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Chang, Shu-Han;Ho, Hui-Yu;Zang, Chi-Zong;Hsu, Ya-Hui;Lin, Mei-Chih;Tseng, Su-Hsiang;Wang, Der-Yuan
- Mass Spectrometry Letters
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- v.12 no.2
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- pp.31-40
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- 2021
Probable human carcinogenic compounds nitrosamines, have been detected as by-product impurities in sartan pharmaceuticals in recent years which has drawn worries for medication safety. To provide a sensitive and effective method for the quality control of sartan pharmaceuticals, this study established a feasible gas chromatography-tandem mass spectrometry (GC-MS/MS) method for simultaneous determination of 13 nitrosamines. The target analytes were separated on a DB-WAX Ultra Inert column (30 m × 0.25 mm; i.d., 0.25 ㎛) and were then subjected to electron impact ionization in multiple reaction monitoring mode. The established method was validated and further employed to analyze authentic samples. Limits of detection (LODs) and limits of quantification (LOQs) of the 13 nitrosamines were 15-250 ng/g and 50-250 ng/g, respectively, which also exhibited intra-day and inter-day accuracies of 91.4-104.8%, thereby satisfying validation criteria. Five nitrosamines, viz., N-nitrosodiethylamine, N-nitrosodimethylamine, N-nitrosodiphenylamine, N-nitrosomorpholine, and N-nitrosopiperidine were detected at concentrations above their LODs in 68 positive samples out of 594 authentic samples from seven sartans.
https://doi.org/10.5478/MSL.2021.12.2.31 인용 PDF KSCI HTML

Jeon, Sun-Young;Youn, Jung-Hye;Ahn, Jeong-Sun
- Korean Journal of Social Welfare
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- v.63 no.1
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- pp.291-316
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- 2011
The purpose of this study is to find out the right strategies for social welfare education and the efficient human resource management of public social workers. Not to make any flaws when looking for the appropriate strategies, this report studies how outcomes of social welfare education influences the performances of public social workers and how the empowerment is connected to the relationship between the social welfare education and the performances of public social workers. For clearer study, a survey was conducted for 396 public social workers and the Structural Equation Model by AMOS was used to analyze the outcome. According to the result, the Fitness Index of the Casual Model, proposed by this study, was similarly matched with that of theological model. The Casual Model proved that it explains the connection between social welfare education, job performance and empowerment. Hence, to improve performance of public social workers, various education and training policies for human resources management are needed and basically associates related social welfare education should do their effort. Also to enhance empowerment of public social workers, various measures are needed.
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Lee, Hye-Won;Lee, Hyang-Lan;Yoo, Jung-Eun;Lee, Sang-Ae;Jang, Hye-Young
- Korean Journal of Social Welfare
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- v.62 no.4
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- pp.149-170
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- 2010
The purpose of this study to develop a human rights education program for improving human rights sensitivity of the teachers in community child center, and verify its effectiveness. For this purpose, pre-program and post-program analysis was conducted by using human rights sensitivity scale on 102 teachers working in community child center. The major results of this study is as follows: First, the teachers' human rights sensitivity was statistically improved. Second, the teachers' ability of situation perception, ability of consequence perception, and ability of consequence perception were statistically improved. Third, the teachers' human rights sensitivity on "the right not to be arrested illegally", "physical liberty of the disabled", "the right to labor by migrant workers", and "freedom from detention" was statistically improved. Based on the research results, practical implications and limitations were discussed for developing human rights education program.
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