• Molecular & Cellular Toxicology
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• 제2권2호
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• pp.75-80
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• 2006

Biomarkers identify various stages and interactions on the pathway from exposure to disease. The three categories of biomarkers are those measuring susceptibility, exposure and effect. Susceptibility biomarkers are identifiable genetic variations affecting absorption, metabolism or response to environmental agents. Biomarkers of exposure indicate the amount of a foreign compound that is absorbed into the body. Biological measurements performed on human tissues are vastly expanding the capabilities of classical epidemiology, which has relied primarily on estimates of human exposure derived form chemical levels in the air, water, and other exposure routes. Biomarkers of exposure indicate the amount of a foreign compound that is absorbed into the body. Biological measurements performed on human tissues are vastly expanding the capabilities of classical epidemiology, which has relied primarily on estimates of human exposure derived form chemical levels in the air, water, and other exposure routes. The biomarker response is typical of chemical pollution by specific classes of compound, such as (i) heavy metals (mercury, cadmium, lead, zinc), responsible for the induction of metallothionein synthesis, and (ii) organochlorinated pollutants (PCBs, dioxins, DDT congeners) and polycyclic aromatic hydrocarbons (PAHs), which induce the mixed function oxygenase (MFO) involved in their bio transformations and elimination. Currently genomic researches are developed in human cDNA clone subarrays oriented toward the expression of genes involved in responses to xenobiotic metabolizing enzymes, cell cycle components, oncogenes, tumor suppressor genes, DNA repair genes, estrogen-responsive genes, oxidative stress genes, and genes known to be involved in apoptotic cell death. Several research laboratories in Korea for kicking off these Environmental Genomics were summarized.

• 한국의류산업학회지
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• 제6권6호
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• pp.810-814
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• 2004

This study is one of the fundamental researches for the development of future smart clothing and textile products using silver(Ag) nano powder. Our study was focused on the blocking or insulating effects of nano-processed textiles from electromagnetic waves. Also, for the surveying of the actual effect to human body, we measure the variation of electroencephalogram which is an indication of human physical symptoms. Among various textiles in this experiment, nano silver processed case has shown the best blocking performance from the electromagnetic waves, which decreases depending on the distance. As a reference model of working environment, we setup the visual stimuli object on the computer that is a source of electromagnetic wave. The power spectrum distribution and the incidence of electroencephalogram was measured. The analysed data has shown that, with nano-processed textiles, ${\beta}$ wave does not appear very often where ${\beta}$ wave appears only to illustrate the stable states of human's body. However, as for the materials without nano processing, the ratio of ${\gamma}$ waves in the total level of electroencephalogram becomes higher in spite of short exposure to visual stimuli in work environment, which shows that the worker becomes stressed. The ${\beta}$ wave electroencephalogram of all materials is drawn in calcarine fissure of occipital lobe to show the convergent distribution, and stronger with block-processed Nano Silver Silk(NSS). The study based on the potential risks of human diseases such as physical fatigue by electromagnetic waves, and has shown that the application of Nano Silver textile for human uses require a proper particle size of it which would not penetrate cellular tissues, and a proper binder and binding treatment for it. However, it is highly required for back-up researches to verify various aspects in applying nano silver to textile products.

• 한국의류학회지
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• 제23권4호
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• pp.551-562
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• 1999

This study was intended to investigate the effect on the human body such as subcutaneous fat thickness the circumference of extremities etc. of the clothing training of putting on thin clothes periodically from the cold period. The subjects were divided into the clothing training group and the non-training group, The training group was asked to wear cool clothes in daily life and to wear the training clothes of T-shirts with half-length sleeves and pants and perform the clothing training for two hours daily three times a week in a cold environment over the period from November to February. The non-training group was asked to lead a life wearing comfortable clothes. Then a comparative experiment was conducted at 15$\pm$1$^{\circ}C$, 50$\pm$5% R, H and 0.25m/sec before and after the clothing training. After the clothing training regardless of gender subcutaneous fat thickness was more increased and total clothing weight per the surface area of the body was decreased in the training group than the non-training group. The training group showed lower skin temperature in the limbs and lower average skin temperature than the non-training group irrespective of gender which proved the effect of the clothing training. The training group was shown to have attendancy toward a greater sense of warmth and a less sense of discomfort which proved the effect of the clothing training.

