• Journal of Microbiology
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• v.39 no.1
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• pp.79-82
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• 2001

The influence of levulinic acid (LA) on the production of copolyester consisting of 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV) by Ralstonia eutropha was investigated. Addition of LA into the culture medium greatly increased the molar fraction of 3HV in the copolyester, indicating that LA can be utilized as a precursor of 3HV. In shake flask culture, the 3HV content in the copolyester increased from 7 to 75 mol% by adding 0.5 to 4.0 g/L LA to the medium containing fructose syrup as a main carbon source. A maximal copolyester concentration of 3.6 g/L (69% of dry cell weight) was achieved with a 3HV content of 40 mo1% in a jar fermentor culture containing 4.0 g/L of LA. When LA (total concentration, 4 g/L) was added repeatedly into a fermentor culture to maintain its concentration at a low level, the copolyester content and the 3HV yield from LA reached up to 85% of dry cell weight and 5.0 g/g, respectively, which were significantly higher than those when the same concentration of the LA was supplied al1 at once. The present results indicated that LA is more effective than propionate or valerate as a cosubstrate fur the production of copolyesters with varying molar fractions of 3HV by R. eutropha.

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.659-665
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• 2003

We have studied the effect of rhEGF on the buccal mucosal ulcer healing. rhEGF was rapidly degraded upon incubation with the hamster buccal mucosal homogenates; The degradation of rhEGF was significantly inhibited by sodium lauryl sulfate (SLS). Eudispert hv hydrogel and Polycarbophil 974P hydrogel were prepared for rhEGF delivery and their mucoadhesiveness was measured by the $Instron^R$ method. The mucoadhesive force of Eudispert hv was significantly greater than that of Polycarbophil 974P. Moreover, rhEGF in Eudispert hv hydrogel remained stable for about 2 months. To evaluate the ulcer healing effect of rhEGF, the buccal mucosal ulcer was induced in golden hamsters using acetic acid. At 24 h after administration of rhEGF/Eudispert hv hydrogel, the ulcerous area was decreased compared with rhEGF solution and, as a result, the curative ratio was $36.8\pm5.68$%. By the addition of SLS (0.5%) to Eudispert hv hydrogel, the curative ratio increased 1.5 times. The mechanism of the action was probably due to a combination of protection of the drug against proteases present in mucosa and prolongation of the release of rhEGF from the formulation at the site of action.

• The Pure and Applied Mathematics
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• v.28 no.3
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• pp.217-234
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• 2021

In this paper, first we introduce the new class of HV-BE-algebra as a generalization of a (hyper) BE-algebra and prove some basic results and present several examples. Then, we construct the HV-BE-algebra associated to a BE-algebra (namely BL-BE-algebra) based on "Begins lemma" and investigate it.

• Journal of Korean Foot and Ankle Society
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• v.25 no.4
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• pp.157-164
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• 2021

Purpose: This study aimed to report the current trends in the management of the hallux valgus (HV) deformity over the last few decades through a survey of the Korean Foot and Ankle Society (KFAS) members. Materials and Methods: A web-based questionnaire containing 34 questions was sent to all KFAS members in September 2021. The questions were mainly related to the preferred techniques and clinical experience in correction in patients with an HV deformity. Answers with a prevalence of ≥50% of respondents were considered a tendency. Results: One hundred and nine (19.8%) of the 550 members responded to the survey. The most common symptom for determining surgical treatment was bunion pain (68.8%), and different surgical techniques were selected according to the following radiological parameters: HV angle 30 to 40 degrees and intermetatarsal angle 15 to 20 degrees. The two procedures most preferred by the respondents were distal chevron osteotomy (55.0%), and proximal chevron osteotomy (21.1%). In an average of 71.6% of respondents, Arkin osteotomy was performed simultaneously during HV surgery. HV accompanied by an overriding deformity of the second toe was most often addressed with a combination of second metatarsal osteotomy and soft tissue rebalancing procedure (35.8%). After HV surgery, the recurrence rate of HV deformity was found to be 12.2% on average and the surgeons who had performed minimally invasive surgery (MIS) for HV comprised 34.9% of the total respondents. Conclusion: This study provides updated information on the current trends in the management of the HV deformity in Korea. Both consensus and variation in the approach to patients with HV were identified by this survey study. Although MIS for HV has increased, it appears the consensus for selecting this method has not yet been established.

