• ETRI Journal
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• 제45권6호
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• pp.939-951
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• 2023

It is critical to estimate the location using only Long-Term Evolution (LTE) and Wi-Fi information gathered by the user's smartphone and deployable for emergency rescue, regardless of whether the Global Positioning System is received. In this research, we used a vehicle to gather LTE and Wi-Fi wireless signals over a large area for an extended period of time. After that, we used the learning technique to create a positioning database that included both collection and noncollection points. We presented a two-step positioning algorithm that utilizes coarse localization to discover a rough location in a wide area rapidly and fine localization to estimate a particular location based on the coarse position. We confirmed our technology utilizing different sorts of devices in four regional types that are generally encountered: dense urban, urban, suburban, and rural. Results presented that our algorithm can satisfactorily achieve the target accuracy necessary in emergency rescue circumstances.

• 한국의학물리학회지:의학물리
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• 제22권4호
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• pp.206-215
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• 2011

다엽콜리메이터, 겐트리회전, 선량율 등에서 형성되는 플루언스 맵을 이용하여 환자 맞춤형 치료 선량검증이 가능한지 알아보았다. 플루언스 맵은 2D 배열 검출기로 측정하였고, 동일 치료계획을 팬톰 내에서 이온전리함, 필름, 유리선량계 등을 이용하여 측정 비교하였다. 목표점에서 체적감마인자(volume gamma index, 3%, 3 mm)기준에 통과율은 $85.22%{\pm}1.7$(RT_target), $89.96%{\pm}2.15$였고, G4는 $95.14%{\pm}1.18$이었다. 선량 전달 오차는 선량이 급격히 변화는 영역(G1, G2, G3)과 주요장기(G4)에서 각각 $11.72%{\pm}0.531$, $-11.47%{\pm}0.991$, $7.81%{\pm}0.857$, $-4.14%{\pm}0.761$이었다. 이온전리함 측정값의 상대오차는 각각 평균 $-1.02%{\pm}0.222$ (Rt_target), $0.96%{\pm}0.294$ (Lt_target)이었다. 필름의 감마인자(3%, 3 mm) 기준 평균 통과율은 $92.59%{\pm}3.312$이었다. 유리선량계 상대 오차는 8.3% (G1), -5.4% (G2), 7.2% (G3), 6.1% (G4)이었다. 체적변조회전방사선 치료(VMAT)시 실시간 플루언스 맵 측정을 통한 실시간 환자 맞춤형 선량 검증이 가능할 것으로 사료되었다.

• KIEE International Transactions on Electrophysics and Applications
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• 제4C권4호
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• pp.145-148
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• 2004

In this study, a DNA chip with a microelectrode array was fabricated using microfabrication technology. Several probe DNAs consisting of mercaptohexyl moiety at their 5' end were immobilized on the gold electrodes by a DNA arrayer. Then target DNAs were hybridized and reacted with Hoechst 33258, which is a DNA minor groove binder and electrochemically active dye. Linear sweep voltammetry or cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. It was derived from Hoechst 33258 and concentrated at the electrode surface through association with the formed hybrid. This suggested that this DNA chip could recognize the sequence specific genes.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 C
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• pp.2125-2127
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• 2004

In this paper, a DNA chip with a microelectrode array was fabricated using microfabrication technology. Several probe DNAs consisting of mercaptohexyl moiety at their 5 end were immobilized on the gold electrodes by DNA arrayer. Then target DNAs were hybridized and reacted with Hoechst 33258, which is a DNA minor groove binder and electrochemically active dye. Linear sweep voltammetry or cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. It was derived from Hoechst 33258 concentrated at the electrode surface through association with formed hybrid. It suggested that this DNA chip could recognize the sequence specific genes.

• 말소리와 음성과학
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• 제4권3호
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• pp.111-117
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• 2012

In this paper, we compare the performance of several speaker adaptation methods for a HMM-based Korean speech synthesis system with small amounts of adaptation data. According to objective and subjective evaluations, a hybrid method of constrained structural maximum a posteriori linear regression (CSMAPLR) and maximum a posteriori (MAP) adaptation shows better performance than other methods, when only five minutes of adaptation data are available for the target speaker. During the objective evaluation, we find that the duration models are insufficiently adapted to the target speaker as the spectral envelope and pitch models. To alleviate the problem, we propose the duration rectification method and the duration interpolation method. Both the objective and subjective evaluations reveal that the incorporation of the proposed two methods into the conventional speaker adaptation method is effective in improving the performance of the duration model adaptation.

