• Journal of Korean Neurosurgical Society
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• v.29 no.12
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• pp.1657-1663
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• 2000

The authors report a case of a 72-year-old woman who presented with intraventricular and subarachnoid hemorrhage of Hunt and Hess grade IV after the rupture of a giant aneurysm arising from the right internal carotid artery. The aneurysm was clipped successfully with the aid of cardiopulmonary bypass(closed chest method), deep hypothermic circulatory arrest, and cerebral protection with barbiturate resulting in moderate disability. We discuss the usefulness and problems related to technique of circulatory arrest and cardiopulmonary bypass using closed chest method, and suggest the possible benefits of open chest method in elderly people and the importance of preoperative plan to coordinate anesthesia and operation.

• Korean Journal of Adult Nursing
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• v.20 no.1
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• pp.135-148
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• 2008

Purpose: This study compared the effects of forced air warming and radiant heating on body temperature and shivering of patients with postoperative hypothermia. Methods: The quasi-experimental study was conducted with two experimental groups who had surgery under general anesthesia; 20 patients of group 1 experimented with the Bair Hugger as a forced air warming and 20 patients of group 2 experimented with the Radiant heater. The study was performed from July 3 to August 31, 2006 in a recovery room of an university hospital in a city. The effects of the experiment were measured by postoperative body temperature and chilling score at arrival and after every 10 minutes. The data were analyzed by t-test or ${\chi}^2$-test, repeated measures ANCOVA using SPSS/WIN 12.0. Results: The mean body temperature showed differences between the Bair Hugger group and Radiant Heater group at 40 minutes(F=-2.579, p=.034), 50minutes(F=-2.752, p=.027), and 60 minutes(F=-2.470, p=.047) after arrival to the recovery room. So, hypothesis 1 was partially accepted. The mean score of shivering showed differences between the Bair Hugger group and the Radiant Heater group, but it had no significant meaning. Hypothesis 2 was not accepted. Conclusion: We need more study to explore the effects and side effects of heating modalities to select a more effective heat treatment. The efficiency of heat modalities with regards to cost benefit, time consumption, and patients' discomfort such as burns should be considered.

• The Journal of Korean Physical Therapy
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• v.10 no.2
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• pp.161-171
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• 1998

Balance can be defined as the ability to maintain the body's center of gravity within the base of support with minimal sway. Falls occur frequently in the elderly persons by the physiological change and dysfunction with age. Injuries resulting from falls include soft tissue damage and fractures of the radius, humerus, and femoral neck other consequences of falls include decreased mobility, reduced confidence, long lies (which can give rise to hypothermia, dehydration and pneumonia), and death Risk factors for falls have beau classified as intrinsic (those related to the individual) and extrinsic(those associated with environmental features), Intrinsic factors include decreased strength, visual deficits, vestibular dysfunction, and decreased vibratory sensation in the feet. Improvement of the balance related to the increased probability for fells in the elderly persons and is important for fall preventions and improvement of the living quality ef the elderly persons

• Biomolecules & Therapeutics
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• v.12 no.3
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• pp.175-178
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• 2004

Rutaecarpine is one of quinazolinocarboline alkaloids found in Evodia rutaecarpa, a Rutaceous plant and it has shown various biological effects including antiinflammation. However, the effect of rutaecarpine on nervous system was not reported yet. In this study we investigated the general pharmacology of rutaecalpine on the central nervous system. Rutaecapine (4O and 400 mg/kg) did not change chemoshock induced by pentylenetetrazole. However, oral administration of rutaecarpine altered motor coordination examined by rotarod test, pentobarbital-induced sleeping time and acetic acid-induced writhing syndrome in mice at the doses of 40 and 400 mg/kg. Rutaecarpine also induced hypothermia in mice at both doses. The results suggest that rutaecapine possesses neuromodulating activities on central nervous system in addition to the various biological effects on the Periphery.

• Korean Journal of Veterinary Service
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• v.26 no.2
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• pp.185-191
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• 2003

There was a mass outbreak of death caused by transport stress and malnutrition in Japanese macaques imported from Japan at a farm stock in Korea, which were diagnosed on the ground of history taking, clinical finding, hematological examination and necropsy. Twenty eight Japanese macaques imported from Japan died suddenly from the 4th day after arrival in a farm. These animals were confined very small cages individually and lose the appetite for 10 days from shipping. Main clinical findings observed from alive Japanese macaques consisted of hypothermia and dehydration. On hematological observation for typical 4 cases showed increased erythrocytes and packed cell volume. On serum biochemical examination for 3 cases showed hypoglycemia, whereas blood urea nitrogen, aspartate aminotransferase and alanine aminotransferase were increased. On necropsy for 3 cases, hemorrhage and congestion were observed on the lung and the walls of stomach and intestine were thinned. Histologically, hemorrhagic pneumonia and enteritis with loss of villi were seen. The death of these animal was caused by poor management during transport, which was resulted in transport stress and malnutrition.

