• Journal of the Korean Society for Precision Engineering
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• v.1 no.2
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• pp.9-25
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• 1984

중품종, 중량생산용의 합리적인 생산 system의 일형태로서 미국 Kearney & Trecker 사가 실용하고 있는 Flexible Manufacturing System(약칭 F.M.S.)을 처음으로 발표한 것은 1960 년대 후반이었다. 그러나 이 FMS도 그 후 얼마동안은 선전마저도 되는일 없이 지내왔다. 그런데 사회의 발전과 더불어 사회의 제품에 대한 요구가 다양화, 단수명화의 방향으로 진보되어, 그 결과, FMS의 중요성이 인식되게 되었다. 그리고 1970 년대후반부터 라고 표현될만한 상황이 일본,미국,서독 등 3개국을 중심으로 표현했다. 당초에는 라고 하는 용어만이 선행한 바람 직하지 못한 점은 있었으나 그후 FMS의 본질을 이해한 System의 도입증가와 함께 FMS 기술도 상당히 발전되어 왔다. 또한 FMS의 가동예의 증가와 더불어 그 도입효과가 눈부시다는 것이 분명해졌다. 이 FMS의 중요성은 , 혹은 라고 하는 말로 집약되는데 당연히 현재로서는 FMS는 공업선진국, 개발 도상국을 막론하고 큰 화제를 불러 일으키고 있다. 따라서 이와같은 중요한 FMS의 상황을 국제적인 관점에서 정확히 파악한다는 것은 매우 중요한 일이다. 그러나 현금에 있어서의 FMS기술의 급속한 진보는 이와같은 관점에서의 상황파악을 매우 어렵게 하고 있다. 이제까지도 예컨데 Scharf와 Schulz, Hutchinson, Spur와 Mertinz 혹은 기계기술협회생산기술조사분과회(일본)의 조사예가 있으나, 상세한 것은 각국별, 혹은 각사별의 해설을 참조하지 않으면 이해할 수 없다. 더우기 이제까지는 기계가공용 FMS가 주체였으나 현대에 이르러서는 FMS의 적용범위는 판금가공, 단조가공, Plastic사출성형가공, 조립 등에 널리 이용되어 왔기때문에 점점 그 현상의 파악이 어려워지고 있다. 따라서, 여기서는 그와같은 FMS의 현상과 장래의 발전동향을 간단히 이해할 수 있도록 개설하고자 한다.

• Structural Engineering and Mechanics
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• v.8 no.4
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• pp.361-382
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• 1999

This paper reviews aspects of current design procedures for seismic design of structures, and specifically examines their relevance to the design of light framed residential buildings under earthquake loading. The significance of the various structural contributions made by the components of cold formed steel framed residential structures subjected to earthquake induced loadings has been investigated. This is a common form of residential construction worldwide. Particular attention is given to aspects related to ductility and overstrength, the latter arising principally from the contributions of the designated "non-structural" components. Based on both analytical and experimental data obtained from research investigations on steel framed residential structures, typical ranges of the ductility reduction factor and overstrength ratios are determined. It is concluded that the latter parameter has a very significant influence on the seismic design of such structures. Although the numerical ranges for the inelastic seismic parameters given in this paper were obtained for Australian houses, the concepts and the highlighted aspects of seismic design methodology are more widely applicable.

• Korean Journal of Applied Biomechanics
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• v.24 no.3
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• pp.259-267
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• 2014

The purpose of this study was to find the relationship between standing posture biomechanics and physical fitness in the elderly. Physical fitness variables and postural variables for 227 (140 women and 87 men) elderly individuals were tested. Physical fitness tests (Korean Institute of Sports Science, 2012) included 3m sit, walk, and return, grip test, 30 second chair sit and stand, sit and reach, figure 8 walks, and 2 minute stationary march. Postural biomechanics variables included resting calcaneal stance position (RCSP), shoulder slope, pelvic slope, knee flexion angle, leg length difference, thoracic angle, and upper body slope. In statistical analysis, multiple regression was conducted by using stepwise selection method via SAS (version 9.2). Analysis for both men and women revealed significant relationships between physical fitness and age, upper body slope, knee flexion angle, leg length difference. Pelvic and thoracic angle were only related to figure 8 walking and sit and reach in women, while RCSP and shoulder slope had no relationship with any physical fitness variables.

