• 제목/요약/키워드: Hwasun area

검색결과 65건 처리시간 0.026초

Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer

  • Jung, Young Ju;Oh, In-Jae;Kim, Youndong;Jung, Jong Ha;Seok, Minkyoung;Lee, Woochang;Park, Cheol Kyu;Lim, Jung-Hwan;Kim, Young-Chul;Kim, Woo-Sung;Choi, Chang-Min
    • Journal of Korean Medical Science
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    • 제33권53호
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    • pp.342.1-342.6
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    • 2018
  • We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, $AptoDetect^{TM}$-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. In a high-risk population corresponding to ${\geq}55years$ of age and ${\geq}30pack-years$, the diagnostic performance was improved, showing 73.3% sensitivity and 90.5% specificity with an area under the curve of 0.88. $AptoDetect^{TM}$-Lung (Aptamer Sciences Inc.) offers the best validated performance to discriminate NSCLC from benign nodule controls in a high-risk population and could play a complementary role in lung cancer screening.

A case of syncope in a villager with hypertrophic cardiomyopathy after hydrogen sulfide exposure by an unauthorized discharge of wastewater

  • Hyeonjun Kim;Seunghyeon Cho;Inho Jung;Sunjin Jung;Won-Ju Park
    • Annals of Occupational and Environmental Medicine
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    • 제35권
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    • pp.34.1-34.8
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    • 2023
  • Background: Hydrogen sulfide is a toxic substance that humans can be exposed to occupationally, and cases of hydrogen sulfide poisoning of workers in industrial sites are commonly reported. However, there have been no cases of poisoning of the public due to an unauthorized discharge of wastewater, so it is important to describe this incident. Case presentation: In a small village in Jeollanam-do, Republic of Korea, accounts of a terrible stench had been reported. A 26-year-old man who lived and worked in a foul-smelling area was taken to the emergency room with a headache, dizziness, nausea, and repeated syncope. A subsequent police and Ministry of Environment investigation determined that the cause of the stench was the unauthorized discharge of 9 tons of wastewater containing hydrogen sulfide through a stormwater pipe while the villagers were sleeping. The patient had no previous medical history or experience of symptoms. Leukocytes and cardiac markers were elevated, an electrocardiogram indicated biatrial enlargement, left ventricular hypertrophy, and corrected QT interval prolongation. Myocardial hypertrophy was detected on a chest computed tomography scan, and hypertrophic cardiomyopathy was confirmed on echocardiography. After hospitalization, cardiac marker concentrations declined, symptoms improved, and the patient was discharged after 7 days of hospitalization. There was no recurrence of symptoms after discharge. Conclusions: We suspect that previously unrecognized heart disease manifested or was aggravated in this patient due to exposure to hydrogen sulfide. Attention should be paid to the possibility of unauthorized discharge of hydrogen sulfide, etc., in occasional local incidents and damage to public health. In the event of such an accident, it is necessary to have government guidelines in place to investigate health impact and follow-up clinical management of exposed residents.

Unusual Radiologic Findings and Pathologic Growth Patterns on Choroid Plexus Papillomas

  • Kim, Tae-Wan;Jung, Tae-Young;Jung, Shin;Kim, In-Young;Moon, Kyung-Sub;Jeong, Eun-Hui
    • Journal of Korean Neurosurgical Society
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    • 제51권5호
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    • pp.272-275
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    • 2012
  • Objective : Choroid plexus papillomas (CPPs) are generally regarded as benign tumors with typical radiologic and pathologic findings. However, they sometimes have unusual findings. We have analyzed radiologic findings and pathologic growth patterns on CPPs. Methods : The study group included 5 male and 5 female patients (age range, 3 months to 58 years : median, 29 years). The study group included 3 pediatric and 7 adult patients. All patients underwent surgery; 9 patients had a gross total resection and 1 patient had a subtotal resection. We analyzed the radiologic findings (location, size, mottle-like appearance, enhancement, calcifications, and hydrocephalus) and pathologic growth patterns (typical papillary, papillary and solid, and papillary and tubular). Results : The median follow-up duration was 21.3 months (range, 4-47.8 months). There were no recurrences after initial treatment. All patients had benign CPPs. Pediatric CPPs were 3.2 cm masses (range, 2.7-4 cm) with homogeneous enhancement and a mottle-like appearance, which pathologically showed the papillary growth pattern. Hydrocephalus was present in all pediatric patients. Postoperatively, subdural hygroma had occurred in two patients. In adults, CPPs were located in the fourth ventricle in 6 patients and suprasellar area in 1 patient. The size varied from 0.5-4.2 cm. Hydrocephalus and calcifications occurred in 3 and 4 patients, respectively. Three patients showed the heterogeneous enhancement without a mottle-like appearance and pathologically showed combined papillary and solid growth in 2 patients and papillary and tubular growth in one. Postoperatively, two patients with large masses had injuries of the brainstem and underwent shunt procedures for aggravation of hydrocephalus. Conclusion : CPPs may show unusual radiologic findings, which preoperatively give the difficulty to be differentiated from other tumors. CPPs with unusual radiologic findings showed the combined pathologic growth patterns.