• The Journal of Korean Physical Therapy
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• v.28 no.2
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• pp.124-127
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• 2016

Purpose: The flexor hallucis longus stretch test can determine the shortness of the flexor hallucis longus muscle by measuring the angle of extension in the first metatarsophalangeal (MTP) joint at maximum ankle dorsiflexion. Less than 30 degrees of the first MTP joint at the maximal ankle dorsiflexion indicates shortness of the flexor hallucis longus muscle. The purpose of this study was to examine the intra- and inter-reliability of the flexor hallucis longus stretch test in subjects with asymmetric hallux valgus (HV) angles. Methods: Sixteen subjects with asymmetric HV angles participated in this study. In sitting position, dorsiflexion angles of the first MTP joint were measured with maximum ankle dorsiflexion on each side. ICC (3,1) and ICC (3,k) models were used, respectively, to assess the intra-reliability and inter-reliability of the flexor hallucis longus stretch test. The paired-t test was used to compare the dorsiflexion angle of the first MTP joint on the side with the smaller HV angle with that of the side with the larger HV angle. Results: The results of the study showed that both intra- and inter-reliability were more than 0.95 of the coefficient. Dorsiflexion angle of the first MTP joint was higher on the side with the smaller HV angle. Conclusion: Use of the flexor hallucis longus stretch test is acceptable in clinical settings because both intra- and inter-reliability were high in subjects with asymmetric HV angles. In addition, shortness of the flexor hallucis longus muscle is associated with HV angle. This study provides useful information for use in management of HV deformity.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.8A
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• pp.639-647
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• 2012

Vision-based on-road vehicle detection is one of the key techniques in automotive driver assistance systems. However, due to the huge within-class variability in vehicle appearance and environmental changes, it remains a challenging task to develop an accurate and reliable detection system. In general, a vehicle detection system consists of two steps. The candidate locations of vehicles are found in the Hypothesis Generation (HG) step, and the detected locations in the HG step are verified in the Hypothesis Verification (HV) step. Since the final decision is made in the HV step, the HV step is crucial for accurate detection. In this paper, we propose using a reduced multivariate polynomial pattern classifier (RM) for the HV step. Our experimental results show that the RM classifier outperforms the well-known Support Vector Machine (SVM) classifier, particularly in terms of the fast decision speed, which is suitable for real-time implementation.

• Fisheries and Aquatic Sciences
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• v.16 no.2
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• pp.131-135
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• 2013

The presence of ostreid herpesvirus 1 (OsHV-1) and the percentage of viral DNA detected in Pacific oyster Crassostrea gigas adults were investigated monthly between May and November 2012 at three locations along the southern coast of Korea. Among 210 oysters examined by polymerase chain reaction (PCR) analysis, OsHV-1 DNA was detected in only one oyster collected in August. The low detection rate of OsHV-1 DNA was consistent with the lack of reported OsHV-1-associated disease in C. gigas cultured in Korea. The sequence of the present PCR product amplified with the C2/C6 primer pair was identical to that of OsHV-1 ${\mu}Var$ except for one nucleotide, and the sequence amplified with Del36-37F2/Del36-37R showed a 605-bp deletion as in OsHV-1 ${\mu}Var$. Although these sequence data are insufficient to determine genotype, the results suggest that the herpesvirus detected was similar to OsHV-1 ${\mu}Var$. This is the first report on the presence of OsHV-1 in adult Pacific oysters cultured in Korea.

