• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2007년도 동계학술발표대회 논문집
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• pp.23-28
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• 2007

In most existing research, it is difficult to evaluate thermal comfort exactly because of reflecting individual ideal or psychological response by subjective questions. Physiological variable was selected in this study to evaluate objectively thermal comfort. MST was appeared very sensitively in indoor temperature and can express correctly thermal comfort of human body. The results of CSV are different each individual feeling sensation, so is difficult to evaluate detailedly thermal comfort unlike TSV. But the results of PP, AIx, ED, SEVR are greatly related to temperature change. So thermal comfort is evaluated more objectively by using PP, AIx, ED, SEVR on behalf of TSV, CSV. Human body was presented physiological feedback by temperature impetus and specially, tendency of heart rate agree with temperature change. Physiological reaction was showed sufficient possibility availing evaluation index of thermal comfort. In the future another one needs to review beside the selected physiological variable.

• 대한인간공학회지
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• 제17권3호
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• pp.13-22
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• 1998

Aircraft and the three-dimensional environment in which they operate are not user-friendly for human beings. As a result, maintaining the proficiencies necessary to safely and efficiently fly an airplane are difficult, and costly. The physiological and emotional status of the human element remains crucial in maintaining safe performance by all crew members. In the study of Hagiwara et al.(1993). they called the physiological and emotional status of the human element into the human alertness or physiological activity and stress, fatigue, circadian rhythm, alcohol. smoking, and self-medication are known the major factors that deteriorate the human alertness. Accordingly. this paper deals with the quantitative and objective performance test based on tracking error and reaction time by means of the new computer test program into which the perception-motion system of human beings is applied. Throughout this experiment using performance test, the results suggest that performance capability in state of sleep deprivation 2 hours and alcoholic 0.05~0.06% in blood were more impaired than one in a normal state, and they further showed statistically significant differences between them, which were influenced by impairment factors of body regulation and pilot's grade. We also obtained the prediction value and the 95% confidence interval of tracking error and reaction time at the normal state for the purpose of distinguishing performance capability between the normal state and the abnormal state. And it is expected that the evaluation of human alertness using performance test will be applied to the quantitative assessment of an each pilot's realistic consciousness/attention, and will lead a flight commander to the accurate decision of mission approval prior to a flight.

• Archives of Pharmacal Research
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• 제16권1호
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• pp.1-5
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• 1993

The reaction of sulfhydryl groups in human serum ablumin with bacteriostatic and hypotensive notrosating agents such as sodium nitorprusside and sodium nitrite has been examined. The low reactivity of sodium nitroprusside to sulfhydral groups in albumin has been observed and the sterical inaccessilibility of the agent site which sulfhydryl group resides was implicated. The reaction of sodium nitrite with albumin was highly influenced by pH and little reactivity was observed at physiological pH. On the other hand, the reaction between albumin and S-nitrosoglutatione, an intermediate induced from the reaction of glutathione and nitrosating agents, resulted in the rapid decrease of free sulfhydryl groups in albumin. S-Nitrosylation of the sulfhydryl group by S-nitrosoglutathione and the subsequent production of mixed disulfide is the probable route of modification. In the physiological system, S-nitroso-glutathione may act as an active intermediate in expressing reacivity of nitrosating agents to sulfhydryl groups in albumin.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1998년도 춘계학술대회논문집
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• pp.167-172
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• 1998

Methods of evaluating the physiological activity of the living body are EEG, EOG, Heart rate, and Rectal temperature, etc. In the study of Hagiwara and Araki(1993), they found positive correlations among performance test, physiological measurement, and subjective feeling measurement. Human alertness of pilot directly influences on the flight performance that accomplishes a lot of vigilance task and procedure execution in flight. Accordingly, this paper deals with the quantitative and objective performance test based on tracking error and reaction time by means of the new computer test program into which the perception-motion system of human beings is applies. Throughout this experiment using performance thst, the results suggest that performance capability in state of sleep deprivation 2 hours and alcoholic 0.05 .apaprox. 0.06% in blood were more impaired than one in a normal state, and they further showed statistically significant differences between them, which were influenced by impairment factors of body regulation and pilot's grade. We also obtained the prediction value and the 95% confidence interval of tracking error and reaction time at the normal state for the purpose of distinguishing performance capability between the normal state and the abnormal state. And it is ecpected that the evaluation of human alertness using performance test will be applied to the quantitative assessment of an each pilot's realistic consciousness/attention, and will lead a flight commander to the accurate decision of mission approval prior to a flight.

• 한국산업융합학회 논문집
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• 제25권1호
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• pp.101-110
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• 2022

For this purpose, the authors proposed and proved usefulness of the modified mean skin temperature which is integrated mean radiation temperature and the effect of floor contacted heat conduction. The mean radiation temperature is applied form factor between half cross-legged human body and surrounding wall of indoor. In addition the floor contacted heat conduction is applied heat transfer coefficient of half cross-legged human body. Eight Korean young men were targeted for the experiment. From the experiment the authors excerpted physiological reaction and psychological reaction in Ondol environment which is combined physiccal environmental factor of artificial climate chamber, air and floor temperature. As a result of the experiment it is confirmed that heat conduction has more impact than heat exchange from existing research for the heat exchange between half cross-legged human body and surrounding wall in Ondol thermal environment. Thereby, it is proved the effectiveness of the modified mean skin temperature which is added floor contacted temperature to the Ondol thermal environmental evaluation index.