Modified Trans-Middle Temporal Gyrus Approach for Trigonal Tumor to Preserve Visual Field

  • Choi, Jeong-Wook;Jung, Shin;Jung, Tae-Young;Jang, Woo-Youl;Moon, Kyung-Sub;Kim, In-Young
    • Journal of Korean Neurosurgical Society
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    • 제50권6호
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    • pp.538-541
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    • 2011
  • Objective : We evaluated a modified trans-middle temporal gyrus (MTG) approach with good postoperative visual preservation for patients with trigonal tumors. Methods : Three patients with a trigonal tumor were treated via the modified trans-MTG approach guided by a neuro-navigator. Modified trans-MTG approach involve the incision at the MTG within 5 mm to the superior temporal sulcus. This approach makes a proper trajectory to the trigone but also reduces the retraction injury of MTG as little as possible to prevent postoperative visual field defect. Preoperative and postoperative visual field examination using perimetry was performed to evaluate the visual field. Results : Three patients underwent surgery for lymphoma in the right trigone, meningioma in the left trigone, and focal enhancing nodule in the right paratrigonal area, respectively. In case of lymphoma, preoperative examination showed a left homonymous hemianopsia : one week later after surgery, a visual field examination was performed and revealed improvement of the visual field defect. In case of the meningioma, the preoperative examination showed no visual field defect : one month later, the visual field had no defect. In case of the enhancing nodule, preoperative visual field testing revealed a partial left homonymous hemianopsia. Visual examination within one month after surgery showed no visual field defect. All three patients treated with the modified trans-MTG approach showed no visual deterioration after surgery. Conclusion : The modified trans-MTG approach provides a safe and useful technique for trigonal tumors without postoperative visual field deterioration and affords adequate exposure of the trigonal tumor with a short trajectory.

제주도 해빈퇴적물의 구성성분 (Compositional Variations of the Beach Sediments in Cheju Island)

  • 지옥미;우경식
    • 한국해양학회지
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    • 제30권5호
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    • pp.480-492
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    • 1995
  • 제주도 해안을 따라 협재, 애월, 이호, 삼양, 함덕, 세화, 표선, 중문, 화순지역 에 분포하는 해빈퇴적물의 구성성분과 그들을 조절하는 요인들을 알아보기 위하여 이 들 퇴적물에 대한 암석학적인 조사를 실시하였다. 각 지역 퇴적물의 평균입도는 각각 협재 2.2$\psi$, 애월 0.8$\psi$, 이호 1.4$\psi$, 삼양 2.4$\psi$, 함덕 1.6$\psi$, 세화 $1.5\psi$, 표선 2.1 $\psi$, 중문 0.4, 화순 0.9$\psi$로 대개 0.4-2.4$\psi$정도이며, 분급도는 표선과 화순지역의 퇴 적물만이 불량하고 애월과 중문지역은 보통이며 나머지 지역은 비교적 양호하다. 각 지역별로 퇴적물을 이루는 주 구성성분들을 살펴 보면, 백색을 띠는 협재, 애월, 함 덕, 세화, 표선지역의 해빈 퇴적물은 탄산염광물로 각질을 이루고 있는 연체동물 (mollusk)과 홍조류(red algae)의 각질파편들이 85%이상으로 포함되며, 흑색을 띠는 이호, 삼양, 화순지역은 화산암암편(rock fragment)이 우세하게 나타난다. 특히, 해빈 퇴적물이 비교적 백색을 띠는 탄산염입자가 우세한 지역 중에서 중문지역의 해빈퇴적 물내에는 화산암 암편의 함량이 다른 지역들 보다 더 높게 나타나며 요선지역에서는 탄산염입자의 암편(intraclast)이 우세하게 나타난다. 입자의 크기에 따른 생물들의 퇴적물에 대한 기여도를 살펴 보면 1-2$\psi$의 크기를 가진 입자들은 주로 석회조류로 이 루어져 있으면, 2-3$\psi$의 입자들은 주로 연체동물의 파편으로 구성된다. 특히, 삼양지 역은 0-1$\psi$를 이루는 구성성분 중 태선류(bryozoan)가 거의 48%를 구성하고 있는 것이 특징이다. 해빈퇴적물의 구성성분을 조절하는 요인들은 하천에 의한 화산암암편의 공 급량, 제주도 해안에 따라 해빈 주변에 분포하는 주변암의 암질(lithology), 연안류 (longshore current)의 방향 및 폭풍의 영향들이 있다. 이호와 삼양지역은 주변에 많 이 분포하는 하천의 발달로 하천을 통하여 공급된 화산암암편의 양이 다른 지역보다 상대적으로 많아 해빈퇴적물이 흑색도 띠며, 그 외의 지역에서는 화산암암편의 공급이 상대적으로 적고 탄산염입자의 공급이 활발하여 해빈퇴적물이 백색을 띠는 것으로 생 각된다. 특히, 중문지역에서는 화산암암편이 주변 하천으로부터 공급되었을 뿐만 아니 라, 이 지역들의 주변에 분포하는 응회암으로부터 폭풍의 영향에 의한 일부 공급되었 을 것으로 생각된다. 또한 표선지역의 해빈퇴적물에 많이 포함되어 있는 탄산염입자의 암편은 천해 교질작용에 의한 고화된 퇴적물이 침식되어 생성된 것으로서, 이는 표선 부근의 천해에서 활발한 천해교질작용이 일어나고 있음을 시사한다.