• Korean Journal of Agricultural Science
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• v.38 no.4
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• pp.703-709
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• 2011

This study was conducted at Korea's typical soil, loamy soil, to figure out the effect of how barley green manure (B), hairy vetch (HV) and the mixed-planting hairy vetch with barley green manure (HV/B) affecting on the yield of rice, usage of nutrient and soil characteristics. Supplying amount of nitrogen from HV, HV/B and B were 172.8 kg $ha^{-1}$, 64.3 kg $ha^{-1}$ and 38.6 kg $ha^{-1}$, respectively. Hairy vetch had the highest plant height and SPAD of rice and next was hairy vetch/barley, chemical fertilizer (CF), none fertilizer (NF), and green manure barley. The amount of rice yield was 5.51 ton $ha^{-1}$ with HV, and 4.24 ton $ha^{-1}$ with HV/B. The chemical characteristics of soil showed lower pH and exchangeable cations (Ca and Mg) at B, HV and HV/B plot rather than that of chemical fertilizer (CF) plot. However, the physical characteristics of soil and the porosity rate showed better tendency at the green manure crops than CF. Nitrogen nutrient balance was showed the most balanced at CF, otherwise field of application of green manure crops were required the appropriate nutrition management if future crops would be cultivated because nitrogen nutrient could be devastated or accumulated.

• Korean Journal of Soil Science and Fertilizer
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• v.47 no.3
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• pp.165-171
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• 2014

Assessment of sustainable production on a cropland can help to determine the most proper management practices. In this study, we evaluated the sustainable production on paddy field treated with green manure crops using sustainability index which based on nutrient index, microbiological index, and crop index related to nutrient-supplying capacity. Especially choosing appropriate indicators from a minimum data set (MDS) were used the principal components analysis (SI-2) as well as expert opinion (SI-1) usually used in sustainability index. Six treatments including the two tillage treatments and two green manure crops were investigated as follows; (i) moldrotary + rotary tillage without green manure crop (Con), with (ii) hairy vetch (Con-HV), and (iii) hairy vetch + green barely (Con-HV+GB), (iv) rotary tillage without green manure crop (Rot), with (ii) hairy vetch (Rot-HV), and (iii) hairy vetch + green barly (Rot-HV+GB). Con-HV and Rot-HV in SI-1 were maintained sustainability while Rot-HV and Rot-HV+GB in SI-2. Especially, treatments (Con and Rot) without green manure crops were more unsustainable than with green manure crops because of the low value of microbiological and crop index than with green manure crops. Meanwhile, sustainability indices and grain yield had the high correlation values ($R^2=0.756$ and 0.928 in SI-1 and SI-2, respectively). These results meant that application of green manure crops such as hairy vetch could improve both yield and soil quality in paddy.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.25 no.6
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• pp.481-488
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• 2022

Purpose: Liver transplantation (LT) is the only curative treatment for acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). In high-volume therapeutic plasma exchange (HV-TPE), extracorporeal liver support filters accumulate toxins and improve the coagulation factor by replacing them. In this study, we aimed to evaluate the effectiveness of HV-TPE in pediatric patients with ALF and ACLF. Methods: We reviewed the records of children waiting for LT at Severance Hospital who underwent HV-TPE between 2017 and 2021. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin (TB and DB), gamma-glutamyl transferase (GGT), ammonia, and coagulation parameter-international normalized ratio (INR) were all measured before and after HV-TPE to analyze the liver function. The statistical analysis was performed using IBM SPSS Statistics for Windows, version 26.0 (IBM Co., Armonk, NY, USA). Results: Nine patients underwent HV-TPE with standard medical therapy while waiting for LT. One had neonatal hemochromatosis, four had biliary atresia, and the other four had ALF of unknown etiology. Significant decreases in AST, ALT, TB, DB, GGT, and INR were noted after performing HV-TPE (930.38-331.75 IU/L, 282.62-63.00 IU/L, 11.75-5.59 mg/dL, 8.10-3.66 mg/dL, 205.62-51.75 IU/L, and 3.57-1.50, respectively, p<0.05). All patients underwent LT, and two expired due to acute complications. Conclusion: HV-TPE could remove accumulated toxins and improve coagulation. Therefore, we conclude that HV-TPE can be regarded as a representative bridging therapy before LT.