• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.339-342
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• 2006

This study was designed to prepare an animal model for partial thickness bum wound which can be employed for testing topical therapy. We first evaluated whether rabbit ear and mouse back skin wound model could differentiate the wound healing process in terms of degree of re epithelialization, required days for complete wound closure, presence of scarring. $2^{nd}$ degree wet bum were prepared on mouse back skin and rabbit ear by applying 5 mL hot water($85{\pm}0.1^{\circ}C$) for 7 see followed by 5 mL ice-cold 0.5% acrynol solution for cooling and disinfecting the inflicted area. After removing the dead epidermis layer at 24 hr, tested dressings were applied for specified time and wound progression was investigated. In mouse model, wound contraction was the primary wound closing mechanism, which is quite different from human wound healing process. In rabbit ear model, epidermal regeneration was the major wound healing process rather than wound contraction and the difference in wound healing property among tested dressings could be clearly demonstrated. A rabbit ear model could differentiate the wound progression among open, occluded and epidermal growth factor(EGF) treated wound. Four sites of circular wound(diameter: 1 cm) on the anterior part of rabbit ear could be employed for the comparative wound healing study. For obtaining reproducible bum wound, degree of bum depth and bum sites should be carefully controlled in addition, employing rabbits of same strain and weight. The result suggests that rabbit ear could be employed as a reliable and human-resembled wound model.

• The Journal of the Korea institute of electronic communication sciences
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• v.5 no.3
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• pp.309-314
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• 2010

In this paper, an intelligent security camera over internet is proposed. Among ISC methods, watersheds based methods produce a good performance in segmentation accuracy. But traditional watershed transform has been suffered from over-segmentation due to small local minima included in gradient image that is input to the watershed transform. And a zone face candidates of detection using skin-color model. last step, face to check at face of candidate location using SVM method. It is extract of wavelet transform coefficient to the zone face candidated. Therefore, it is likely that it is applicable to read world problem, such as object tracking, surveillance, and human computer interface application etc.

• Journal of information and communication convergence engineering
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• v.7 no.2
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• pp.223-230
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• 2009

For pulse trigger way and the energy injection rate according to PET ($Pause^{10-90}$ $Energy^{20-40}$ $Trigger^{1-7}$) function, indeed, human body condition, period of dormancy in this research about this back correctly adjustment possible and designed harmless micro carrying along style hair exclusion so that can design and manufacture and run special quality examination and Xenon flash lamp to crawl in human body. Because creating individual's skin model to do stable treatment by light transmission way by skin impedance and measure, must embody treatment special quality of most suitable that draw skin color, energy, wave length, approximately, transmission time, pulse delay etc. and want. Specially, saved standard of war treatment pulse modeling by skin impedance, and manufacture pulse modeling system of most suitable by skin subordinate, and embody suitable treatment pulse. Specially, embody as could do root of a hair exclusion being emitted in pulse form using multi wave length of 560nm, 590nm, 640nm, 755nm and embodied clinical data. If become research repletion furthermore little more, is seen that can approximate in commercialization.

• Tribology and Lubricants
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• v.30 no.1
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• pp.36-45
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• 2014

Understanding steel/skin contact phenomena is important for the study of object manipulation in robotics and has been a topic of great interest. In this study, pig skin was taken as a surrogate model for human skin, and its adhesive, friction, and deformation behaviors were measured under various exposure times to air. Indentation, friction, and scratch tests were performed at $25^{\circ}C$ and 45% relative humidity. The influences of adhesion and deformation on the coefficient of friction were characterized; the pig skin was found to be sensitive to the sliding velocity and normal load under the controlled experimental conditions.

• Journal of Korean Institute of Industrial Engineers
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• v.12 no.2
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• pp.13-19
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• 1986

The purpose of this paper is to develop a 3-dimensional human model, an ergonomic CAD (Computer-Aided Design) system which would be very helphul in ergonomic design. An interactive program was developed, in which a user could change layout, body size, skin volume, and posture of the human model. As an example, effect of inclination of a steering wheel on visibility of a display panel was demonstrated. he result showed that ergonomic design can be aided by the 3-dimensional human model, and by the perspective graph by which design and evaluation process can be carried out more effectively.