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집약화 관점의 농촌중심지 거점기능 강화 방향에 관한 주민인식 연구 - 전라남도 화순군 면소재지를 중심으로 - (A Study on Residents' Perceptions toward the direction of strengthening the base function from the perspective of Compact City in Rural Downtowns - Focused on Rural Market Towns in Hwasun-gun, Jeollanam-do, Korea -)

  • 박성진
    • 한국농촌건축학회논문집
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    • 제20권1호
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    • pp.93-101
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    • 2018
  • The area to be surveyed is the three-seat of Myeon office in Hwasun-gun, Jeollanam-do, where population is declining. Satisfaction with the use of local residents of rural central areas providing life services in the back area was identified, focusing on sustainable development and the compact cities. Based on the results of the study, the recommendations are as follows. First, the local spaces to be surveyed need a shift to a walk-centered choice and social structure, not a must-oriented, activity-centric structure. This not only improves the neighborhood of rural areas, but also increases the frequency of pedestrian exchange and helps keep the community afloat. Second, it could enhance the convenience of residents by reviving stocks in existing commercial areas and integrating public services. Finally, it has the effect of taking care of the socially disadvantaged and immigrants in terms of space welfare, and securing jobs through locally customized community businesses.

동복천 일대의 식물상 (Flora of Dongbok Stream Areal)

  • 임동옥;박양규;유윤미
    • 한국환경생태학회지
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    • 제17권4호
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    • pp.346-359
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    • 2004
  • 2002년 2월부터 8월까지 전라남도 화순군 동복천 지역에 대한 식물상을 조사한 결과 75과 158속 174종 31변종 1품종으로 총 206종류였다 수생식물은 16과 23속 26종 3변종으로 총 29종류가 확인되었으며 정수식물은 22종류, 침수식물 4종류, 부엽식물 2종류 및 부유식물 1종류였다. 귀화식물은 10과 17속 17종 2변종으로 총 19종류가 확인되었다. 본 조사지역의 회귀식물과 보호야생식물종의 서식처조사결과 산림청에서 지정한 회귀식물은 흑삼릉 1종이 관찰되었다.

폐암 환자들에서 Gefitinib (Iressa)에 의한 피부 부작용 (Cutaneous Adverse Reactions Induced by Gefitinib (Iressa) in Lung Cancer Patients)

