• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.27-34
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• 2003

I studied connection between meridians and Dianxian(癲癎, Epilepsy). Dianxian is caused by Feun(風) based on the Blood-Deficiency(血虛) which is induced by Heart-deficiency(心虛). Therefore, when Heart and blood are in deficient condition(心血虛), Heart meridian(心經) and Pericardium meridian(心包經) can be easily affected by Feng(風), which is main cause of Dianxian. Furthermore, Liver heat(肝熱) is another main cause of Dianxian. It shows along Liver meridian(肝經) and affects Pericardium Meridian(心包經). Heart, Pericardium and Liver are main organs of human psychoconscious activities, and also are main pathological organs of Dianxian. Dianxian progresses in several ways and simtoms of Dianxian are variant according to the deficiency-exess state(虛實) of Stomach and Spleen meridians(脾胃經). So, I concluded that controling Heart, Pericardium, Liver, Stomach and Spleen meridians can make therapeutical effects on Dianxian. So I report it for the better treatment, and it shoud need further study.

• Journal of Gastric Cancer
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• v.15 no.2
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• pp.139-142
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• 2015

Hepatic metastasis of early gastric cancer (EGC) following subtotal gastrectomy with lymphadenectomy is rare. We report the case of a 61-year-old male patient who was diagnosed with EGC that was initially treated using endoscopic submucosal dissection (ESD) and subsequently underwent laparoscopic subtotal gastrectomy. Histopathological examination of the patient's ESD specimen showed a moderately differentiated tubular adenocarcinoma invading the submucosa without lymphatic invasion. The deep margin of the specimen was positive for adenocarcinoma, and he subsequently underwent laparoscopic distal gastrectomy. The patient developed liver metastasis 15 months after the operation and then underwent liver resection. Histology of the resected specimen confirmed the diagnosis of two foci of metastatic adenocarcinoma originating from stomach cancer. Immunohistochemical analysis of the specimen demonstrated overexpression of human epidermal growth factor receptor 2. The patient was treated with trastuzumab in combination with chemotherapy consisting of capecitabine and cisplatin. Twenty-four months after the operation, the patient remained free of recurrence.

• The Korea Journal of Herbology
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• v.23 no.2
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• pp.67-79
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• 2008

Objectives : The author studied on criterions and concepts of the four seasons, and also examined about outbreak, rise and decline, remedy and prescription of diseases. Methods : We researched that increase and decrease of vigor and up and down of Yin and Yang in human body are controled by sunlight through the literature. Results : The relationship between the human's five viscera and four seasons has the homeostasis as a result of the compatibility and rivalry process. Between of the human's five viscera and four seasons, the spleen plays important role of four seasons. The reason is that the liver, the heart, the lungs and the kidneys manages the 72 days in spring, summer, autumn and winter, repectively. However, the spleen arranges and regulates the liver, the heart, the lungs and the kidneys through the 18days of each season's ending, respectively. These are the basis of Lee Dong Won's(李東垣) 'The Spleen Strength Theory(補脾論). In four seasons, We make prescription harmonized with the energy such as rising in spring, floating in summer, astriction in autumn, preservation in winter. Conclusions : These results suggest that the criterion and the conception of the four seasons may be important role to remedy for diseases and to prescribe and to use of medicine.

• Molecules and Cells
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• v.44 no.11
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• pp.851-860
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• 2021

Label-free optical diffraction tomography (ODT), an imaging technology that does not require fluorescent labeling or other pre-processing, can overcome the limitations of conventional cell imaging technologies, such as fluorescence and electron microscopy. In this study, we used ODT to characterize the cellular organelles of three different stem cells-namely, human liver derived stem cell, human umbilical cord matrix derived mesenchymal stem cell, and human induced pluripotent stem cell-based on their refractive index and volume of organelles. The physical property of each stem cell was compared with that of fibroblast. Based on our findings, the characteristic physical properties of specific stem cells can be quantitatively distinguished based on their refractive index and volume of cellular organelles. Altogether, the method employed herein could aid in the distinction of living stem cells from normal cells without the use of fluorescence or specific biomarkers.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.217-226
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• 2007

1. Objectives The purpose of this study was to evaluate whether use of Yeoldahanso-tang(熱多寒少湯) may injure the liver function. We clinically studied the change of liver function rest in patients who were admitted in Dongseo Oriental Medical Hospital. 2. Methods We analyzed rhe serum alkaline phosphatase(AIP), aspartate aminotransferase(AST), alanine aminotransferase(ALT), ${\gamma}$-glutamyl transpeptidase(${\gamma}$-GT), total bilirubin of 25 patients from 1st. July. 2004 to 15th. October. 2007 admitted in Dongseo Oriental Medical Hospital. Liver function test were done on admission and before discharge. 3. Results For most patients, the values of AIP, AST, ALT, ${\gamma}$-GT and total bilirubin were within normal range or decreased. 4. Conclusions This study suggests that Yeoldahanso-tang(熱多寒少湯) does not injure liver function of human.

