• Bulletin of the Korean Chemical Society
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• v.32 no.8
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• pp.2593-2598
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• 2011

Polyphenols (PPs) are known as antioxidant compounds having benign biological activities. In this paper, a series of hybrid molecules between the free or acetyl protected polyphenol compounds were synthesized and their in vitro antioxidant activity (DPPH assay) and cholinesterase [acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] inhibition activities were evaluated. As expected, free phenolic hybrid compounds (6 and 8) showed better antioxidant activity than acetyl protected hybrid compounds (5 and 7) from DPPH assay. But the contrast result was obtained from BuChE inhibition assay. Acetyl protected hybrid compounds (5 and 7) showed better inhibition activity for BuChE than free phenolic hybrid compounds (6 and 8). Specifically, 10 (AcFA-AcFA) were shown as an effective inhibitor of BuChE ($IC_{50}=2.3{\pm}0.3{\mu}M$) and also had a great selectivity for BuChE over AChE (more than 170 fold). Inhibition kinetic studies with acetyl protected compounds (5, 7, 9, and 10) indicated that 5, 7 and 10 are a hyperbolic mixed-type inhibition and 10 is a competitive inhibition type. The binding affinity (Ki) value of 10 to BuChE is $2.32{\pm}0.15{\mu}M$.

• Journal of the Korean Geotechnical Society
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• v.30 no.4
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• pp.21-34
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• 2014

This paper studies the time-dependent behaviors of tunnel and surrounding ground due to tunnel deterioration. In the first part, the literature on deterioration characteristics of tunnels was reviewed. In the second part, a numerical analysis was performed to investigate the behavior of concrete lining on the typical section of Korean high-speed rail tunnel (weathered rock) after determination of input variables related to deterioration impact. The result shows that the settlement at the crown of tunnel and surface ground increased up to 7.0% and 30.2% of the total settlements during construction stage, respectively, and the internal convergence reduction of 9.0 mm for concrete linings was generated within 30 years after completion of tunnel construction. Also the loosening height increased up to 2.55 times of tunnel height within 50 years, which is higher than that of Terzaghi's recommendation on ultimate state. Due to this process of extending zones, it is found that additional loads were applied to concrete lining with the axial stress about 3.20~3.66 MPa, which accelerates tunnel deterioration. Finally the quantitative design approach to evaluate time-dependent behavior of lining and surrounding ground due to tunnel deterioration was proposed.

• Journal of the Korea Concrete Institute
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• v.21 no.6
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• pp.781-788
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• 2009

Mechanical properties of steel-concrete interface were evaluated on the basis of experimental observations. The properties included bond strength, unbounded and bonded friction angles, residual level of friction angle, mode I fracture energy, mode II bonded fracture energy and unbonded slip-friction energy under different levels of normal stress, and shape parameters to define geometrical shape of failure envelope. For this purpose, a typical type of constitutive model of describing steel-concrete interface behavior was presented based on a hyperbolic three-parameter Mohr-Coulomb type failure criterion. The constitutive model depicts the strong dependency of interface behavior on bonding condition of interface, bonded or unbounded. Values of the interface parameters were determined through interpretation of experimental results, geometry of failure envelope and sensitivity analysis. Nonlinear finite element analysis that incorporates steel-concrete interface as well as material nonlinearities of concrete and steel were performed to predict the experimental results.

• Journal of Korean Association for Spatial Structures
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• v.2 no.3 s.5
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• pp.81-92
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• 2002

