• The Journal of Korean Society for Radiation Therapy
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• v.30 no.1_2
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• pp.161-167
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• 2018

Purpose : This study evaluates the usefulness of the Modified Hybrid-VMAT scheme with consideration of background radiation when establishing a treatment plan for multiple bone metastatic cancer including multiple tumors on the same axis. Materials and Methods : The subjects of this study consisted of five patients with multiple bone metastatic cancer on the same axis. The planning target volume(PTV) prescription dose was 30 Gy, and the treatment plan was established using Ray Station(Ray station, 5.0.2.35, Sweden). In the treatment plan for each patient, two or more tumors were set as one isocenter. A volumetric modulated arc therapy(VMAT) plan, a hybrid VMAT(h) plan with no consideration of background radiation, and a modified hybrid VMAT(mh) with consideration of background radiation were established. Then, using each dose volume histogram(DVH), the PTV maximum dose($D_{max}$), mean dose($D_{mean}$), conformity index(CI), and homogeneity index(HI) were compared among the plans. In addition, the organ at risk(OAR) of each treatment site was evaluated, and the total MU(Monitor Unit) and treatment time were also analyzed. Results : The PTV $D_{max}$ values of VMAT, VMAT(h) and VMAT(mh) were 3188.33 cGy, 3526 cGy, and 3285.67 cGy, the $D_{mean}$ values were 3081 cGy, 3252 cGy, and 3094 cGy; the CI values were $1.35{\pm}0.19$, $1.43{\pm}0.12$, and $1.30{\pm}0.06$; the HI values were $1.06{\pm}0.01$, $1.14{\pm}0.06$, and $1.09{\pm}0.02$; and the VMAT(h) OAR value was increased 3 %, and VMAT(mh) OAR value was decreased 18 %, respectively. Furthermore, the mean MU values were 904.90, 911.73, and 1202.13, and the mean beam on times were $128.67{\pm}10.97$, $167.33{\pm}7.57$, and $190.33{\pm}4.51$ respectively. Conclusions : Applying Modified Hybrid-VMAT when treating multiple targets can prevent overdose by correcting the overlapping of doses. Furthermore, it is possible to establish a treatment plan that can protect surrounding normal organs more effectively while satisfying the inclusion of PTV dose. Long-term follow-up of many patients is necessary to confirm the clinical efficacy of Modified Hybrid-VMAT.

• BMB Reports
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• v.42 no.11
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• pp.737-742
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• 2009

Hypoxia-inducible factor-$1{\alpha}/{\beta}$ (HIF-$1{\alpha}/{\beta}$) is a heterodimeric transcriptional activator that mediates gene expression in response to hypoxia. HIF-$1{\alpha}$ has been noted as an effective therapeutic target for ischemic diseases such as myocardiac infarction, stroke and cancer. By using a yeast two-hybrid system and a random peptide library, we found a 16-mer peptide named F29 that directly interacts with the bHLH-PAS domain of HIF-$1{\alpha}$. We found that F29 facilitates the interaction of the HIF-$1{\alpha/\beta}$ heterodimer with its target DNA sequence, hypoxia-responsive element (HRE). The transient transfection of an F29-expressing plasmid increases the expression of both an HRE-driven luciferase gene and the endogenous HIF-1 target gene, vascular endothelial growth factor (VEGF). Taken together, we conclude that F29 increases the DNA-binding ability of HIF-$1{\alpha}$, leading to increased expression of its target gene VEGF. Our results suggest that F29 can be a lead compound that directly targets HIF-$1{\alpha}$ and increases its activity.

• The Journal of the Acoustical Society of Korea
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• v.22 no.7
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• pp.562-572
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• 2003

A matched-target model inversion method was developed for a passive sonar to estimate the position of moving targets. Based on the well known matched-field processing in underwater acoustics, the method finds target position by matching the measured target directions and frequencies with the corresponding values of the proposed target model. For the efficient and accurate estimations, the parameter searching was accomplished using a hybrid optimizing method, which first starts with a global optimization such as generic algorithm or simulated annealing then applies a local optimization of a simple down hill algorithm. The suggested method was testified using simulations for three different moving scenarios. The simulation results showed that the method is robust in convergence, even under the situation of over 5 times standard deviation of Gaussian distribution of measured error, and is practical in calculation time as well.

• Journal of the Korea Fashion and Costume Design Association
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• v.13 no.1
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• pp.47-57
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• 2011

As the development of denim products using new differentiated materials plays an important role regardless of their target age groups, there is an increasing need for the development of premium denim designs for senior women using various materials. As part of the strategy to develop such a design for the senior generation, a market survey was performed regarding commercially available premium denim products in the market, and the current trends in the denim market were researched and analyzed to make use of the results in design development. In addition, a differentiated material, hybrid yarn using conjugated dyeing (HYCD) was applied to use several washing techniques capable of highlighting the unique features of denim clothing. The design of four items including a jacket, vest, capri pants and long pants were suggested. These items were differentiated from other products by emphasizing their details such as stitching and pockets. In light of the current consumer trend to select denim jeans on the basis of their fashion-ability (e.g., silhouette or color) rather than practicality or price, it is considered meaningful to develop high value added, premium jean products for the senior generation using diverse materials and details. At the same time, performing further studies designed to demonstrate the stability and reliability of the developed products through consumers' comparative assessment is required.