• Environmental Mutagens and Carcinogens
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• v.26 no.2
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• pp.35-40
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• 2006

Background: Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Inorganic arsenic induces a spectrum of tumors including hepatocellular carcinoma in mice. Methods: Pregnant C3H mice were supplied with drinking water containing 50 ppm sodium arsenite during their pregnancy. The protein expression profile in the liver of 0.5-day-old. male offsprings exposed transplacentally to sodium arsenite was analyzed using protein 2D gel electrophoresis followed by mass spectrometry (MALDI-TOF). Results: Expression of proteins such as hydroxymethylglutaryl-CoA synthase mitochondrial precursor (HMG-CoA synthase), ${\beta}$-actin (cytoplasmic 1) and apolipoprotein A-IV precursor (Apo-AIV) were induced in mouse liver by sodium arsenite, while uricase (urate oxidase), guanine nucleotidebinding protein beta subunit 2-like 1 (RACK1) and fructose-bisphosphate aldolase B (Aldolase 2) were down-regulated. Summary: Expression of proteins that have been implicated in carcinogenesis, such as HMG-CoA, ${\beta}$-actin, and RACK1, was regulated in the liver of mice transplacentally exposed to inorganic arsenic.

• Toxicological Research
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• v.11 no.2
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• pp.267-271
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• 1995

A single large dose of ethanol as well as chronic ethanol consumption produces alcoholic fatty liver in human and experimental animals. We examined the effects of YH439, a potential hepatoprotective agent, on alcoholic fatty liver generation in adult female rats. In rats treated with YH439 (250 mg/kg, po) 4 hr prior to a single dose of ethanol (6 g/kg, po), a significant decrease in hepatic triglyceride accumulation was observed. YH439 also has an inhibitory effect on hepatic triglyceride and cholesterol accumulation induced by repeated ethanol treatments for one week. Because it has been known that induction of alcoholic fatty liver is associated with lipid peroxidation and/or hepatic glutathione depression, the effect of YH439 on these parameters was determined in the livers of rats treated with ethanol. Coadministration with YH439 inhibited MDA formation and gIutathione depression induced by acute or repeated ethanol administration. In order to determine the effect of YH439 on ethanol metabolism in vivo, disappearance of ethanol from blood was measured. In rats treated with a single dose of ethanol (6 g/kg, po), the ethanol concentration in blood reached a peak approximately 120 min following the treatment which declined linearly for 18 hrs. YH439 had no effect on the decline of blood ethanol concentration regardless of the dose of ethanol given to rats. These results in this study suggest that YH439 has an inhibitory effect on fatty liver generation induced by acute or repeated ethanol consumption through a mechanism not directly related to the rate of ethanol metabolism in vivo.

• Parasites, Hosts and Diseases
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• v.46 no.3
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• pp.139-143
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• 2008

Ingestion of raw animal liver has been suggested as a possible mode of infection of human toxocariasis, We evaluated the relationship between toxocariasis and the ingestion of raw meat in patients with eosinophilia of unknown etiology. The study population consisted of 120 patients presenting with peripheral blood eosinophilia (> $500\;cells/{\mu}l$ or > 10% of the white blood cell count). They were divided into 2 groups: 104 seropositive patients based on a Toxocara excretory-secretory IgG ELISA and 16 seronegative patients. While 25.0% of seronegative patients had a recent history of eating raw cow liver, 87.5% of seropositive patients had this history. Multivariate statistical analysis showed that a recent history of eating raw cow liver was related to an increased risk of toxocariasis. Collectively, it is proposed that raw cow liver is a significant infection source of toxocariasis in the patients with eosinophilia of unknown etiology.

• The Journal of the Society of Stroke on Korean Medicine
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• v.10 no.1
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• pp.27-32
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• 2009

Object : The purpose of this study was to evaluate whether herbal medication may injure the liver function and kidney function in stroke patients. Method : We observed the serum AST, ALT, r-GTP, Creatinine, BUN of 78 patient from May 1. 2008 to June 30. 2009 admitted in Oriental Hospital of Daejeon University. Liver function and Kidney function tests were done on admission and before discharge. And all patients take herbal medicine with Western medicine. Result : AST, ALT, r-GTP, Creatinine, BUN decreased on discharge compared with the value on admission. The liver function and kidney function test score(AST, ALT, r-GTP, Creatinine, BUN) by administration period of herbal medication was not significantly changed. Conclusion : This study suggests that general herbal medication does not injure liver function and kidney function of human.

• Reproductive and Developmental Biology
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• v.31 no.3
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• pp.145-152
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• 2007

Transgenic mice were generated by microinjecting a plasmid DNA containing the SV40 (simian virus 40) large T antigen (Tag) gene fused with mouse albumin promoter/enhancer sequences into fertilized one-cell mouse embryos. Among eleven founder transgenic animals, four developed hepatocellular carcinoma, two showed kidney cancer and one developed skin and brain tumors. Three stable transgenic lines, #1-2, #1-6 and #1-11 were established. Members of the lines #1-6 and #1-11 reproducibly developed liver tumors by 8 to 10 weeks of age but did not exhibit any phenotypic changes in other tissues. Histological changes loading to liver tumor formation occurred with predictable kinetics and could be classified into three distinct stages; (a) newborn to 3 weeks of age, characterized by hyperplastic hepatocytes with reduced amounts of cytoplasm without any nuclear alterations, (b) between 4 to 8 weeks of age, characterized by diffuse liver cell dysplasia without observable tumor nodules, and (c) 9 weeks of age and thereafter, characterized by hepatocellular carcinomas in the background of extensive liver dysplasia. Metastasis to the lung from a liver carcinoma was observed in #1-11 founder animal. This transgenic mouse system displays similarities with human liver cancers in a number of aspects and provides a useful model for the study of molecular events involved in hepatocarcinogenesis.