The objective of this paper is to help to make decision of the appropriate structural types in long span structured building due to range of span. For the intention, based on 7 forces of structural element, it is analized the relationships among 6 configurations of structural element(d/1), 25 structural types, 4 materials, and span-length known with 186 sample from 1850 to 1996. 1) bending forces: $club(1/100{\sim}1/10),\;plate(1/100{\sim}1/10),\;rahmen(steel,\;10{\sim}24m)\;simple\;beam(PC,\;10{\sim}35m)$ 2) shearing forces: $shell(1/100{\sim}1/1000)\;hyperbolic\;paraboloids(RC,25{\sim}97m)$ 3) shearing+bending forces: plate, folded $plate(RC21{\sim}59m)$ 4) compression axial forces: club, $arch(RC,\;32{\sim}65m)$ 5) compression+tension forces: shell, braced dome $shell(RC,\;40{\sim}201m),\;vault\;shell(RC,\;16{\sim}103m)$ 6) compression+tension axial forces: $rod(1/1000{\sim}1/100)$, cable(below 1/1000)+rod, coble+rod+membrane(below 1/1000), planar $truss(steel,\;31{\sim}134m),\;arch\;truss(31{\sim}135m),\;horizontal\;spaceframe(29{\sim}10\;8m),\;portal\;frame(39{\sim}55m),\;domical\;space\;truss(44{\sim}222m),\;framed\;\;membrane(45{\sim}110m),\;hybrid\;\;membrane\;(42{\sim}256m)$ 7) tension forces: cable, membrane, $suspension(60{\sim}150m),\;cable\;\;beam(40{\sim}130m),\;tensile\;membrane(42{\sim}136m),\;cable\;-slayed(25{\sim}90m),\;suspension\;membrane(24{\sim}97m),\;single\;layer\;pneumatic\;structure(45{\sim}231m),\;double\;layer\;pneumatic\;structures(30{\sim}44m)$

• Journal of the Korean Geosynthetics Society
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• v.10 no.2
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• pp.21-28
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• 2011

Several theoretical soil nonlinear models to predict damping ratio, which is one of the typical dynamic properties of soils, it is impractical to predict damping ratio. The resonant column and torsional shear test(RC-TS) is used to represent the dynamic behavior of soils from intermediate to medium shear strains. A limitation of RC-TS is measure precise shear strain in large strains and the modified equivalent radius($R_{eq}$) was obtained using both modified hyperbolic model and Ramberg-Osgood model. Bonneville clays were tested using RC-TS test to obtain rotation and torque. The measured rotation and torque were then compared with calculated rotation and torque using curve-fitting method. Then, the nonlinear soil model parameters were obtained and the equivalent radius was calculated using the model parameters.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.57-64
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• 2005

Since the allowable bearing capacities of piles in weathered/fractured rock are mainly governed by settlement, the load-displacement behavior of the rock socketed pile should be well known. To predict pile head settlement at the design stage, the exact understanding of the load-transfer mechanisms is essential. Therefore, in this research, the load-transfer mechanisms of drilled shaft socketed into weathered rock was investigated. For that, 5 cast-in-place concrete piles with diameters of 1,000 mm were socketed into weathered gneiss. The static axial load tests and the load-transfer measurements were performed to examine the axial resistant behavior of the piles. A comprehensive field/laboratory testing program on weathered rock at the field test sites was also performed to describe the in situ rock mass conditions quantitatively. And then, the effect of rock mass condition on the load transfer mechanism was investigated. The side shear resistance of the pile in moderately weathered rock reached to yielding point at a few millimeter displacements, and after that, the rate of resistance increment dramatically decreased. However, that in the highly /completely weathered rock did not show the obvious yielding point, and gradually increased showing the hyperbolic pattern until with the relatively high displacement (>10 mm). The end bearing-displacement curves showed linear increase at least until with the base displacement of approximately 10 mm, regardless rock mass conditions.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.13 no.2
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• pp.11-20
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• 1993

Nonlinear inelastic behavior of an HP saddle shell has been examined by a finite element computer program developed on a Cray Y-MP. The mesh convergence is studied using three progressively refined finite element mesh models, $16{\times}16$, $32{\times}32$ and $64{\times}64$, for the elastic and inelastic analyses. It is shown that the $32{\times}32$ mesh model gives a solution that is very close to that given by the $64{\times}64$ mesh model, thus, showing a convergence. The inelastic analysis shows that the shell has a tremendous capacity to redistribute the stresses. At the ultimate, the concrete cracks and the reinforcement yieldings are spread out all over the shell, indicating that the stress distribution in the shell is approaching that given by the classical membrane theory. The present computer program provides a very useful tool for evaluating the nonlinear ultimate behavior of concrete shells during the design process.

