• Korean Journal of Oriental Medicine
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• v.13 no.1 s.19
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• pp.29-35
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• 2007

As epidemics were spread over the whole Pyeongan province at 1524, Jungjong commanded the government officers like Kim Sunmong to publish Sokbyeokonbang, known as Ganuibyeokonbang, to cope with the epidemics. They regarded the cause of epidemics as abnormal climate, pathogen or grudge, and named the disease on the basis of cause. To prevent epidemics they presented three kinds of method. They used a charm to calm the people, used Sohaphyangwon to keep from getting infected with them and emphasized the importance of individaul sanitation. They proposed compound herb remedies like Sipsintang, Hyangsosan, Seungmagalgeuntang and so forth according to the symptoms. They presented lots of single herbs used for food or easily seeking herbs to lighten the people's expense, in addition.

• Journal of Society of Preventive Korean Medicine
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• v.12 no.2
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• pp.145-157
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• 2008

There were many books on infectious disease prevention act, and still remained 5 books including Ganuibyeokonbang. Epidemics were seriously ill and widely contagious, so it was important to prevent them. Therefore, they wrote various preventive measures from epidemics on those books. They emphasized medication, and used not only compound prescriptions but also singular ones. They wrote 5 compound prescriptions including Sohaphyangwon and many singular ones on Ganuibyeokonbang, and they used folk medicine such as red-beans준 for practical use on that book. On Sinchanbyeokonbang, they emphasized Hyangsosan and presented many prescriptions to specialize in epidemics. Heojun presented various prescriptions for Dangdokyeok on Byeokyeoksinbang, and he excluded incantation methods to cope with epidemics medically. Since Ganuibyeokonbang they had tried to improve personal hygiene such as boiling clothes of patients.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1285-1290
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• 2004

From a view point of Hyungsang medicine a study is made on depressive syndromes through 'Donguibogam(東醫寶鑑)' ,'Clinical lectures by Mr. Jeesan(芝山先生 臨床學特講)' and other literature. Depressed energy(?) originally meant the disorder of vital energy in the circulation of nature with the lapse of time. In later, it has been changed to mean the disease of man, especially related to the mind. Depressive syndromes come from the stagnation of the Ki or the abnormal circulation(rising, falling, coming and going), which happens when man cannot adjust oneself to the circumstances due to the disharmony between internal and external conditions. Depressive syndrome easily attacks the following types of persons; Dam type person with excessive Ki and deficient Hyung(形), manly woman, womanly man, Bird type person who shows a great variety of emotion, Turtle type person declined to melancholy, Ki type person apt to be depressive, and Shin type person with upward gush of the fire. It also attacks the persons who have smudgy face with the scar between eyebrows, those whose pulses are mixture of two different kinds and those whose pulses extend on two ranges in Jeesan's diagram. Depressive syndromes recorded in 'Donguibogam' are globus hystericus, chest congestion, gastric discomfort, cough and asthma caused by depressed Ki, abdominal mass, edema, and tympanites. The most effective prescriptions for depressive syndromes are Eajintang(二陳湯), Guibitang(歸脾湯), Hyangsosan(香蘇散), and Gamisachiltang(加味四七湯).

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.77-86
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• 2011