• Journal of Chest Surgery
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• v.24 no.7
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• pp.669-673
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• 1991

Fructose-l, 6-diphosphate as an additive to cold crystalloid cardioplegia [St. Thomas sol.] was studied prospectively in 60 patients undergoing open heart surgery from January 1, 1991, to June 30, 1991. Thirty patients received cardioplegia with FDP[group I ] and 30 patients received cardioplegia without FDP [group II ]. There were no differences between two groups pre-operatively with regard to age, heart disease, cross-clamp time, cardiac enzymes, or hemodynamic measurements [p>0.05]. Cardiopulmonary bypass was established using ascending aorta and vena cava cannulation employing moderate systemic hypothermia [30oC nasopharyngeal temperature] and hemodilution All patients received cardioplegia through the aortic root at aortic root pressure of 80mm Hg. The composition of the cardioplegic solution and its delivery were identical in both groups except for the addition of FDP[1.5 mg/mL] in group I. The cardioplegic infusate consisted of St. Thomas Hospital solution. The initial dose was infused through the aortic root. Topical myocardial cooling with saline slush was employed in all patients. Recorded operative data were cardiopulmonary bypass and cross-clamp times, amount of cardioplegic infusate. Blood samples for assessment of lactate dehydrogenase [LDH], creatine kinase [CK] and transaminases [GOT, GPT] were obtained before and at 1,2,3,7th postoperative period. Better myocardial protection effect was noted in group I than group II with respect to the % change of cardiac enzymes, although the differences were not significant. We conclude that FDP is a safe additive to crystalloid cardioplegia and may be beneficial in open heart surgery patients.

• Journal of Chest Surgery
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• v.24 no.10
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• pp.951-959
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• 1991

The level of serum potassium concentration is very important aspect in postoperative cardiac patients The postoperative cardiac arrhythmia and digitalis intoxication are known to be closely related with hypokalemia and also to cause the irreversible cardiac dysfunction. In this study, the changes of the level in serum and urine concentrations during, after extracorporeal circulation[EGG], Predict and Postdict periods are analyzed and compared statistically with postoperative cardiac patients 46 persons according to divided 8 groups. 1. There was no difference significantly in concentrations of serum and urine potassium in each period according to age, sex and disease types. 2. There was no difference significantly in concentrations of serum and urine potassium in each period according to the use of normothermia and hypothermia. 3. There was no difference significantly in concentrations of serum and urine potassium in each period according to the length of extracorporeal circulation time and aortic cross clamping time. 4. There was no difference significantly in concentrations of serum and urine potassium in each period according to the amount of the infused cardioplegic solution and level of Hct.

• Journal of Chest Surgery
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• v.5 no.1
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• pp.29-34
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• 1972

Interventricular Septal Defect is probably the most common congenital cardiac lesion. Despite rapid technical advances and increasing surgical experience the risk of surgical intervention for correction of Ventricular Septal Defect in infants with pulmonary hypertension remains formidable. Since Sirak et al [1959] reported a succesful case of two stage approach to their surgical correction, it has led to a policy of primary palliation,followed by complete correction as a secondary procedure, after age 3 to 4 years. Most surgeon prefer to perform complete correction of Ventricular Septal Defect when body weight exceeds 30 Lbs. and before development of so-called Eisenmengers complex, for the good postoperative results. Authors report 2 cases of Ventricular Septal Defect with pulmonary hupertenslon, who was underwent pulmonary artery banding as a palliative procedure in the Department of Surgery,Severance Hospital Yonsei University. Case 1:4 year old male, initially a complete correction of Ventricular Septal Defect was attempted by the help of mild hypothermia and extracorporeal circulation. During the procedure of a construction of an extracorporeal by- pass, a sudden cardiac arrest developed. After resuscitation of the heart,pulmonary artery banding was performed as a palliation. On the first postoperative day the patient developed generalized tonic convulsion, cyanosis, vomiting and eventually shock. Patient discharged home after a full recovery. Case 2.: 9 month old female, the pulmonary artery constricted with Teflon patch successfully. After the patients first postoperative day several cyanotic spells developed followed by 3 cardiac arrests. This repeated until when she expired with respiratory failure.

• Journal of Chest Surgery
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• v.29 no.2
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• pp.219-222
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• 1996

A 34-year-old man was admitted to the hospital because of ascites, abdominal fullness. computed tomography and cavography revealed inferior vena cavil occlusion just above the hepatic vein and diagnosed as Budd-Chiari syndrome. conservative medical therapy failed to control the symptoms produced from both portal hypertension and versa caval stasis. Therefore, under extracorporeal circulation with moderate hypothermia and normal cardiac contraction, membranoto y and inferior vena casa venoplasty with Gore-tex (10mm) was performed. Postoperatively, physical examination revealed oral ulceration, subcutaneous thrombophlebitis, folliculitic lesions. uveitis And increased reactivity of the skin to needle punctures. 10 month later, superior vena ciiva obstruction symptom was found. Hehcet's disease was diagnosed.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.2 no.1
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• pp.7-11
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• 2002

Isovaleric acidemia is an inborn error in metabolism due to a defect in isovaleryl-CoA dehydrogenase. Accumulation of serum isovaleric acid causes poor feeding, vomiting, lethargy, hypothermia, convulsion, mental retardation, etc. It is inherited as an autosomal recessive trait. Since the first reports of isovaleric acidemia by Tanaka et al in 1966, more than 60 cases have been reported. There are two clinically different presentations of isovaleric acidemia, with about half the patients presenting with an acute severe neonatal form and about half with a chronic intermittent form. The difference in clinical presentation may not be a consequence of differing severities of the causative mutation, but a result of the timing of application of catabolic stress or the ability to form isovalerylglycine. We described here clinical and organic acid analytical findings of in 3 cases isovaleric acidemia.