• Journal of IKEEE
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• v.21 no.3
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• pp.309-319
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• 2017

The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor ($IC_{50}$) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology - Jadavpur University - India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.5 no.5
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• pp.442-446
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• 2004

Computer simulation of a swaging manufacturing process is presented in this paper. Commercially available software has been used to develop the simulation algorithm. Based on the experience gained from trial runs, simulation of a tube swaging process has been carried out. The material parameters "n" (strain hardening exponent) and "K" (plastic modulus) are obtained from actual tensile test measurements of the tube material. Two different geometries for the die and the tube have been used in this work and a comparison made. Numerical simulation of the swaging process has been performed using the commercially available HyperMesh(r) for pre-processing, LS-DYNA(r) for analysis and LS-TAURUS(r) for post-processing. Some of the results obtained from this study are compared with those available in the literature.

• Journal of Korean Association for Spatial Structures
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• v.20 no.2
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• pp.51-58
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• 2020

Recently, deep learning that is the most popular and effective class of machine learning algorithms is widely applied to various industrial areas. A number of research on various topics about structural engineering was performed by using artificial neural networks, such as structural design optimization, vibration control and system identification etc. When nonlinear semi-active structural control devices are applied to building structure, a lot of computational effort is required to predict dynamic structural responses of finite element method (FEM) model for development of control algorithm. To solve this problem, an artificial neural network model was developed in this study. Among various deep learning algorithms, a recurrent neural network (RNN) was used to make the time history response prediction model. An RNN can retain state from one iteration to the next by using its own output as input for the next step. An eleven-story building structure with semi-active tuned mass damper (TMD) was used as an example structure. The semi-active TMD was composed of magnetorheological damper. Five historical earthquakes and five artificial ground motions were used as ground excitations for training of an RNN model. Another artificial ground motion that was not used for training was used for verification of the developed RNN model. Parametric studies on various hyper-parameters including number of hidden layers, sequence length, number of LSTM cells, etc. After appropriate training iteration of the RNN model with proper hyper-parameters, the RNN model for prediction of seismic responses of the building structure with semi-active TMD was developed. The developed RNN model can effectively provide very accurate seismic responses compared to the FEM model.

• The KIPS Transactions:PartC
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• v.9C no.6
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• pp.865-874
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• 2002

HTTP (HyperText Transfer Protocol) is a transfer protocol used by the World Wide Web distributed hypermedia system to retrieve the objects. Because HTTP is a connection oriented protocol, it uses TCP (Transmission control Protocol) as a transport layer. But it is known that HTTP interacts with TCP badly. it is discussed about factors affecting the performance or HTTP over TCP, the transaction time obtained by the per-transaction TCP connections for HTTP access and the TCP slow-start overheads, and the transaction time for T-TCP (Transaction TCP) which is one or methods improving the performance or HTTP over TCP. Average waiting time and average turnaround time are important parameters to satisfy QoS (Quality of Service) of end users. Formulas for calculating two parameters are derived. Such formulas can be used for the environment in which each TCP or T-TCP transaction time is same or different. Some experiments and computational experiences indicate that the proposed formulas are well acted, can be applied to the environment which the extension of bandwidth is necessary, and time characteristics of T-TCP are superior to that of TCP. Also, the load distribution method of web server based on the combination of bandwidths is discussed to reduce average waiting time and average turnaround time.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.314-321
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• 2019

The Self-Adaptive Vision Correction Algorithm (SAVCA) developed in this study was suggested for improving usability by modifying four parameters (Modulation Transfer Function Rate, Astigmatic Rate, Astigmatic Factor and Compression Factor) except for Division Rate 1 and Division Rate 2 among six parameters in Vision Correction Algorithm (VCA). For verification, SAVCA was applied to two-dimensional mathematical benchmark functions (Six hump camel back / Easton and fenton) and 30-dimensional mathematical benchmark functions (Schwefel / Hyper sphere). It showed superior performance to other algorithms (Harmony Search, Water Cycle Algorithm, VCA, Genetic Algorithms with Floating-point representation, Shuffled Complex Evolution algorithm and Modified Shuffled Complex Evolution). Finally, SAVCA showed the best results in the engineering problem (speed reducer design). SAVCA, which has not been subjected to complicated parameter adjustment procedures, will be applicable in various fields.