This paper aims to find out the unique Oriental Medical characteristics of the prescription Gami-Bojeongsan(加味普正散), which can only be found in "Cheong-gang Euigam(晴崗醫鑑)" and the records of diagnosis by Kim Yeong Hoon. First, clues regarding Gami-Bojeongsan (加味普正散) in "Cheong-gang Euigam(晴崗醫鑑)" and the records of diagnosis by Kim Yeong Hoon have been collected, and then the origin of Gami-Bojeongsan(加味普正散) has been studied. Moreover, changes of prescriptions for common cold in East Asian Medicine have been looked into from historical perspective, and their connection to Gami-Bojeongsan(加味普正散) has also been researched. Lastly, connection of prescriptions for common cold found in royal records of the Chosun Dynasty to Gami-Bojeongsan(加味普正散) has been confirmed. The results are as follow: 1) Gami-Bojeongsan(加味普正散) is a most frequently used prescription in the records of diagnosis by Kim Yeong Hoon, and was used mostly in winter. It includes various modified versions. 2) Prescriptions that adopt Cyperi Rhizoma(香附子) as the sovereign medicinal, such as Gami-Bojeongsan(加味普正散), include Hyangsosan(香蘇散) of "Hejijufang(和劑局方)" and Hyang-gal-tang (香葛湯) of "Dexiaofang(得效方)". Hyang-gal-tang(香葛湯) is thought to have adopted Korean characteristics through "Dong-Eui-Bo-Gam (東醫寶鑑)" and "Je-Jung-Shin-Pyeon(濟衆新編)", and have continued its existence until it reached Gami-Bojeongsan(加味普正散). 3) These characteristics can be found in the royal records of the Chosun Dynasty, and also in Shin-Su-Tae-Eul-San(神授太乙散) of "Euibang-Yuchui (醫方類聚)".

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.1
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• pp.41-51
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• 2007

목적 : OVA에 유도된 천식 쥐 모델에 향소산가미방을 투여한 후 $PPAR{\gamma}$의 변화를 조사하여 향소산가미방의 천식 치료 기전을 알아보고자 하였다. 대상 및 방법 : 8주된 암컷 BALB/c 마우스에 첫 날과 14일 후에 20 ${\mu}g$의 OVA를 알루미니윰 하이드록사이드 1mg과 혼합한 후 총 200 ${\mu}g$를 복강 내로 주입하여 감작시켰다. 처음 감작시킨 날로부터 21,22,23일 후에 천식 모델에 사용하는 초음파 분무기를 이용하여 세 번째 감작시켜서 천식 마우스 모델을 만들었다. 천식 마우스 모델을 만드는 기간 중 OVA를 복강 내로 주입한 후 19일째에 24시간의 간격으로 향소산가미방을 7일 동안 경구 투여하여 향소산가미방의 효과를 조사하였다. 기관지폐포세척술은 마지막 감작 후 72시간 후에 실행하고 기관지폐포 세척액의 총 세포수를 측정하였다. $PPAR{\gamma}$의 발현은 천식 마우스 모델의 폐와 향소산가미방을 투여한 마우스 모델의 폐를 적출한 후 Western blotting 방법을 아용하여 측정하였다. 병리 조직학적 검사는 hematoxylin 2 and eosin-Y 염색을 이용하여 조사하였다. 결과 : 정상 군과 비교하여 OVA감작 천식 쥐 모델에서는 72시간 후에 총 세포 수가 증가하였다. 특히 OVA감작 천식 군에서 증가된 호산구의 수가 향소산가미방을 투여 한 쥐 군에서는 유의하게 감소하였다. OVA감작 천식 쥐 모델에서 72시간 후에 정상 군과 비교하여 핵 내에서의 $PPAR{\gamma}$단백질의 발현이 약간 증가하였다. 그러나 향소산가미방을 투여한 쥐 모델에서는 세포질과 핵 내에서 $PPAR{\gamma}$단백질의 발현이 유의하게 증가하였다. 조직학적 검사상 정상 군과 비교하여 OVA 감작된 천식 쥐 모델에서는 폐포, 세기관지, 기도내강 주변에 많은 염증 세포들이 있었다. 그러나 가미향소산 을 투여 한 후에는 염증 세포들이 유의하게 감소하였다. 결론 : 가미향소산은 $PPAR{\gamma}$작용제로서 역할을 하며, 천식에 대한 치료제 또는 예방제를 개발하는 데 후보 물질이 될 것으로 사료된다.