  • 윤숙정;이지범;김규식;김영철
    • Tuberculosis and Respiratory Diseases
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    • 제61권2호
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    • pp.150-156
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    • 2006
  • 배 경: 최근 폐암 환자에서 사용하는 표적치료 항암약물인 gefitinib (Iressa)은 종양세포의 표피성장인자 수용체의 티로신 키나아제 활동을 선택적으로 억제하여 종양 세포의 성장에 관여하는 신호를 차단함으로써 치료효과를 나타낸다. Gefitinib 복용에 의한 피부 부작용으로 여드름양 발진, 피부 건조증, 모발 변화 등이 알려져 있다. 대상 및 방법: 2004년 10월부터 2005년 9월까지 화순전남대병원에서 비소세포 폐암으로 진단받고 gefitinib을 복용 중인 환자들 중 피부 부작용이 발생하여 피부과에 의뢰된 환자 23명을 대상으로 임상 양상을 분석하였다. 결 과: 나이는 23-72세였고, 비소세포 폐암의 종류는 선암 17명, 편평상피세포 폐암 5명이었고, 여자 6명, 남자 17명이었다. 가장 흔한 부작용은 여드름양 발진으로 15명(65.2%)에서 발생하였으며, 주로 두피, 얼굴, 가슴, 등 부위에 무증상의 홍반성 구진으로 나타나며 대부분 gefitinib 복용 1달 이내에 발생하였다. 여드름양 발진의 빈도는 gefitinib 치료에 대한 반응과 유의한 상관관계를 보이지 않았고, 조직 형에 따른 차이도 관찰되지 않았다. 피부 소양증은 9명(39.1%)에서 발생하였으며 경도의 전신 소양증이 가장 많았고, 특히 눈 주변의 소양증을 호소하였다. 인설을 동반한 피부 건조증이 6명(26.1%)에서 발생하였고, 손발바닥의 홍반과 표피 박탈이 5명(21.7%), 손톱이나 발톱주변에 조갑주위염이 5명(21.7%)에서 발생하였다. 드물게 모발이 부러지거나 겨드랑이, 오금에 간찰진이 발생하였다. 결 론: 본 연구에서 gefitinib에 의한 다양한 피부 부작용들을 관찰할 수 있었다. Gefitinib을 처방하는 의사들은 피부 부작용에 대한 관심이 필요하며 환자들에게 피부 관리에 대한 교육과 필요한 경우 피부과 의사와 함께 피부 부작용을 치료함으로써 부작용을 경감시킬 수 있었다.

Prediction of Residual Axillary Nodal Metastasis Following Neoadjuvant Chemotherapy for Breast Cancer: Radiomics Analysis Based on Chest Computed Tomography

  • Hyo-jae Lee;Anh-Tien Nguyen;Myung Won Song;Jong Eun Lee;Seol Bin Park;Won Gi Jeong;Min Ho Park;Ji Shin Lee;Ilwoo Park;Hyo Soon Lim
    • Korean Journal of Radiology
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    • 제24권6호
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    • pp.498-511
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    • 2023
  • Objective: To evaluate the diagnostic performance of chest computed tomography (CT)-based qualitative and radiomics models for predicting residual axillary nodal metastasis after neoadjuvant chemotherapy (NAC) for patients with clinically node-positive breast cancer. Materials and Methods: This retrospective study included 226 women (mean age, 51.4 years) with clinically node-positive breast cancer treated with NAC followed by surgery between January 2015 and July 2021. Patients were randomly divided into the training and test sets (4:1 ratio). The following predictive models were built: a qualitative CT feature model using logistic regression based on qualitative imaging features of axillary nodes from the pooled data obtained using the visual interpretations of three radiologists; three radiomics models using radiomics features from three (intranodal, perinodal, and combined) different regions of interest (ROIs) delineated on pre-NAC CT and post-NAC CT using a gradient-boosting classifier; and fusion models integrating clinicopathologic factors with the qualitative CT feature model (referred to as clinical-qualitative CT feature models) or with the combined ROI radiomics model (referred to as clinical-radiomics models). The area under the curve (AUC) was used to assess and compare the model performance. Results: Clinical N stage, biological subtype, and primary tumor response indicated by imaging were associated with residual nodal metastasis during the multivariable analysis (all P < 0.05). The AUCs of the qualitative CT feature model and radiomics models (intranodal, perinodal, and combined ROI models) according to post-NAC CT were 0.642, 0.812, 0.762, and 0.832, respectively. The AUCs of the clinical-qualitative CT feature model and clinical-radiomics model according to post-NAC CT were 0.740 and 0.866, respectively. Conclusion: CT-based predictive models showed good diagnostic performance for predicting residual nodal metastasis after NAC. Quantitative radiomics analysis may provide a higher level of performance than qualitative CT features models. Larger multicenter studies should be conducted to confirm their performance.

부인두강 종양으로 발현한 두개외 수막종 (Extracranial Meningioma as a Parapharyngeal Space Tumor)

  • 이대웅;최정욱;오승은;이준규;임상철
    • 대한두경부종양학회지
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    • 제26권2호
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    • pp.259-261
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    • 2010
  • The meningiomas are slowly growing tumors arising from meningoepithelial cells and they generally occur in the intracranial space. Tumor extension to the extracranial structures occurred in about 20 percent of intracranial meningiomas. Meningiomas extending to the cervical area are uncommom. Beacuse these patients complain of localized symptoms, sometimes those tumors have been operated as cervical tumors. In this report, we incidentally found a meningioma in the left parapharyngeal space in a 63-year-old female, who was confirmed by histopathologic diagnosis to have meningioma. We report herewith this case with the review of literatures.