• International Journal of Computer Science & Network Security
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• v.22 no.5
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• pp.294-302
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• 2022

Detection of fake news is a complex and a challenging task. Generation of fake news is very hard to stop, only steps to control its circulation may help in minimizing its impacts. Humans tend to believe in misleading false information. Researcher started with social media sites to categorize in terms of real or fake news. False information misleads any individual or an organization that may cause of big failure and any financial loss. Automatic system for detection of false information circulating on social media is an emerging area of research. It is gaining attention of both industry and academia since US presidential elections 2016. Fake news has negative and severe effects on individuals and organizations elongating its hostile effects on the society. Prediction of fake news in timely manner is important. This research focuses on detection of fake news spreaders. In this context, overall, 6 models are developed during this research, trained and tested with dataset of PAN 2020. Four approaches N-gram based; user statistics-based models are trained with different values of hyper parameters. Extensive grid search with cross validation is applied in each machine learning model. In N-gram based models, out of numerous machine learning models this research focused on better results yielding algorithms, assessed by deep reading of state-of-the-art related work in the field. For better accuracy, author aimed at developing models using Random Forest, Logistic Regression, SVM, and XGBoost. All four machine learning algorithms were trained with cross validated grid search hyper parameters. Advantages of this research over previous work is user statistics-based model and then ensemble learning model. Which were designed in a way to help classifying Twitter users as fake news spreader or not with highest reliability. User statistical model used 17 features, on the basis of which it categorized a Twitter user as malicious. New dataset based on predictions of machine learning models was constructed. And then Three techniques of simple mean, logistic regression and random forest in combination with ensemble model is applied. Logistic regression combined in ensemble model gave best training and testing results, achieving an accuracy of 72%.

• Fire Science and Engineering
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• v.26 no.2
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• pp.40-52
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• 2012

This paper presents the uncertainty analysis results of fire modeling input parameters for motor control center in switchgear room of nuclear power plants. FDS (Fire Dynamics simulator) 5.5 was used to simulate the fire scenario and Latin Hyper Cube Monte Carlo simulations were employed to generate random samples for FDS input parameters. The uncertainty analysis results of input parameters are compared with those of the model uncertainty analysis and sensitivity analysis approaches of NUREG-1934. The study results show that the input parameter uncertainty analysis approach may lead to more conservative results than the uncertainty analysis and sensitivity analysis methods of NUREG-1934.

• Journal of Korea Water Resources Association
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• v.55 no.10
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• pp.761-774
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• 2022

Accurate hydrologic prediction is essential to analyze the effects of drought, flood, and climate change on flow rates, water quality, and ecosystems. Disentangling the uncertainty of the hydrological model is one of the important issues in hydrology and water resources research. Hydrologic data assimilation (DA), a technique that updates the status or parameters of a hydrological model to produce the most likely estimates of the initial conditions of the model, is one of the ways to minimize uncertainty in hydrological simulations and improve predictive accuracy. In this study, the two ensemble-based sequential DA techniques, ensemble Kalman filter, and particle filter are comparatively analyzed for the daily discharge simulation at the Yongdam catchment using airGRdatassim. The results showed that the values of Kling-Gupta efficiency (KGE) were improved from 0.799 in the open loop simulation to 0.826 in the ensemble Kalman filter and to 0.933 in the particle filter. In addition, we analyzed the effects of hyper-parameters related to the data assimilation methods such as precipitation and potential evaporation forcing error parameters and selection of perturbed and updated states. For the case of forcing error conditions, the particle filter was superior to the ensemble in terms of the KGE index. The size of the optimal forcing noise was relatively smaller in the particle filter compared to the ensemble Kalman filter. In addition, with more state variables included in the updating step, performance of data assimilation improved, implicating that adequate selection of updating states can be considered as a hyper-parameter. The simulation experiments in this study implied that DA hyper-parameters needed to be carefully optimized to exploit the potential of DA methods.

• Communications for Statistical Applications and Methods
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• v.19 no.5
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• pp.705-720
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• 2012

In this paper, we introduce a hierarchical Bayesian model to simultaneously estimate the thresholds of each 6 cities. It was noted in the literature there was a dramatic increases in the number of deaths if the mean temperature passes a certain value (that we call a threshold). We estimate the difference of mortality before and after the threshold. For the hierarchical Bayesian analysis, some proper prior distribution of parameters and hyper-parameters are assumed. By combining the Gibbs and Metropolis-Hastings algorithm, we constructed a Markov chain Monte Carlo algorithm and the posterior inference was based on the posterior sample. The analysis shows that the estimates of the threshold are located at $25^{\circ}C{\sim}29^{\circ}C$ and the mortality around the threshold changes from -1% to 2~13%.

• Journal of Korea Foundry Society
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• v.28 no.1
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• pp.25-30
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• 2008

To develop a functionally graded microstructure of cylindrical liner, effect of centrifugal casting parameters such as pouring temperature of hyper-eutectic Al-Si alloy melt, mold pre-heating temperature, and rotational frequency of mold on distribution of primary Si particles across wall thickness were investigated. Segregation tendency of Si particles toward inner side of cylindrical liner increased as the increase of rotational frequency of mold, pouring temperature of melt and mold pre-heating temperature. Especially, distribution density of primary Si particles within 1.5 mm from inner surface of cylindrical liner was above 35% under the centrifugal casting condition of $750^{\circ}C$ melt pouring temperature, $300^{\circ}C$ mold pre-heating temperature, and 2500 rpm mold rotational frequency.