• Herbal Formula Science
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• v.12 no.1
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• pp.1-27
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• 2004

The following are the conclusions obtained by the philological study of the prescriptions introduced in Dongeuybogam such as Pyungwuisan, Pyungwuisan-added prescriptions, Pyungwuisan blended prescriptions: 1. Pyungwuisan and drugs based on Pyungwuisan were prescribed for stomach diseases, food poisoning, indigestion, impaired spleen, symptoms developed by dampness, diseases caused by changing water, diarrhea, edema, malignant malaria, an intestinal convulsion, blood in excrement, malaria, abortion, sparrow eye. 2. Dual prescriptions using Pyungwuisan and other independent prescriptions were applied to internal diseases concerning digestion, diarrhea and dysentery, abscess, intestinal swelling jaundice, symptoms developed by dampness, malaria, vomit, etc. 3. Etiological factors and diseases for which Pyungwuisan and medicines based on Pyungwuisan, dual prescriptions using Pyungwuisan were prescribed, were surveyed to include indigestion, weak spleen and stomach, drying dampness of spleen and stomach, dysfunctioning gall bladder, infection, damaged internals, external sensitiveness and internal damage, hypochondria, chilliness due to lack of chi. 4. A prescription for each disease needed specially added medicines to Pyungwuisan as the following: 1) For indigestion and dyspepsia, Pyungwuisan were prescribed with optional addition of Hoisaengsan, Sagunjatang, Ryukgunjatang, Ijintang, Sosihotang, etc., according to the symptoms, and were most frequently used with aromatic and digestive medicines such as mawwa medivata fermentata, malt, natgrass galingale rhizome, vilous amomum fruit, aucklandia root, round cardamom seed etc. 2) For diseases originated from damage by coldness, Pyungwuisan was taken with suitable amount of Jichulhwan, Hyangsosan, Hyangyusan, according to the symptoms. 3) For diarrhea and dysentery, Pyungwuisan were prescribed with the recipes of Oryeongsan, Sambaektang, Ijintang. 4) For jaundice, prescriptions always included natgrass galingale rhizome in the recipe of Pyungwuisan. 5) For malaria, mostly added prescriptions to Pyungwuisan were Sagunjatang, Ryukgunjatang, Ijintang, with usual addition of antifebrile dichroa root, tsaoko, green tangerine orange peel. 6) Pyungwuisan was prescribed with Hoisaengsan for vomit, with Oryeongsan for edema, and with kinds of Ueolgukhwan for hypochondria.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.2
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• pp.252-260
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• 2002

Introduction Urticaria is widely spread disease. About 15-20 $\%$ of population has experienced at least once in a life time. The etiology of urticaria is uncertain till now, and the affcting factors are various chemical material, physical factors, alcohol, fever, exercise, and hormone, etc. The symptoms of urticaria are small or large wheal-erythema reaction and itching or tingling sense. Cause there is no probe to detect the urticaria clearly, the treatment of urticaria is symptomatic. And mostly urticaria can be chronic and very hard to treat it fundamentally. Nowadays, many trials to treat the urticaria in oriental medical way show good curability. In this paper I'd like to report the treatment rate and degree of urticaria patients mostly using anti-histamine medication. Subjects From the outpatients who visited Korean Hospital of Kyunghee Kangnam during 2000-4 and 2002-1, the 36 chronic urticaria patients, at least more than 4 weeks from onset and 2weeks of treatment period, were chosen. Methods I evaluated the results of treatment with the following scale. Very Good: The all symptoms are clearly disappeared or one third of symptoms remain and sometimes eruption is appeared. Good: Half of the symptoms are improved but most of symptoms remain. No Change: No change appears before and after treatment. Worse: The degree and duration of eruption get worse than pre-treatment state. Results For Acupuncture treatment, I chose the several Acu points like Hapgok(합곡), Taichung(대충), Gokji(곡지), Yanggok(양곡), Yanggea(양계), and lmeup(족임읍), and usually lasted it 15 minutes. With the acupuncture treatment and herb medicine, 2-3 times a week, the patients whose treatment period was 2 to 4 weeks were 17(47.2$\%$), 4 to 8 weeks were 11(30.5$\%$), 8 to 12 weeks were 3(8.3$\%$), 12 to 16 weeks were 3(8.3$\%$), longer than 16 weeks were 2(5.5$\%$) Collecting the statistics of the frequency of prescripted herb medicine, Hyangsosan(향소산) was prescripted 21 times(58.3$\%$), Hyangsapyungwisan(향사평위산) was 15 times(41.6$\%$), Hwapisan(화피산) was 9 times(25$\%$), Yangwitang(양위탕) was 6 times(16.6$\%$), Bojungikkitang(보중익기탕가미) was 4 times(11.1$\%$), Yongdamsagantang (용담사간탕가미) was 4 times(11.1$\%$). The result of the treatments, evaluating with mentioned rate scale, was 11 cases(30.5$\%$) were Very Good degree, 19 cases(52.7$\%$) were Good , 6 cases(16.6$\%$) were No Change. No cases were Worse degree. Conclusion According to this research, we could say that chronic urticaria can be treated with Oriental medical methods. But more precise probes in both Oriental and Western medicine to diagnose the chronic urticaria should be established and we need to make standards for testing and diagnosing the chronic urticaria.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.3
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• pp.646-669
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• 2004

