• Korean Institute of Interior Design Journal
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• 제18권4호
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• pp.31-42
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• 2009

Though Adolf Loos, an architect of 1920s said 'ornament is sin', feature of decoration has big gravity in modern architecture & its design trend. Embellishment as a new genre that combined new cultures, trends, and technologies is finally ascribing to skin design approach. For instance it is preference to rags, coarse fabric, external shape of fragments. Expressing surface as a ceremony in architecture or indoor design is also belong to the same category. In this respect, as a new approach on skin, the study focuses on visual and spatial changes that stimulate user's sensibilities consequently since skin design is based on human senses and sensibilities. As skin design expands the scope of human experiences comprehensively, and classify boundaries between internal parts and external parts or make them ambiguous, aesthetic embodiment on new trends is getting done. Through skins on buildings, a message is transmitted to a whole city, an opportunity for the city to be expanded into a new space is created, and human senses are stimulated through refusing a traditional sides by rediscovering decorations in space design and adapting the sides made in limitlessly-expressed styles. Thus, as a new approach on the skins that transmit a message through human senses, the study is to contemplate skin design, and to interpret them as works to eliminate boundaries among architecture, fashion, interior/exterior space design(especially exhibition and international fair)following their suits. Through interpreting this subject, the study is to understand and analyze comtemporary expansion situation on interactions among fashion and architecture, and interior design.

• Journal of Pharmaceutical Investigation
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• 제24권3호spc1호
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• pp.41-47
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• 1994

The effect of Azone and ethanol on the electrical properties of human and hairless mouse skin was studied and the results were compared. The complex electrical impedance was measured as a function of frequency, and resistance and capacitance were determined from Nyquist plot. After the treatment of human-heat separated epidermis with Azone, contrary to the expectation, resistance increased about 60% and it did not change with time. Capacitance also increased; immediately after the treatment, it was about 110% of pretreatment value and it increased further with time. On the other hand, when hairless mouse skin was treated with Azone, marked changes occured; resistance fell almost to the value of bathing medium itself and capacitance increased to about 200% of its pretreatment value. Similar result were obtained when hairless mouse skin was treated with 100% ethanol. The results suggest that there are differences in the strength of barrier properties of stratum corneum (SC) between human and hairless mouse skin. Overall, the results provide further mechanistic insight into ion conduction through the skin and into the role of SC lipids in skin capacitance.

• Archives of Pharmacal Research
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• 제20권1호
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• pp.34-38
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• 1997

Recombinant human epidermal growth factor (rhEGF), a polypeptide of 53 amino acid residues, is subject to degradation by numerous enzymes, especially proteases, when it is applied on the skin for the treatment of open wound. Amastatin, aprotinin, bestatin, EDTA, EGTA, gabexate, gentamicin, leupeptin, and TPCK were investigated for the possible protease inhibitors, which may use to protect rhEGF from degradation by the enzymes in the skin. Skin homogenates containing protease inhibitors and rhEGF were incubated at $37^{\circ}C$ for 30 minutes. After the reaction was stopped with trifluoroacetic acid, the amount of rhEGF remaining in the sample was determined with an HPLC method. The percentages of rhEGF degraded, at the skin/PBS ratio of 0.25, in the mouse, rat, and human skin homogenate were 85%, 70%, and 46%, respectively. The degree of degradation of rhEGF in the cytosolic fraction was higher than that in the membrane fraction and these enzyme reactions were completed in 30 minutes. Bestatin, EGTA, and TPCK showed significant inhibitory effects on the degradation of rhEGF in the two fractions (p<0.05), while the other protease inhibitors had no significant inhibitory effects or, even resulted in deleterious effects. Therefore, the formulation containing one or several inhibitors among these effective inhibitors would be a promising topical preparation of rhEGF for the treatment of open wound.

• Tribology and Lubricants
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• 제29권3호
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• pp.167-170
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• 2013

The friction behavior of human skin is determined by the complex interplay of the material and surface properties of the skin, as well as the contacting material, and strongly depends on the contact parameters (e.g., pressure and sliding velocity) and the presence of substances such as water, sweat, or skin surface lipids at the interface. Including a study on the effect of a surface's physical roughness for skin sliding over the surface, various studies have been conducted to understand human tactile sensibility. However, to investigate products in relation to human tactile sensibility, more objective research is needed. This study performed sliding experiments between the skin and the surfaces of phone cases to understand how the texture, friction, and stick-slip characteristics are related. Eight phone case surfaces with different topologies and chemical (or mechanical) compatibilities with skin were prepared and tested multiple times.