• Journal of Preventive Medicine and Public Health
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• v.25 no.4 s.40
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• pp.333-342
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• 1992

The purpose of this study is to estimate the minimum optimal scale(MOS) of the self-employed health insurance associations. Considering the high proportion of operating expenses, the author have selected 254 regional health insurance associations eon the 1990 Finance Report of the self-employed health insurance programs. Both a quadratic function and a hyperbolic function were chosen for the analysis. The dependent variables are the average maintenance cost per insured person and per household, and the independent variables are the number of insured members and of household The minimum optimal scale was obtained from the differentiation of the quadratic function. Major findings are summarized as follows: 1. The M.O.S. was calculated as 166,174 members (27,442 households) for the rural self-employed health insurance associations and 258,462 members (75,446 households) for the urban. Providing that both the rural and urban health insurance associations would be integrated, the M.O.S. be found to become 231,687 members (68,101 households) 2. Compared with the optimal minimum scale, the magnitude of the current health insurance association found to be much smaller, less than half of the optimal scale. 3. In order to reduce the operating cost, it is necessary to enlarge the operational scale of self-employed health insurance associations.

• Geomechanics and Engineering
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• v.4 no.3
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• pp.173-190
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• 2012

With recent growing interests in the Performance-Based Seismic Design and Assessment Methodology, more realistic modeling of a structural system is deemed essential in analyzing, designing, and evaluating both newly constructed and existing buildings under seismic events. Consequently, a shallow foundation element becomes an essential constituent in the implementation of this seismic design and assessment methodology. In this paper, a contact interface fiber section element is presented for use in modeling soil-shallow foundation systems. The assumption of a rigid footing on a Winkler-based soil rests simply on the Euler-Bernoulli's hypothesis on sectional kinematics. Fiber section discretization is employed to represent the contact interface sectional response. The hyperbolic function provides an adequate means of representing the stress-deformation behavior of each soil fiber. The element is simple but efficient in representing salient features of the soil-shallow foundation system (sliding, settling, and rocking). Two experimental results from centrifuge-scale and full-scale cyclic loading tests on shallow foundations are used to illustrate the model characteristics and verify the accuracy of the model. Based on this comprehensive model validation, it is observed that the model performs quite satisfactorily. It resembles reasonably well the experimental results in terms of moment, shear, settlement, and rotation demands. The hysteretic behavior of moment-rotation responses and the rotation-settlement feature are also captured well by the model.

• Journal of the Society of Disaster Information
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• v.3 no.1
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• pp.37-53
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• 2007

Various difficult problems occur due to insufficient bearing capacity or excessive settlements when constructing roads or large complexes. Accurate predictions on the final settlement and consolidation time can help in choosing the ground improvement method and thus enables to save time and expense of the whole project. Asaoka's method is probably the most frequently used for settlement prediction which are based on Terzaghi's one dimensional consolidation theory. Empirical formulae such as Hyperbolic method and Hoshino's method are also often used. However, it is known that the settlement predicted by these methods do not match with the actual settlements. Furthermore these methods cannot be used at design stage when there is no measured data. To find an elaborate method in predicting settlement in embankments using various test results and actual settlement data from domestic sites, Back-Propagation Neural Network(BPNN) and Recurrent Neural Network(RNN) were employed and the most suitable model structures were obtained. Predicted settlement values by the developed models were compared with the measured values as well as numerical analysis results. Analysis of the results showed that RNN yielded more compatible predictions with actual data than BPNN and predictions using cone penetration resistance were closer to actual data than predictions using SPT results. Also, it was found that the developed method were very competitive with the numerical analysis considering the number of input data, complexity and effort in modelling. It is believed that RNN using cone penetration test results can make a highly efficient tool in predicting settlements if enough field data can be obtained.