• Journal of the Korean institute of surface engineering
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• v.46 no.6
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• pp.242-247
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• 2013

Zr-Al-N coatings were synthesized by the hybrid coating system combining arc ion plating and DC magnetron sputtering from a Zr and an Al target in argon-nitrogen atmosphere, respectively. By changing the power applied on the Al cathodes, the Zr-Al-N coatings with various Al contents were deposited. The microstructure and chemical compositions of the Zr-Al-N coatings were studied by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM). With increasing of Al content in the coatings, the solid solution (Zr, Al)N crystallites were observed in the Zr-Al-N coatings. The nanohardness of the Zr-Al-N coatings exhibited a maximum value of 42 GPa for the Zr-Al (7.9 at.%)-N, and decreased with further increase in Al content in the coatings. The oxidation and corrosion behavior of the Zr-Al-N coatings revealed better properties compared than those of ZrN coatings due to the formation of a solid solution.

• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.12 no.1
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• pp.7-16
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• 2016

This paper presents the measurement and analysis results for the cooling performance of ground-coupled heat pump (GCHP) system using a cooling tower as a supplemental heat rejector. In order to demonstrate the performance of the hybrid approach, we installed the monitoring equipments including sensors for measuring temperature and power consumption, and measured operation parameters from May 1 to October 30, 2014. The results showed that the entering source temperature of brine returning from the ground heat exchanger was in a range of design target temperature. Leaving load temperatures to building showed an average value of $11.4^{\circ}C$ for cooling season. From the analysis, the daily performance factor (PF) of geothermal heat pumps ranged from 4.4 to 5.2, while the daily PF of hybrid GCHP system varied from 3.0 to 4.0 over the entire cooling season.

• IE interfaces
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• v.23 no.2
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• pp.147-155
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• 2010

Reliability allocation is defined as a problem of determination of the reliability for subsystems and components to achieve target system reliability. The determination of both optimal component reliability and the number of component redundancy allowing mixed components to maximize the system reliability under resource constraints is called reliability-redundancy allocation problem(RAP). The main objective of this study is to suggest a mathematical programming model and a hybrid parallel genetic algorithm(HPGA) for reliability-redundancy allocation problem that decides both optimal component reliability and the number of component redundancy to maximize the system reliability under cost and weight constraints. The global optimal solutions of each example are obtained by using CPLEX 11.1. The component structure, reliability, cost, and weight were computed by using HPGA and compared the results of existing metaheuristic such as Genetic Algoritm(GA), Tabu Search(TS), Ant Colony Optimization(ACO), Immune Algorithm(IA) and also evaluated performance of HPGA. The result of suggested algorithm gives the same or better solutions when compared with existing algorithms, because the suggested algorithm could paratactically evolved by operating several sub-populations and improve solution through swap, 2-opt, and interchange processes. In order to calculate the improvement of reliability for existing studies and suggested algorithm, a maximum possible improvement(MPI) was applied in this study.

• Journal of Advanced Marine Engineering and Technology
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• v.32 no.2
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• pp.284-291
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• 2008

This study presents an aerodynamic design and numerical analysis of a centrifugal compressor in gas turbines for SOFC-gas turbine hybrid system application. Total-to-total pressure ratio of the compressor is 3.6:1 that could be used widely for small and large SOFC-gas turbine systems. The compressor consists of a centrifugal impeller and a wedge diffuser. Conceptual design and aerodynamic design with mean line analysis and quasi-3D analysis are performed, and aerodynamic parameters as well as design variables are discussed from the design results. A numerical analysis based on the Reynolds-averaged Navier-Stokes equation was performed for the flow analysis of the compressor. The results show that the centrifugal compressor designed meets the design target, and the aerodynamic parameters and results of the compressor can be used for the aerodynamic design of centrifugal compressors and the feasibility study of SOFC-gas turbine system design.

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.3
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• pp.349-356
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• 2004

The automatic recognition of transport containers using image processing is very hard because of the irregular size and position of identifiers, diverse colors of background and identifiers, and the impaired shapes of identifiers caused by container damages and the bent surface of container, etc. In this paper we propose and evaluate a novel recognition algorithm for container identifiers that effectively overcomes these difficulties and recognizes identifiers from container images captured in various environments. The proposed algorithm, first, extracts the area containing only the identifiers from container images by using CANNY masking and bi-directional histogram method. The extracted identifier area is binarized by the fuzzy binarization method newly proposed in this paper. Then a contour tracking method is applied to the binarized area in order to extract the container identifiers which are the target for recognition. In this paper we also propose and apply a novel ART2-based hybrid network for recognition of container identifiers. The results of experiment for performance evaluation on the real container images showed that the proposed algorithm performs better for extraction and recognition of container identifiers compared to conventional algorithms.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11b
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• pp.140-143
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• 2005

The hybrid CAE/CAT methods are widely applied to product development in various fields because this method can predict the response of the whole system when a part of the system is changed. Especially, the hybrid CAE/CAT method is very useful to predict tile vehicle NVH characteristics after changing some parts of the vehicle. Target parts can be established on the basis of test models and FE models of the prototype constructed in the planning stage of car development. In this study, the topic was focused on the proper test-based FBS application process to predict vehicle NVH characteristic. First, the test-based FBS method was apply to vehicle substructure and car-body. And then the test-based model was replaced with FE model to apply hybrid CAE/CAT method. The replaced FE model was modified through the optimization process. The interior noise in vehicle during the drive was predicted with Modified FE model, then the predicted results were verified by experimenting with actual modified model.