• Korean Journal of Medicinal Crop Science
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• 제17권5호
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• pp.321-327
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• 2009

Sunlight, and in particular its UV component, is the major environmental trigger that underlies the major signs of human skin and skin cancer in general. Therefore, this study was carried out to investigate the UV protection effects of R. coreanus. R. coreanus was extracted by ultra high pressure extraction process at 500 MPa and $30^{\circ}C$ for 5 and 15 minutes. The cytotoxicity of the extracts extracted by ultra high pressure process on human dermal fibroblast cell CCD-986sk, human kidney normal cell HEK293, and human lung normal cell HEL299 was measured as 17.5%, 16.5% and 14.0%, respectively in adding $1.0\;mg/m{\ell}$ of the samples, which was much lower than that from conventional water extraction method at $100^{\circ}C$ as 23.2%, 22.5%, 21.2%. The secretion of $NO^-$ from macrophage showed $15.9\;{\mu}M$ on the R. coreanus extract from this process, which was higher than others. Prostaglandin $E_2$ ($PGE_2$) production from UV-induced human skin cells was also greatly decreased down to $510\;pg/m{\ell}$, compared to the control. From the results, we considered that the extracts from R. coreanus could be potent natural materials for skin anti-inflammation agent, and could be used as a potential anti-aging for the photo-damaged skin.

• Transactions of the Korean Society of Mechanical Engineers B
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• 제39권2호
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• pp.147-152
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• 2015

We designed, fabricated, and tested the capacitive microsensors for skin piloerection monitoring. The performance of the skin piloerection monitoring sensor was characterized using the artificial bump, representing human skin goosebump; thus, resulting in the sensitivity of $-0.00252%/{\mu}m$ and the nonlinearity of 25.9 % for the artificial goosebump deformation in the range of $0{\sim}326{\mu}m$. We also verified two successive human skin piloerection having 3.5 s duration on the subject's dorsal forearms, thus resulting in the capacitance change of -6.2 fF and -9.2 fF compared to the initial condition, corresponding to the piloerection intensity of $145{\mu}m$ and $194{\mu}m$, respectively. It was demonstrated experimentally that the proposed sensor is capable to measure the human skin piloerection objectively and quantitatively, thereby suggesting the quantitative evaluation method of the qualitative human emotional state for cognitive human-machine interfaces applications.

• Korean Journal of Pharmacognosy
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• 제48권3호
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• pp.202-207
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• 2017

The purpose of this study was to investigate the skin irritation of bee venom (melittin) in human. Skin irritation test was performed at 0.05% bee venom by 48 h single patch test in 30 healthy volunteers with no skin disease and skin sensitization test was performed by local lymph node assay in animal. In single patch test, 28 human subjects showed no reaction and 2 subjects showed 1+ or 3+ grade skin reaction. In a skin sensitization test of bee venom conducted using mice. no erythema was observed on the dorsal side of mice up to 8 days after application of bee venom on the skin. The results of the average stimulation index by ATP values showed that there was no irritation to the mice skin at 0.005% and 0.01% of bee venom. Therefore, bee venom is not likely to induce a significant skin irritation under 0.05% concentration.

• Journal of the Korean Society of Industry Convergence
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• 제3권4호
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• pp.307-317
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• 2000

The purpose of this study is to form a calculation formula of the mean skin temperature on the human body in a heated room by the use of floor heating system. Korean traditional floor heating system is a long way from being defunct. The floor heating systems based on hot water have been coming into wide use mainly in the apartment house. However, it is considered that the design process and evaluation method for the floor heating systems in the standpoint of human being are not established so far. In the floor heating systems, air temperature as well as floor temperature should be considered as physical factors which affect the sensation of human body. Furthermore, extremely few studies have been performed on the sitting with legs crossed posture sedentary which is the typical dwelling life style of residents from the ancient times in Korea, while a large number of studies on the influence of the floor heating systems on the human body in standing and sitting on a chair sedentary have been carried out. Especially, it is essential to elucidate how mean skin temperature on the human body is affected by thermal conduction in the contact area between the sitting with legs crossed posture sedentary human body and floor including thermal radiation due to the combination of air temperature and floor temperature, but the studies dealt with such issues have hardly been performed. Based on the above statements, the influence of the environment condition due to the combination of air temperature and floor temperature is discussed in the present investigation through theoretical of mean skin temperature on the human body in the floor heating systems.

• Journal of Information Processing Systems
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• 제10권2호
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• pp.283-299
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• 2014

Skin detection is used in many applications, such as face recognition, hand tracking, and human-computer interaction. There are many skin color detection algorithms that are used to extract human skin color regions that are based on the thresholding technique since it is simple and fast for computation. The efficiency of each color space depends on its robustness to the change in lighting and the ability to distinguish skin color pixels in images that have a complex background. For more accurate skin detection, we are proposing a new threshold based on RGB and YUV color spaces. The proposed approach starts by converting the RGB color space to the YUV color model. Then it separates the Y channel, which represents the intensity of the color model from the U and V channels to eliminate the effects of luminance. After that the threshold values are selected based on the testing of the boundary of skin colors with the help of the color histogram. Finally, the threshold was applied to the input image to extract skin parts. The detected skin regions were quantitatively compared to the actual skin parts in the input images to measure the accuracy and to compare the results of our threshold to the results of other's thresholds to prove the efficiency of our approach. The results of the experiment show that the proposed threshold is more robust in terms of dealing with the complex background and light conditions than others.

• Journal of Ginseng Research
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• 제44권3호
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• pp.496-505
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• 2020

Background: Panax ginseng is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means "cure for all". Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation. Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extract in vitro and HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG in vivo. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin. Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In the in vivo experiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone. Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.