• 한국위성정보통신학회논문지
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• 제9권1호
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• pp.102-106
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• 2014

본 논문에서는, 이중대역 안테나를 가진, 인체 거치용 단말장치 모사구조의 HAC(보청기 EMC) 지수가 실재환경으로부터 받는 영향에 대한 관찰이 이뤄진다. 첫째, 부착형 이동통신 장치에 필수적인 인접 구조를 고려한 이중대역 내장형 안테나가 설계된다. 이 설계는 모사구조의 제작을 통해 실제의 모습을 갖춘다. 둘째, 이 장치의 HAC 지수는 손에 부착하기 전과 후에 대해 모의시험 및 측정을 통해 얻어진다. 특히, 실재 장치의 전자장 모의시험 결과는 표준 측정법에 의해 타당성이 확인된다. 마지막으로, HAC 기주는 대역, 실장환경, 손(인체) 효과의 관점에서 분석된다.

• 한국전자파학회논문지
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• 제23권3호
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• pp.314-319
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• 2012

본 논문에서는 MICS(Medical Implant Communication Service, 402~405 MHz)와 ISM(The Industrial, Scientific and Medical, 2.40~2.48 GHz) 대역에서 동작하는 인체 통신 중계용 안테나를 제안하고, 인체의 영향을 고려한 안테나 성능에 대한 분석을 하였다. 제안된 안테나는 loop 안테나와 영차 공진 안테나로 구성되어 있다. Loop 안테나는 ISM 대역에서 동작하며, MICS 대역에서의 동작은 loop 안테나와 영차 공진기의 용량성 결합에 의해 요구 성능을 만족할 수 있도록 구현하였다. 근거리장에 인체가 존재할 때 인체가 안테나에 미치는 영향을 분석하기 위하여 인체 팬텀을 이용하여 시뮬레이션과 측정을 하였다. 시뮬레이션 및 측정 결과, 제안된 안테나는 MICS와 ISM 대역에서 대역폭을 만족하였고, 측정된 이득값은 MICS 대역에서 -28.53 dBi, ISM 대역에서 3.85 dBi였다. 또한, 설계된 안테나의 이중 대역 특성은 인체 내 외부 간의 통신 중계 용도로 적절하다고 사료된다.

• 동의생리병리학회지
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• 제16권4호
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• pp.626-629
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• 2002

In Oriental medicine, Five Mental is a concept for understanding of man's mental structure. Spirit and body is inseparable relation in Oriental Medicine. Function of spirit and body is regarded as one in Oriental Medical physiology. Spirit is the essence of a function which an organism reveal, and it is regarded in the same with life. For this reason, identification spirit with life is special feature of Oriental Medicine. In Confucianism, Li(理) refers to nature's discipline, which everything under the sun shares. It is similar to the concept of Shin(神) in a broad sense and Sung(性) is similar to that of Shin(神) in a narrow sense. Confucianism's principle is similar to Oriental medicine's, in that they classify Sung(性) into Gi-Jil-Ji-Sung(氣質之性) and Bon-Yeon-Ji-Sung(本然之性), that Sung(性) acts upon man differently according to his disposition, and that materials have an effect on Shin(神)'s action. According to mind's action, there are Human mind(人心) and Moral mind(道心). Human mind(人心) is defined as a mental action of higher degree and Moral mind(道心) is conceived as a mental action related to body. It is similar to Oriental medicine's principle in which Shin(神) is classified into Hun(魂) and Beak(魄) according to its action. Yi(意) is self-control and application, and Zhi(志) is a conscious state in which basic acts towards the object are fixed regularly. Those are similar to the concepts of Oriental medicine.