• Journal of Microbiology
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• v.35 no.1
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• pp.40-46
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• 1997

The pWHM220 cosmid with a 24-kb insert cloned from Streptomyces albus ATCC 21838 induces the biosynthesis of a polysther antibiotic similar to salinomycin in Streptomyces invidans. We have analyzed this region by DNA sequencing as well as Southern blot hybridization with type I and type II polyketide synthase (PKS) probes. Surprisingly, we found another set of type II SKS genes only 10-kb from the original PKS genes, salABCDE. The DNA sequence revealed two complete open reading frames (ORFs) named salB2 and salC2, and one partial ORF that does not resemble any known DNA or deduced protein sequence. The salC2 should code for chain length determining factor while the deduced amino acid sequence encoded by salB2 exhibits high similarity to .betha.-ketoacyl synthase from different PKS gene clusters. The highest identity was found for .betha.-keetoacyl synthases from S. argillaceus (MtmP. 59.1% identity), the mithramycin producer and from S. venezuelae ISP5230 (JadA, 52.3% identity), the jadomycin producer. The SalC2 protein clearly resembles its counterparts in order aromatic PKS gene clusters that are believed to influence the length of the polyketide chain. The highest identities observed were to that of S. argillaceus (MtmK, 62.3%) and S. venezuelae ISP 5230 (JadB, 55.1%) proteins, Moreover, the deduced amino acid sequences of the salB2 and salC2 products were 29.0% identical.

• Journal of Korea Port Economic Association
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• v.21 no.1
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• pp.59-72
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• 2005

There were many theoretical studies using mathematical models about a yard storage capacity in a container terminal so far, but a simulation approach is newly popularizing. The reason why the simulation studies about yard storage capacity were a few was that once the most important part in a container terminal was a quay part. However, from the economic crisis year of 1977, the yard storage part in a container terminal became a critical resource because of the shortage of SOC investment resources. Therefore, after discharging or loading even through there was a waiting in the quay part or not, it can be swiftly improved the efficiency of a container terminal if it was handled rapidly or smoothly in a container yard. So the accurate assessment of yard storage capacity in a container terminal was needed. This study planed to assess the operation capability of a container yard via a simulation model. The model included many chatacteristics of three Korean container terminals such as Gamman Hanjin, Uam, and Hutchinson Busan at the period of 1999 to 2000. The 95% percentile was chosen as a criterion for judging of the storage capability by the recommendation of KPC (1998) and JWD (1998). A simulation approach with system dynamics concept considering the multi-directional impacts within the related variables can probavly foresee the future storage capacity of a terminal not just the past.

• Molecules and Cells
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• v.42 no.3
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• pp.210-217
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• 2019

The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which senescence amelioration in normal aging cells is mediated by the recovered mitochondrial function upon Ataxia telangiectasia mutated (ATM) inhibition. However, it remains elusive whether this mechanism is also applicable to senescence amelioration in accelerated aging cells. In this study, we examined the role of ATM inhibition on mitochondrial function in Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) cells. We found that ATM inhibition induced mitochondrial functional recovery accompanied by metabolic reprogramming, which has been known to be a prerequisite for senescence alleviation in normal aging cells. Indeed, the induced mitochondrial metabolic reprogramming was coupled with senescence amelioration in accelerated aging cells. Furthermore, the therapeutic effect via ATM inhibition was observed in HGPS as evidenced by reduced progerin accumulation with concomitant decrease of abnormal nuclear morphology. Taken together, our data indicate that the mitochondrial functional recovery by ATM inhibition might represent a promising strategy to ameliorate the accelerated aging phenotypes and to treat age-related disease.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
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• 2004.11a
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• pp.65-70
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• 2004