By treating skin diseases with Hyungsang medicine and reviewing the clinical cases of them through classifying skin diseases into general care and into Hyungsang medical care, the writer came to the conclusion as followings. The skin is a house of Kyungnak, and it' s a place which Ki comes in and out, which human body controls conditions of his physiological function and which doctors can make a diagnosis from seeing it. The skin is subject to lung and large intestine in the point of organ, but in the point of movement, to spleen and stomach. Skin diseases come from unbalance of Ki and Hyul, mostly from fever in blood and also from Dam, Wind, Dampness and Dryness because of including fire. Generally skin diseases are treated according to classifying into distinctive symptoms, region, cause or time being occurred, and concomitant symptoms. After being divided into man and woman, age and youth, fatness and leanness, Jung Ki Shin Hyul type, visceral figures, Yukkyung shapes on Hyungsang medicine method, the remedy of skin diseases which is combined common meditation with Hyungsang medical method is efficacious. In distinguishing into man and woman, age and youth, man gets sick mainly by drinking liquor and exhausting Jung, woman is taken ill generally by indigestion and Damwha, especially by drinking liquor. Young child gets ill mostly from inherent weakness, but in many cases he is occurred by disturbed digestion, so he must be taken care of ingesting food. The aged becomes ill from weakening, so he must be treated according to reasons of diseases. To fatness and leanness, skin diseases are showed symptoms by weakened Yang, insufficient Yin or excess fever on the theory of upper and lower parts, by unbalance of Ki and Hyul on the theory of left and right, by Dryness and Dampness on the theory of front and rear and by insufficiency of vitality and combined fever on the theory of inside and outside. Therefore doctors must cure the symptoms according to the theory of upper and lower, left and right, front and rear and inside and outside. In type of Jung Ki Shin Hyul, the balances between Jung-Hyul and Shin-Ki are important points. Concretely Jung type comes to easily shortage of Jung or gathering abnormally Dampness and Dam, Ki type is easy to make a mass with Ki or to be deficient of Ki, Shin type comes to press seven emotions togather or to be insufficient of Yin and fever inside, and Hyul type is inclined to be deficient of Hyul and to become feverish or to be deficient of Ki. Therefore on the ground of the above reasons skin diseases come into existence. Inclusively in Jung-Hyul type , Ki must be moved on the base of full Jung-Hyul, so Wukmijiwhangtang or Samultang is prescribed basically. In Shin-Ki type , Jung-Hyul is saved on the base of moving Ki, so Hyangsosan or Yijintang is the proper prescription. Considering the visceral figures, doctors judge for diagnosis and remedy by putting together the elements, that is, great and small sizes of a set of features (eye, ear, mouth, nose), color and temper. The yukkyung types are classified according to many or few of Ki-Hyul, and then skin diseases appear by being inclined toward one side between Ki and hyul, or among the six atmospheric elements(wind, cold, heat, dampness, dryness, and fire). Especially because Yangmyung type is full of much Ki and Hyul, and also has much fever in stomach, he gets skin symptoms frequently. So his prescription is based on taking off fever in stomach, and also he must be careful about regimen certainly.