• 한국실내디자인학회논문집
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• 제41호
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• pp.146-154
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• 2003

The purpose of this study is, According to society changing fast, human life is changing in the direction of complexity and variety, the middle class and multiple structure have been generated in relation between architecture and function. Accordingly, considering the analyzed elements of the main floor space planning and relation of the factors in space planning of Seoul s public libraries. The Public Library is variety of function is abstracted to the plan for Space Composition Form from future public library, analysis of “This point of user, how to composition is the space of different function” and “How to is the connection between the educational function and the other function, complexity of space.” With above distinctive themes and the research, the typology of public library in seoul city, At the first, the research shows that the public library is 8 type, and high in typology of “TYPE 7 (A3-B2-Cl)”. Secondary, There appears public library, such as in the satisfaction of the One-Function-User is high in “TYPE 3 (A1-B2-C3)”, in the satisfaction over the Two-Function-User is high in “TYPE 6 (A3-B1-C1)”

• 대한관절경학회지
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• 제1권1호
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• pp.1-8
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• 1997

The anterior cruciate ligament(ACL) is, perhaps, the most intriguing component of the knee joint. Initially referred to crucial ligament because of the cruciate or crossed arrangement or the anterior and posterior ligaments within the knee. the irony or the ACL being crucial to the well-being or the joint has only recently appreciated. The anterior cruciate ligament of human knee joint is a complex structure and its orientation, construct and biology arc directly related to the knee function as a constraint of knee joint motion. In addition to its functional role as a static stabilizer or the knee. the ACL has a unique neurovascular system. The vascular anatomy of the ACL plays a crucial role in the repair and reconstruction of the ligament, and the neuroreceptors found in its substance suggest a possible proprioceptive role for the ligament. The structural complexity of the ACL allows the ligament to function through the normal range of motion as a static stabilizer or the knee. hut it also makes the exact duplication of this structure very difficult. A comprehensive knowledge or the anatomy of the ACL can provide the orthopedic surgeon with a blueprint for the idealized repair and reconstruction of this most complex structure.

• Journal of Korean Neurosurgical Society
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• 제64권3호
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• pp.340-345
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• 2021

Humans do not have tails; however, a congenital anomaly named "human tail" has been recognized since old times. In contrast with its impactful name, the anomaly itself is not fatal, and thus it has not been considered as a clinically serious symptom. However, many case reports suggested that retention of "the tail" is closely associated with spinal cord malformation and should be treated with care by neurosurgeons. Therefore, this review summarizes our knowledge regarding the anatomy, function, and development of the tail as a general structure in mammals. Learning the basic knowledge regarding tail anatomy and development would help clinicians to understand the "human tail" more concisely and to select more appropriate examinations or treatments in relation to this congenital anomaly.

• 간호행정학회지
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• 제6권3호
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• pp.431-449
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• 2000

The purpose of this study is to contribute to a understanding the philosophical foundation of Parse's and Watson's theory of nursing. Parse's human becoming Research Methodology, Principle and main concepts are based on existential phenomenology. And Watson's theory of human care indicate that the optimal method for studying and inquiring theory of trans-personal caring is phenomenological-existential methodology. The chief theme of this study ist to illuminate how ideas and concepts of existential phenomenology are applied to Parse's and watson's theory of nursing. Content of this Study are summarized as follow; 1. Principles, concepts, theoretical structure of Man-Living-Health theory were investigated in Parse's theory of nursing as Human science. 2. Essential assumptions, chief concepts and methodology of human science and human care were investigated in Watson's theory of trans- personal caring. 3. Phenomenological analysis of "Human being" und poetic thinking of truth were described in the context of the Heidegger's fundamental ontology und existential phenomenology. 4. Meaning of existential subjectivity, freedom and choice war interpreted according to Sartre's existential philosophy 5. Phenomenological analysis of perception und function of body were investigated in the context of Merleauponty's existential phenomenology. 6. Ultimately this study provided how ideas and concepts of existential phenomenology war applied to Parse's und Watson's nursing theory und methodology.

• 복식
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• 제54권7호
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• pp.41-54
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• 2004

This study purposed to apply function form content, the three concepts that have been discussed by many philosophers since ancient times, to fashion design. Specific research goals are : first, to define fashion design based on the three concepts : and second, to examine how each of the three concepts function-oriented, form-oriented and content-oriented design have been expressed in women's fashion in the $20^{th} century. For these purposes. the author considered Morris' semiotics, which is the theoretical background of the three concepts, reviewed previous researches in design area, and applied the findings to fashion design. According to the result of applying the threefold structure of semiotics. which is the theoretical background of the three concepts, the pragmatic dimension of fashion design comprehends all functional rules related to the use of dress such as body motion and protection, health and safety. air flow and durability, and its syntactic dimension comprehend all the formal elements of visual design such as the structure, shape, line, color and material of dress. The semantic dimension of fashion design includes the symbolic meanings of dress expressed by emotion, sentiment and images. The three dimensions exist interdependently with one another. According to the result of considering the characteristics of the three concepts in the scope of women's fashion in the $20^{th} century. function-oriented design is characterized by practicality and simplicity, and has been expressed as the fashion of functionalism in the 1920s, that of minimalism in the 1960s, and the basic style from 1970s to 1980s, 1990s and the present. Form-oriented design has pursued aestheticism, putting stress upon form, and has been expressed with organic shapes imitating patterns found in nature in the 1950s and with optical art fashion in the 1960s. Content-oriented design attaches importance to transmission of delicate meanings related to the mental world of human beings, and is represented with symbolic forms. Such a characteristic has been expressed in fashion in the early 20th century influenced by surrealism and, with various types of design breaking established forms as well as metaphors and humors that characterize design in the late 20th century.

