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Effect of Yonggak-san on the Immuno-regulatory and Apoptosis of Leukemia cells  

Oh Chan Ha (Division of Biotechnology, Woosuk University)
Kwon Jin (Department of Health Administration. Kunjang College)
Lee Kwang Gyu (College of Oriental Medicine. Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.16, no.5, 2002 , pp. 932-937 More about this Journal
Abstract
The purpose of this research was to investigate the effect of Yonggak-san (YGS) on the immune reaction and apoptosis of leukemia cells. Administration of YGS(500 mg/kg) enhanced proliferation of splenocytes, thymocytes and mesenteric lymph node cells, and also YGS accelerated subpopulation of splenic Band T, thymic T and mesenteric lymph node-T lymphocytes, especially significantly increased CD4+-TH cells in BALB/c mice. YGS accelerated phagocytic activity and production of nitric oxide in peritoneal macrophages. YGS induced apoptosis of transplanted-L1210 cells in vivo, increased apoptotic cell death of cultured-L1210 and/or Molt4 human leukemia cells, decreased of mitochondrial transmembrane potential of both cells in vitro. These results suggest that YGS have an immune-regulatory effect and anti-cancer property.
Keywords
Yonggak-san(龍角散); Immune reaction; apoptosis; leukemia cells; phagocytic activity;
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