Modulation of biotransformation enzymes is one mechanism by which a diet high in fruits and vegetable may influence cancer risk. Inhibition of cytochrome P450s (CYP) and concomitant induction of conjugating enzymes are hypothesized to reduce the impact of carcinogens in humans. Thus, exposure to types and amounts of phytochemicals may influence disease risk. Like other xenobiotics, many classes of phytochemicals are rapodly conjugated with glutathione, glucuronide, and sulfate moieties and excreted in urine and bile. In humans, circulating phytochemical levels very widely among individuals even in response to controlled dietary interventions. Polymorphisms in biotransformation enzymes, such as the glutathione S-transferases (GST), UDP-glucuronosyltransferases (UGT), and sulfotransferases (SULT), may ocntribute to the variability in phytochemical clearance and efficacy; polymorphic enzymes with lower enzyme activity prolong the half-lives of phytochmicals in vivo. Isothiocyanates (ITC) in cruciferous vegetables are catalyzed by the four major human GSTs: however reaction velocities of the enzymes differ greatly. In some observational studies of cancer, polymorphisms in the GSTMI and GSTTI genes that result in complete lack of GSTM1-1 protein, respectively, confer greater protection from cruciferous vegetable in individuals with these genotypes. Similarly, we have shown in a controlled dietary trial that levels of GST-alpha-induced by ITC-are higher in GSTMI-null individuals exposed to cruciferous vegetablse. The selectivity of glucuronosyl conjugation of flavonoids is dependent both on flavonoid structure as well as on the UGI isozyme involved in its conjuagtion. The effects of UGI polymorphisms on flavonoid clearnace have not been examind; but polymorphisms affect glucuronidation of several drugs. Given the strong interest in the chemopreventive effects of flavonoids, systematic evaluation of these polymorphic UGTs and flavonoid pharmacokinetics are warranted. Overall, these studies suggest that for phytochemicals that are metabolized by, and affect activity of, biotransformation enzymes, interactions between genetic polymorphisms in the enzymes and intake of the compounds should be considered in studies of cancer risk. Genetic polymorphisms in biotransformation enzymes may account in prat for individual variation in metabolism of a wide range of phytochemicals and their ultimate impact on health.

• Journal of the Korean Society of Clothing and Textiles
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• v.36 no.8
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• pp.837-848
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• 2012

This study examines how the overseas residence experience of Korean consumers influences the relationship of global fashion brand knowledge and brand choice confidence. We contrast two kinds of consumer brand knowledge, using the concepts of Alba and Hutchinson's expertise and familiarity. Considering the effect of positive affect on intuitive information processing, the present study investigated the role of positive affect in consumer brand knowledge and brand choice confidence link. The proposed model was tested with structural-equation analysis. The results show that expertise and familiarity effect the positive affect. Positive affect, in turn, influences brand choice confidence. The results indicate that the processes underlying global fashion brand knowledge and brand choice confidence link are different between the consumers with overseas residence experience for more than a year and the consumers without it. The route from expertise to positive affect has a significant impact on the consumers with overseas residence experience but not on the consumers without it; however, the route from familiarity to positive affect and the path from positive affect to brand choice confidence have a greater impact on the consumers without overseas residence experience than the consumers with it. We find that the consumers with overseas residence experience favor expertise in the process underlying global fashion brand knowledge and brand choice confidence link, whereas the consumers without it favor familiarity and affect based thought.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.4
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• pp.205-212
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• 2001

One of the important characteristics of biological systems os their ability to change im-portant properties in response to small environmental signals. The molecular mechanisms that biological molecules utilize to sense and respond provide interesting models for the development of "smart" polymeric biomaterials with biomimetic properties. An important example of this is the protein coat of viruses, which contains peptide units that facilitate the trafficking of the virus into the cell via endocytosis, then out of the endosome into the cytoplasm, and from there into the nucleus, We have designed a family of synthetic polymers whose compositions have been de-signed to mimic specific peptides on viral coats that facilitate endosomal escape. Our biomimetic polymers are responsive to the lowered pH whinin endosomes, leading to distruption of the en-dosomal membrane and release of important biomolecular druges such as DNA, RNA, peptides and proteins to the cytoplasm before they are trafficked to lysosomes and degraded by lysosomal en-zymes. In this article, we review our work on the design, synthesis and action of such smart, pH-sensitive polymers.

• Journal of Microbiology and Biotechnology
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• v.5 no.2
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• pp.74-79
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• 1995

Sequence analysis of a DNA region encompassing the site of hybridization to actl, the gene for type II minimal polyketide synthase (PKS) for actinorhodin biosynthesis, from Streptomyces ablus revealed three more complete open reading frames additional to the already found two genes, plausibly encoding ${\beta}-ketoacyl$ synthase/acyl transferase (KS/AT) and chain length determining factor (ClF). The open reading frames (ORFs) were named salA, salD, and salE, from the upstream. In the homology analysis of the deduced amino acid sequences, SalA resembles the Streptomyces glaucescens Tcml, decaketide cyclase, SalD resembles acyl carrier protein in type II PKS, and SalE resembles the Actlll ketoreductase, The whole 4.4 kb of DNA sequence obeys the same conservation pattern as other type II PKSs. Therefore, we suggest that the 4.4 kb DNA from Streptomyces albus encompasses genes encoding enzymes for polyketide biogenesis in the organism and its organization is type II. The exsitence of SaIA, an analogue of the aromatic cyclase, revealed a relatedness of the 4.4 kb DNA with the aromatic PKS.