• 한국실내디자인학회논문집
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• 제20권3호
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• pp.127-134
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• 2011

Interior design has diverse functions and roles according to recent changes in life and cultural style. As the meaning of space varies, the furniture as another element of the space should also be planned and included in the beginning of the project to accomplish its functional role on the finished space and not only be placed. The relationship between Interior space and furniture should be studied and understood at the same realm because they have a complementary relationship. The final destination of design, which is very challenging to accommodate people, the designer needs to approach to the interior space and furniture in a cognitive view. The study of Semiotics views in a knowledgeable and epistemological way every element as a sign and by the relationship of their characters it makes to understand the structure of the signs. Charles Sanders Peirce, a leader of Semiotics in USA, classified the structure of Sign into Representamen, Object and Interpretant to complete the theory which could systematically describe physical characteristic and function of the Sign and its significance in practical use. Peirce stated that all nine types of Sign would be generated if each structure of Sign in combined with three categories of Sign such as Firstness, Secondness, and Thirdness. In this study, based on Peirce's nine types of Sign, the interrelationship between space and furniture in interior design was investigated with examples in Living Space, Office Space, and Commercial Space, respectively. In the category of Representamen, which can be classified into Qualisign, Sinsign, and Legisign, it is a feature of Living Space to be expressed in harmonized and stabilized ways. In Office Space vertical/horizontal elements and open expression are differently showed depending on fields. And splendid and interesting expressions are showed in Commercial Space. In the category of Object, which can be classified into Icon, Index, and Symbol, each function of Sign has distinctly been showed as Symbol in Living Space, Index in Office Space, and Icon in Commercial Space, respectively. In the category of Interpretant, which can be classified into Rheme, Dicisign, and Argument, it was found that space image of Living Space is transferred to human being, Office Space regulates human bing, and Commercial Space binds human being with the space. In conclusion the function of the interior space and the furniture could be explained in another way with re-interpretation of interrelationship among interior space elements in the concept of Semiotics. It is expected that interpretation with Semiotics in interior design will grow to new theory of design.

• IMMUNE NETWORK
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• 제2권3호
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• pp.150-157
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• 2002

Background: Although Tat plays a role as a potent transactivator in the viral gene expression from the Human Immunodeficiency Virus type 1 long terminal repeat (HIV-1 LTR), it does not function efficiently in rodent cells implying the absence of a human specific factor essential for Tat-medicated transactivation in rodent cells. In previous experiments, we demonstrated that one of chimeric forms of TAR (transacting responsive element) of HIV-1 LTR compensated the restriction in rodent cells. Methods: To characterize the nature of the compensation, we tested the effects of several upstream binding factors of HIV-1 LTR by simple substitution, and also examined the role of the configuration of the upstream binding factor(s) indirectly by constructing spacing mutants that contained insertions between Sp1 and TATA box on Tat-mediated transactivation. Results: Human Sp1 had no effect whereas its associated factors displayed differential effects in human and rodent cells. In addition, none of the spacing mutants tested overcame the restriction in rodent cells. Rather, when the secondary structure of the chimeric HIV-1 TAR construct was destroyed, the compensation in rodent cells was disappeared. Interestingly, the proper interaction between Sp1 and TATA box binding proteins, which is essential for Tat-dependent transcription, was dispensable in rodent cells. Conclusion: This result suggests that the human-specific Tat cofactor acts to allow Tat to interact effectively in a ribonucleoprotein complex that includes Tat, cellular factors, and TAR RNA, rather than be associated with the HIV-1 LTR upstream DNA binding factors.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
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• pp.26-51
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• 2003

Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.

• 혜화의학회지
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• 제21권1호
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• pp.23-31
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• 2012

Allopathic medicine has had a lot of limits though it has maintained the status of mainstream medicine, therefore these days there has been a growing interests in traditional medicine of East Asia. According to this trend, the integration between allopathic medicine and traditional medicine has become a hot issue and the need of mutual understanding on their physiology and pathology increases. However, understanding of traditional medical theory based on ying-yang, five phases, viscera and bowels is still difficult to be accepted to allopathic medical fields. Therefore, this research tried to investigate the similarity and differences of the structures between five viscera and organs. As a result, this research found that the investigation and understanding on viscera in traditional medicine or organs in allopathic medicine has in common in some degree. However, the integration and comparison between two medicines should be done cautiously because there still are the basal different points of understanding of human structure and function.

• 한국자기공명학회논문지
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• 제12권1호
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• pp.40-50
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• 2008

Ghrelin is a unique peptide hormone that releases growth factor and it stimulates appetite. It comes from pre pro-ghrelin by the post translational modification process and its innate functions are known as food up-take and the growth hormone regulation. Therefore, the structural information of ghrelin precursor is of importance in understanding it function. From our results, we found that the solution structure of ghrelin is mostly random coil conformation at neutral pH value and the structural population changes with pH environments. Data from circular dichroism in different TFE concentrations revealed that the secondary structure changes from random coil to a-helix and the isodichroic point is observed at 202nm, implying that two equilibrium states exist between random coil and helical structure.