• 수산해양교육연구
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• 제18권2호
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• pp.77-84
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• 2006

This research evaluates thermal comfort by comparing the case of maintain cooing temperature of room with the case of raising it at the point of time that human body begins to adapt. An experiment uses constant temperature & humidity chamber 2 places. Pretesting room make up summer season environment, the testing room control by air-conditioner. In condition that maintain temperature of $33^{\circ}C$. The subjects stay in the pretesting room during the 30 minute for the heat storage amount of the normal summertime. The subjects stay in the testing room under each case (case 1: maintaining $24^{\circ}C$, case 2: maintaining $26^{\circ}C$, case 3: up $1^{\circ}C$ after maintaining $24^{\circ}C$ during 30 minute, case 4: up $1^{\circ}C$ after maintaining $26^{\circ}C$ during 40 minute). 1. Result of comparison of case 1 and case 2 appears that thermal sensitive vote examine from slight cool to cool and thermal comfort examine slight comfort by temperature rise at human body adaptation point of time.2. Test of case 3 and case 4 appear similar value at thermal sensitive vote and thermal comfort.3. Through the case 2 and case 4, continuous thermal comfort maintain at $24^{\circ}C$, if raise $26^{\circ}C$, same thermal comfort maintain after a human body adaptation temperature rising effect bring energy saving.

• Journal of Korean Biological Nursing Science
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• 제17권2호
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• pp.188-210
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• 2015

Purpose: The purpose of this study was to develop syllabuses of basic nursing science subjects (Structure and Function of Human Body, Pathogenic Microbiology, Pathophysiology, and Mechanisms and Effects of Drug) based on learning outcomes. Methods: We developed a 3-phase plan to develop the syllabuses. In the first phase, The Korean Society of Biological Nursing Science (KSBNS) held a workshop in May, 2013 in which professors who are in charge of basic nursing science subjects shared opinions about learning outcomes. As a result, initial prototype syllabuses came out. In the second phase, revised syllabuses based on learning outcomes were presented and discussed in the conference held by KSBNS in November, 2013. In the last phase, a research team who taught basic nursing science subjects finalized the syllabuses during the meetings. Results: Syllabuses of 4 basic nursing science subjects were developed. Conclusion: These syllabuses of 4 subjects need to be disseminated throughout nursing colleges. Further revision needs to be made according to the circumstances and context of each school.

• 대한약침학회지
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• 제25권4호
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• pp.354-363
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• 2022

Objectives: This study aimed to assess the adverse effects of Rasaraj Rasa tablets after repeated oral administration for 180 days in Wistar rats. Methods: Wistar rats were divided into five groups, of which three were treated with 54, 162, and 270 mg/kg body weight of Rasaraj Rasa, respectively, which correspond to one, three, and five times the proposed human therapeutic dose, for 180 days consecutively. The fifth group (satellite) also received 270 mg/kg body weight of Rasaraj Rasa for 180 days. Body weight and food intake were measured weekly. At the end of the study, all rats were sacrificed, and their blood, serum, and organs were collected and examined using hematology, serum biochemistry, gross pathology, and histopathology tests. In contrast, the satellite group was kept for 4 weeks after treatment. Results: No significant treatment-related toxicological findings were observed in the clinical features, body weight, laboratory findings, and pathological findings of the high-dose treated groups, when compared to those of the control group. Conclusion: The no-observed-adverse-effect-level for Rasaraj Rasa in Wistar rats is set at 270 mg/kg body weight.

• Biomolecules & Therapeutics
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• 제1권2호
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• pp.266-269
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• 1993

The acute toxicity of a recombinant human interferon $\alpha$A (code name: LBD-007) was evaluated in both sexes of ICR mice, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007 was not considered to induce any toxic effect on the mice in mortalities, clinical findigs, body weights and gross findings. It is suggested that LD$_{50}$ values in mice would be $>48{\times}10^8$ IU/kg in the oral, subcutaneous or intravenous routes.s.