from the literature. Costs were calculated from unit cost treatment of epithelial ovarian cancer patients at various stages of disease in King Chulalongkorn Memorial Hospital (KCMH) in the year 2011. Parameter uncertainty was tested in probabilistic sensitivity analysis by using Monte Carlo simulation. One-way sensitivity analysis was used to explore each variable's impact on the uncertainty of the results. Results: Approximated life expectancy of best supportive care was 0.182 years and its total cost was 26,862 Baht. All four alternative treatments increased life expectancy. Life expectancy of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 0.510, 0.513, 0.566, and 0.570 years, respectively. The total cost of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 113,000, 124,302, 139,788 and 151,135 Baht, respectively. PLD followed by topotecan had the highest expected quality-adjusted life-years but was the most expensive of all the above strategies. The incremental cost-effectiveness ratios (ICER) of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 344,643, 385,322, 385,856, and 420,299 Baht, respectively. Conclusions: All of the second-line chemotherapy strategies showed certain benefits due to an increased life-year gained compared with best supportive care. Moreover, gemcitabine as second-line chemotherapy followed by best supportive care in progressive disease case was likely to be more effective strategy with less cost from health care provider perspective. Gemcitabine was the most cost-effective treatment among all four alternative treatments. ICER is only an economic factor. Treatment decisions should be based on the patient benefit.

• Journal of Korean Society of Environmental Engineers
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• v.36 no.12
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• pp.821-827
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• 2014

The 4major river project has caused changes in flow and water quality patterns in major rivers in Korea including the Nakdong River where several toxicant release accidents have had occurred. Three dimensional hydrodynamic model, the Environmental Fluid Dynamics Code (EFDC), was applied to evaluate the effect of geomorphological change of the river on the advection and dispersion patterns of a conservative toxic pollutant. A hypothetical scenario was developed using historical data by assuming a toxic release from an upstream location. If there is a toxic release at the Gumi Industrial Complex, the toxic material would be detected after 2.22 and 9.83 days at Chilgok and Gangjung weir, respectively, in the new river system. It was estimated that they took at least 12 times longer than those with the river conditions before the project. Effect of relocation of intake towers for Daegu Metro City to upstream of Gumi City was also evaluated using the developed modeling system. It was observed that hydraulic residence time would be increased due to decreased flow rate and thus due to lowered water level. However, peak concentration differences were found to be about 2% lower in both places due to increased dispersion effect after the relocation.

• Journal of Digital Convergence
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• v.15 no.10
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• pp.579-588
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• 2017

The purpose of this study was to examine the effect of anxiety and depression on health-related QOL(Quality of Life) of middle aged women and to test hypothetical model of QOL. This study is a pathway analysis study using 1692 middle aged women whose age range is between 40 and 64. This study was performed as secondary analysis using the data from the 2015 Korean Social Psychological Anxiety Examination Survey. Data were analyzed using descriptive statistics, correlation analysis and pathway analysis. As a result, Stress, social support, aged preparation, self-esteem, anxiety, depression and QOL showed significant correlation. Anxiety was directly affected by stress(.21, p=.009) and social support(-.05, p=.046). Depression was directly affected by stress(.28, p=.016), social support(-.10, p=.008) and self-esteem(-.38, p=.039). Both anxiety(-.16, pp=.009) and depression(-.17, p=.011) had effect on QOL but depression was mediated by anxiety in affecting to QOL. Anxiety and depression of middle aged women affect to QOL and QOL is affected by depression via anxiety. It suggests that it needs to provide nursing intervention for mental health such as anxiety and depression for QOL of middle aged women.

• 전자공학회논문지 IE
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• v.49 no.2
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• pp.65-74
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• 2012

The purpose of this study is to verify the prediction of mastery-approach goal orientation, task value, and self-regulated learning strategy on academic satisfaction and achievement of cyber engineering university students. For this study, 219 engineering students of H cyber university who enrolled in the spring semester of 2011 was chosen and completed web surveys. A hypothetical model proposed included mastery-approach goal orientation, task value, and self-regulated learning strategy as predictors, and academic satisfaction and achievement as criteria variables. The results of this study through multiple regression analysis indicated that task value(${\beta}$=.401) and self-regulated learning strategy(${\beta}$=.401) predicted significantly on academic satisfaction. In addition, self-regulated learning strategy(${\beta}$=.301) and mastery-approach goal orientation(${\beta}$=.196) predicted significantly on academic achievement. The result of this study suggested that mastery-approach goal orientation, task value, and self-regulated learning strategy should be considered for improving academic satisfaction and achievement in cyber engineering education.

• Ecology and Resilient Infrastructure
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• v.7 no.3
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• pp.189-198
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• 2020

Wetlands, which provide various ecological services, have been regarded as an important nature-based solution for, for example, sustainable water quality improvement and buffering of impacts from climate change. Although the importance of conserving wetlands to reduce the impacts of various perturbations (e.g., changes of land use, climate, and hydrology) has been acknowledged, the possibility of applying these efforts as a nature-based solution in a macro-scale (e.g., landscape) has been insufficient. In this study, we examine the possibility of ecological network analysis that provides an engineering solution as a nature-based solution. Specifically, we analyzed how land use change affects the structural and functional characteristics (connectivity, network efficiency, and clustering coefficient) of the ecological networks by using the ecological networks generated by multiple dispersal models of the hypothetical inhabiting species in wetlandscape. Changes in ecological network characteristics were analyzed through simultaneously removing wetlands, with two initial conditions for surface area, in the zones where land use change occurs. We set a total number of four zones of land use change with different wetland densities. All analyses showed that mean degree and network efficiency were significantly reduced when wetlands in the zones with high wetland density were removed, and this phenomenon was intensified especially when zones contained hubs (nodes with high degree). On the other hand, we observed the clustering coefficient to increase. We suggest our approach for assessing the impacts of land use change on ecological networks, and with additional analysis on betweenness centrality, we expect it can provide a nature-based engineering solution for creating alternative wetlands.