• 동의생리병리학회지
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• 제18권6호
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• pp.1896-1903
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• 2004

Anglicae dahuricae Radix (ADR), the dried roots of Angelica Dahurica Benth et Hook (Umbelliferae), is a traditional herbal medicine used to treat colds, headache, skin diseases such as acne and possess analgesic, antipyretic and drainage effects. In the present study, the author evaluated the effect of ADR on regulation of inflammatory reaction. ADR reduced the ear-swelling responses derived from compound 48/80 in dose-dependent manner significantly. ADR inhibited the PMA plus A23187-induced productions of IL (Interleukin)-8, IL-1β, granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-α from human mast cells (HMC)-1. In addition, ADR blocked PMA plus A23187-induced ERK1/2 phosphorylation. Ⅰ suggest that ADR regulates inflammatory reaction through inhibition of inflammatory cytokines such as IL-8, IL-1β and GM-CSF.

• 한국조경학회지
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• 제43권3호
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• pp.43-51
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• 2015

삭막한 도시환경으로부터 오는 스트레스는 도시민들에게 다양한 질병을 발생시키거나 건강을 악화시키는 반면, 자연은 인간에게 긍정적인 치유효과를 준다. 자연을 통한 치유프로그램은 활동공간의 특성에 따라 숲치유와 원예치료로 구분할 수 있다. 그러나 치유프로그램에 대한 연구는 독립적으로 이루어져 다양한 프로그램의 적용과 연계에 따른 효과를 파악하는데 한계가 있다. 따라서 본 연구는 숲치유와 원예치료의 생리적 심리적 효과를 비교 분석하여 각 프로그램의 효과와 차이점을 밝혀 향후 치유프로그램 개발과 치유공간 설계의 기초자료를 제공하고자 한다. 실험은 숲치유 5명, 원예치료 5명의 피험자를 대상으로 5일간의 프로그램에 대한 사전사후검사를 실시하였다. 생리적 반응은 혈압, 맥박, 코티솔 변화량으로 측정하였고, 심리적 반응은 기분상태검사로 측정하였다. 분석방법은 통계프로그램 SPSS 18.0 for windows의 분산분석(ANOVA)과 대응표본 T-test를 실시하였다. 연구결과, 1) 숲치유와 원예치료는 생리적, 심리적으로 모두 긍정적 효과를 보이며, 2) 숲치유는 원예치료보다 생리적 이완과 스트레스 감소에 더 효과적이고, 3) 원예치료는 숲치유보다 우울감 감소에 더 효과적인 경향이 있는 것으로 나타났다. 위 결과는 각 치유프로그램의 특징을 파악함으로써, 향후 치유프로그램 개발과 치유공간 설계를 위한 기초자료와 지침 설정에 도움이 될 것으로 기대한다.

• 대한인간공학회지
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• 제4권2호
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• pp.17-24
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• 1985

To compare heart rate, $O_2$ uptake, $Vo_2$ ($O_2$ consumption), blood pressure (systolic, diastolic), reaction time, stability, flicker fusion value during 4 load levels with Rs (self-paced respiration) and Rp (paced respiration), 4 subjects participated in this experiment 1 hour/day, 6 days/week for 9 weeks. The cycle of Rp is 6 sec. (inspiration: 3 sec. & expiration: 3 sec.) Implications of the results are discussed in terms of the change in the physiological responses and human performance by the respiratory pattern. The results are as follows, 1. The changing magnitude of heart rate with Rp was larger than with Rs and the variance during load level 4 was significant. 2. The $Vo_2$ with Rp was smaller than with Rs and maximal $O_2$ uptake given load levels with Rp occurred and for two subjects, it significantly moved from low load level to high load level. 3. The changing magnitude of blood pressure was not consistent but the systolic pressure with Rp was smaller at rest than with Rs. 4. The score of reaction time test and stability test with Rp was better than with Rs.

• 동의생리병리학회지
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• 제16권5호
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• pp.932-937
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• 2002

The purpose of this research was to investigate the effect of Yonggak-san (YGS) on the immune reaction and apoptosis of leukemia cells. Administration of YGS(500 mg/kg) enhanced proliferation of splenocytes, thymocytes and mesenteric lymph node cells, and also YGS accelerated subpopulation of splenic Band T, thymic T and mesenteric lymph node-T lymphocytes, especially significantly increased CD4+-TH cells in BALB/c mice. YGS accelerated phagocytic activity and production of nitric oxide in peritoneal macrophages. YGS induced apoptosis of transplanted-L1210 cells in vivo, increased apoptotic cell death of cultured-L1210 and/or Molt4 human leukemia cells, decreased of mitochondrial transmembrane potential of both cells in vitro. These results suggest that YGS have an immune-regulatory effect and anti-cancer property.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.426-429
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• 1997

This paper describes the relationship among physiological, behavioral signal, and subjective evaluation depending on arousal level. Nz and reaction time hall similar pattern with KSS level, but eyeblink rate was different from these two parameters. Eyeblink rate increased slowly from KSS level 1 to 5, and had high increasing rate at KSS 7. But it showed steep descent at KSS level 9. From the result of reaction time test, since human performance was decreased rapidly above the KSS level 5, it is desirable to give a subject some stimulus such as sound or aroma to rise arousal level above the KSS level 3.