• Korean Journal of Human Ecology
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• v.18 no.2
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• pp.501-507
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• 2009

Atopic dermatitis is one of the most common skin disease in children and a characteristic chronically recurrent form of dermatitis with a hereditary tendency, affecting infants and may extend to the childhood or th the adult age. Environmental factors, stress, and foodstuffs such as milk, egg may cause atopic dermatitis. Nc/Nga mice were used as an animal model for human atopic dermatitis. The divided by 4group such as normal group, BMAC group, FK506 group, MR group for this study raised in conventional conditions. To investigate effect of Chamomile German on atopic dermatitis in NC/Nga mice, the serum IgE and IgG1 level were measured while the severity degree of the skin lesion was examined by the naked eyes of two volunteers who were unaware of the treatment status. The results were the followings. 1. The score on the severity degree of skin dermatitis in FK 506 and MR group was lower than that in control group. 2. The serum IgE level in control group was higher 25% than that in normal group. 3. The serum level of IgE in FK506 and MR group compares to control group was decreased. 4. The serum IgG1 level was decreased more than 3.5 times in FK506 compared to control group while MR group had significantly less the serum IgG1 than control group. From the above results, treatment of Chamomile German oil had the effect on atopic dermatitis in NC/Nga mice. If scientific researches on aroma oil are performed in various way, aroma oil will be used to cure skin dermatitis as a alternative therapy in the future.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.214-216
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• 2006

Expressive face and human body gestures are among the main non-verbal communication channels in human-human interaction. Understanding human emotions through body gesture is one of the necessary skills both for humans and also for the computers to interact with their human counterparts. Gesture analysis is consisted of several processes such as detecting of hand, extracting feature, and recognizing emotions. Skin color information for tracking hand gesture is obtained from face detection region. We have revealed relationships between paricular body movements and specific emotions by using HMM(Hidden Markov Model) classifier. Performance evaluation of emotional human body recognition has experimented.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.27 no.2
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• pp.59-67
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• 2001

• Proceedings of the KAIS Fall Conference
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• 2012.05a
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• pp.182-186
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• 2012

human tyrosinase (hTyr) catalyzes first and the rate limiting step in the synthesis of polymerized pigment, melanin which determines skin, hair and eye colors. Mutation of hTyr often brings about decrease of melanin production and further albinism. Meanwhile, a number of cosmetic companies providing skincare products for woman in Asia-Pacific region have tried to develop inhibitors to bright skin color for several decades. In this study, we built a 3D structure by comparative modeling technique based on the crystal structure of tyrosinase from bacillus megaterium as a template to serve structural information of hTyr. According to our model and sequence analysis of type 3 copper protein family proteins, two copper atoms of active site located deep inside are coordinated with six strictly conserved histidine residues coming from four-helix-bundle. Cavity which accommodates substrates was like funnel shape of which entrance was wide and expose to solvent. In addition, protein-substrate and protein-inhibitor complex were modeled with the guide of van der waals surface generated by in house software. Our model suggested that only phenol group or its analogs can fill the binding site near nuclear copper center because inside of binding site has narrow shape relatively. In conclusion, the results of this study may provide helpful information for designing and screening new anti-melanogensis agents.

• Journal of Radiation Industry
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• v.17 no.4
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• pp.489-499
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• 2023

Isoegomaketone(IK), isolated from the radiation-induced mutant cultivar of Perilla frutescens var. crispa, is a major phytochemical compound that has attracted attention in pharmacological research. In this study, we demonstrated that IK exerts anti-inflammatory and protective effects on human mast cells and in an atopic dermatitis mouse model. IK inhibited tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and IL-8 expression in human mast cells (HMC-1) stimulated with phorbol myristate acetate(PMA) and calcium ionophore A23187 (PMACI). IK significantly reduced the PMACI-induced phosphorylation of ERK and JNK, but not p38. IK also inhibited the PMACI-induced phosphorylation of STAT1 and STAT3. Oral administration of IK in atopic dermatitis mouse model ameliorated skin inflammation severity, as measured by skin thickness and pro-inflammatory cytokine levels such as TNF-α, IL-8, IL-4, and IL-13. These results might suggest that IK is a potent therapeutic agent against skin inflammation and atopic dermatitis.