• Biomedical Science Letters
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• v.11 no.2
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• pp.175-183
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• 2005

The two major isoflavones in soy, genistein and daidzein, are well known to prevent hormone-dependent cancers by their anti estrogenic activity. The exact molecular mechanisms for the protective action are, however, not provided yet. It has been reported that genistein and daidzein have a potential anticancer activity through their antiproliferative effect in many hormone-dependent cancer cell lines. Transforming growth $factor-\beta1(TGF-\beta1)$ has also been found to have cell growth inhibitory effect, especially in mammary epithelial cells. This knowledge led to a hypothetical mechanism that the soy isoflavones-induced growth inhibitory effect can be derived from the regulation of $TGF-\beta1$ and $TGF-\beta$ receptors. In order to test this hypothesis, the effects of the soy isoflavones at various concentrations and periods on the expression of $TGF-\beta1$and $TGF-\beta$ receptors were investigated by using Northern blot analysis in human breast carcinoma epithelial cell lines, an estrogen receptor positive cell line (MCF-7) and an estrogen receptor negative cell line (MDA-MB-231). As a result, only genistein has shown a profound dose-dependent effect on $TGF-\beta1$ expression in the $ER^+$ cell line within the range of doses tested, and the expression levels are correspondent to their inhibitory activities of cell growth. Moreover, daidzein showed down-regulated $TGF-\beta1$ expression at a low dose, the cell growth proliferation was promoted at the same condition. Therefore, antiproliferative activity of the soy isoflavones can be mediated by $TGF-\beta1$ expression, and the effects are mainly, if not all, occurred by ER dependent pathway. The expression of $TGF-\beta$ receptors was induced at a lower dose than the one for $TGF-{\beta}1$ induction regardless of the presence of ER, and the expression patterns are similar to those of the cell growth inhibition. These results indicated that the regulation of $TGF-\beta$ receptor expression as well, prior to $TGF-\beta1$ expression, may be involved in the antiproliferative activity of soy isoflavones. Little or no expression of $TGF-\beta$ receptors was found in the MCF-7 and MDA-MB-231 cells, suggesting refractory properties of the cells to growth inhibitory effect of the $TGF-\beta$. The soy isoflavones can seemingly restore the sensitivity of growth inhibitory responses to $TGF-\beta1$ by re-inducing $TGF-\beta$ receptors expression. In conclusions, our findings presented in this study show that the antitumorigenic activity of the soy isoflavones could be mediated by not only $TGF-\beta1$induction but $TGF-\beta$ receptor restoration. Thus, soy isoflavones could be good model molecules to develop new nonsteroidal antiestrogenic chemopreventive agents, associated with, regulation of $TGF-\beta$ and its receptors.

• Journal of Music and Human Behavior
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• v.12 no.1
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• pp.65-94
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• 2015

The number of theoretical orientations and approaches in music therapy has risen sharply. This development of new theories may contribute to the advancement of specific therapeutic techniques; however, it can also lead to increased confusion for consumers and professionals for clinical and practical reasons. Due to these concerns, therapists often debate questions such as the following: what is the most effective therapeutic approach, what is the most ethical and professional course of action when clients do not appear to benefit from therapy, and is it possible to integrate ideas and techniques from multiple frameworks and theories in order to better serve the client? This paper describes a new way of thinking for music therapists called Integral Thinking in Music Therapy (ITMT), proposed by Kenneth Bruscia as a comprehensive approach to addressing the clinical needs of the client. ITMT is a way of thinking that embraces existing models and theories, suggests when a particular approach is indicated with its own value, and helps us to move away from one-way thinking to a more comprehensive approach in order to better serve our clients. This article illustrates the basic premise and clinical application as well as a hypothetical application of ITMT based on an actual case study.

• Environmental and Resource Economics Review
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• v.13 no.3
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• pp.337-366
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• 2004

Contingent Valuation Method (CVM), as non-market valuation approach, has been criticized on that respondents may not realistically reflect their budget constraints in answering willingness to pay (WTP) for hypothetical CV questions. This paper empirically estimates the income calibration factor associated with CV responses through combining travel cost method and contingent valuation method in a utility-theoretic framework. The joint model of recreation demand function and contingent WTP function was applied to an important case study on the Man Kyoung River system, whose water quality is at issue because of the Sae Alan Kum reclamation project. Relevant economic variables such as price, income and water quality had significant influence as anticipated by the economic theory. Equally important, the income calibration factor was not significantly different from one, suggesting that the systematic discrepancies of CV responses relative to the actual behavior was not detected at least in terms of budget exaggeration. Overall, this study supports the notion that carefully designed CVM studies can provide informative data on individuals' willingness to pay for environmental quality changes.