• BMB Reports
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• 제43권11호
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• pp.711-719
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• 2010

Kinomics is an emerging and promising approach for deciphering kinomes. Chemical kinomics is a discipline of chemical genomics that is also referred to as "chemogenomics", which is derived from chemistry and biology. Chemical kinomics has become a powerful approach to decipher complicated phosphorylation-based cellular signaling networks with the aid of small molecules that modulate kinase functions. Moreover, chemical kinomics has played a pivotal role in the field of kinase drug discovery as it enables identification of new molecular targets of small molecule kinase modulators and/or exploitation of novel functions of known kinases and has also provided novel chemical entities as hit/lead compounds. In this short review, contemporary chemical kinomics technologies such as activity-based protein profiling, T7 kinasetagged phages, kinobeads, three-hybrid systems, fluorescenttagged kinase binding assays, and chemical genomic profiling are discussed along with a novel allosteric Bcr-Abl kinase inhibitor (GNF-2/GNF-5) as a successful application of chemical kinomics approaches.

• 전기의세계
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• 제26권1호
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• pp.87-90
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• 1977

Various simulation techniques were developed in the modeling of biological system during the last decades. Mostly analog and hybrid simulation techniques have been used. The authors chose the Digital Analog Simulation (DAS) technique by using the MIMIC language to simulate the saccadic eye movement system performances on the digital computer. There have been various models presented by many investigators after Young & Stark's sampled-data model. The eye movement model chosen by the authors is Robinson's model III which shows the parallel information processing characteristics clearly to the double-step input stimuli. In the process of simulation, the parameter and constants used were based on the neurophysiological data of the human and animals. The analog model blocks were converted to the corresponding MIMIC block diagrams and programmed into the MIMIC statements. The program was run on the CDC Cyber 72-14 computer. The essential input stimulus was double-step of 5 and 10 degrees, and target durations chosen were 50,100 and 150 msec. The results obtained by the DAS technqiue were in good agreement with analog simulation carried out by other investigators as well as with the experimental human saccadic eye movement responses to double-step target movements.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 영호남 합동 학술대회 및 춘계학술대회 논문집 센서 박막 기술교육
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• pp.65-70
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• 2006

In this study, a DNA chip with a microelectrode array was fabricated using microfabrication technology. Several probe DNAs consisting of mercaptohexyl moiety at their 5 end were immobilized on the gold electrodes by DNA arrayer. Then target DNAs were hybridized and reacted with Hoechst 33258, which is a DNA minor groove binder and electrochemically active dye. Linear sweep voltammetry or cyclic voltammetry showed a difference between target DNA and control DNA in the anodic peak current values. It was derived from Hoechst 33258 concentrated at the electrode surface through association with formed hybrid. It suggested that this DNA chip could recognize the sequence specific genes.

• 설비공학논문집
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• 제16권2호
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• pp.111-120
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• 2004

The optimal design method of indoor thermal environment using CFD coupled simulation and genetic algorithms (GA) is developed in this study. CFD could analyze the thermal environment considering the distribution of temperature, velocity, etc. in a room. Therefore, It would be appropriate to use CFD for the optimal design method considering their distribution. In this paper, the optimal design means the most appropriate boundary conditions of the room among the conditions where the design target of indoor therm environment is achieved. Two step optimal indoor thermal environment design method is proposed. It includes the GA for searching the optimal indoor thermal environment design. To examine the performance of this method, the optimal design of hybrid ventilation system, which uses the natural cross ventilation and the radiation-cooling panel is conducted. The optimal design which satisfies the design target (thermal comfort, minimum cooling load, minimum vertical temperature difference) is found using two step optimal design method.

• 시스템엔지니어링학술지
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• 제1권1호
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• pp.67-72
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• 2005

Design and optimization study has been performed to obtain a supersonic air.launching mission for the nanosat launcher. Given mission is to launch 10kg payload to target orbit of $700km{\times}700km$. Additional design constraints are imposed by the mother plane. After the required velocity is obtained, the stag ing optimization is carried out. Serial analyses for the propulsion system and aerodynamics are performed then, the rocket trajectory optimization has been carried out. After several mission design and optimization iterations, the optimized mission which satisfies the mission target is obtained. Total weight of the three-staged air-launching rocket is 1231.4kg and the payload weight is 10 kg.